Nuclear factor, erythroid-derived 2, like 2 signaling pathway (Rattus norvegicus)

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***CYTOPLASMp21ERK1/2MEK1/2MKK3/6JNK1/2EXTRACELLULAR SPACEPKCp62PI3KNUCLEUSMgst2GlutathioneActc1Map3k1HrasMap2k2Gstm2Prkd1Akr1b10Pik3r5Cul3Psmc4Psmc3Dhcr7Mapk3MafgROSRanPrkcgAtmGsrHerpud1PrkcdCrebbpBach1Sod1FosPsmc5PrkcaMap2k3Abcc1Yy1Nfe2l2UbbDnajb9Map2k6Smarca4ActbMaffSlc35a2Akr7a2Pik3r6Abcc3Atf4FosJunGsto2Sqstm1Gsk3bAbcc4TrigonellinePsmc1Pik3c2bPrkceSlc35b1Psmc2Prkd3Gstm3Psmc6Map2k5PrkczHmox1RrasPik3c3Map3k5KrasLdhbPik3caBrca1Cbr1GssAtf4PrkcbGclmGstt1Akr7a3Pik3cbAldh3a1Gsta2Gstp1Keap1MafkPrkcqRras2Acta1Cacng6Fosl1Gstt2Pik3cdPik3c2aDnajc5Cdkn1aGstm4Pik3r2Gstm5Akt1Pik3cgFmo1Me1Nqo2Hsp90ab1Prdx1Slc2a1Aox1Mgst3***Slc7a11Ep300Keap1Sod2MrasDnajb4Mapk1Xpo1Gsta4CebpaPik3r3Scarb1Txn1Fth1Mapk8Cdc34Pik3r1Eif2ak3Mgst1DRUGS METABOLISMUV RADIATIONRESPIRATORY BURSTINFLAMATORY CYTOKINESHEAVY METALSGstm1Acta2PgdUsp14Taldo1PrkciRbx1Pmf1Map3k7Map2k1NFE2L2 DEGRADATION BY UBIQUITIN PROTEASOMERaf1Gsta1Ube2kGstk1Gsto1Ub2Mapk14Actg2Bach1Mapk9Gpx2Nqo1NrasMapk7Akr1a1Sqstm1GclcActg1Txnrd1Ephx1Tp53AldoaFynPik3c2gUgdhNfe2l2Slc1a4PrkchBard1Map2k7VcpPik3r4Mdm2Gsta3FtlSod3G6pdKeap1Actc1Acta2ActbActa1Actg1Actg2Nfe2l2Nfe2l2


Description

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Bibliography

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History

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CompareRevisionActionTimeUserComment
106970view13:43, 17 September 2019MaintBotHMDB identifier normalization
94539view08:01, 21 September 2017EgonwModified title
91468view03:27, 4 March 2017Richard10Modified title
82999view04:24, 17 November 2015Mkutmonfix outdated identifiers
78474view10:28, 7 January 2015MaintBotadded missing graphIds
71118view00:41, 7 October 2013Richard10Update
71117view00:35, 7 October 2013Richard10Periodical save, work in progress
69742view09:13, 11 July 2013EgonwAdded a ChEBI id for ROS.
68372view03:37, 4 July 2013Richard10progress
68135view11:56, 1 July 2013DdiglesOntology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
58962view18:36, 21 February 2013MaintBotUpdated Ensembl data source
56342view20:39, 5 January 2013MaintBotModified categories
54389view21:57, 28 November 2012Richard10Specify description
54337view03:03, 28 November 2012Richard10Specify description
54336view03:00, 28 November 2012Richard10Periodical save, work in progress
54335view02:57, 28 November 2012Richard10Specify description
54334view02:49, 28 November 2012Richard10New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
***GeneProduct
Abcc1GeneProductENSRNOG00000022305 (Ensembl)
Abcc3GeneProduct71101 (RGD)
Abcc4GeneProduct620266 (RGD)
Acta1GeneProduct2025 (RGD)
Acta2GeneProduct81633 (Entrez Gene)
ActbGeneProduct628837 (RGD)
Actc1GeneProduct2026 (RGD)
Actg1GeneProduct1304556 (RGD)
Actg2GeneProduct2027 (RGD)
Akr1a1GeneProduct68346 (RGD)
Akr1b10GeneProduct1308277 (RGD)
Akr7a2GeneProduct620311 (RGD)
Akr7a3GeneProduct628635 (RGD)
Akt1GeneProduct2081 (RGD)
Aldh3a1GeneProduct2088 (RGD)
AldoaGeneProduct2089 (RGD)
Aox1GeneProduct54349 (Entrez Gene)
Atf4GeneProduct621863 (RGD)
AtmGeneProduct1593265 (RGD)
Bach1GeneProduct1306693 (RGD)
Bard1GeneProduct621072 (RGD)
Brca1GeneProduct2218 (RGD)
Cacng6GeneProductENSRNOG00000057852 (Ensembl)
Cbr1GeneProduct2286 (RGD)
Cdc34GeneProduct1305411 (RGD)
Cdkn1aGeneProduct69328 (RGD)
CebpaGeneProduct2326 (RGD)
CrebbpGeneProduct2401 (RGD)
Cul3GeneProduct1308190 (RGD)
DRUGS METABOLISM

UV RADIATION RESPIRATORY BURST INFLAMATORY CYTOKINES

HEAVY METALS
Dhcr7GeneProduct621769 (RGD)
Dnajb4GeneProduct1305826 (RGD)
Dnajb9GeneProduct3070 (RGD)
Dnajc5GeneProduct620516 (RGD)
Eif2ak3GeneProduct70884 (RGD)
Ep300GeneProduct170915 (Entrez Gene)
Ephx1GeneProduct2557 (RGD)
Fmo1GeneProduct2622 (RGD)
FosGeneProduct2626 (RGD)
Fosl1GeneProduct2627 (RGD)
Fth1GeneProduct2635 (RGD)
FtlGeneProduct61813 (RGD)
FynGeneProduct2641 (RGD)
G6pdGeneProductENSRNOG00000056728 (Ensembl)
GclcGeneProduct619868 (RGD)
GclmGeneProduct619871 (RGD)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Gpx2GeneProduct727780 (RGD)
Gsk3bGeneProduct70982 (RGD)
GsrGeneProduct621747 (RGD)
GssGeneProduct2752 (RGD)
Gsta1GeneProduct2753 (RGD)
Gsta2GeneProduct2754 (RGD)
Gsta3GeneProduct24421 (Entrez Gene)
Gsta4GeneProduct1309970 (RGD)
Gstk1GeneProduct735188 (RGD)
Gstm1GeneProduct2755 (RGD)
Gstm2GeneProduct2756 (RGD)
Gstm3GeneProduct620381 (RGD)
Gstm4GeneProduct1565825 (RGD)
Gstm5GeneProduct61964 (RGD)
Gsto1GeneProduct70952 (RGD)
Gsto2GeneProduct1310764 (RGD)
Gstp1GeneProduct2758 (RGD)
Gstt1GeneProduct2765 (RGD)
Gstt2GeneProduct29487 (Entrez Gene)
Herpud1GeneProduct620818 (RGD)
Hmox1GeneProduct2806 (RGD)
HrasGeneProduct293621 (Entrez Gene)
Hsp90ab1GeneProduct1303075 (RGD)
JunGeneProduct2943 (RGD)
Keap1GeneProduct621619 (RGD)
KrasGeneProduct2981 (RGD)
LdhbGeneProduct2997 (RGD)
MaffGeneProduct1309531 (RGD)
MafgGeneProduct619953 (RGD)
MafkGeneProduct628633 (RGD)
Map2k1GeneProduct70495 (RGD)
Map2k2GeneProduct61888 (RGD)
Map2k3GeneProductENSRNOG00000006612 (Ensembl)
Map2k5GeneProduct29568 (Entrez Gene)
Map2k6GeneProduct620666 (RGD)
Map2k7GeneProduct1560043 (RGD)
Map3k1GeneProduct620966 (RGD)
Map3k5GeneProduct1306431 (RGD)
Map3k7GeneProduct1309438 (RGD)
Mapk14GeneProduct70496 (RGD)
Mapk1GeneProduct70500 (RGD)
Mapk3GeneProductENSRNOG00000053583 (Ensembl)
Mapk7GeneProduct621505 (RGD)
Mapk8GeneProduct116554 (Entrez Gene)
Mapk9GeneProduct628847 (RGD)
Mdm2GeneProduct1305332 (RGD)
Me1GeneProduct3074 (RGD)
Mgst1GeneProduct70927 (RGD)
Mgst2GeneProduct1311218 (RGD)
Mgst3GeneProduct1306373 (RGD)
MrasGeneProduct3111 (RGD)
NFE2L2

DEGRADATION BY

UBIQUITIN PROTEASOME
Nfe2l2GeneProduct620360 (RGD)
Nqo1GeneProduct2503 (RGD)
Nqo2GeneProduct1303320 (RGD)
NrasGeneProduct3205 (RGD)
PgdGeneProductENSRNOG00000023562 (Ensembl)
Pik3c2aGeneProduct1310389 (RGD)
Pik3c2bGeneProduct1306541 (RGD)
Pik3c2gGeneProduct620231 (RGD)
Pik3c3GeneProduct620899 (RGD)
Pik3caGeneProduct170911 (Entrez Gene)
Pik3cbGeneProduct620917 (RGD)
Pik3cdGeneProduct1310990 (RGD)
Pik3cg GeneProduct1306468 (RGD)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct68341 (RGD)
Pik3r3GeneProduct621042 (RGD)
Pik3r4GeneProduct363131 (Entrez Gene)
Pik3r5GeneProduct1563261 (RGD)
Pik3r6GeneProduct1560850 (RGD)
Pmf1GeneProduct1584694 (RGD)
Prdx1GeneProduct620039 (RGD)
PrkcaGeneProduct3395 (RGD)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcdGeneProduct67383 (RGD)
PrkceGeneProduct61925 (RGD)
PrkcgGeneProductENSRNOG00000054371 (Ensembl)
PrkchGeneProduct621888 (RGD)
PrkciGeneProduct620961 (RGD)
PrkcqGeneProduct620968 (RGD)
PrkczGeneProduct3399 (RGD)
Prkd1GeneProduct620964 (RGD)
Prkd3GeneProduct1310236 (RGD)
Psmc1GeneProduct621097 (RGD)
Psmc2GeneProduct3428 (RGD)
Psmc3GeneProduct61905 (RGD)
Psmc4GeneProduct621102 (RGD)
Psmc5GeneProduct708376 (RGD)
Psmc6GeneProduct1308825 (RGD)
ROSMetaboliteCHEBI:26523 (ChEBI)
Raf1GeneProduct3531 (RGD)
RanGeneProduct620367 (RGD)
Rbx1GeneProduct1308453 (RGD)
RrasGeneProduct1311443 (RGD)
Rras2GeneProduct1310793 (RGD)
Scarb1GeneProduct2302 (RGD)
Slc1a4GeneProduct735146 (RGD)
Slc2a1GeneProduct3704 (RGD)
Slc35a2GeneProduct2293497 (RGD)
Slc35b1GeneProduct727783 (RGD)
Slc7a11GeneProduct1309275 (RGD)
Smarca4GeneProduct621728 (RGD)
Sod1GeneProduct3731 (RGD)
Sod2GeneProduct3732 (RGD)
Sod3GeneProduct3733 (RGD)
Sqstm1GeneProduct113894 (Entrez Gene)
Taldo1GeneProduct620674 (RGD)
Tp53GeneProduct3889 (RGD)
TrigonellineMetaboliteHMDB0000875 (HMDB)
Txn1GeneProduct621157 (RGD)
Txnrd1GeneProduct61959 (RGD)
Ub2GeneProduct
UbbGeneProduct621562 (RGD)
Ube2kGeneProduct1311626 (RGD)
UgdhGeneProduct621879 (RGD)
Usp14GeneProduct1311825 (RGD)
VcpGeneProduct621595 (RGD)
Xpo1GeneProduct620517 (RGD)
Yy1GeneProduct3982 (RGD)

Annotated Interactions

No annotated interactions

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