BDNF pathway (Mus musculus)

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NucleusCytoplasmSH2BFrs2Bcl2 - Cell survivalTrkBCrebp75PlasminogenResponse ElementtPAPLC-gammap53Shc1ApoptosisRac1NF-kappa-BCdc42PAI-1BaxPro-BdnfMapk1, 672, 5Bdnf61581, 2, 5, 827793, 64, 71, 64, 772, 77Plasmin4, 7


Brain-derived neurotrophic factor (BDNF) is a growth factor found in the central and peripheral nervous systems. BDNF binds to two well-characterized receptors, TrkB and p75 (aka, low-affinity nerve growth factor receptor) to influence neuronal cell survival and differentiation. In the hippocampus, BDNF activity is also implicated in learning and memory.

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  1. Lassus P, Roux P, Zugasti O, Philips A, Fort P, Hibner U; ''Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
  2. Yeo GS, Connie Hung CC, Rochford J, Keogh J, Gray J, Sivaramakrishnan S, O'Rahilly S, Farooqi IS; ''A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.''; Nat Neurosci, 2004 PubMed Europe PMC Scholia
  3. Taylor RC, Cullen SP, Martin SJ; ''Apoptosis: controlled demolition at the cellular level.''; Nat Rev Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  4. Cho E, Lee KJ, Seo JW, Byun CJ, Chung SJ, Suh DC, Carmeliet P, Koh JY, Kim JS, Lee JY; ''Neuroprotection by urokinase plasminogen activator in the hippocampus.''; Neurobiol Dis, 2012 PubMed Europe PMC Scholia
  5. Li Y, Liu J, Hudson M, Kim S, Hatch NE; ''FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling.''; J Cell Biochem, 2010 PubMed Europe PMC Scholia
  6. Thomas A, Giesler T, White E; ''p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
  7. Neeley EW, Berger R, Koenig JI, Leonard S; ''Prenatal stress differentially alters brain-derived neurotrophic factor expression and signaling across rat strains.''; Neuroscience, 2011 PubMed Europe PMC Scholia
  8. Thompson WL, Van Eldik LJ; ''Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected].''; Brain Res, 2009 PubMed Europe PMC Scholia
  9. Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y, Liu Y, Rui L; ''SH2B regulation of growth, metabolism, and longevity in both insects and mammals.''; Cell Metab, 2010 PubMed Europe PMC Scholia


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120589view19:26, 17 December 2021Khanspersadded xref
117863view10:15, 23 May 2021EweitzModified title
90939view23:21, 18 December 2016AlexanderPicoRemoved old genmapp info
90921view23:33, 17 December 2016AlexanderPicoModified description
89973view18:41, 6 October 2016Mkutmonfix unconnected lines
87321view07:25, 21 July 2016EgonwApoptosis is a pathway.
87320view07:25, 21 July 2016EgonwReverted to the four mouse genes and changed the species of the pathway to mouse.
85554view08:31, 29 May 2016EgonwReplaced a mim-conversion with Arrow.
82351view11:41, 26 September 2015EgonwConverted a four mouse gene identifiers to human identifiers.
77496view17:23, 18 September 2014KhanspersOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
70073view09:06, 12 July 2013Mkutmonfixed unconnected lines
69043view17:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
59221view20:14, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57736view21:59, 1 February 2013MaintBotModified categories
57735view21:59, 1 February 2013MaintBotModified title
47371view10:52, 16 March 2012KuroiRFinalized presence of proteins
47370view10:27, 16 March 2012KuroiRPeriodical save, work in progress
47369view10:17, 16 March 2012KuroiRPeriodical save, work in progress
47368view10:07, 16 March 2012KuroiRPeriodical save, work in progress
47367view09:57, 16 March 2012KuroiRPeriodical save, work in progress
47366view09:47, 16 March 2012KuroiRPeriodical save, work in progress
47365view09:37, 16 March 2012KuroiRPeriodical save, work in progress
47364view09:26, 16 March 2012KuroiRPeriodical save, work in progress
47363view09:16, 16 March 2012KuroiRPeriodical save, work in progress
47362view09:04, 16 March 2012KuroiRNew pathway

External references


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NameTypeDatabase referenceComment
BaxGeneProductENSMUSG00000003873 (Ensembl)
Bcl2 - Cell survivalGeneProductENSMUSG00000057329 (Ensembl)
BdnfGeneProductENSMUSG00000048482 (Ensembl)
Cdc42GeneProductENSMUSG00000006699 (Ensembl)
CrebGeneProductENSMUSG00000025958 (Ensembl)
Frs2GeneProductENSMUSG00000020170 (Ensembl)
MapkGeneProductENSMUSG00000024558 (Ensembl)
PAI-1GeneProductENSMUSG00000037411 (Ensembl)
PlasminGeneProductENSMUSG00000059481 (Ensembl)
PlasminogenGeneProductENSMUSG00000059481 (Ensembl)
Pro-BdnfGeneProductENSMUSG00000048482 (Ensembl)
Rac1GeneProductENSMUSG00000001847 (Ensembl)
Response ElementGeneProduct
Shc1GeneProductENSMUSG00000042626 (Ensembl)
TrkBGeneProductENSMUSG00000055254 (Ensembl)
p53GeneProductENSMUSG00000059552 (Ensembl)
p75GeneProductENSMUSG00000000120 (Ensembl)
tPAGeneProductENSMUSG00000031538 (Ensembl)

Annotated Interactions

No annotated interactions

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