Delta-Notch Signaling Pathway (Rattus norvegicus)

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GO->PMTranslocationDemethylationEndoplasmic reticulumIntracellular DomainGene SymbolMolecular associationPM->NUEndosomeAccession Number: NetPath 3; cellmap:3UbiquitinationNU->CYDICDDeacetylationSumoylationCY->NUGlycosylationDesumoylationICD-- ICDPM->NUProteolytic CleavagePlasma membraneMethylationCYPM->NUCytoplasmDMolecule in the pathwayDDDephosphorylationRecruitmentAutophosphorylationCY->NUECICDDeubiquitinationNucleusGONU->CYPMNUPM->CYENCY->NUCY->NUICDAcetylationExtracellularLigandControlInhibitionNU->CYGolgi apparatusReceptorDPM->NUCY->NUActivation(Protein-protein interaction)ICDReactioin through unknown mechanisms/moleculesPhosphorylationDMitochondrionPalmitoylationGO->PMProteins in a complex interactionEREnzyme complexGamma secretase complexMTICDNotch3Smad3Hes5Notch1Hdac1NovNotch1Sin3aFhl1PCAFTp53DTX1Skp2LfngCirMapk1CntfRBPSUHPsenenAppSkp2Notch1NcstnMef2cNcor2Yy1Notch4JunJag2Notch3EgfNotch2NumblNCOR1APH1AFBXW7Notch2Dll4Stat3Notch1Ep300Notch4Notch2NCOR1FurinNotch1Smad4Snw1Adam10EgfrHes6Dll1Gsk3bPik3r2Hdac2Notch3Jag1Cdk2Dll1Akt1NumbRing1MfngSKP1AMaml1Hey1Ascl1Maml3NfkbiaGsk3bRelaDTX1ItchAdam17Maml2Hivep3Psen2Cntn1Stat3Ep300Cul1Pofut1SpenHey2MAGEA1Notch2Notch1Smad1GATA1Wdr12Tcfe2aNcor2Jag2Aph1bJag2Hes1Tle1Lef1Mapk3Jak2LckSKP1APsen1Dll4Jag1Dll1RelaCntfrRBX1Jag1Pik3r1SAP30


Description

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP61(r20805) with a 87% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69380view18:56, 8 July 2013MaintBotUpdated to 2013 gpml schema
67150view10:13, 26 June 2013Christine ChichesterOntology Term : 'Notch signaling pathway' added !
41695view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
35710view23:19, 12 February 2010AlexanderPico
34080view19:12, 9 December 2009MaintBotAutomatic update of empty xrefs
31407view20:51, 13 August 2009MaintBotFixed text labels
31005view01:03, 30 July 2009MaintBotConverted from Homo sapiens
21099view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Delta-Notch NetPath 3]] moved to [[Pathway:WP199]]: Moved to stable identifier
7988view13:46, 7 January 2008MaintBot[[Pathway:Rat:Delta-Notch NetPath 3]] moved to [[Pathway:Rattus norvegicus:Delta-Notch NetPath 3]]: Renaming species
7618view16:04, 18 December 2007MaintBotfixed category names
7214view12:33, 4 November 2007MaintBotAdded categories to GPML
6531view22:19, 22 May 2007A.Pandeygpml file for [[Rat:Delta-Notch_NetPath_3]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APH1AGeneProduct365872 (Entrez Gene)
Adam10GeneProduct29650 (Entrez Gene)
Adam17GeneProduct57027 (Entrez Gene)
Akt1GeneProduct24185 (Entrez Gene)
Aph1bGeneProduct300802 (Entrez Gene)
AppGeneProduct54226 (Entrez Gene)
Ascl1GeneProduct64186 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene)
CirGeneProduct362149 (Entrez Gene)
CntfGeneProduct25707 (Entrez Gene)
CntfrGeneProduct313173 (Entrez Gene)
Cntn1GeneProduct117258 (Entrez Gene)
Cul1GeneProduct362356 (Entrez Gene)
DTX1GeneProduct
Dll1GeneProduct84010 (Entrez Gene)
Dll4GeneProduct311332 (Entrez Gene)
EgfGeneProduct25313 (Entrez Gene)
EgfrGeneProduct24329 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
FBXW7GeneProduct
Fhl1GeneProduct25177 (Entrez Gene)
FurinGeneProduct54281 (Entrez Gene)
GATA1GeneProduct25172 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
Hdac1GeneProduct297893 (Entrez Gene)
Hdac2GeneProduct84577 (Entrez Gene)
Hes1GeneProduct29577 (Entrez Gene)
Hes5GeneProduct79225 (Entrez Gene)
Hes6GeneProduct316626 (Entrez Gene)
Hey1GeneProduct155437 (Entrez Gene)
Hey2GeneProduct155430 (Entrez Gene)
Hivep3GeneProduct313557 (Entrez Gene)
ItchGeneProduct311567 (Entrez Gene)
Jag1GeneProduct29146 (Entrez Gene)
Jag2GeneProduct29147 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LckGeneProduct313050 (Entrez Gene)
Lef1GeneProduct161452 (Entrez Gene)
LfngGeneProduct170905 (Entrez Gene)
MAGEA1GeneProduct493750 (Entrez Gene)
Maml1GeneProduct303101 (Entrez Gene)
Maml2GeneProduct689844 (Entrez Gene)
Maml3GeneProduct310405 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mef2cGeneProduct499497 (Entrez Gene)
MfngGeneProduct315119 (Entrez Gene)
NCOR1GeneProduct54299 (Entrez Gene)
Ncor2GeneProduct360801 (Entrez Gene)
NcstnGeneProduct289231 (Entrez Gene)
NfkbiaGeneProduct25493 (Entrez Gene)
Notch1GeneProduct25496 (Entrez Gene)
Notch2GeneProduct29492 (Entrez Gene)
Notch3GeneProduct56761 (Entrez Gene)
Notch4GeneProduct406162 (Entrez Gene)
NovGeneProduct81526 (Entrez Gene)
NumbGeneProduct29419 (Entrez Gene)
NumblGeneProduct292732 (Entrez Gene)
PCAFGeneProduct301164 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Pofut1GeneProduct311551 (Entrez Gene)
Psen1GeneProduct29192 (Entrez Gene)
Psen2GeneProduct81751 (Entrez Gene)
PsenenGeneProduct292788 (Entrez Gene)
RBPSUHGeneProduct297767 (Entrez Gene)
RBX1GeneProduct300084 (Entrez Gene)
RelaGeneProduct309165 (Entrez Gene)
Ring1GeneProduct309626 (Entrez Gene)
SAP30GeneProduct
SKP1AGeneProduct
Sin3aGeneProduct363067 (Entrez Gene)
Skp2GeneProduct294790 (Entrez Gene)
Smad1GeneProduct25671 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smad4GeneProduct50554 (Entrez Gene)
Snw1GeneProduct500695 (Entrez Gene)
SpenGeneProduct365981 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Tcfe2aGeneProduct171046 (Entrez Gene)
Tle1GeneProduct362533 (Entrez Gene)
Tp53GeneProduct24842 (Entrez Gene)
Wdr12GeneProduct363237 (Entrez Gene)
Yy1GeneProduct24919 (Entrez Gene)

Annotated Interactions

No annotated interactions
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