Vitamin B7 (biotin) biosynthesis pathway (Zea mays)

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Disjunct reactions / unknown compartmentsPeroxisome Mitochondria1-3L-alaninefatty acid catabolismApo-proteins2.6.1.627-keto-8-aminopelargonic acidGRMZM2G110932NADPATPDAPA transporterS-adenosylmethionine7,8-diaminopelargonic acidPlastid6.3.3.3dethiobiotin2.8.1.6biotin6.3.4.15biotinylated-protein(s)S-adenosylmethio-2-oxobutanoateCO2PO4ADPMethionine5-deoxyadenosine2.8.1.7adrenodoxin reductaseadrenodoxin, mitochondrial ferredoxinNADPHbiotin6.3.4.15biotinylated-protein(s)Apo-proteins7-keto-8-aminopelargonic acid2.6.1.627,8-diaminopelargonic acidS-adenosylmethionineS-adenosylmethio-2-oxobutanoateKAPA transporterbiotin transporterbiotin6.3.4.15biotinylated-protein(s)Apo-proteinsbiotin transporter7-keto-8-aminopelargonic acidKAPA transporter2.3.1.47pimeloyl-CoACO2CoAbiotinseed biotin-binding protein biotin ligaseseed biotin-binding proteinunknown methyl acceptorSAM-dependent methyl transferase (BioC-like)methylated acceptorS-adenosylmethionineS-adenosylhomocysteinebiotinseed biotin-binding proteinbiotinidase for seed biotin-binding proteinbiotinbiotin transporterGRMZM2G102156GRMZM2G095400GRMZM2G452523GRMZM2G032280GRMZM2G307561GRMZM2G322314LOC100285690GRMZM2G087692GRMZM2G704475GRMZM2G013607GRMZM5G856338S-adenosylmethionineGRMZM2G102156


Description

Biotin-dependent enzymes catalyze carboxylation, decarboxylation, or transcarboxylation reactions in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. In plants, five biotin-containing proteins have been characterized so far, only four of them catalysts: two structurally distinct acetyl-CoA carboxylases, 3-methylcrotonyl-CoA carboxylase and geranoyl-CoA carboxylase. The fifth is a noncatalytic biotin protein that accumulates in seeds and is thought to play a role in storing biotin (Nikolau et al., 2003). Biotin is synthesized from pimeloyl-CoA in four steps, of which the first is peroxisomal; the other three steps are almost surely mitochondrial. The source of pimeloyl-CoA is not known in plants, but appears to differ from those in bacteria (Lin and Cronan, 2011). One of the possibilities - it might come from fatty acid degradation via the concerted action of β-, α-, and ω-oxidation enzymes in peroxisomes (Magliano et al., 2011) The ligase that attaches biotin to carboxylases is present in cytosol, plastids, and mitochondria. Seed biotin-binding proteins are probably biotinylated by a special enzyme, not by the ligases that act on biotin-dependent enzymes (Job et al., 2001). Seed biotin-binding proteins may act as biotin reserves; if so, a biotinidase is required to cleave the biotin-lysine bond (Alban et al., 2000)

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Ontology Terms

 

Bibliography

  1. Nikolau BJ, Ohlrogge JB, Wurtele ES; ''Plant biotin-containing carboxylases.''; Arch Biochem Biophys, 2003 PubMed Europe PMC
  2. Picciocchi A, Douce R, Alban C; ''The plant biotin synthase reaction. Identification and characterization of essential mitochondrial accessory protein components.''; J Biol Chem, 2003 PubMed Europe PMC
  3. Gerdes S, Lerma-Ortiz C, Frelin O, Seaver SM, Henry CS, de Crécy-Lagard V, Hanson AD; ''Plant B Vitamin Pathways and their Compartmentation: a Guide for the Perplexed.''; J Exp Bot, 2012 PubMed Europe PMC

History

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79813view16:50, 16 April 2015Mkutmonfixed unconnected lines
78445view10:27, 7 January 2015MaintBotadded missing graphIds
74392view05:51, 16 April 2014EgonwRemoved a data source where no ID was given.
73528view23:38, 29 January 2014KhanspersModified title
71956view23:22, 23 October 2013MaintBotremoved data source from nodes without identifier
70257view21:42, 15 July 2013MaintBotupdated to 2013 schema
65174view19:10, 5 June 2013MaintBotModified categories
54646view02:01, 6 December 2012SvetaGModified description
54645view01:53, 6 December 2012SvetaGModified description
54644view01:47, 6 December 2012SvetaGAdded literature
54643view01:34, 6 December 2012SvetaGModified title
54640view22:35, 5 December 2012SvetaGPeriodical save, work in progress
54639view22:15, 5 December 2012SvetaGPeriodical save, work in progress
54638view21:55, 5 December 2012SvetaGPeriodical save, work in progress
54637view21:24, 5 December 2012SvetaGPeriodical save, work in progress
54636view21:14, 5 December 2012SvetaGPeriodical save, work in progress
54635view20:53, 5 December 2012SvetaGModified title
53366view00:28, 6 November 2012PjaiswalModified title
53179view19:19, 30 October 2012PjaiswalModified categories
53178view19:19, 30 October 2012PjaiswalOntology Term : 'vitamin and vitamin metabolites signaling pathway' added !
53177view19:18, 30 October 2012PjaiswalOntology Term : 'plant cell' added !
53176view19:17, 30 October 2012PjaiswalNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
2.3.1.47Protein2.3.1.47 (Enzyme Nomenclature)
2.6.1.62Protein2.6.1.62 (Enzyme Nomenclature)
2.8.1.6Protein2.8.1.6 (Enzyme Nomenclature)
2.8.1.7Protein2.8.1.7 (Enzyme Nomenclature)
5-deoxyadenosineMetabolite
6.3.3.3Protein6.3.3.3 (Enzyme Nomenclature)
6.3.4.15Protein6.3.4.15 (Enzyme Nomenclature)
7,8-diaminopelargonic acidMetabolite
7-keto-8-aminopelargonic acidMetabolite
ADPMetabolite
ATPMetabolite
Apo-proteinsProtein
CO2Metabolite
CoAMetabolite
DAPA transporterGeneProduct
GRMZM2G013607GeneProductGRMZM2G013607 (Gramene Maize)
GRMZM2G032280GeneProductGRMZM2G032280 (Gramene Maize)
GRMZM2G087692GeneProductGRMZM2G087692 (Gramene Maize)
GRMZM2G095400GeneProductGRMZM2G095400 (Gramene Maize)
GRMZM2G102156GeneProductGRMZM2G102156 (Gramene Maize)
GRMZM2G110932GeneProductGRMZM2G110932 (Gramene Maize)
GRMZM2G307561GeneProductGRMZM2G307561 (Gramene Maize)
GRMZM2G322314GeneProductGRMZM2G322314 (Gramene Maize)
GRMZM2G452523GeneProductGRMZM2G452523 (Gramene Maize)
GRMZM2G704475GeneProductGRMZM2G704475 (Gramene Maize)
GRMZM5G856338GeneProductGRMZM5G856338 (Gramene Maize) putative pseudogene
KAPA transporterGeneProduct
L-alanineMetabolite
LOC100285690GeneProductLOC100285690 (Gramene Maize)
MethionineMetabolite
NADPMetabolite
NADPHMetabolite
PO4Metabolite
S-adenosylhomocysteineMetabolite
S-adenosylmethio-2-oxobutanoateMetabolite
S-adenosylmethionineMetabolite
SAM-dependent methyl transferase (BioC-like)Protein
adrenodoxin reductaseProteinAdx1
adrenodoxin, mitochondrial ferredoxinProteinAdxR
biotinMetabolite
biotin transporterGeneProduct
biotinidase for seed biotin-binding proteinProtein
biotinylated-protein(s)Metabolite
dethiobiotinMetabolite
fatty acid catabolismPathway
methylated acceptorMetabolite
pimeloyl-CoAMetabolite
seed biotin-binding proteinProtein
seed biotin-binding protein biotin ligaseProtein
unknown methyl acceptorMetabolite

Annotated Interactions

No annotated interactions

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