Vitamin B1 (thiamin) biosynthesis and salvage pathway (Zea mays)

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1-3 PlastidPeroxisome Mitochondriaor/anddegradation (including catalysis-induced)and repairGRMZM2G027663Glycinehydroxymethylpyrimidine phosphate synthase (HMPPS)(4-amino-2-methylpyrimidin-5-yl)methyl phosphateATPNUDIX hydrolaseUNKNOWN5-aminoimidazole ribotidethiamine diphosphate transporter(4-amino-2-methylpyrimidin-5-yl)methyl diphosphatehydroxymethylpyrimidine phosphate kinase ThiDNADadenylated thiazole carboxylatethiazole biosynthetic enzyme (Thi4)4-methyl-5-(2-hydroxyethyl)-thiazole phosphate (HET-P)hydrolase?thiamine monophosphatethiamine phosphate pyrophosphorylase (TMP-PPase)thiaminethiamine monophosphate phosphatase (ThMPase)nicotinamideThi4 enzymeAMPPO4H2OMet, 5'dAHCOOHCONAD(P)NAD(P)HSAMhydroxymethylpyrimidine kinase4-amino-5-phosphonooxymethyl-2-methylpyrimidineADPPPithiamine diphosphatethiamine diphosphatethiamine diphosphate transporterthiamine diphosphate transporterthiamine diphosphatethiamine diphosphatedegradation (including catalysis-induced)and repairthiamine degradation products transporterthiamine transporter (?)thiamine monophosphatethiaminethiamine monophosphate phosphatase (ThMPase)thiamine diphosphatePhosphoric acidWaterthiamine pyrophosphokinase (TPPK))ATP/GTPAMP/GMPdegradation (including catalysis-induced)and repairthiamine degradation products transporter (?)thiamine monophosphate transporter (?)hydroxymethylpyrimidine (phosphate) [HMP(P)] transporter(4-amino-2-methylpyrimidin-5-yl)methylthiamin-triphosphatasethiamine triphosphatethiamine diphosphatethiamin-triphosphate synthaseUNKNOWNCOG0212UNKNOWNUNKNOWNhydroxyethylthiazole kinase4-methyl-5-(2-hydroxyethyl)thiazole (HET)4-methyl-5-(2-hydroxyethyl)-thiazole phosphate (HET-P)thiaminase II (TenA1)4-amino-2-methyl-5-aminomethylpyrmidine or others4-amino-5-phosphonooxymethyl-2-methylpyrimidinethiaminase II homolog (TenA2)thiamine diphosphate transporterthiamine transporter4-methyl-5-(2-hydroxyethyl)-thiazole transporterhydroxymethylpyrimidine (HMP) transporterthiamine4-methyl-5-(2-hydroxyethyl)-thiazolethiamine diphosphate(4-amino-2-methylpyrimidin-5-yl)methylGRMZM2G401934GRMZM2G018375GRMZM2G074097GRMZM2G055458GRMZM5G864815GRMZM2G094558GRMZM2G078283GRMZM2G148896GRMZM2G080501GRMZM2G031461GRMZM2G001904GRMZM2G118515GRMZM2G124911ADPATPGRMZM2G401934(4-amino-2-methylpyrimidin-5-yl)methyl phosphateInactive


Description

Thiamin, in its active form thiamin diphosphate (ThDP), is the cofactor for transketolases, decarboxylases, and other enzymes that make or break C-C bonds. Thiamin contains pyrimidine and thiazole moieties, which are synthesized separately in plastids and then coupled together in plastids to yield thiamin monophosphate (ThMP) (Goyer, 2010; Rapala-Kozik, 2011). The next steps are (in unknown order) export from the plastid and hydrolysis to thiamin (Goyer, 2010). Thiamin then is converted to ThDP in the cytosol. A remarkable feature of the pathway is that the thiazole synthesis protein Thi4 uses itself as sulphur donor for thiazole formation and undergoes only a single turnover (Chatterjee et al., 2011). This makes thiazole energetically very costly to produce, and puts a high premium on salvaging thiazole moieties from ThDP breakdown. Biosynthesis and metabolism of thiamin and it's various derivatives (mono-, di- , tri- phosphates) and degradation products in plants (or other organisms) are far from being elucidated. This diagram is an attempt to capture the current state of the field

Quality Tags

Ontology Terms

 

Bibliography

  1. Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP; ''Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.''; Nature, 2011 PubMed Europe PMC
  2. Goyer, A; ''''; , PubMed Europe PMC
  3. Gerdes S, Lerma-Ortiz C, Frelin O, Seaver SM, Henry CS, de Crécy-Lagard V, Hanson AD; ''''; , PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107279view14:37, 17 September 2019MaintBotChEBI identifier normalization
89946view14:12, 6 October 2016MkutmonModified description
78450view10:27, 7 January 2015MaintBotadded missing graphIds
73524view23:37, 29 January 2014KhanspersModified title
72344view18:51, 10 November 2013AriuttaAdd identifiers matching specified data node labels
72343view18:31, 10 November 2013AriuttaPeriodical save, work in progress
72342view18:21, 10 November 2013AriuttaPeriodical save, work in progress
71903view17:54, 22 October 2013MaintBotRemoved source from datanodes with empty id
70253view21:38, 15 July 2013MaintBotupdated to 2013 schema
54920view05:07, 12 December 2012SvetaGModified description
54919view05:06, 12 December 2012SvetaGSpecify description
54918view05:03, 12 December 2012SvetaGSpecify description
54917view04:57, 12 December 2012SvetaGLiterature added
54916view04:50, 12 December 2012SvetaGModified description
54915view04:48, 12 December 2012SvetaGModified description
54910view23:47, 11 December 2012SvetaGEdited pathway
54909view23:45, 11 December 2012SvetaGPeriodical save, work in progress
54908view23:35, 11 December 2012SvetaGPeriodical save, work in progress
54907view23:25, 11 December 2012SvetaGPeriodical save, work in progress
54906view21:16, 11 December 2012SvetaGPeriodical save, work in progress
54905view21:06, 11 December 2012SvetaGPeriodical save, work in progress
54904view20:33, 11 December 2012SvetaGEdits
54903view20:20, 11 December 2012SvetaGPeriodical save, work in progress
54902view19:57, 11 December 2012SvetaGPeriodical save, work in progress
54901view19:47, 11 December 2012SvetaGPeriodical save, work in progress
54900view19:36, 11 December 2012SvetaGPeriodical save, work in progress
54899view19:16, 11 December 2012SvetaGPeriodical save, work in progress
54727view18:35, 7 December 2012SvetaGModified title
53368view00:29, 6 November 2012PjaiswalModified title
53367view00:29, 6 November 2012PjaiswalModified title
53105view01:08, 30 October 2012MaintBotModified categories
53027view23:55, 25 October 2012PjaiswalModified categories
53026view23:54, 25 October 2012PjaiswalOntology Term : 'vitamin and vitamin metabolites signaling pathway' added !
53025view23:54, 25 October 2012PjaiswalOntology Term : 'plant cell' added !
53024view23:53, 25 October 2012PjaiswalNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(4-amino-2-methylpyrimidin-5-yl)methyl diphosphateMetaboliteCHEBI:16761 (ChEBI)
(4-amino-2-methylpyrimidin-5-yl)methyl phosphateMetaboliteCHEBI:15422 (ChEBI)
(4-amino-2-methylpyrimidin-5-yl)methyl phosphateMetaboliteCHEBI:18032 (ChEBI)
(4-amino-2-methylpyrimidin-5-yl)methylMetaboliteCHEBI:16892 (ChEBI)
4-amino-2-methyl-5-aminomethylpyrmidine or othersMetabolite
4-amino-5-phosphonooxymethyl-2-methylpyrimidineMetaboliteCHEBI:16892 (ChEBI)
4-methyl-5-(2-hydroxyethyl)-thiazole phosphate (HET-P)Metabolite
4-methyl-5-(2-hydroxyethyl)-thiazole transporterProtein
4-methyl-5-(2-hydroxyethyl)-thiazoleMetaboliteCHEBI:9533 (ChEBI)
4-methyl-5-(2-hydroxyethyl)thiazole (HET)Metabolite
5-aminoimidazole ribotideMetaboliteCHEBI:28843 (ChEBI)
ADPMetabolite
AMPMetabolite
AMP/GMPMetabolite
ATPMetabolite
ATP/GTPMetabolite
COMetaboliteCHEBI:17245 (ChEBI)
COG0212GeneProduct
  • 5-formyltetrahydrofolate cycloligase paralog implicated in thiamin metabolism
  • Type your comment here
GRMZM2G001904GeneProductGRMZM2G001904 (Gramene Maize)
GRMZM2G018375GeneProductGRMZM2G018375 (Gramene Maize)
GRMZM2G027663GeneProductGRMZM2G027663 (Gramene Maize)
GRMZM2G031461GeneProductGRMZM2G031461 (Gramene Maize)
GRMZM2G055458GeneProductGRMZM2G055458 (Gramene Maize)
GRMZM2G074097GeneProductGRMZM2G074097 (Gramene Maize)
GRMZM2G078283GeneProductGRMZM2G078283 (Gramene Maize)
GRMZM2G080501GeneProductGRMZM2G080501 (Gramene Maize)
GRMZM2G094558GeneProductGRMZM2G094558 (Gramene Maize)
GRMZM2G118515GeneProductGRMZM2G118515 (Gramene Maize)
GRMZM2G124911GeneProductGRMZM2G124911 (Gramene Maize)
GRMZM2G148896GeneProductGRMZM2G148896 (Gramene Maize)
GRMZM2G401934GeneProductGRMZM2G401934 (Gramene Maize)
GRMZM5G864815GeneProductGRMZM5G864815 (Gramene Maize)
GlycineMetabolite
H2OMetabolite
HCOOHMetaboliteCHEBI:30751 (ChEBI)
Met, 5'dAMetabolite
NAD(P)MetaboliteCHEBI:25524 (ChEBI)
NAD(P)HMetaboliteCHEBI:13392 (ChEBI)
NADMetaboliteCHEBI:13389 (ChEBI)
NUDIX hydrolaseGeneProduct
PO4Metabolite
PPiMetabolite
Phosphoric acidMetaboliteCHEBI:26078 (ChEBI)
SAMMetaboliteCHEBI:15414 (ChEBI)
Thi4 enzymeMetaboliteinactivated by donation of H2S group during catalysis
UNKNOWNMetabolite
WaterMetaboliteCHEBI:15377 (ChEBI)
adenylated thiazole carboxylateMetabolite
hydrolase?GeneProduct
hydroxyethylthiazole kinaseGeneProduct2.7.1.50 (Enzyme Nomenclature)
hydroxymethylpyrimidine (HMP) transporterProtein
hydroxymethylpyrimidine (phosphate) [HMP(P)] transporterProtein
hydroxymethylpyrimidine kinaseGeneProduct2.7.1.49 (Enzyme Nomenclature)
hydroxymethylpyrimidine phosphate kinase ThiDGeneProduct2.7.4.7 (Enzyme Nomenclature)
hydroxymethylpyrimidine phosphate synthase (HMPPS)GeneProduct
nicotinamideMetaboliteCHEBI:17154 (ChEBI)
thiamin-triphosphataseGeneProduct3.6.1.28 (Enzyme Nomenclature)
thiamin-triphosphate synthaseGeneProduct2.7.4.15 (Enzyme Nomenclature)
thiaminase II (TenA1)GeneProduct3.5.99.2 (Enzyme Nomenclature)
thiaminase II homolog (TenA2)GeneProduct3.5.99.2 (Enzyme Nomenclature)
thiamine degradation products transporterProtein
thiamine degradation products transporter (?)Protein
thiamine diphosphate transporterProtein
thiamine diphosphateMetaboliteCHEBI:9532 (ChEBI)
thiamine monophosphate phosphatase (ThMPase)GeneProduct
thiamine monophosphate phosphatase (ThMPase)GeneProductGRMZM2G057140 (MaizeGDB)
  • No identifier given, so I think this identifier best matches the given label. See also http://pathway.gramene.org/MAIZE/NEW-IMAGE?type=ENZYME&object=GBWI-76117-MONOMER
  • Type your comment here
thiamine monophosphate transporter (?)Protein
thiamine monophosphateMetaboliteCHEBI:9533 (ChEBI)
thiamine phosphate pyrophosphorylase (TMP-PPase)GeneProduct2.5.1.3 (Enzyme Nomenclature)
thiamine pyrophosphokinase (TPPK))GeneProduct2.7.6.2 (Enzyme Nomenclature)
thiamine transporterProtein
thiamine transporter (?)Protein
thiamine triphosphateMetabolite
thiamineMetaboliteCHEBI:26948 (ChEBI)
thiazole biosynthetic enzyme (Thi4)GeneProduct

Annotated Interactions

No annotated interactions

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