Thymic stromal lymphopoietin (TSLP) signaling pathway (Homo sapiens)

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MAP2K2S226MAPK3T207T202Y204DissociationSurvival and chemotaxis ofeosinophilsTSLPCRLF2STAT1Y701STAT3STAT4Y705S727Y693MAPK1T185Y187PTPN11JAK2Y542Y1007Y1008JAK1Y570Y1034Y1035IL7RMAP2K1S222S218MAPK14T180Y182NFKBIARELBPRELANFKB1NFKB2MAPK8T183Y185RELARELBNFKB1NFKB2TECY519PI3KRPS6S236S236EIF4EBP1T70MTORC1AKT1T308S473GAB2PSTAT6Y641Thymic stromal lymphopoietin signaling pathwaySRCY419STAT5BY699STAT5AY694CCL11Dentritic cell-mediatedTh2 responseProliferation ofpre-ALL cellsCell proliferationAnti-apoptosisDentritic cell migrationInvasion of trophoblastsAirway inflammatory responseSTAT5BY699STAT5AY694STAT3S727Y705MAPK9T183Y185MYCIL8IL2RAIL6CISHTNFSF4NUCYNUCYNUCYNUCYNUCYNUCYNUCYYES1LCKY426Y394BTKY551FESY713HCKT412FYNY411Y420LYNY397Cell proliferationAirway inflammatory response


Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine involved in regulation of a broad spectrum of biological processes. The TSLP receptor complex consists of the IL-7 receptor alpha subunit and its unique TSLPR subunit (gene symbol CRLF2). TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP can also activate dendritic cells, CD4+ T cells and CD8+ T cells. TSLP not only activate the JAK/STAT pathway but also induce phosphorylation of other signaling molecules including PI3K/Akt, ERK1/2 and JNKs. Aberrant TSLP signaling is implicated in a number of the development of diseases, including asthma, atopic dermatitis, eosinophilic eosophagitis and acute lymphoid leukemia.

Description source: NetPath

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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120724view01:31, 24 December 2021EweitzStandardize font, weight, case
117845view15:15, 22 May 2021EweitzModified title
105841view23:12, 15 August 2019KhanspersModified description
96065view17:58, 15 February 2018KhanspersModified description
86071view07:28, 29 June 2016MirellaKalafatiModified title
85046view09:39, 10 April 2016EgonwReplaced a mim-conversion with mim-stimulation.
78549view10:30, 7 January 2015MaintBotadded missing graphIds
77474view06:24, 15 September 2014NetPathPeriodical save, work in progress
72104view21:49, 24 October 2013AlexanderPicoadded EC number for PI3K complex
71374view18:38, 17 October 2013MaintBotAutomated update of data sources
70626view23:08, 18 August 2013MaintBotupdated gpml from NetPath
68943view17:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
67728view11:55, 26 June 2013DdiglesOntology Term : 'interleukin-2 family mediated signaling pathway' added !
57845view18:21, 4 February 2013MaintBotModified categories
48521view06:58, 1 June 2012NetPathOntology Term : 'Jak-Stat signaling pathway' added !
48520view06:57, 1 June 2012NetPathOntology Term : 'cytokine mediated signaling pathway' added !
48519view06:54, 1 June 2012NetPathModified description
48518view06:51, 1 June 2012NetPathModified description
48517view06:48, 1 June 2012NetPathNew pathway

External references


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NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
BTKProtein695 (Entrez Gene)
CCL11Rna6356 (Entrez Gene)
CISHRna1154 (Entrez Gene)
CRLF2Protein64109 (Entrez Gene)
EIF4EBP1Protein1978 (Entrez Gene)
FESProtein2242 (Entrez Gene)
FYNProtein2534 (Entrez Gene)
GAB2Protein9846 (Entrez Gene)
HCKProtein3055 (Entrez Gene)
IL2RARna3559 (Entrez Gene)
IL6Rna3569 (Entrez Gene)
IL7RProtein3575 (Entrez Gene)
IL8Rna3576 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
LCKProtein3932 (Entrez Gene)
LYNProtein4067 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
MTORC1Complex2475 (Entrez Gene)
MYCRna4609 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKB2Protein4791 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
PI3KComplex2.7.1.153 (Enzyme Nomenclature)
PIK3CAProtein5290 (Entrez Gene)
PIK42AProtein55361 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RELBProtein5971 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT4Protein6775 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
STAT6Protein6778 (Entrez Gene)
TECProtein7006 (Entrez Gene)
TNFSF4Rna7292 (Entrez Gene)
TSLPProtein85480 (Entrez Gene)
YES1Protein7525 (Entrez Gene)

Annotated Interactions

No annotated interactions

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