Type III interferon signaling (Homo sapiens)

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The recently identified type III interferon group consists of three IFN-λ (lambda) genes encoding molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively). These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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105848view23:14, 15 August 2019KhanspersModified description
86876view07:41, 14 July 2016Mkutmonfixed redundant ontology tags
86875view07:40, 14 July 2016MkutmonOntology Term : 'interleukin-28B signaling pathway' added !
86874view07:40, 14 July 2016MkutmonOntology Term : 'interleukin-28A signaling pathway' added !
86873view07:39, 14 July 2016MkutmonOntology Term : 'PW:0000892' removed !
86872view07:39, 14 July 2016MkutmonOntology Term : 'interleukin-29 signaling pathway' added !
86871view07:39, 14 July 2016MkutmonOntology Term : 'PW:0000893' removed !
70107view18:58, 12 July 2013MaintBotupdated to 2013 schema
58406view22:12, 12 February 2013MaintBotModified categories
58123view13:44, 8 February 2013Sham.ukModified title
58122view13:43, 8 February 2013Sham.ukSpecify description
58121view13:42, 8 February 2013Sham.ukSpecify description
58118view13:19, 8 February 2013Sham.ukPeriodical save, work in progress
58117view13:18, 8 February 2013Sham.ukSpecify description
58116view13:14, 8 February 2013Sham.ukupdate
57857view18:38, 4 February 2013Sham.ukOntology Term : 'Jak-Stat signaling pathway' added !
57854view18:35, 4 February 2013Sham.ukOntology Term : 'interferon lambda3 signaling pathway' added !
57853view18:34, 4 February 2013Sham.ukOntology Term : 'interferon lambda2 signaling pathway' added !
57851view18:34, 4 February 2013Sham.ukOntology Term : 'interferon lambda1 signaling pathway' added !
57849view18:34, 4 February 2013Sham.ukModified description
57844view18:20, 4 February 2013MaintBotModified title
46945view14:01, 7 March 2012Sham.uknew pathway
46944view13:57, 7 March 2012Sham.ukNew pathway

External references


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NameTypeDatabase referenceComment
IL10RBGeneProduct3588 (Entrez Gene)
IL28AGeneProduct282616 (Entrez Gene)
IL28BGeneProduct282617 (Entrez Gene)
IL28RAGeneProduct163702 (Entrez Gene)
IL29GeneProduct282618 (Entrez Gene)
IRF9GeneProduct10379 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)

Annotated Interactions

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