PPAR signaling pathway (Mus musculus)

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1KetogenesisScd1Pck1RxrbSlc27a4GykCpt1aCyp7a1Cpt1bRxraPltpCyp4a30b-psSlc27a1AcadlCyp27a1cytochrome P450 4A14-likeScd2Cyp4a10Slc27a5Mmp1aMe1Aqp7Cd36RxrgAcsl5Scd3Acsl4Primary bile acid biosynthesisRxrgSlc27a4Sorbs1LplAdipocytokine signaling pathwayAcsl1Fatty acid metabolismApoa5AcadmFabp6Acaa1aCyp4a31Cpt1cFabp7Plin1Ucp1Fabp1RxraFabp4Fabp3Fabp4Cyp4a29-psRxrbSynthesis and degradation of ketone bodiesRxrgPpardAcaa1bIlkAcsbg1Cpt2Cyp4a12bAcox2Acox3Cyp4a14Acsbg2Slc27a6DbiPck2RxrbSlc27a2PparaGk2RxraPdpk1Cyp4a32Mmp1bApoa2AdipoqApoa1Cyp4a12aNr1h3Olr1Acsl3Cyp8b1Fabp5Fabp3unsaturated fatty acidsFabp1Cd36Scp2Fads2Hmgcs2Acsl6Apoc3Glycerophospholipid metabolismEhhadhUbcPpargScd4Fabp2Slc27a1Acox1Angptl4saturated fatty acidseicosanoidCiprofibrateNSAIDs9-cis-Retinoic acidLipid transportLipogenesisCholesterol metabolismFatty acid transportFatty acid oxidationLipid metabolismAdipocyte differentiationAdaptive thermogenesisCell survivalGluconeogenesisUbiquitinationunsaturated fatty acids9-cis-Retinoic acidunsaturated fatty acidseicosanoidNSAIDsThiazolidine derivative9-cis-Retinoic acidLiverSkeletal muscleSkeletal muscleAdipocyteAdipocyte


Description

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Adapted from KEGG: http://www.genome.jp/kegg/pathway/mmu/mmu03320.html

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Ontology Terms

 

Bibliography

  1. Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed

History

View all...
CompareRevisionActionTimeUserComment
97554view14:57, 24 May 2018Fehrhartupdated identifiers
94204view21:10, 25 August 2017DeSladded chebi ID for compound class thiazolidines
91094view01:04, 4 January 2017Khanspersadded lit ref
91093view01:02, 4 January 2017Khanspersconnected interactions, updated xrefs
90819view18:41, 14 December 2016KhanspersOntology Term : 'cell of skeletal muscle' added !
90818view18:41, 14 December 2016KhanspersOntology Term : 'CL:0000187' removed !
90817view18:40, 14 December 2016KhanspersOntology Term : 'muscle cell' added !
90816view18:40, 14 December 2016KhanspersOntology Term : 'white fat cell' added !
90514view19:51, 20 November 2016AlexanderPicoOntology Term : 'signaling pathway' added !
90513view19:51, 20 November 2016AlexanderPicoOntology Term : 'PW:0000003' removed !
90512view19:50, 20 November 2016AlexanderPicoOntology Term : 'signaling pathway' added !
90511view19:50, 20 November 2016AlexanderPicoOntology Term : 'PW:0000003' removed !
90507view20:11, 19 November 2016AlexanderPicoOntology Term : 'signaling pathway' added !
90506view20:02, 19 November 2016AlexanderPicoOntology Term : 'transcription factor mediated signaling pathway' added !
69143view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67603view11:31, 26 June 2013DdiglesOntology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
53110view01:23, 30 October 2012MaintBotModified categories
52058view10:39, 2 October 2012ThomasModified description
52057view10:38, 2 October 2012ThomasModified description
52056view10:37, 2 October 2012ThomasModified description
52055view10:35, 2 October 2012ThomasNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
9-cis-Retinoic acidMetaboliteHMDB02369 (HMDB)
Acaa1aGeneProduct113868 (Entrez Gene) Original kegg element: gene;21;mmu:113868 mmu:235674
Acaa1bGeneProduct235674 (Entrez Gene) Original kegg element: gene;21;mmu:113868 mmu:235674
AcadlGeneProduct11363 (Entrez Gene) Original kegg element: gene;23;mmu:11363
AcadmGeneProduct11364 (Entrez Gene) Original kegg element: gene;22;mmu:11364
Acox1GeneProduct11430 (Entrez Gene) Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Acox2GeneProduct93732 (Entrez Gene) Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Acox3GeneProduct80911 (Entrez Gene) Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Acsbg1GeneProduct94180 (Entrez Gene) Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Acsbg2GeneProduct328845 (Entrez Gene) Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Acsl1GeneProduct14081 (Entrez Gene) Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Acsl3GeneProduct74205 (Entrez Gene) Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Acsl4GeneProduct50790 (Entrez Gene) Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Acsl5GeneProduct433256 (Entrez Gene) Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Acsl6GeneProduct216739 (Entrez Gene) Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Adipocytokine signaling pathwayGeneProductpath:mmu04920 (KEGG Genes) Original kegg element: map;34;path:mmu04920
AdipoqGeneProduct11450 (Entrez Gene) Original kegg element: gene;53;mmu:11450
Angptl4GeneProduct57875 (Entrez Gene) Original kegg element: gene;41;mmu:57875
Apoa1GeneProduct11806 (Entrez Gene) Original kegg element: gene;61;mmu:11806
Apoa2GeneProduct11807 (Entrez Gene) Original kegg element: gene;46;mmu:11807
Apoa5GeneProduct66113 (Entrez Gene) Original kegg element: gene;64;mmu:66113
Apoc3GeneProduct11814 (Entrez Gene) Original kegg element: gene;57;mmu:11814
Aqp7GeneProduct11832 (Entrez Gene) Original kegg element: gene;7;mmu:11832
Cd36GeneProduct12491 (Entrez Gene) Original kegg element: gene;11;mmu:12491
CiprofibrateMetaboliteQ3496452 (Wikidata)
Cpt1aGeneProduct12894 (Entrez Gene) Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Cpt1bGeneProduct12895 (Entrez Gene) Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Cpt1cGeneProduct78070 (Entrez Gene) Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Cpt2GeneProduct12896 (Entrez Gene) Original kegg element: gene;26;mmu:12896
Cyp27a1GeneProduct104086 (Entrez Gene) Original kegg element: gene;60;mmu:104086
Cyp4a10GeneProduct13117 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp4a12aGeneProduct277753 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp4a12bGeneProduct13118 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp4a14GeneProduct13119 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp4a29-psGeneProduct230639 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp4a30b-psGeneProduct435802 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp4a31GeneProduct666168 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp4a32GeneProduct100040843 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp7a1GeneProduct13122 (Entrez Gene) Original kegg element: gene;33;mmu:13122
Cyp8b1GeneProduct13124 (Entrez Gene) Original kegg element: gene;58;mmu:13124
DbiGeneProduct13167 (Entrez Gene) Original kegg element: gene;63;mmu:13167
EhhadhGeneProduct74147 (Entrez Gene) Original kegg element: gene;25;mmu:74147
Fabp1GeneProduct14080 (Entrez Gene) Original kegg element: gene;44;mmu:14080
Fabp2GeneProduct14079 (Entrez Gene) Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Fabp3GeneProduct14077 (Entrez Gene) Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Fabp4GeneProduct11770 (Entrez Gene) Original kegg element: gene;40;mmu:11770
Fabp5GeneProduct16592 (Entrez Gene) Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Fabp6GeneProduct16204 (Entrez Gene) Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Fabp7GeneProduct12140 (Entrez Gene) Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Fads2GeneProduct56473 (Entrez Gene) Original kegg element: gene;56;mmu:56473
Fatty acid metabolismPathwayWP336 (WikiPathways) Original kegg element: map;35;path:mmu00071
Gk2GeneProduct14626 (Entrez Gene) Original kegg element: gene;8;mmu:14626 mmu:14933
Glycerophospholipid metabolismGeneProductpath:mmu00564 (KEGG Genes) Original kegg element: map;52;path:mmu00564
GykGeneProduct14933 (Entrez Gene) Original kegg element: gene;8;mmu:14626 mmu:14933
Hmgcs2GeneProduct15360 (Entrez Gene) Original kegg element: gene;37;mmu:15360
IlkGeneProduct16202 (Entrez Gene) Original kegg element: gene;43;mmu:16202
LplGeneProduct16956 (Entrez Gene) Original kegg element: gene;30;mmu:16956
Me1GeneProduct17436 (Entrez Gene) Original kegg element: gene;65;mmu:17436
Mmp1aGeneProduct83995 (Entrez Gene) Original kegg element: gene;39;mmu:83995 mmu:83996
Mmp1bGeneProduct83996 (Entrez Gene) Original kegg element: gene;39;mmu:83995 mmu:83996
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
Nr1h3GeneProduct22259 (Entrez Gene) Original kegg element: gene;59;mmu:22259
Olr1GeneProduct108078 (Entrez Gene) Original kegg element: gene;29;mmu:108078
Pck1GeneProduct18534 (Entrez Gene) Original kegg element: gene;9;mmu:18534 mmu:74551
Pck2GeneProduct74551 (Entrez Gene) Original kegg element: gene;9;mmu:18534 mmu:74551
Pdpk1GeneProduct18607 (Entrez Gene) Original kegg element: gene;45;mmu:18607
Plin1GeneProduct103968 (Entrez Gene) Original kegg element: gene;10;mmu:103968
PltpGeneProduct18830 (Entrez Gene) Original kegg element: gene;47;mmu:18830
PparaGeneProduct19013 (Entrez Gene) Original kegg element: gene;14;mmu:19013
PpardGeneProduct19015 (Entrez Gene) Original kegg element: gene;16;mmu:19015
PpargGeneProduct19016 (Entrez Gene) Original kegg element: gene;18;mmu:19016
Primary bile acid biosynthesisGeneProductpath:mmu00120 (KEGG Genes) Original kegg element: map;51;path:mmu00120
RxraGeneProduct20181 (Entrez Gene) Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
RxrbGeneProduct20182 (Entrez Gene) Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
RxrgGeneProduct20183 (Entrez Gene) Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Scd1GeneProduct20249 (Entrez Gene) Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Scd2GeneProduct20250 (Entrez Gene) Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Scd3GeneProduct30049 (Entrez Gene) Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Scd4GeneProduct329065 (Entrez Gene) Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Scp2GeneProduct20280 (Entrez Gene) Original kegg element: gene;20;mmu:20280
Slc27a1GeneProduct26457 (Entrez Gene) Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Slc27a2GeneProduct26458 (Entrez Gene) Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Slc27a4GeneProduct26569 (Entrez Gene) Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Slc27a5GeneProduct26459 (Entrez Gene) Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Slc27a6GeneProduct225579 (Entrez Gene) Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Sorbs1GeneProduct20411 (Entrez Gene) Original kegg element: gene;38;mmu:20411
Synthesis and degradation of ketone bodiesPathwayWP543 (WikiPathways) Original kegg element: map;50;path:mmu00072
Thiazolidine derivativeMetaboliteCHEBI:35622 (ChEBI)
UbcGeneProduct22190 (Entrez Gene) Original kegg element: gene;62;mmu:22190
Ucp1GeneProduct22227 (Entrez Gene) Original kegg element: gene;66;mmu:22227
cytochrome P450 4A14-likeGeneProduct640109 (Entrez Gene) Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
eicosanoidMetaboliteCHEBI:23899 (ChEBI)
saturated fatty acidsMetaboliteCHEBI:26607 (ChEBI)
unsaturated fatty acidsMetaboliteCHEBI:27208 (ChEBI)

Annotated Interactions

No annotated interactions

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