Thyroid stimulating hormone (TSH) signaling pathway (Homo sapiens)

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1, 2CCND3CCND3MAP2K1PMAPK3PPIK3R2PKAPIP2IP3cAMPPIP3DAGNUCYProteinTSH signal transduction pathwayLigandEnzyme ComplexReceptorCell proliferationmRNABRAFEGR1STAT1 PAX8PCGARAF1MYCSCRIBJUNHRASTTF2KCNIP3TTF1GNB1GNG2TSHBE2F1FOSTSHRSTAT3PPDPK1PIK3CAPPIK3R1CDK2PPSRCpMAP2K3PMAP2K6PAKT1PPRKCZRPS6KB1MAPK1PPRB1PCREB1PDE4DPPGNAI1GTPGNA13GTPGNAI2GTPGNA12GTPGNAO1GTPGNAQGTPGNAI3GTPMYL12BDePRALGDSGNASJAK2GTPPJAK1PRPS6MTORPADCY2ADCY3CDK2PCDK4PRPS6KA1PPLD1PLCB1RAP1BGTPRAP1AGTPRHOACCNE1MAPK14CDKN1BPCCND3CDK4RAP1GAPPPNUCYPKANUCYSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeAPEX1APEX1NUCYProteinProtein


Human thyroid-stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in the regulation of the hypothalamus-pituitary-thyroid axis by stimulating production and secretion of the thyroid hormone from the thyroid gland and – on a longer time scale – growth and differentiation of thyrocytes. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.

NetPath ( is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, please cite the NetPath website until the pathway is published.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Telikicherla D, Ambekar A, Palapetta SM, Dwivedi SB, Raju R, Sharma J, Prasad TsK, Ramachandra Y, Mohan SS, Maharudraiah J, Mukherjee S, Pandey A; ''A comprehensive curated resource for follicle stimulating hormone signaling.''; BMC Res Notes, 2011 PubMed Europe PMC Scholia
  2. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


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67727view11:55, 26 June 2013DdiglesOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
44635view18:24, 22 September 2011KhanspersModified categories
44634view18:23, 22 September 2011KhanspersModified description
44561view14:04, 20 September 2011DrrenugoelNew pathway

External references


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NameTypeDatabase referenceComment
ADCY2GeneProduct108 (Entrez Gene)
ADCY3GeneProduct109 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
APEX1GeneProduct328 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CGAGeneProduct1081 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
E2F1Rna1869 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
FOSRna2353 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GNA13GeneProduct10672 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAI3GeneProduct2773 (Entrez Gene)
GNAO1GeneProduct2775 (Entrez Gene)
GNAQGeneProduct2776 (Entrez Gene)
GNASGeneProduct2778 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNG2GeneProduct54331 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNRna3725 (Entrez Gene)
KCNIP3GeneProduct30818 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
MYCRna4609 (Entrez Gene)
MYL12BGeneProduct103910 (Entrez Gene)
PAX8Rna7849 (Entrez Gene)
PDE4DGeneProduct5144 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCB1GeneProduct23236 (Entrez Gene)
PLD1GeneProduct5337 (Entrez Gene)
PRKCZGeneProduct5934 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RALGDSGeneProduct5900 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene)
RAP1GAPGeneProduct5909 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RHOAGeneProduct3480 (Entrez Gene)
RPS6GeneProduct6194 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SCRIBGeneProduct23513 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1 GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TSHBGeneProduct7252 (Entrez Gene)
TSHRGeneProduct7253 (Entrez Gene)
TTF1Rna7270 (Entrez Gene)
TTF2Rna8458 (Entrez Gene)

Annotated Interactions

No annotated interactions

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