Butyrate-induced histone acetylation (Homo sapiens)

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21Acetylated HistoneButyrateHDACsButyrateCitrateAcetyl CoATCAcycleAKTGlucoseBeta oxidationAcetyl CoACitrateACLLipidbiosynthesisButyrateButyrate


Metabolism of butyrate is suggested to be an energy source for histone acetylation.

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Ontology Terms



  1. Davie JR; ''Inhibition of histone deacetylase activity by butyrate.''; J Nutr, 2003 PubMed Europe PMC
  2. Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ; ''The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation.''; Mol Cell, 2012 PubMed Europe PMC


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105116view13:51, 8 July 2019DeSlChanged ID for HDACs from Wikidata to InterPro
102201view14:53, 9 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
89148view21:58, 22 August 2016AriuttaOntology Term : 'classic metabolic pathway' added !
88590view19:35, 11 August 2016Mkutmonfix unconnected lines
73980view11:32, 13 March 2014MaintBotClarified what inhibits the HDACs.
73979view11:30, 13 March 2014MaintBot
73978view11:23, 13 March 2014MaintBotConverted 'beta oxidaton' to a label.
73977view11:14, 13 March 2014MaintBot
73976view11:09, 13 March 2014MaintBotMore identifiers.
73975view11:02, 13 March 2014MaintBotMore identifiers and fixed AKT and ACL to be protein.
73974view10:58, 13 March 2014MaintBotUsed ChEBI instead of InChIs (for now)
73973view10:47, 13 March 2014MaintBotModified description
69937view20:01, 11 July 2013Mkutmonfixed unconnected lines
69009view17:46, 8 July 2013MaintBotUpdated to 2013 gpml schema
57918view20:38, 4 February 2013MaintBotModified categories
54005view10:13, 18 November 2012EgonwCompleted the diagram
54004view09:59, 18 November 2012EgonwEnsured all translocations are now MIM conversions (as suggested on the ML).
53994view19:16, 17 November 2012Egonw
53993view18:03, 17 November 2012EgonwAdded InChIs.
53933view13:23, 16 November 2012EgonwAdded reference and several interactions
53932view13:15, 16 November 2012EgonwAdded the core metabolites
53931view13:01, 16 November 2012EgonwNew pathway

External references


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NameTypeDatabase referenceComment
ACLProteinP53396 (Uniprot-TrEMBL)
AKTProteinP31749 (Uniprot-TrEMBL)
Acetyl CoAMetaboliteCHEBI:15351 (ChEBI)
Acetylated HistoneComplexQ36293 (Wikidata)
ButyrateMetaboliteCHEBI:17968 (ChEBI)
CitrateMetaboliteCHEBI:35808 (ChEBI)
GlucoseMetaboliteCHEBI:17634 (ChEBI)
HDACsProteinIPR000286 (InterPro)
Lipid biosynthesisPathwayWP357 (WikiPathways)
TCA cyclePathwayWP78 (WikiPathways)

Annotated Interactions

No annotated interactions

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