miRNA Biogenesis (Homo sapiens)

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Mature sequence hsa-miR-146a-5p Accession: MIMAT0000449Previous: hsa-miR-146;hsa-miR-146aMature sequence hsa-miR-146a-3pAccession: MIMAT0004608Previous: hsa-miR-146a*Stem-loop sequence hsa-mir-146a Accession: MI0000477 Previous: hsa-mir-1461, 2pre-miRNARNA polymerase IITranscriptionpri-miRNAsNucleusDROSHARANGTPDICER1XPO5DGCR8CytoplasmDICER1TRBPmiRNA duplexDNApre-miRNA5'3'3'5'5'3'5'3'5'3'


microRNA biogenesis + an example of a miRBase entry.

As an example immature hsa-mir-146a is shown

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Ontology Terms



  1. Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC, Lai EC; ''Widespread regulatory activity of vertebrate microRNA* species.''; RNA, 2011 PubMed Europe PMC
  2. Wienholds E, Plasterk RH; ''MicroRNA function in animal development.''; FEBS Lett, 2005 PubMed Europe PMC


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96864view23:59, 14 April 2018AlexanderPicoOntology Term : 'classic metabolic pathway' added !
96863view23:58, 14 April 2018AlexanderPicoswapped datanodes for labels where generic
96862view23:55, 14 April 2018AlexanderPicoconverted all interactions to graphical lines; nothing connecting datanodes
96779view17:25, 5 April 2018Khansperschanged board height
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96776view17:13, 5 April 2018Khanspersremoved extra item
96772view12:44, 5 April 2018Marvin M2Updated layout and changed lines into graphical lines
96714view15:38, 29 March 2018Fehrhartconverted interactions to graphical lines
96713view15:34, 29 March 2018Fehrhartconverted interaction to graphical lines
78504view10:29, 7 January 2015MaintBotadded missing graphIds
71236view14:53, 16 October 2013MaintBotAutomated update of data sources
70022view01:52, 12 July 2013AlexanderPicoModified title
68897view17:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
59099view22:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
53823view12:37, 14 November 2012SusanAdding literature
53822view12:33, 14 November 2012SusanModified description
53821view12:32, 14 November 2012SusanOntology Term : 'microRNA pathway' added !
53106view01:11, 30 October 2012MaintBotModified categories
52989view17:36, 25 October 2012SusanNew pathway

External references


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NameTypeDatabase referenceComment
DGCR8GeneProductENSG00000128191 (Ensembl)
DICER1GeneProductENSG00000100697 (Ensembl)
DROSHAGeneProductENSG00000113360 (Ensembl)
GTPMetaboliteHMDB01440 (HMDB)
RANGeneProduct5901 (Entrez Gene)
TRBPProteinQ15633 (Uniprot-TrEMBL)
XPO5GeneProductENSG00000124571 (Ensembl)

Annotated Interactions

No annotated interactions

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