Heterochronic gene regulation of development (Caenorhabditis elegans)

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1-3C. elegans Larval StagesL1lin-4LIN-66LIN-14LIN-28mir-48mir-241mir-84DAF-12let-7LIN-46HBL-1L2L3L4ADULTLIN-41HBL-1LIN-29


Description

The heterochronic pathway, regulating larval development in Caenorhabditis elegans, is shown. Caenorhabditis elegans is a good model for studying heterochronic genes,due to its invariant cell lineages.

Heterochronic is associated with the development of cells or tissues at a "different" time relative to other developmental events. Changes in developmental timing are thought to be a driving force of morphological evolution.

Regulatory relationships shown here are supported by genetic data, but not all are direct. Lin-42 is not shown, as its complex expression pattern and genetic interactions suggest that it acts at multiple steps through out the pathways, making its precise placement difficult. In the absence of ligand DAF-12 represses let-7 family miRNAs.

Arrows indicate activation - Bars indicate repression.

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Ontology Terms

 

Bibliography

  1. Abbott AL; ''Heterochronic genes.''; Curr Biol, 2003 PubMed
  2. Moss EG; ''Heterochronic genes and the nature of developmental time.''; Curr Biol, 2007 PubMed
  3. Resnick TD, McCulloch KA, Rougvie AE; ''miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans.''; Dev Dyn, 2010 PubMed

History

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CompareRevisionActionTimeUserComment
96861view23:39, 14 April 2018AlexanderPicoOntology Term : 'signaling pathway' added !
96860view23:39, 14 April 2018AlexanderPicoconnected one last line
96795view09:51, 9 April 2018DeSlConnected unconnected lines.
96775view17:02, 5 April 2018KhanspersModified description
96682view17:58, 26 March 2018Asios OliaAdded literature reference
96681view17:56, 26 March 2018Asios OliaModified description
96680view17:55, 26 March 2018Asios OliaModified description
96679view17:53, 26 March 2018Asios OliaModified description
96678view17:35, 26 March 2018Asios OliaAdded literature reference
96244view13:41, 2 March 2018FehrhartCorrected spelling error
96209view09:27, 28 February 2018Asios Olialarva to larval correction
96208view09:26, 28 February 2018Asios OliaDescriptor for L1 to L4 to adult elements
68466view20:27, 5 July 2013MaintBotUpdated to 2013 gpml schema
53146view02:10, 30 October 2012MaintBotModified categories
49514view01:27, 20 July 2012MaintBotOntology Term : 'signaling pathway pertinent to development' added !
49137view19:49, 6 July 2012KyookModified description
49136view19:48, 6 July 2012Kyookadd reference
49135view19:44, 6 July 2012KyookFigure 4 PMID:20232378
49134view19:37, 6 July 2012KyookPeriodical save, work in progress
49133view19:27, 6 July 2012KyookPeriodical save, work in progress
49132view19:17, 6 July 2012KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DAF-12GeneProductF11A1.3 (WormBase)
HBL-1GeneProductF13D11.2 (WormBase)
LIN-14GeneProductT25C12.1 (WormBase)
LIN-28GeneProductF02E9.2 (WormBase)
LIN-29GeneProductW03C9.4 (WormBase)
LIN-41GeneProductC12C8.3 (WormBase)
LIN-46GeneProductR186.4 (WormBase)
LIN-66GeneProductB0513.1 (WormBase)
let-7RnaC05G5.6 (WormBase)
lin-4RnaF59G1.6 (WormBase)
mir-241RnaF56A12.4 (WormBase)
mir-48RnaF56A12.3 (WormBase)
mir-84RnaB0395.4 (WormBase)

Annotated Interactions

No annotated interactions

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