Regulation of Microtubule Cytoskeleton (Homo sapiens)

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1, 2MicrotubulePlus End ProteinsMT Polymerization+/- endDestabilizingPlus EndDelivery toMT Plus EndsNeurotrophinsActin FilamentsPIP3Focal AdhesionMT Catastrophe+ end GrowthPromotingRTK"DynamicMicrotubules"MT StabilityMinus EndRhoTAULL5bTPPPLIMKTESKMAPKAPKDVLPKCPAR6TAOKSPRED1ROCKRAC1MARKCFLGSK3BMARK2PAR3PAR1PTENAKTERKCDC42PIK3GNAQ WNTLPRSTAT3STMNPAKPRKACAAURKBCAMKCDK1MCAKXMAP215ICISRhoGEFc-ABLTRIOTIAM1SRCCLASPCLIPMAP1BCRMP2EB1APCmDIAmDIAEB1CLIPCLIPCLIPCLASPEB1APCRAC1RhomDIA1GNAQ RhoRhoMAP1BERKPIP3


Description

Microtubules (MTs) are essential for vesicle transport, cellular polarity and the segregation of chromosomes during mitosis. MTs are dynamic, undergoing assembly and depolymerization (primarily at the "plus end") by processes actively regulated by signaling pathways. The tubulin dimers that constitute MTs (depicted in green) are bound and sequestered by stathmin (STMN), enhancing MT dynamics by increasing rapid depolymerization (a.k.a., "MT catastrophe"). MT dynamics are also enhanced by collapsin response mediator protein (CRMP2), which increases MT growth by promoting the addition of tubulin dimers onto microtubule plus ends. Other proteins that associate with assembled MTs include those that stabilize MTs (e.g. tau or MAPT), those that promote assembly (e.g., XMAP215), and those that maintain MTs in a dynamic state (e.g., MAP1B). Complexes between the adenomateous polyposis coli (APC) protein and plus end binding proteins (e.g., EB1) stabilize MTs by increasing the duration of the MT elongation phase. MT instability is promoted by several nonmotile kinesins from the kinesin-13 family, e.g., the mitotic centromere associated kinesin, MCAK, by accelerating the transition to catastrophe by weakening the lateral interactions between the protofilaments. Upstream from these processes, major signaling pathways act to regulate MT dynamics, e.g., those converging on GSK3B, a kinase which targets tau and CRMP2.


Reference: https://www.cellsignal.com/contents/science-pathway-research-cytoskeletal/regulation-of-microtubule-dynamics-signaling-pathway/pathways-micro

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Etienne-Manneville S; ''From signaling pathways to microtubule dynamics: the key players.''; Curr Opin Cell Biol, 2010 PubMed Europe PMC
  2. Anitei M, Hoflack B; ''Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways.''; Nat Cell Biol, 2011 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106497view21:44, 4 September 2019KhanspersModified description
105803view22:51, 15 August 2019KhanspersModified description
105148view19:54, 11 July 2019AlexanderPicoFixed node labels
105051view23:46, 2 July 2019AlexanderPicoModified description
105050view23:45, 2 July 2019AlexanderPicoModified description
94910view23:58, 12 October 2017Khanspersconnected interactions
94754view15:29, 5 October 2017Mkutmonfix unconnected line
90889view22:33, 15 December 2016Khanspersadded lit refs
90888view22:30, 15 December 2016Khanspersfilled in missing parts, updated unconnected etc
90699view01:24, 13 December 2016KhanspersModified description
87632view08:54, 25 July 2016LindarieswijkOntology Term : 'cell-extracellular matrix signaling pathway' added !
79994view20:37, 29 April 2015ZariAnnotated PAR3, mDIA*
78570view14:50, 7 January 2015MaintBotadded missing graphIds
70100view18:46, 12 July 2013MaintBotupdated to 2013 schema
59187view18:52, 22 February 2013MaintBotUpdated Ensembl data source
47074view00:04, 15 March 2012KhanspersModified categories
45644view14:47, 26 October 2011CarlosBorrotoSpecify description
44788view16:12, 3 October 2011CarlosBorrotoPeriodical save, work in progress
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44725view19:34, 28 September 2011CarlosBorrotoAdd AGT, AGTR1 and AGTR2
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External references

DataNodes

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NameTypeDatabase referenceComment
AKTGeneProductENSG00000142208 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
AURKBGeneProductENSG00000178999 (Ensembl)
CAMKGeneProductENSG00000152495 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDK1GeneProductENSG00000170312 (Ensembl)
CFLGeneProductENSG00000165410 (Ensembl)
CLASPGeneProductENSG00000074054 (Ensembl)
CLIPGeneProductENSG00000130779 (Ensembl)
CRMP2GeneProductENSG00000092964 (Ensembl)
DVLGeneProductENSG00000107404 (Ensembl)
EB1GeneProductENSG00000101367 (Ensembl)
ERKGeneProductENSG00000133216 (Ensembl)
GNAQ GeneProductENSG00000156052 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
ICISGeneProduct
LIMKGeneProductENSG00000106683 (Ensembl)
LL5bGeneProductENSG00000144824 (Ensembl)
LPRGeneProductENSG00000132670 (Ensembl)
MAP1BGeneProductENSG00000131711 (Ensembl)
MAPKAPKGeneProductENSG00000162889 (Ensembl)
MARK2GeneProductENSG00000072518 (Ensembl)
MARKGeneProductENSG00000116141 (Ensembl)
MCAKGeneProductENSG00000142945 (Ensembl)
PAKGeneProductENSG00000149269 (Ensembl)
PAR1GeneProductENSG00000072518 (Ensembl)
PAR3GeneProduct2151 (Entrez Gene)
PAR6GeneProductENSG00000102981 (Ensembl)
PIK3GeneProductENSG00000121879 (Ensembl)
PKCGeneProductENSG00000154229 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
ROCKGeneProductENSG00000067900 (Ensembl)
RhoGeneProductENSG00000163914 (Ensembl)
RhoGEFGeneProduct
SPRED1GeneProductENSG00000166068 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STMNGeneProductENSG00000117632 (Ensembl)
TAOKGeneProductENSG00000160551 (Ensembl)
TAUGeneProductENSG00000186868 (Ensembl)
TESKGeneProductENSG00000070759 (Ensembl)
TIAM1GeneProductENSG00000156299 (Ensembl)
TPPPGeneProductENSG00000171368 (Ensembl)
TRIOGeneProductENSG00000038382 (Ensembl)
WNTGeneProductENSG00000154342 (Ensembl)
XMAP215GeneProduct
c-ABLGeneProductENSG00000097007 (Ensembl)
mDIA1GeneProduct1729 (Entrez Gene)
mDIAGeneProduct1729 (Entrez Gene)

Annotated Interactions

No annotated interactions

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