Fatty Acid Omega Oxidation (Homo sapiens)

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Dodecanoate, or lauric acid, is found in the fats and oils of both plants and animals, especially coconut and palm kernel oil. This pathway shows the degradation of dodecanoate leading to beta oxidation.

Created by Magali Jaillard, Marijke Vermeer, Michiel Adrieans, Ron Schormans and Chris Evelo.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms



No bibliography


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106417view21:59, 28 August 2019KhanspersModified description
105596view04:48, 10 August 2019KhanspersModified description
102305view20:59, 17 December 2018KhanspersModified description
102304view20:59, 17 December 2018Khanspersremoved GenMAPP comment
94194view14:36, 25 August 2017DeSlAdded ID for 14-hydroxytetradecanoic acid.
90917view23:18, 17 December 2016AlexanderPicoModified description
85418view15:17, 14 May 2016EgonwPacked.
85417view15:09, 14 May 2016MaintBotModified description
85416view15:09, 14 May 2016EgonwCleaned up, and added a few metabolite IDs.
68882view17:26, 8 July 2013MaintBotUpdated to 2013 gpml schema
67247view10:26, 26 June 2013Christine ChichesterOntology Term : 'fatty acid omega degradation pathway' added !
45265view18:46, 7 October 2011AlexanderPicoOntology Term : 'fatty acid metabolism' added !
45263view18:45, 7 October 2011AlexanderPicoOntology Term : 'fatty acid metabolic pathway' added !
45262view18:45, 7 October 2011AlexanderPicoOntology Term : 'fatty acid degradation pathway' added !
41031view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
31999view13:16, 14 August 2009MaintBotFixed group labels
21113view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Fatty Acid Omega Oxidation BiGCaT]] moved to [[Pathway:WP206]]: Moved to stable identifier
14131view14:28, 21 May 2008MichielConnected gene-groups to reaction arrows
14120view14:13, 21 May 2008MichielConnector update
14118view14:12, 21 May 2008MichielConnected connectors
14116view14:10, 21 May 2008MichielGrouped genes
8046view13:46, 7 January 2008MaintBot[[Pathway:Human:Fatty Acid Omega Oxidation BiGCaT]] moved to [[Pathway:Homo sapiens:Fatty Acid Omega Oxidation BiGCaT]]: Renaming species
7645view16:06, 18 December 2007MaintBotfixed category names
7354view12:42, 4 November 2007MaintBotAdded categories to GPML
6317view22:17, 22 May 2007Evelogpml file for [[Human:Fatty_Acid_Omega_Oxidation_BiGCaT]]

External references


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NameTypeDatabase referenceComment
-OOC-(CH2)10-COO-MetaboliteCHEBI:76273 (ChEBI)
ADH1AGeneProduct124 (Entrez Gene)
ADH1BGeneProduct125 (Entrez Gene)
ADH1CGeneProduct126 (Entrez Gene)
ADH4GeneProduct127 (Entrez Gene)
ADH6GeneProduct130 (Entrez Gene)
ADH7GeneProduct131 (Entrez Gene)
ALDH1A1GeneProduct216 (Entrez Gene)
ALDH2GeneProduct217 (Entrez Gene)
Beta OxidationPathway
CH3-(CH2)10-COO-MetaboliteCHEBI:30805 (ChEBI)
CYP1A1GeneProduct1543 (Entrez Gene)
CYP1A2GeneProduct1544 (Entrez Gene)
CYP2A6GeneProduct1548 (Entrez Gene)
CYP2D6GeneProduct1565 (Entrez Gene)
CYP2E1GeneProduct1571 (Entrez Gene)
CYP3A4GeneProduct1576 (Entrez Gene)
CYP4A11GeneProduct1579 (Entrez Gene)
HO-CH-(CH2)10-COO-MetaboliteCHEBI:39567 (ChEBI)
HOC-(CH2)10-COO-Metabolite3084276 (PubChem-compound) 14-hydroxytetradecanoic acid

Annotated Interactions

No annotated interactions

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