G Protein Signaling Pathways (Mus musculus)

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1, 2CellResponseCytoskeletalChangesProtein Kinase CCellResponseTranscriptionTranscriptionG betaGqGiGscAMPPhosphodiesterasesProtein Kinase AAdenylate CyclasesAKAPsPhosphatase 2BG 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


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP35(r20751) with a 94% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC
  2. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106872view13:35, 17 September 2019MaintBotHMDB identifier normalization
89955view18:03, 6 October 2016Mkutmonfix unconnected lines
71315view17:16, 17 October 2013MaintBotAutomated update of data sources
69088view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
67261view10:28, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
41275view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35313view08:15, 12 February 2010ThomasModified description
35312view08:15, 12 February 2010Thomasadded literature
32954view19:06, 28 September 2009MaintBotConnected edges
32366view13:45, 15 August 2009MaintBotFixed text labels
32005view13:18, 14 August 2009MaintBotFixed group labels
31410view20:53, 13 August 2009MaintBotFixed text labels
30884view00:18, 30 July 2009MaintBotConverted from Homo sapiens
21165view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:G Protein Signaling]] moved to [[Pathway:WP232]]: Moved to stable identifier
8074view13:46, 7 January 2008MaintBot[[Pathway:Mouse:G Protein Signaling]] moved to [[Pathway:Mus musculus:G Protein Signaling]]: Renaming species
7659view16:07, 18 December 2007MaintBotfixed category names
7226view12:41, 4 November 2007MaintBotAdded categories to GPML
19469view22:19, 22 May 2007C.Redferngpml file for [[Mouse:G_Protein_Signaling]]
19468view22:19, 22 May 2007BruceConklingpml file for [[Mouse:G_Protein_Signaling]]
6449view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:G_Protein_Signaling]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Adcy1GeneProduct432530 (Entrez Gene)
Adcy2GeneProduct210044 (Entrez Gene)
Adcy3GeneProduct104111 (Entrez Gene)
Adcy4GeneProduct104110 (Entrez Gene)
Adcy5GeneProduct224129 (Entrez Gene)
Adcy6GeneProduct11512 (Entrez Gene)
Adcy7GeneProduct11513 (Entrez Gene)
Adcy8GeneProduct11514 (Entrez Gene)
Adcy9GeneProduct11515 (Entrez Gene)
Akap10GeneProduct56697 (Entrez Gene)
Akap1GeneProduct11640 (Entrez Gene)
Akap11GeneProduct219181 (Entrez Gene)
Akap12GeneProduct83397 (Entrez Gene)
Akap13GeneProduct75547 (Entrez Gene)
Akap2GeneProduct11641 (Entrez Gene)
Akap3GeneProduct11642 (Entrez Gene)
Akap4GeneProduct11643 (Entrez Gene)
Akap5GeneProduct238276 (Entrez Gene)
Akap6GeneProduct238161 (Entrez Gene)
Akap7GeneProduct432442 (Entrez Gene)
Akap8GeneProduct56399 (Entrez Gene)
Akap9GeneProduct100986 (Entrez Gene)
Arhgef1GeneProduct16801 (Entrez Gene)
Ca2+MetaboliteHMDB0000464 (HMDB)
Calm1GeneProduct12313 (Entrez Gene)
DAGMetaboliteC00165 (KEGG Compound)
Gna11GeneProduct14672 (Entrez Gene)
Gna12GeneProduct14673 (Entrez Gene)
Gna13GeneProduct14674 (Entrez Gene)
Gna14GeneProduct14675 (Entrez Gene)
Gna15GeneProduct14676 (Entrez Gene)
Gnai1GeneProduct14677 (Entrez Gene)
Gnai2GeneProduct14678 (Entrez Gene)
Gnai3GeneProduct14679 (Entrez Gene)
GnalGeneProduct14680 (Entrez Gene)
Gnao1GeneProduct14681 (Entrez Gene)
GnaqGeneProduct14682 (Entrez Gene)
GnasGeneProduct14683 (Entrez Gene)
GnazGeneProduct14687 (Entrez Gene)
Gnb1GeneProduct14688 (Entrez Gene)
Gnb2GeneProduct14693 (Entrez Gene)
Gnb3GeneProduct14695 (Entrez Gene)
Gnb5GeneProduct14697 (Entrez Gene)
Gng10GeneProduct14700 (Entrez Gene)
Gng11GeneProduct66066 (Entrez Gene)
Gng12GeneProduct14701 (Entrez Gene)
Gng13GeneProduct64337 (Entrez Gene)
Gng3GeneProduct14704 (Entrez Gene)
Gng4GeneProduct14706 (Entrez Gene)
Gng5GeneProduct14707 (Entrez Gene)
Gng7GeneProduct14708 (Entrez Gene)
Gng8GeneProduct14709 (Entrez Gene)
Gngt1GeneProduct14699 (Entrez Gene)
Gngt2GeneProduct14710 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
IP3MetaboliteHMDB0001143 (HMDB)
Itpr1GeneProduct16438 (Entrez Gene)
Kcnj3GeneProduct16519 (Entrez Gene)
KrasGeneProduct16653 (Entrez Gene)
NrasGeneProduct18176 (Entrez Gene)
PRKACGGeneProduct
Pde1aGeneProduct18573 (Entrez Gene)
Pde1bGeneProduct18574 (Entrez Gene)
Pde1cGeneProduct18575 (Entrez Gene)
Pde4aGeneProduct18577 (Entrez Gene)
Pde4bGeneProduct18578 (Entrez Gene)
Pde4cGeneProduct110385 (Entrez Gene)
Pde4dGeneProduct238871 (Entrez Gene)
Pde7aGeneProduct18583 (Entrez Gene)
Pde7bGeneProduct29863 (Entrez Gene)
Pde8aGeneProduct18584 (Entrez Gene)
Pde8bGeneProduct218461 (Entrez Gene)
Plcb3GeneProduct18797 (Entrez Gene)
Ppp3caGeneProduct19055 (Entrez Gene)
Ppp3ccGeneProduct19057 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
PrkacbGeneProduct18749 (Entrez Gene)
Prkar1aGeneProduct19084 (Entrez Gene)
Prkar1bGeneProduct19085 (Entrez Gene)
Prkar2aGeneProduct19087 (Entrez Gene)
Prkar2bGeneProduct19088 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
PrkccGeneProduct18752 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene)
PrkchGeneProduct18755 (Entrez Gene)
PrkciGeneProduct18759 (Entrez Gene)
PrkcqGeneProduct18761 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Prkd1GeneProduct18760 (Entrez Gene)
Prkd3GeneProduct75292 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
RrasGeneProduct20130 (Entrez Gene)
Slc9a1GeneProduct20544 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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