Glial Cell Differentiation (Homo sapiens)

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1213HypoxiaDownregulationMyelin Proteins3TPPPMBPMAGPLP1miR-206GAP43CNPMSNNeural Stem CellGlial Cell DifferentiationOligodendrocyte ProgenitorAxon MyelinationFilopodia Extension


Glial cells, consisting of microglia, astrocytes, and oligodendrocyte lineage cells as their major components, constitute a large fraction of the mammalian brain. Originally considered as purely non-functional glue for neurons, decades of research have highlighted the importance as well as further functions of glial cells. Source: Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Lehotzky A, Lau P, Tokési N, Muja N, Hudson LD, Ovádi J; ''Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.''; Glia, 2010 PubMed Europe PMC
  2. Curtis R, Hardy R, Reynolds R, Spruce BA, Wilkin GP; ''Down-regulation of GAP-43 During Oligodendrocyte Development and Lack of Expression by Astrocytes In Vivo: Implications for Macroglial Differentiation.''; Eur J Neurosci, 1991 PubMed Europe PMC
  3. Cai J, Tuong CM, Zhang Y, Shields CB, Guo G, Fu H, Gozal D; ''Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation.''; J Pathol, 2012 PubMed Europe PMC


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107580view05:34, 23 October 2019KhanspersModified description
106432view23:23, 28 August 2019KhanspersModified description
105608view04:53, 10 August 2019KhanspersModified description
97827view15:34, 9 June 2018EgonwUndo revision 97764 by [[Special:Contributions/DeSl|DeSl]] ([[User talk:DeSl|Talk]]) Text cannot be copied from other websites.
97766view13:30, 7 June 2018DeSlOntology Term : 'stem cell' added !
97765view13:30, 7 June 2018DeSlOntology Term : 'neural cell' added !
97764view13:29, 7 June 2018DeSlModified description
97759view13:25, 7 June 2018DeSlOntology Term : 'glial cell' added !
94751view15:27, 5 October 2017Ryanmillerchanged unconnected lines to graphical lines
87535view02:06, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87534view02:06, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway pertinent to development' added !
63194view20:52, 8 May 2013MaintBotUpdating gpml version
59086view22:06, 21 February 2013MaintBotUpdated Ensembl data source
53125view01:45, 30 October 2012MaintBotModified categories
50555view05:04, 17 August 2012NsalomonisSpecify description
50552view04:54, 17 August 2012NsalomonisPeriodical save, work in progress
50549view04:34, 17 August 2012NsalomonisPeriodical save, work in progress
50548view04:14, 17 August 2012NsalomonisPeriodical save, work in progress
50547view04:08, 17 August 2012NsalomonisSpecify description
50542view03:41, 17 August 2012NsalomonisSpecify description
50541view03:34, 17 August 2012NsalomonisPeriodical save, work in progress
50538view03:31, 17 August 2012NsalomonisSpecify description
50537view03:24, 17 August 2012NsalomonisPeriodical save, work in progress
50536view03:03, 17 August 2012NsalomonisPeriodical save, work in progress
50534view02:47, 17 August 2012NsalomonisNew pathway

External references


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NameTypeDatabase referenceComment
CNPGeneProductENSG00000173786 (Ensembl)
GAP43GeneProductENSG00000172020 (Ensembl)
MAGGeneProductENSG00000105695 (Ensembl)
MBPGeneProductENSG00000197971 (Ensembl)
MSNGeneProductENSG00000147065 (Ensembl)
PLP1GeneProductENSG00000123560 (Ensembl)
TPPPGeneProductENSG00000171368 (Ensembl)
miR-206GeneProductENSG00000207604 (Ensembl)

Annotated Interactions

No annotated interactions

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