Valine Biosynthesis (Saccharomyces cerevisiae)

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12-keto-isovalerateBAT2L-glutamateCO22,3-dihydroxy-isovalerate2-oxoglutarateH2ONADPILV22 pyruvate2-aceto-lactateBAT1ILV6NADPHILV3H+


Description

Biosynthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan proceeds via a common pathway to chorismate, at which point the pathway branches(CITS:[Jones][1943992]). One branch proceeds to tyrosine and phenylalanine, and the other to tryptophan (CITS:[Jones]). The series of reactions to chorismate, called the shikimate pathway, and the series of reactions from chorismate to tryptophan have been found to be common to all eukaryotes and prokaryotes studied thus far (as reported in (CITS:[1943992])). In contrast, there appears to be two separate routes for tyrosine and phenylalanine biosynthesis from chorismate, only one of which has been found in S. cerevisiae (CITS:[1943992]). S. cerevisiae, similar to E. coli, synthesize tyrosine and phenylalanine via the intermediate 4-hydroxyphenylpyruvate and phenylpyruvate, respectively, whereas some other organisms synthesize them via arogenate (CITS:[1943992]). Aromatic amino acid biosynthesis in S. cerevisiae is controlled by a combination of feedback inhibition, activation of enzyme activity, and regulation of enzyme synthesis (CITS:[Jones][1943992]). The carbon flow through the pathways is regulated primarily at the initial step and the branching points by the terminal end-products. The initial step of chorismate biosynthesis can be catalyzed by two isoenzymes Aro3p or Aro4p, whereby Aro3p is inhibited by phenylalanine, and Aro4p by tyrosine (CITS:[Jones][1943992]). The first step in the phenylalanine-tyrosine branch is feedback inhibited by tyrosine and activated by tryptophan, and the first step in the tryptophan branch is feedback inhibited by tryptophan (CITS:[1943992]). The transcriptional activator GCN4 regulates most of the genes encoding for the aromatic amino acid biosynthetic enzymes; however, no GCN4 regulation was found for TYR1 of the tyrosine branch, ARO7 of the tyrosine and phenylalanine branch or TRP1 of the tryptophan branch, (CITS:[1943992]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

  1. Holmberg S, Petersen JG; ''Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae.''; Curr Genet, 1988 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107012view13:46, 17 September 2019MaintBotHMDB identifier normalization
89647view15:58, 23 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
78390view10:25, 7 January 2015MaintBotadded missing graphIds
74144view10:57, 1 April 2014EgonwReplaced InChIs and an InChIKey with more traditional identifiers.
73386view16:36, 25 January 2014EgonwAdded metabolite identifiers and cat indications.
69640view20:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67741view11:57, 26 June 2013DdiglesOntology Term : 'valine biosynthetic pathway' added !
53534view19:33, 8 November 2012EgonwMarked two further metabolites as such.
53533view19:30, 8 November 2012EgonwMarked InChIKeys as such.
53532view19:29, 8 November 2012EgonwConverted general nodes into Metabolite DataNodes.
41878view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36650view22:39, 9 April 2010MaintBotDescription and bibliography added from SGD
20673view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Valine Biosynthesis]] moved to [[Pathway:WP2]]: Moved to stable identifier
12897view08:07, 17 May 2008MaintBotautomated metabolite conversion
9005view14:14, 7 January 2008MaintBotAdded to category $category
9003view14:14, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2 pyruvateMetaboliteCHEBI:15361 (ChEBI)
2,3-dihydroxy-isovalerateMetaboliteCHEBI:49072 (ChEBI)
2-aceto-lactateMetabolite13999770 (PubChem-compound)
2-keto-isovalerateMetaboliteCHEBI:11851 (ChEBI)
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
BAT1GeneProductS000001251 (SGD)
BAT2GeneProductS000003909 (SGD)
CO2MetaboliteCHEBI:16526 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
ILV2GeneProductS000004714 (SGD)
ILV3GeneProductS000003777 (SGD)
ILV6GeneProductS000000515 (SGD)
L-glutamateMetabolite56-86-0 (CAS)
NADPHMetabolite53-57-6 (CAS)
NADPMetaboliteHMDB0000217 (HMDB)

Annotated Interactions

No annotated interactions
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