SREBF and miR33 in cholesterol and lipid homeostasis (Mus musculus)

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1-9FASNPpargc1aSrebf1Mir33Med15Nr1h3Sirt1SCDMtorHmgcrSirt6PparaSrebf2MIR33BHmgcs1LdlrABCA1PRKAA1


Description

This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2011(r44729) with a 72% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT; ''Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.''; J Biol Chem, 2010 PubMed
  2. Rodgers JT, Puigserver P; ''Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.''; Proc Natl Acad Sci U S A, 2007 PubMed
  3. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T; ''MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo.''; Proc Natl Acad Sci U S A, 2010 PubMed
  4. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH; ''SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.''; EMBO J, 2007 PubMed
  5. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM; ''An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.''; Nature, 2006 PubMed
  6. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P; ''mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.''; Nature, 2007 PubMed
  7. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM; ''Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.''; Genes Dev, 2010 PubMed
  8. Joseph T Rodgers, Pere Puigserver; ''The nuclear hormone receptor LXR—best known for sensing cholesterol metabolites—also responds to glucose. The findings give LXR a central role in modulating the body's response to metabolic inputs.''; Nature Medicine, 2007
  9. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P; ''Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.''; EMBO J, 2007 PubMed

History

CompareRevisionActionTimeUserComment
87683view08:55, 25 July 2016LindarieswijkOntology Term : 'homeostasis pathway' added !
69904view19:29, 11 July 2013MaintBotupdating to 2013 schema
59006view20:28, 21 February 2013MaintBotUpdated Ensembl data source
45986view21:18, 1 December 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCA1GeneProduct
FASNGeneProduct
HmgcrGeneProductENSMUSG00000021670 (Ensembl)
Hmgcs1GeneProductENSMUSG00000079301 (Ensembl)
LdlrGeneProductENSMUSG00000032193 (Ensembl)
MIR33BGeneProduct
Med15GeneProductENSMUSG00000012114 (Ensembl)
Mir33GeneProductENSMUSG00000065465 (Ensembl)
MtorGeneProductENSMUSG00000028991 (Ensembl)
Nr1h3GeneProductENSMUSG00000002108 (Ensembl)
PRKAA1GeneProduct
PparaGeneProductENSMUSG00000022383 (Ensembl)
Ppargc1aGeneProductENSMUSG00000029167 (Ensembl)
SCDGeneProduct
Sirt1GeneProductENSMUSG00000020063 (Ensembl)
Sirt6GeneProductENSMUSG00000034748 (Ensembl)
Srebf1GeneProductENSMUSG00000020538 (Ensembl)
Srebf2GeneProductENSMUSG00000022463 (Ensembl)

Annotated Interactions

No annotated interactions
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