Notch Signaling Pathway (Drosophila melanogaster)

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The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.

Source: KEGG

Adapted from KEGG:

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Ontology Terms



  1. Weinmaster G; ''The ins and outs of notch signaling.''; Mol Cell Neurosci, 1997 PubMed Europe PMC Scholia


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111052view14:43, 3 July 2020L DupuisConnected line
110031view18:29, 13 April 2020Khanspersupdated interactions, replaced lines with graphics
109432view09:57, 17 March 2020L DupuisConverted interaction to graphical line (where applicable)
109399view16:27, 16 March 2020L DupuisConverted interactions to graphical lines
97076view18:28, 26 April 2018TeacupConnected lines
79442view06:36, 22 March 2015EgonwUpdated the 'Uniprot-TrEMBL' data source spelling.
79347view17:10, 21 March 2015Khanspersupdate
79346view17:09, 21 March 2015KhanspersReverted to version '11:20, 26 June 2013' by Khanspers
68724view21:58, 6 July 2013MaintBotUpdated to 2013 gpml schema
67523view11:20, 26 June 2013DdiglesOntology Term : 'Notch signaling pathway' added !
62826view04:33, 3 May 2013MaintBotUpdated UniProt data source
40899view22:35, 1 March 2011MaintBotRemoved redundant pathway information and comments
35615view16:01, 12 February 2010Thomasadded literature
35614view16:00, 12 February 2010ThomasModified description
21117view11:30, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:Notch Signaling Pathway KEGG]] moved to [[Pathway:WP208]]: Moved to stable identifier
8519view14:01, 7 January 2008MaintBotAdded to category $category
8517view14:01, 7 January 2008A.J.CaroloUploaded new pathway

External references


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NameTypeDatabase referenceComment
AcGeneProductFBgn0000022 (FlyBase)
DeltaGeneProductDL_DROME (Uniprot-TrEMBL)
DeltexGeneProductFBgn0000524 (FlyBase)
DshGeneProductFBgn0000499 (FlyBase)
E(spl)-CGeneProductESM8_DROME (Uniprot-TrEMBL)
FringeGeneProductFBgn0011591 (FlyBase)
GrouchoGeneProductFBgn0001139 (FlyBase)
NotchGeneProductNOTC_DROME (Uniprot-TrEMBL)
NumbGeneProductFBgn0002973 (FlyBase)
ScGeneProductFBgn0004170 (FlyBase)
SerrateGeneProductFBgn0004197 (FlyBase)
Su(H)GeneProductRBJK_DROME (Uniprot-TrEMBL)
VgGeneProductFBgn0003975 (FlyBase)
hairlessGeneProductFBgn0001169 (FlyBase)
presenilinGeneProductFBgn0019947 (FlyBase)

Annotated Interactions

No annotated interactions

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