Cell Differentiation - Index (Homo sapiens)

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1CardiacMusclePluripotent Stem CellChondrocyteMesodermProgenitorSkeletalMuscleMIR128-1MIR9-1HDAC5MIR302DMIR24-2MIR302CMIR181B2TLX1MIR16-1MIR192SRFMIR155MIR24-1MIR2861MIR146AMIR109SRFMIR221MIR302BMIR16-2MIR302ELEFTY2TLX3LEFTY1MIR203MIR150MIR181B1MIR17MIR181A1TLX2MIR296TGF-betaMIR199A1MIR181CSTAT3MIR124-1MIR181DMIR122MIR150MIR146BMIR181A2?MIR199A2MIR302AMIR133BMIR223MIR106AMIR24-1MIR1-1MIR9-2MIR9-3MIR20AMIR451AMIR222MIR1-1MIR133BMEF2CMEF2BMEF2AMEF2DMYOD1OsteoblastLymphoidProgenitorHematopoieticProgenitorMyeloidProgenitorMIR181A2MIR181A1T-CellsGranulocytesMonocytesRed BloodCellsEndodermProgenitorMIR133A2MIR133A1MIR133BMIR1-1EctodermProgenitorMIR133A2MIR133A1MIR133BMIR1-1KeratinocytesNeural CrestStem CellNeural Stem CellSmooth MuscleAstrocytesGlial cellsNeuronsmiRs in Muscle Cell DifferentiationSRF and miRs in Smooth Muscle Differentiation and Proliferation MIR133A2MIR133A1MIR133A2MIR133A1MIR223MIR155MIR17MIR145MIR221MIR133BMIR133A2MIR133A1MIR222MIR1-1MIR206MIR214MIR26A1MIR26A2


Description

miRNAs regulation of differentiation of numerous cell types.

This diagram shows progressive commitment and subsequent differentiation of various lineages from pluripotent stem cells. Some examples of the influence by miRNAs on specific cell fates are shown. The pathway is based on Fig 2 from Ivey and Srivastava.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Ivey KN, Srivastava D; ''MicroRNAs as regulators of differentiation and cell fate decisions.''; Cell Stem Cell, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
108731view10:00, 27 January 2020DeSlConnected unconnected line, compressed layout.
108677view20:11, 17 January 2020KhanspersModified description
108676view20:10, 17 January 2020KhanspersModified description
108675view20:08, 17 January 2020Khanspersadded lit ref
108674view20:06, 17 January 2020Khanspersupdated layout for clarity
108644view23:55, 14 January 2020Khansperswork in progress
108642view22:10, 14 January 2020Khanspersoverhaul
106352view21:37, 21 August 2019KhanspersModified description
105552view06:12, 9 August 2019KhanspersModified description
102994view14:34, 31 January 2019Mkutmonupdated outdated ensembl id
102991view14:21, 31 January 2019Mkutmonupdated outdated ensembl id
102162view19:56, 4 December 2018Khanspersupdated xrefs for miRNAs
95144view02:53, 17 November 2017AlexanderPicoconnected interactions
82903view14:34, 11 November 2015JmeliusCorrect outdated id
80381view18:29, 12 June 2015AlexanderPicoModified description
80342view00:52, 9 June 2015Khanspersupdated color and type for miRNA nodes
69036view17:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
59213view19:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
44987view14:34, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to development' added !
44465view18:47, 14 September 2011MaintBotModified categories
44317view19:12, 2 September 2011Khanspersadded pathway identifiers
44310view22:53, 1 September 2011Samuel SklarNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?GeneProduct
HDAC5GeneProductENSG00000108840 (Ensembl)
LEFTY1GeneProductENSG00000243709 (Ensembl)
LEFTY2GeneProductENSG00000143768 (Ensembl)
MEF2ARnaENSG00000068305 (Ensembl)
MEF2BRnaENSG00000213999 (Ensembl)
MEF2CRnaENSG00000081189 (Ensembl)
MEF2DRnaENSG00000116604 (Ensembl)
MIR1-1RnaENSG00000199017 (Ensembl)
MIR106ARnaENSG00000207602 (Ensembl)
MIR109Rna
MIR122RnaENSG00000207778 (Ensembl)
MIR124-1RnaENSG00000275677 (Ensembl)
MIR128-1RnaENSG00000207654 (Ensembl)
MIR133A1GeneProductENSG00000283927 (Ensembl)
MIR133A2GeneProductENSG00000284508 (Ensembl)
MIR133BRnaENSG00000199080 (Ensembl)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR146ARnaENSG00000277727 (Ensembl)
MIR146BRnaENSG00000202569 (Ensembl)
MIR150RnaENSG00000207782 (Ensembl)
MIR155GeneProductENSG00000283904 (Ensembl)
MIR16-1RnaENSG00000208006 (Ensembl)
MIR16-2RnaENSG00000198987 (Ensembl)
MIR17GeneProductENSG00000284536 (Ensembl)
MIR181A1RnaENSG00000207759 (Ensembl)
MIR181A2RnaENSG00000207595 (Ensembl)
MIR181B1RnaENSG00000207975 (Ensembl)
MIR181B2RnaENSG00000207737 (Ensembl)
MIR181CRnaENSG00000207613 (Ensembl)
MIR181DRnaENSG00000207585 (Ensembl)
MIR192RnaENSG00000207648 (Ensembl)
MIR199A1RnaENSG00000207752 (Ensembl)
MIR199A2RnaENSG00000208024 (Ensembl)
MIR203RnaENSG00000207568 (Ensembl)
MIR206GeneProductENSG00000207604 (Ensembl)
MIR20AGeneProductENSG00000283762 (Ensembl)
MIR214GeneProductENSG00000283844 (Ensembl)
MIR221GeneProductENSG00000207870 (Ensembl)
MIR222GeneProductENSG00000207725 (Ensembl)
MIR223GeneProductENSG00000284567 (Ensembl)
MIR24-1RnaENSG00000207617 (Ensembl)
MIR24-2RnaENSG00000276797 (Ensembl)
MIR26A1GeneProductENSG00000199075 (Ensembl)
MIR26A2GeneProductENSG00000207789 (Ensembl)
MIR2861Rna
MIR296RnaENSG00000276373 (Ensembl)
MIR302ARnaENSG00000207927 (Ensembl)
MIR302BRnaENSG00000274389 (Ensembl)
MIR302CRnaENSG00000199102 (Ensembl)
MIR302DRnaENSG00000199145 (Ensembl)
MIR302ERnaENSG00000221703 (Ensembl)
MIR451ARnaENSG00000273915 (Ensembl)
MIR9-1RnaENSG00000207933 (Ensembl)
MIR9-2RnaENSG00000273878 (Ensembl)
MIR9-3RnaENSG00000207819 (Ensembl)
MYOD1RnaENSG00000129152 (Ensembl)
SRF and miRs in Smooth Muscle Differentiation and Proliferation PathwayWP1991 (WikiPathways)
SRFRnaENSG00000112658 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TGF-betaPathway
TLX1GeneProductENSG00000107807 (Ensembl)
TLX2GeneProductENSG00000115297 (Ensembl)
TLX3GeneProductENSG00000164438 (Ensembl)
miRs in Muscle Cell DifferentiationPathwayWP1991 (WikiPathways)

Annotated Interactions

No annotated interactions

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