Glucocorticoid and Mineralcorticoid Metabolism (Homo sapiens)

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1, 2CHO=O=OHOGlucocorticoidsCH11b, 21-Dihydroxy-3,20-5b-Pregnan-18-alC11-Deoxycortisol3OH317a,21-Dihydroxy-5b-17a,21-Dihydroxy-5b-Pregnane-3,11,20-trioneH33O3a-OH-5b-Pregnane-20-oneOHO11b,17a 21-Trihydroxy-5bPregnane 3,20-dione=O=OOHProgesterone DegradationCHO2HOCHCHC2=OCH3a,11b,21-Trihydroxy-20-Oxo-5b-Pregnan-18-al2HOCH5b-Pregnane-3,20-dioneOUrocortisoneHOOCOHCHOOHCHCH3CHChemical structures shownfor metabolites in tealCCCGlucuronidesOH=O-OHHO=OOHUrocortisolCholesterolSteroid Hormone Signaling18-HydroxycorticosteroneCYP17A13a-Hydroxysteroid Dh3-Oxo-5b-Steroid DhCortisol(R)20-hydroxysteroid DhHSD3B2ProgesteroneHSD11B117a-OH-pregnenoloneCYP21A2Cortisone beta-reductaseCholesterol BiosynthesisCortisoneHSD11B2Pregnenolone11-DeoxycorticosteronePregnanediolAndrogen Synthesis and Metabolism20b-Hydroxysteroid DhCYP11B23B-OH-delta-Steroid DhHSD3B13a-Hydroxysteroid DhCortisolAldosteroneHSD3B1Corticosterone 18-Monooxy17-OH-progesteroneCYP11A1CYP17A1CorticosteroneCortolone


Description

Mineralocorticoid and glucocorticoid receptors act as homodimers via canonical pentadecamer hormone response elements to regulate transcription. Glucocorticoid, but as yet not mineralocorticoid, receptors have been shown also to modulate AP-1- and NFκB-induced transcription by direct protein-protein interactions. The role of 11β-hydroxysteroid dehydrogenase in conferring aldosterone specificity on epithelial mineralocorticoid receptors has been proven by the demonstration of sequence mutations in all cases of apparent mineralocorticoid excess examined to date. The autosomal form of aldosterone resistance (pseudohypoaldosteronism) has been shown to reflect loss-of-function mutations in epithelial sodium channel subunit sequence. (Patho)physiological roles for aldosterone and glucocorticoid membrane receptors, and for the recently described nuclear receptors for 11–ketosteroids in 11β–hydroxysteroid dehydrogenase–protected epithelia, remain to be established. [1]

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Ontology Terms

 

Bibliography

  1. Fardella CE, Miller WL; ''Molecular biology of mineralocorticoid metabolism.''; Annu Rev Nutr, 1996 PubMed Europe PMC
  2. Funder JW; ''Glucocorticoid and mineralocorticoid receptors: biology and clinical relevance.''; Annu Rev Med, 1997 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
102525view20:03, 3 January 2019Khanspersconverted interactions to graphical lines (chemical structures)
102356view19:40, 20 December 2018Fehrhartfixed a line
98650view09:58, 26 September 2018EgonwWP496 is not about signalling. WP170 is not perfect, but better.
98649view09:30, 26 September 2018EgonwModified description
96253view15:11, 2 March 2018Fehrhartconnected lines and changed interactions to graphical lines
96038view15:54, 15 February 2018DeSlModified description
96035view15:52, 15 February 2018DeSlAdded 2 lit refs
96034view15:46, 15 February 2018DeSlOntology Term : 'glucocorticoid biosynthetic pathway' added !
95658view13:08, 16 January 2018DeSlRemoved licence number and last modified part.
95657view13:08, 16 January 2018DeSlrewrote '&' to 'and' for integration with Latex
78497view10:28, 7 January 2015MaintBotadded missing graphIds
72079view20:40, 24 October 2013EgonwRemoved a dangling "Metabolite" that accidentally sneaked in in revision 15409.
71371view18:37, 17 October 2013MaintBotAutomated update of data sources
71251view20:44, 16 October 2013MaintBotAutomated update of data sources
67282view10:31, 26 June 2013Christine ChichesterOntology Term : 'C21-steroid hormone biosynthetic pathway' added !
63196view20:52, 8 May 2013MaintBotUpdating gpml version
62690view21:31, 1 May 2013MaintBotupated uniprot data source
54707view13:48, 7 December 2012AndraRDF Tidy
41092view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
38932view21:50, 24 September 2010AlexanderPicofixed grouping
38899view20:21, 24 September 2010Thomasadded pathway link
38827view11:45, 24 September 2010Thomasadded pathway link
34463view18:28, 10 December 2009MaintBotAutomatic update of empty xrefs
32571view13:38, 17 August 2009Thomas
32373view16:49, 15 August 2009MaintBotFixed text labels
32369view16:33, 15 August 2009Thomas
32008view13:19, 14 August 2009MaintBotFixed group labels
21175view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:WP237]]: Moved to stable identifier
15409view23:10, 27 May 2008Khanspersconnectors fix
14503view01:02, 23 May 2008KhanspersAdded connectors, groups, metabolites
14499view00:53, 23 May 2008KhanspersPeriodical save, work in progress
14492view00:43, 23 May 2008KhanspersPeriodical save, work in progress
14488view00:32, 23 May 2008KhanspersPeriodical save, work in progress
14484view00:22, 23 May 2008KhanspersPeriodical save, work in progress
13070view11:13, 17 May 2008MaintBotautomated metabolite conversion
8078view13:46, 7 January 2008MaintBot[[Pathway:Human:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:Homo sapiens:Glucocorticoid Mineralocorticoid Metabolism]]: Renaming species
7661view16:07, 18 December 2007MaintBotfixed category names
7360view12:42, 4 November 2007MaintBotAdded categories to GPML
6326view22:17, 22 May 2007M.Liebermangpml file for [[Human:Glucocorticoid_Mineralocorticoid_Metabolism]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)20-hydroxysteroid DhGeneProduct1.1.1.53, similiar SP:2BHD STREX
11-DeoxycorticosteroneMetabolite64-85-7 (CAS)
17-OH-progesteroneMetaboliteHMDB00374 (HMDB)
17a-OH-pregnenoloneMetaboliteHMDB00363 (HMDB)
18-HydroxycorticosteroneMetaboliteHMDB00319 (HMDB)
20b-Hydroxysteroid DhGeneProduct1.1.1.53, similiar SP:2BHD STREX
3-Oxo-5b-Steroid DhGeneProduct3O5B (Uniprot-TrEMBL)
3B-OH-delta-Steroid DhGeneProduct
3a-Hydroxysteroid DhGeneProductSPs:DIDH RAT
AldosteroneMetabolite52-39-1 (CAS)
Androgen Synthesis and MetabolismPathwayWP496 (WikiPathways)
CYP11A1GeneProduct1583 (Entrez Gene)
CYP11B2GeneProduct1585 (Entrez Gene)
CYP17A1GeneProduct1586 (Entrez Gene)
CYP21A2GeneProduct1589 (Entrez Gene)
Cholesterol BiosynthesisPathwayWP197 (WikiPathways)
CholesterolMetabolite57-88-5 (CAS)
Corticosterone 18-MonooxyGeneProductEC number: 1.14.15.5
CorticosteroneMetabolite50-22-6 (CAS)
CortisolMetabolite50-23-7 (CAS)
Cortisone beta-reductaseGeneProduct1.3.1.3
CortisoneMetaboliteHMDB02802 (HMDB)
CortoloneMetabolite516-42-7 (CAS)
HSD11B1GeneProduct3290 (Entrez Gene)
HSD11B2GeneProduct3291 (Entrez Gene)
HSD3B1GeneProduct3283 (Entrez Gene)
HSD3B2GeneProduct3284 (Entrez Gene)
PregnanediolMetabolite80-92-2 (CAS)
PregnenoloneMetabolite145-13-1 (CAS)
ProgesteroneMetabolite57-83-0 (CAS)
Steroid Hormone SignalingPathwayWP170 (WikiPathways)

Annotated Interactions

No annotated interactions

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