Nuclear Receptors (Rattus norvegicus)

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1Nuclear receptor TLXNR3 SUPERFAMILYGlucocorticoid ReceptorAndrogen ReceptorProgesterone ReceptorNR5 SUPERFAMILYOxysterols ReceptorSteroid Hormone ReceptorOrphan NuclearOrphan Nuclear ReceptorReceptorThyroid ReceptorVitamin D3 ReceptorRetinoic Acid Receptor RXRSteroidogenic ReceptorNR4 SUPERFAMILYPeroxisome ProliferatorNR2 SUPERFAMILYRetinoic Acid ReceptorCoup Transcription FactorNR0 SUPERFAMILYEstrogen ReceptorActivated ReceptorNuclear Receptor ROROrphan ReceptorNR1 SUPERFAMILYOrphan ReceptorHepatocyte Nuclear FactorNR2E1ThraNR1D2VdrPpargRorcNr2f1RoraHnf4aNr2f2Nr3c1Ror1Esr1RARBEsrraArEsrrbRxraRargNr1h2RxrbNr5a1ThrbNr4a2Nr5a2Nr1h3ThrbPgrRaraPpardEsr2RargPparaNr2f6Nr2c2Nr0b1Nr1i2Nr4a1PpargRxrgNr1i3


Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia (wikipedia:Nuclear_receptor)


This pathway was inferred from Homo sapiens pathway WP170(r21037) with a 92% conversion rate.

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Ontology Terms



  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia


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89864view12:34, 6 October 2016MkutmonModified description
69973view21:15, 11 July 2013MaintBot
69972view21:15, 11 July 2013MaintBotupdated to 2013 schema
67532view11:22, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
41715view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35768view00:11, 13 February 2010AlexanderPico
34094view19:17, 9 December 2009MaintBotAutomatic update of empty xrefs
32001view13:17, 14 August 2009MaintBotFixed group labels
31009view01:04, 30 July 2009MaintBotConverted from Homo sapiens
21135view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Nuclear Receptors]] moved to [[Pathway:WP217]]: Moved to stable identifier
8288view13:46, 7 January 2008MaintBot[[Pathway:Rat:Nuclear Receptors]] moved to [[Pathway:Rattus norvegicus:Nuclear Receptors]]: Renaming species
7764view16:16, 18 December 2007MaintBotfixed category names
7436view12:42, 4 November 2007MaintBotAdded categories to GPML
19522view22:20, 22 May 2007M.Ramirezgpml file for [[Rat:Nuclear_Receptors]]
6579view22:20, 22 May 2007E.Tuninskygpml file for [[Rat:Nuclear_Receptors]]

External references


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NameTypeDatabase referenceComment
ArGeneProduct24208 (Entrez Gene)
Esr1GeneProduct24890 (Entrez Gene)
Esr2GeneProduct25149 (Entrez Gene)
EsrraGeneProduct293701 (Entrez Gene)
EsrrbGeneProduct299210 (Entrez Gene)
Hnf4aGeneProduct25735 (Entrez Gene)
NR1D2GeneProduct259241 (Entrez Gene)
NR2E1GeneProduct684085 (Entrez Gene)
Nr0b1GeneProduct58850 (Entrez Gene)
Nr1h2GeneProduct58851 (Entrez Gene)
Nr1h3GeneProduct58852 (Entrez Gene)
Nr1i2GeneProduct84385 (Entrez Gene)
Nr1i3GeneProduct65035 (Entrez Gene)
Nr2c2GeneProduct50659 (Entrez Gene)
Nr2f1GeneProduct81808 (Entrez Gene)
Nr2f2GeneProduct113984 (Entrez Gene)
Nr2f6GeneProduct245980 (Entrez Gene)
Nr3c1GeneProduct24413 (Entrez Gene)
Nr4a1GeneProduct79240 (Entrez Gene)
Nr4a2GeneProduct54278 (Entrez Gene)
Nr5a1GeneProduct83826 (Entrez Gene)
Nr5a2GeneProduct60349 (Entrez Gene)
PgrGeneProduct25154 (Entrez Gene)
PparaGeneProduct25747 (Entrez Gene)
PpardGeneProduct25682 (Entrez Gene)
PpargGeneProduct25664 (Entrez Gene)
RARBGeneProduct24706 (Entrez Gene)
RaraGeneProduct24705 (Entrez Gene)
RargGeneProduct685072 (Entrez Gene)
Ror1GeneProduct362550 (Entrez Gene)
RoraGeneProduct300807 (Entrez Gene)
RorcGeneProduct368158 (Entrez Gene)
RxraGeneProduct25271 (Entrez Gene)
RxrbGeneProduct361801 (Entrez Gene)
RxrgGeneProduct83574 (Entrez Gene)
ThraGeneProduct81812 (Entrez Gene)
ThrbGeneProduct24831 (Entrez Gene)
VdrGeneProduct24873 (Entrez Gene)

Annotated Interactions

No annotated interactions
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