Cell engulfment (Caenorhabditis elegans)

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1, 2NucleusCell targetted for deathIntegrins?UnknownCED-4CED-9CED-10/Rac1CED-5/DOCK180Engulfing CellEGL-1CED-9CED-6CED-1/SREC?CED-2/CrkIIactinpolymerizationActive CED-3ProteaseCED-3CED-7CED-7/ABC1PSR-1?CED-42EGL-12CED-4???


A model of apoptotic cell engulfment.

Caenorhabditis (from Caeno and rhabditis = rod like stick shaped) elegans is a free living (non parasitic) transparent roundworm (nematode).

C. elegans was the first organism to have its whole genome sequenced and it neuronal wiring described.

The C. elegans engulfment pathway removes the dying ("corpse") cells by using receptor signals then identifying the dying cells and eventually engulfing them.

The final process involves the recycling of the remaining cell particles of the dead engulfed cells.

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Ontology Terms



  1. Gumienny TL, Hengartner MO; ''How the worm removes corpses: the nematode C. elegans as a model system to study engulfment.''; Cell Death Differ, 2001 PubMed Europe PMC
  2. Conradt B, Xue D; ''Programmed cell death.''; WormBook, 2005 PubMed Europe PMC


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96247view13:46, 2 March 2018FehrhartModified description
96195view14:16, 25 February 2018EgonwModified description
96194view19:38, 23 February 2018Asios OliaModified description
96193view19:37, 23 February 2018Asios OliaModified description
89458view13:10, 15 September 2016Mkutmonremove space in ontology term id
79239view19:04, 16 March 2015MaintBotused graphical lines for receptor graphics
79237view18:48, 16 March 2015CgroveFixing unconnected lines
79236view18:21, 16 March 2015CgroveFixing unconnected lines
79207view12:03, 12 March 2015EgonwMove the pathway closer to the title, to have it larger on the website.
78460view10:27, 7 January 2015MaintBotadded missing graphIds
77208view23:20, 5 August 2014Cgrovecleaning up
77207view23:17, 5 August 2014Cgrovecleaning up
76300view22:30, 27 June 2014Kyook
76299view22:24, 27 June 2014Kyook
76297view21:42, 27 June 2014Kyookupdate - periodic save
76296view21:06, 27 June 2014Kyookupdate work in progress
76295view19:58, 27 June 2014Kyookupdating pathway using Programmed Cell Death WormBook Chapter (Conradt 2005).
68500view21:26, 5 July 2013MaintBotUpdated to 2013 gpml schema
68499view21:24, 5 July 2013KhanspersReverted to version '10:07, 26 June 2013' by Khanspers
68470view20:32, 5 July 2013MaintBotUpdated to 2013 gpml schema
67106view10:07, 26 June 2013Christine ChichesterOntology Term : 'phagocytosis pathway' added !
53147view02:11, 30 October 2012MaintBotModified categories
49089view18:01, 5 July 2012Kyookadded reference
49088view17:43, 5 July 2012KyookSpecify description
49087view17:34, 5 July 2012KyookOntology Term : 'apoptotic cell death pathway' added !
49086view17:34, 5 July 2012Kyookfinished
49085view17:32, 5 July 2012KyookPeriodical save, work in progress
49083view17:21, 5 July 2012KyookNew pathway

External references


View all...
NameTypeDatabase referenceComment
Active CED-3 ProteaseGeneProductC48D1.2 (WormBase)
CED-1/SREC?GeneProductY47H9C.4 (WormBase)
CED-10/Rac1GeneProductC09G12.8 (WormBase)
CED-2/CrkIIGeneProductY41D4B.13 (WormBase)
CED-3GeneProductC48D1.2 (WormBase)
CED-4GeneProductC35D10.9 (WormBase)
CED-5/DOCK180GeneProductC02F4.1 (WormBase)
CED-6GeneProductF56D2.7 (WormBase)
CED-7/ABC1GeneProductC48B4.4 (WormBase)
CED-7GeneProductC48B4.4 (WormBase)
CED-9GeneProductT07C4.8 (WormBase)
EGL-1GeneProductF23B12.9 (WormBase)
PSR-1?GeneProductF29B9.4 (WormBase)

Annotated Interactions

No annotated interactions

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