Alzheimers Disease (Mus musculus)

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1-17ATP depletionp-alpha-SecretaseLower energy production?Mitochondrial dysfunctionsAPP-alphaAICDEndoplasmic reticulum (ER)NeuronMicrogliaOligomeric intracellular ABCalcium overloadNeuronal injuryMitochondiral dysfunctionAggr. amyloidC83Amyloid Beta (AB)IronHydrogen peroxideInduction of ApoptosisIP3ApoptosisOxidative PhosphorylationCopperModulation of gene expressionCell DeathCalciumProtein oxidationNONae1AppCalcium Signaling PathwayApbb1Gm2221Adam10Bace1PsenenPsen1NcstnAph1aIdeMmeLplApoeLrp1FasTnfrsf1aFaddCasp8Cx ICx IICx IIICx IVCx VAPP processingbeta-Secretasegamma-SecretaseHsd17b10Fall in mitochondrialsAPP-betaC99membrane potentialIncreased ROSDegredationInactivationBidGm10121Calm21500003O03RikBadCALM2CALM3Calml3Calm4Ppp3caPpp3cbPpp3ccPpp3r1Ppp3r22010110P09RikAdam17Psen2Apaf1Casp9Casp3AB AggregationOligomeric ABalpha-synucleinSncaSenileplaqueNACGPCRGrin1Cacna1cGrin2aGrin2bGrin2cGrin2dCacna1dCacna1fCacna1sGnaqPlcb1Plcb2Plcb3Plcb4TnfIl1bMapk1Mapk3Casp12ApoptosisRyr3PsenenAtp2a2Atp2a1Atp2a3Eif2ak3Ern1Atf6Itpr1Itpr2Itpr3CalciumCalciumER stressCapn1Capn2Trp53Cdk5r1Nos1Cdk5TauGsk3bPPCasp3Casp7Paired helical filaments (PHFs)Neurofibrillarytangles (NFTs)ABApoptosisDNA damageInflammationLipid peroxidationONOO-


Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2059(r45384) with a 90% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Dickson DW; ''Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?''; J Clin Invest, 2004 PubMed Europe PMC
  2. Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G; ''Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.''; Aging Cell, 2008 PubMed Europe PMC
  3. Shen Y, He P, Zhong Z, McAllister C, Lindholm K; ''Distinct destructive signal pathways of neuronal death in Alzheimer's disease.''; Trends Mol Med, 2006 PubMed Europe PMC
  4. Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A; ''Presenilin-mediated signal transduction.''; Physiol Behav, 2007 PubMed Europe PMC
  5. Parihar MS, Hemnani T; ''Alzheimer's disease pathogenesis and therapeutic interventions.''; J Clin Neurosci, 2004 PubMed Europe PMC
  6. Mattson MP; ''Pathways towards and away from Alzheimer's disease.''; Nature, 2004 PubMed Europe PMC
  7. Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE; ''Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.''; Exp Gerontol, 2006 PubMed Europe PMC
  8. Small DH, Mok SS, Bornstein JC; ''Alzheimer's disease and Abeta toxicity: from top to bottom.''; Nat Rev Neurosci, 2001 PubMed Europe PMC
  9. Bezprozvanny I, Mattson MP; ''Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.''; Trends Neurosci, 2008 PubMed Europe PMC
  10. Takuma K, Yan SS, Stern DM, Yamada K; ''Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.''; J Pharmacol Sci, 2005 PubMed Europe PMC
  11. Hölscher C; ''Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.''; Neurobiol Dis, 1998 PubMed Europe PMC
  12. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH; ''Neurotoxicity induces cleavage of p35 to p25 by calpain.''; Nature, 2000 PubMed Europe PMC
  13. Bojarski L, Herms J, Kuznicki J; ''Calcium dysregulation in Alzheimer's disease.''; Neurochem Int, 2008 PubMed Europe PMC
  14. Ivins KJ, Thornton PL, Rohn TT, Cotman CW; ''Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.''; Neurobiol Dis, 1999 PubMed Europe PMC
  15. Gandy S; ''The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease.''; J Clin Invest, 2005 PubMed Europe PMC
  16. Avila J; ''Tau phosphorylation and aggregation in Alzheimer's disease pathology.''; FEBS Lett, 2006 PubMed Europe PMC
  17. Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M; ''Induction of neuronal death by ER stress in Alzheimer's disease.''; J Chem Neuroanat, 2004 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106866view13:34, 17 September 2019MaintBotHMDB identifier normalization
104989view04:20, 28 June 2019Khanspersremoved KEGG comment
104988view04:19, 28 June 2019KhanspersModified description
97336view12:18, 10 May 2018EgonwUndo revision 97322 by [[Special:Contributions/Lovnish.thakur|Lovnish.thakur]] ([[User talk:Lovnish.thakur|Talk]])
97322view17:31, 9 May 2018Lovnish.thakurModified title
85337view16:16, 7 May 2016EgonwReplaced a mim-conversion with Arrow.
78427view10:26, 7 January 2015MaintBotadded missing graphIds
75216view20:19, 9 May 2014Khanspersadded lit refs
75213view20:13, 9 May 2014Khanspersadded states, changed some pathway nodes to labels
71747view20:19, 17 October 2013MaintBotAutomated update of data sources
69161view18:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
59061view21:01, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45977view20:57, 1 December 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1500003O03RikGeneProduct56398 (Entrez Gene)
2010110P09RikGeneProduct70261 (Entrez Gene)
APP processingPathway
Adam10GeneProductENSMUSG00000054693 (Ensembl)
Adam17GeneProductENSMUSG00000052593 (Ensembl)
Apaf1GeneProductENSMUSG00000019979 (Ensembl)
Apbb1GeneProductENSMUSG00000037032 (Ensembl)
Aph1aGeneProductENSMUSG00000015750 (Ensembl)
ApoeGeneProductENSMUSG00000002985 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
AppGeneProductENSMUSG00000022892 (Ensembl)
Atf6GeneProductENSMUSG00000026663 (Ensembl)
Atp2a1GeneProductENSMUSG00000030730 (Ensembl)
Atp2a2GeneProductENSMUSG00000029467 (Ensembl)
Atp2a3GeneProductENSMUSG00000020788 (Ensembl)
Bace1GeneProductENSMUSG00000032086 (Ensembl)
BadGeneProductENSMUSG00000024959 (Ensembl)
BidGeneProductENSMUSG00000004446 (Ensembl)
CALM2GeneProduct
CALM3GeneProduct
Cacna1cGeneProductENSMUSG00000051331 (Ensembl)
Cacna1dGeneProductENSMUSG00000015968 (Ensembl)
Cacna1fGeneProductENSMUSG00000031142 (Ensembl)
Cacna1sGeneProductENSMUSG00000026407 (Ensembl)
Calcium Signaling PathwayPathway
CalciumMetaboliteHMDB0000464 (HMDB)
Calm2GeneProductENSMUSG00000036438 (Ensembl)
Calm4GeneProductENSMUSG00000033765 (Ensembl)
Calml3GeneProductENSMUSG00000063130 (Ensembl)
Capn1GeneProductENSMUSG00000024942 (Ensembl)
Capn2GeneProductENSMUSG00000026509 (Ensembl)
Casp12GeneProductENSMUSG00000025887 (Ensembl)
Casp3GeneProductENSMUSG00000031628 (Ensembl)
Casp7GeneProductENSMUSG00000025076 (Ensembl)
Casp8GeneProductENSMUSG00000026029 (Ensembl)
Casp9GeneProductENSMUSG00000028914 (Ensembl)
Cdk5GeneProductENSMUSG00000028969 (Ensembl)
Cdk5r1GeneProductENSMUSG00000048895 (Ensembl)
Cell DeathPathwayWP254 (WikiPathways)
CopperMetaboliteHMDB0000657 (HMDB)
Cx IGeneProduct
Cx IIGeneProduct
Cx IIIGeneProduct
Cx IVGeneProduct
Cx VGeneProduct
DNA damagePathway
Eif2ak3GeneProductENSMUSG00000031668 (Ensembl)
Ern1GeneProductENSMUSG00000020715 (Ensembl)
FaddGeneProductENSMUSG00000031077 (Ensembl)
FasGeneProductENSMUSG00000024778 (Ensembl)
GPCRGeneProduct
Gm10121GeneProductENSMUSG00000062813 (Ensembl)
Gm2221GeneProductENSMUSG00000090825 (Ensembl)
GnaqGeneProductENSMUSG00000024639 (Ensembl)
Grin1GeneProductENSMUSG00000026959 (Ensembl)
Grin2aGeneProductENSMUSG00000059003 (Ensembl)
Grin2bGeneProductENSMUSG00000030209 (Ensembl)
Grin2cGeneProductENSMUSG00000020734 (Ensembl)
Grin2dGeneProductENSMUSG00000002771 (Ensembl)
Gsk3bGeneProductENSMUSG00000022812 (Ensembl)
Hsd17b10GeneProductENSMUSG00000025260 (Ensembl)
Hydrogen peroxideMetaboliteHMDB0003125 (HMDB)
IP3MetaboliteHMDB0001498 (HMDB)
IdeGeneProductENSMUSG00000056999 (Ensembl)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
IronMetaboliteHMDB0000692 (HMDB)
Itpr1GeneProductENSMUSG00000030102 (Ensembl)
Itpr2GeneProductENSMUSG00000030287 (Ensembl)
Itpr3GeneProductENSMUSG00000042644 (Ensembl)
Lipid peroxidationPathwayWP1878 (WikiPathways)
LplGeneProductENSMUSG00000015568 (Ensembl)
Lrp1GeneProductENSMUSG00000040249 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
MmeGeneProductENSMUSG00000027820 (Ensembl)
Modulation of gene expressionPathwayWP1821 (WikiPathways)
NOMetaboliteHMDB0003378 (HMDB)
Nae1GeneProductENSMUSG00000031878 (Ensembl)
NcstnGeneProductENSMUSG00000003458 (Ensembl)
Nos1GeneProductENSMUSG00000029361 (Ensembl)
ONOO-MetaboliteHMDB0002179 (HMDB)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
Plcb1GeneProductENSMUSG00000051177 (Ensembl)
Plcb2GeneProductENSMUSG00000040061 (Ensembl)
Plcb3GeneProductENSMUSG00000024960 (Ensembl)
Plcb4GeneProductENSMUSG00000039943 (Ensembl)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl)
Ppp3cbGeneProductENSMUSG00000021816 (Ensembl)
Ppp3ccGeneProductENSMUSG00000022092 (Ensembl)
Ppp3r1GeneProductENSMUSG00000033953 (Ensembl)
Ppp3r2GeneProductENSMUSG00000028310 (Ensembl)
Protein oxidationPathway
Psen1GeneProductENSMUSG00000019969 (Ensembl)
Psen2GeneProductENSMUSG00000010609 (Ensembl)
PsenenGeneProductENSMUSG00000036835 (Ensembl)
Ryr3GeneProductENSMUSG00000057378 (Ensembl)
SncaGeneProductENSMUSG00000025889 (Ensembl)
TauGeneProductENSMUSG00000018411 (Ensembl)
TnfGeneProductENSMUSG00000024401 (Ensembl)
Tnfrsf1aGeneProductENSMUSG00000030341 (Ensembl)
Trp53GeneProductENSMUSG00000059552 (Ensembl)

Annotated Interactions

No annotated interactions
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