Follicle stimulating hormone (FSH) signaling pathway (Homo sapiens)

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1FSH signaling pathwaySteroidogenesisMAPK1PFSHBFSHRCGAMAPK3AKT1PPFSHBCGARPS6TSC2PCREB1PHIST3H3PRPS6KB1PDePFOXO1PMAPK14PGRK6RPS6KB2PRAF1PEIF4EBP1PSRCSGK1PMTORPPAPPL1PRKCACYP19A1PRKACAAREGBDNFRHEBFSHRPProteinProteinmRNALigandReceptorProteinProtein - protein dissociationEnzyme complexSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMolecule


The Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH) and Chorionic Gonadotropin. FSH controls the growth and maturation of follicles in the females and spermatogenesis in males. FSH is a heterodimer and shares a common alpha sub-unit with the other glycoprotein hormones in its family and has a specific beta subunit that confers receptor specificity and biological activity to the hormone. FSH acts through the FSH receptor (FSHR), a G protein coupled receptor that is expressed exclusively on the granulosa cells of ovaries and Sertoli cells of the testis in humans. FSH signaling involves activation of adenylyl cyclase activity and the increased production of cAMP. This activates the cAMP dependent protein kinases such as PKA, PKB and PKC that, in turn, lead to the phosphorylation of specific transcription factors such as cAMP response element binding protein (CREB) and Forkhead box protein O1 (FOXO1). In addition to activation of PI3K/Akt module, PKA also induces p38 mapk which, in turn, controls other kinase cascades. Activated Akt also induces the mTOR axis that stimulates mRNA translation by phosphorylating p70 S6 kinase and, consequently, the 40 S ribosomal protein S6 that results in the activation of eukaryotic initiation factor (eIF) 4E. It also indirectly aids in the activation of extracellular signal-regulated protein kinases (ERKs). FSH induces important genes required for steroidogenesis as well as growth and maturation of germ cells. The important target genes include aromatase (CYP19A1), the lutenizing hormone receptor (LHR) and the vascular endothelial growth factor (VEGF).

Please access this pathway at NetSlim database.

If you use this pathway, please cite following paper: Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., Prasad, T. S. K., Ramachandra, Y. L., Mohan, S. S., Maharudraiah, J., Mukherjee, S. and Pandey, A. (2011). A comprehensive curated resource for Follicle Stimulating Hormone signaling. BMC Research Notes. 4, 408.

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  1. Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., Prasad, T. S. K., Ramachandra, Y. L., Mohan, S. S., Maharudraiah, J., Mukherjee, S., Pandey, A.; '' A comprehensive curated resource for Follicle Stimulating Hormone signaling. ''; BMC Research Notes. 4, 408., 2011 PubMed Europe PMC Scholia


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120721view01:25, 24 December 2021EweitzStandardize weight
120720view01:24, 24 December 2021EweitzStandardize font, weight, case
118421view14:21, 27 May 2021Marvin M2added pubmed id
117727view12:34, 22 May 2021EweitzModified title
115917view16:55, 20 March 2021EgonwCopied the NetPath paper into the literature list
115910view13:34, 20 March 2021EgonwModified description
101857view15:27, 14 November 2018DeSlAdded lit. reference from description to PW.
86080view10:09, 29 June 2016MirellaKalafatiModified title
78536view10:30, 7 January 2015MaintBotadded missing graphIds
68985view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
67257view10:27, 26 June 2013Christine ChichesterOntology Term : 'follicle-stimulating hormone signaling pathway' added !
48445view15:07, 24 May 2012NetPathModified description
45593view10:14, 18 October 2011JyotiModified description
45592view10:13, 18 October 2011JyotiModified description
45279view19:02, 7 October 2011AlexanderPicoOntology Term : 'granulosa cell' added !
45277view19:01, 7 October 2011AlexanderPicoOntology Term : 'follicle stimulating hormone secreting cell' added !
44632view18:19, 22 September 2011KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
APPL1Protein26060 (Entrez Gene)
AREGRna374 (Entrez Gene)
BDNFRna627 (Entrez Gene)
CGAProtein1081 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CYP19A1Rna1588 (Entrez Gene)
EIF4EBP1Protein1978 (Entrez Gene)
FOXO1Protein2308 (Entrez Gene)
FSHBProtein2488 (Entrez Gene)
FSHRProtein2492 (Entrez Gene)
GRK6Protein2870 (Entrez Gene)
HIST3H3Protein8290 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
PRKACAProtein5566 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RHEBProtein6009 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
RPS6KB2Protein6199 (Entrez Gene)
SGK1Protein6446 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
TSC2Protein7249 (Entrez Gene)

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