Histone Modifications (Homo sapiens)

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Description

Histones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the enzymes that catalyze the modifications, where known.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T; ''Regulation of chromatin structure by site-specific histone H3 methyltransferases.''; Nature, 2000 PubMed
  2. Wikipedians; ''''; http://en.wikipedia.org/wiki/Histone_methyltransferase,
  3. Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, Shilatifard A; ''COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.''; J Biol Chem, 2002 PubMed
  4. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T; ''A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.''; Genes Dev, 2004 PubMed
  5. Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, Mollah S, Cook RG, Shabanowitz J, Hunt DF, Allis CD; ''Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.''; Mol Cell Biol, 2002 PubMed
  6. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D; ''Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.''; Genes Dev, 2002 PubMed


History

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CompareRevisionActionTimeUserComment
87373view09:56, 22 July 2016MaintBotadded missing graphids
83012view09:44, 17 November 2015LindarieswijkPeriodical save, work in progress
83011view09:37, 17 November 2015LindarieswijkSpecify description
83010view09:35, 17 November 2015LindarieswijkSpecify description
83008view09:33, 17 November 2015LindarieswijkPeriodical save, work in progress
83007view09:26, 17 November 2015LindarieswijkSpecify description
83006view09:25, 17 November 2015LindarieswijkSpecify description
83004view09:24, 17 November 2015LindarieswijkSpecify description
83003view09:23, 17 November 2015LindarieswijkPeriodical save, work in progress
69927view19:51, 11 July 2013AlexanderPicoModified title
62439view23:49, 28 April 2013AlexanderPicoModified description
62438view23:44, 28 April 2013AlexanderPicoModified categories
62437view23:43, 28 April 2013AlexanderPicoOntology Term : 'altered transcription pathway' added !
62436view23:38, 28 April 2013AlexanderPicoRe-added lit refs
62435view23:31, 28 April 2013AlexanderPicoHistone 3 and 4 complete
62434view23:17, 28 April 2013AlexanderPicoH3 done... now H4
62433view22:49, 28 April 2013AlexanderPicoStill working...
62432view22:07, 28 April 2013AlexanderPicoStill working on adding proper datanodes
62431view21:37, 28 April 2013AlexanderPicoModified title
62430view21:36, 28 April 2013AlexanderPicoUpdating datanodes to represent genes and states
62374view00:56, 28 April 2013MaintBotModified title
62373view00:55, 28 April 2013MaintBotModified categories
58693view18:34, 19 February 2013MaintBotModified categories
57673view20:24, 31 January 2013KhanspersModified description
57672view20:24, 31 January 2013KhanspersRemoved comment
54033view20:31, 18 November 2012EgonwAdded some phosphorylation and citrullination.
54024view18:35, 18 November 2012EgonwAdded more observed acetylations
54023view17:23, 18 November 2012EgonwIt all happens in the nucleus. Well, I'm a chemist... :)
54022view17:21, 18 November 2012EgonwAnother useful reference.
54021view17:13, 18 November 2012EgonwAdded a description of this pathway.
54020view17:10, 18 November 2012EgonwAdded a demo catalyst; haven't figured out which does this trimethylation.
54019view17:08, 18 November 2012EgonwOK, one more to the front :(
54018view17:07, 18 November 2012EgonwHopefully fixed the z-order.
54017view17:04, 18 November 2012EgonwAdded a few more possible acetylation sites.
54016view16:56, 18 November 2012EgonwThis reference is general, and not the primary citation for that methylation.
54015view16:54, 18 November 2012EgonwNew pathway

External references

Datanodes

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NameTypeDatabase referenceComment
AEBP2GeneProductENSG00000139154 (Ensembl)
ASH1LGeneProductENSG00000116539 (Ensembl)
DOT1LGeneProductENSG00000104885 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EHMT1GeneProductENSG00000181090 (Ensembl)
EHMT2GeneProduct10919 (Entrez Gene)
EZH1GeneProductENSG00000108799 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
H3Protein
H3F3AGeneProductENSG00000163041 (Ensembl)
H3F3BGeneProductENSG00000132475 (Ensembl)
H4Protein
HIST1H3AGeneProductENSG00000275714 (Ensembl)
HIST1H3BGeneProductENSG00000274267 (Ensembl)
HIST1H3CGeneProductENSG00000278272 (Ensembl)
HIST1H3DGeneProductENSG00000197409 (Ensembl)
HIST1H3EGeneProductENSG00000274750 (Ensembl)
HIST1H3FGeneProductENSG00000277775 (Ensembl)
HIST1H3GGeneProductENSG00000273983 (Ensembl)
HIST1H3HGeneProductENSG00000278828 (Ensembl)
HIST1H3IGeneProductENSG00000275379 (Ensembl)
HIST1H3JGeneProductENSG00000197153 (Ensembl)
HIST1H4AGeneProductENSG00000278637 (Ensembl)
HIST1H4BGeneProductENSG00000278705 (Ensembl)
HIST1H4CGeneProductENSG00000197061 (Ensembl)
HIST1H4DGeneProductENSG00000277157 (Ensembl)
HIST1H4EGeneProductENSG00000276966 (Ensembl)
HIST1H4FGeneProductENSG00000274618 (Ensembl)
HIST1H4GGeneProductENSG00000275663 (Ensembl)
HIST1H4HGeneProductENSG00000158406 (Ensembl)
HIST1H4IGeneProductENSG00000198339 (Ensembl)
HIST1H4JGeneProductENSG00000197238 (Ensembl)
HIST1H4KGeneProductENSG00000273542 (Ensembl)
HIST1H4LGeneProductENSG00000275126 (Ensembl)
HIST2H3AGeneProductENSG00000203852 (Ensembl)
HIST2H3CGeneProductENSG00000203811 (Ensembl)
HIST2H3DGeneProductENSG00000183598 (Ensembl)
HIST4H4GeneProductENSG00000197837 (Ensembl)
MLL2GeneProductENSG00000167548 (Ensembl)
MLL3GeneProductENSG00000055609 (Ensembl)
MLL4GeneProductENSG00000105663 (Ensembl)
MLL4GeneProductENSG00000272333 (Ensembl)
MLL5GeneProductENSG00000005483 (Ensembl)
MLLGeneProductENSG00000118058 (Ensembl)
NSD1GeneProductENSG00000165671 (Ensembl)
PRDM2GeneProductENSG00000116731 (Ensembl)
SETBP1GeneProductENSG00000152217 (Ensembl)
SETD1AGeneProductENSG00000099381 (Ensembl)
SETD1BGeneProductENSG00000139718 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SETD3GeneProductENSG00000183576 (Ensembl)
SETD4GeneProductENSG00000185917 (Ensembl)
SETD5GeneProductENSG00000168137 (Ensembl)
SETD6GeneProductENSG00000103037 (Ensembl)
SETD7GeneProductENSG00000145391 (Ensembl)
SETD8GeneProductENSG00000183955 (Ensembl)
SETD9GeneProductENSG00000155542 (Ensembl)
SETDB1GeneProductENSG00000143379 (Ensembl)
SETDB2GeneProductENSG00000136169 (Ensembl)
SETGeneProductENSG00000119335 (Ensembl)
SETMARGeneProductENSG00000170364 (Ensembl)
SMYD1GeneProductENSG00000115593 (Ensembl)
SMYD2GeneProductENSG00000143499 (Ensembl)
SMYD3GeneProductENSG00000185420 (Ensembl)
SMYD4GeneProductENSG00000186532 (Ensembl)
SMYD5GeneProductENSG00000135632 (Ensembl)
SUV39H1GeneProductENSG00000101945 (Ensembl)
SUV39H2GeneProductENSG00000152455 (Ensembl)
SUV420H1GeneProductENSG00000110066 (Ensembl)
SUV420H2GeneProductENSG00000133247 (Ensembl)

Annotated Interactions

No annotated interactions

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