Nucleotide Excision Repair (Homo sapiens)

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14, 24, 62, 85, 91...52, 57, 90, 10252, 10242, 526, 9, 30, 38, 45...36, 48, 50, 53, 68...33, 72, 73, 80, 88...28, 32, 79, 8219, 31, 34, 50, 67...1, 3, 5, 13, 17...7, 23, 26, 27, 41...6, 45, 46, 6516, 55, 5821, 34, 3552, 10252517037, 7552, 57, 90, 10237, 754, 7, 41, 74, 9533, 72-74, 80...772, 4, 10, 18, 38...71, 8121, 34, 3551525442, 52, 5749, 61, 64, 9770, 97, 10015778, 7512, 71, 81, 101nucleoplasmGTF2H5 POLR2J UBC(153-228) GTF2H3 CDK7 POLR2J RNF111UBC(305-380) POLR2B COPS3 UBC(609-684) UBC(77-152) MNAT1 UBA52(1-76) POLR2K EP300 XRCC1 UBC(609-684) TC-NERincisioncomplex:5'-inciseddamagedDNA:trimmednascentmRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFCUBC(153-228) UBC(305-380) UVSSA UBB(1-76) GTF2H1 ERCC2 Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2POLR2F USP7 XAB2 complexPOLR2C PAR-PARP1 ERCC2 UBC(77-152) CUL4B DDB1 POLD1 GTF2H2 TFIIH CorePOLD4 CCNH POLR2G Ub-595-UBC(533-608) POLR2H MonoUb-K164-PCNA DDB1 ERCC2 UBC(533-608) UBC(77-152) GTF2H3 USP7 POLR2F RPA heterotrimerUBC(305-380) UBC(609-684) UBC(457-532) UBC(305-380) UBC(381-456) UBB(77-152) POLR2L USP7 DDB1 POLR2J UBC(609-684) POLR2C COPS7B UBE2V2 RBX1 excised DNA fragmentwith lesionRAD23A Ub-519-UBC(457-532) ERCC8:DDB1:CUL4:RBX1:COP9 SignalosomeGTF2H2 UBA52(1-76) UBC(1-76) ERCC2 POLE RFC5 CUL4A UBC(305-380) LIG1,LIG3:XRCC1RAD23B NAMZNF830 ZNF830 UBC(153-228) HMGN1 POLR2D ERCC3 CUL4A TC-NERpre-incisioncomplex:OpenbubbledamagedDNAtemplate:RPA:ERCC5:trimmed nascent mRNAUSP7 Ub-671-UBC(609-684) RPS27A(1-76) ISY1 GTF2H1 XPC:RAD23:CETN2:Distorted dsDNA:UV-DDBRAD23A CDK7 DDB1 PRPF19 RFC4 UBC(305-380) CUL4B UBC(609-684) GTF2H4 POLD3 GTF2H3 HMGN1 COPS5 UBE2N:UBE2V2Ub,SUMO,K63polyUb:XPC:RAD23:CETN2UbUb-63-UBA52(1-76) UBC(305-380) POLE2 GTF2H4 UBC(229-304) POLD1 PAR-DDB2 CUL4A XPA UBC(609-684) GTF2H4 POLR2F damaged DNA with 5' incision COPS7A PAR-DDB2 EP300 GTF2H3 MNAT1 CUL4B RPA2 GTF2H3 UBA52(1-76) UBC(381-456) UBA52(1-76) RBX1 ERCC3 POLR2K RPA3 (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNACHD1L ERCC2 CUL4B POLD2 damaged DNA substrate:nascent mRNA hybrid UBC(533-608) AQR UBC(77-152) UBC(1-76) UBC(229-304) CETN2 DDB2 XPA UBA52(1-76) Ub,p-S2,S5-POLR2A GTF2H2 PiUBC(457-532) RFC2 Ub-291-UBC(229-304) UBA52(1-76) PAR-PARP2 GTF2H2 AQR UBC(381-456) CHD1L ERCC2 DDB1 DDB2 UBA52(1-76) RFC2 UBC(77-152) POLR2B GTF2H4 POLR2I POLR2B MCRS1 UBC(229-304) CCNH POLR2H GTF2H4 RAD23B UBC(1-76) UBB(77-152) ERCC6 POLR2K RPS27A(1-76) POLR2K RBX1 POLR2C Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2RAD23A POLR2B ERCC5 ZNF830 UBB(1-76) POLR2E RBX1 UBC(229-304) RPA3 Ub-XPC UBC(381-456) RAD23A UBC(381-456) ERCC8 ERCC4 ERCC5 ERCC8 XPA UBB(1-76) GTF2H1 ERCC8 POLR2B PPiPOLR2K CUL4B POLE4 UBC(457-532) POLE4 GTF2H1 CUL4A RFC4 UBC(305-380) ERCC2 RFC3 PRPF19 POLR2L UBC(609-684) GTF2H4 Ub-63-UBC(1-76) USP7 UBC(533-608) UBC(457-532) UVSSA RPS27A(1-76) POLR2J POLR2E UBC(533-608) CCNH CUL4B ZNF830 COPS4 GTF2H5 HyperphosphorylatedRNA Pol II:DamagedDNAtemplate:nascentmRNAhybrid:TFIIH:ERCC6PAR-DDB2 COPS8 GTF2H5 UBB(1-76) CUL4A UBC(305-380) ERCC3 UVSSA RPA3 POLK UBB(1-76) UBC(609-684) UBC(609-684) DDB1 COPS2 POLD4 COPS7A Open bubble damaged DNA template:trimmed nascent mRNA CDK7 UBC(229-304) UBC(609-684) INO80C RFC2 ERCC3 UBB(77-152) MNAT1 POLE4 GTF2H5 POLR2K CETN2 UBC(457-532) USP45ERCC3 UBB(77-152) POLR2E CDK7 CCNH RPA2 UBC(609-684) GTF2H2 RFC2 Distorted dsDNA UBC(381-456) UBC(381-456) GTF2H5 POLR2E AQR GTF2H2 DDB1 POLR2I GTF2H4 POLR2F PRPF19 DDB1 XPA POLR2L CUL4B ERCC3 POLD2 GTF2H3 ERCC6 DDB1 POLR2H Ub,p-S2,S5-POLR2A UBC(533-608) PARP1 UVSSA TCEA1 GTF2H3 UBC(457-532) ERCC6 RBX1 DDB1 POLR2G Ub-ERCC1 CHD1L UBC(1-76) ERCC3 PAR-PARP1 UBC(381-456) Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1UBC(381-456) Ub-139-UBB(77-152) GTF2H2 GTF2H4 Ub-215-UBB(153-228) ERCC4 damaged DNA substrate:nascent mRNA hybrid UBA52(1-76) POLR2L GTF2H1 ERCC4 Ub-63-UBC(1-76) UBC(457-532) POLR2L GTF2H5 ERCC1 POLR2E POLR2C Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300CUL4B RPA3 SUMO2-C93-UBE2I UBC(153-228) CUL4B UBE2I-G93-SUMO2 PPIE Distorted dsDNA PAR-DDB2 GTF2H5 PPIE CUL4B XPA RUVBL1 UBB(153-228) EP300 RPA2 HMGN1 Open bubble damaged DNA template:trimmed nascent mRNA RAD23RBX1 UBC(381-456) XPA POLR2G UBC(153-228) UBC(609-684) XAB2 COPS5 GTF2H2 PAR-PARP1 UBB(153-228) PAR-PARP1 Ub-519-UBC(457-532) COPS3 UBC(153-228) UBC(229-304) ERCC3 CHD1LRPA1 UBC(533-608) Ub,p-S2,S5-POLR2A RPS27A(1-76) GTF2H5 Ub,p-S2,S5-POLR2A POLR2E ERCC2 ERCC3 Ub-671-UBC(609-684) POLR2J ISY1 ERCC1 UBB(153-228) USP7 NAD+POLR2K ZNF830 UBC(381-456) RBX1 GPS1 GTF2H5 TFPT Ub-63-RPS27A(1-76) UBB(1-76) UBC(229-304) GTF2H4 TCEA1 Distorted dsDNA UBC(457-532) POLR2J PAR-PARP1 UBC(153-228) XAB2 UBC(533-608) LIG1 ERCC3 PPIE NFRKB RFC2 DDB1 TC-NER incisioncomplexRAD23B ERCC3 RPA2 YY1 UBE2V2 PARP1 RFC2 POLR2D UbEP300 GTF2H2 UBC(457-532) POLR2G DDB1 POLR2D UBB(1-76) PAR-DDB2 RFC1 UBC(457-532) POLR2H UBC(229-304) Ub-XPC UBB(77-152) MonoUb-K164-PCNA MNAT1 MonoUb-K164-PCNA POLE4 POLR2E GTF2H1 ERCC8 POLR2K MNAT1 UBA52(1-76) UBC(457-532) POLR2J UBC(457-532) RPA3 MonoUb-K164-PCNA EP300 UBC(77-152) GTF2H5 INO80B ERCC2 RPA2 UBB(1-76) UBC(381-456) ERCC2 SSB-dsDNA PiRBX1 CHD1L UVSSA POLK DDB1 ERCC1 UBC(457-532) UBC(457-532) DDB1 UBB(1-76) Ub:ERCC6COPS6 POLE2 UBC(533-608) UBC(533-608) POLR2G RFC4 damaged DNA substrate:nascent mRNA hybrid UBC(457-532) POLR2I ERCC3 POLR2E UBB(77-152) UBB(153-228) UBB(153-228) POLR2D RBX1 GTF2H3 RPA2 HMGN1 RAD23B CCNH UBC(77-152) UBA52(1-76) UBC(153-228) POLR2B GTF2H5 POLR2H USP7 POLR2K POLR2I PPiPOLR2D UBC(77-152) CUL4A UBA52(1-76) GTF2H3 POLR2E MNAT1 PAR-DDB2 UBC(1-76) RAD23A GTF2H3 CUL4B RPA3 UBB(77-152) EP300POLD4 AQR UBC(533-608) Ub-ERCC6 UBB(153-228) UBC(229-304) RFC3 UBC(609-684) RPS27A(1-76) PARP2 RPS27A(1-76) UBC(457-532) ERCC8 COPS4 Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1LPOLR2F ERCC3 CUL4A DDB1 POLR2E UBC(153-228) ISY1 Ub:ERCC1SUMO1,2,3:UBE2ICUL4B UBB(153-228) CUL4A UBB(153-228) POLK UBC(1-76) XPADDB1 UBC(381-456) EP300 UBC(609-684) RFC4 POLK RPA1 UBC(533-608) UBC(77-152) UBC(153-228) UBC(381-456) MNAT1 PAR-DDB2 POLD3 UBC(1-76) PCNAhomotrimer,MonoUb:K164-PCNA homotrimerPOLR2C UBC(533-608) CDK7 PAR-PARP1 PRPF19 ZNF830 GTF2H5 UBC(381-456) UBC(533-608) UBC(1-76) AQR INO80D ERCC3 GTF2H4 POLR2K POLR2D ERCC2 p-S2,S5-POLR2A PAR-PARP2 GTF2H1 GTF2H1 HMGN1 ERCC8 dNTPPOLR2B RFC5 GTF2H1 UBA52(1-76) ISY1 EP300 POLR2F Ub-215-UBB(153-228) UBB(1-76) ERCC3 CUL4A XPC UBA52(1-76) POLD,POLE Ub-215-UBC(153-228) CCNH UBB(77-152) XPA UBC(77-152) POLR2H UBC(609-684) RPA2 DamageddsDNAwithopentranscriptionbubble:Hyperphosphorylated RNA Pol II:TFIIHUBB(77-152) RFC1 LIG3 COPS7A ADPCUL4B POLR2I UBE2I-G92-SUMO3 UBC(381-456) POLR2L AQR XPC RPA2 Ub-291-UBC(229-304) RBX1 GTF2H2 POLR2H GTF2H1 ERCC3 XPA Ub-63-UBB(1-76) CUL4B PPIE POLE GTF2H3 SUMO3 POLR2F UBB(77-152) POLR2G PAR-PARP1 UBB(153-228) ERCC5 COPS8 POLR2H AQR POLD3 RAD23A CUL4B PRPF19 RPA2 Ub-367-UBC(305-380) POLR2H GTF2H5 UBC(153-228) UBC(153-228) POLR2J SUMO1 RAD23B PARP2 ERCC2 CCNH UBB(1-76) XAB2 UBC(1-76) RPA3 POLR2C POLR2H POLR2G RPS27A(1-76) damaged DNA with 5' incision PIAS1,3GTF2H2 RPA1 ERCC6 PRPF19 POLR2L ERCC1 UBC(381-456) UBC(305-380) CDK7 ERCC2 RPA2 GTF2H4 Damaged dsDNA with open transcription bubble UBC(229-304) POLE3 RBX1 ERCC2 POLR2F MNAT1 GTF2H4 UBC(305-380) POLR2F POLR2C POLR2F POLD2 UBB(153-228) UBB(1-76) CDK7 CHD1L UVSSA ISY1 PIAS3 GTF2H2 PCNA UBC(229-304) POLE CETN2 GTF2H3 CETN2 CDK7 RFC1 CDK7 RPA1 UBC(229-304) GTF2H3 UBC(457-532) CUL4A UBC(609-684) CDK7 GTF2H4 RPS27A(1-76) UBB(1-76) RPA3 UBC(1-76) ACTL6A POLD3 USP7 POLD3 CUL4A POLR2C RFC5 POLE GTF2H1 incised DNA without lesion:trimmed nascent mRNA ERCC6 GTF2H1 Ub-XPC UBC(153-228) GTF2H3 CUL4A MonoUb-K164-PCNA ERCC4 CETN2 UBC(609-684) UBC(77-152) UBB(153-228) PAR-PARP2 POLR2L UBC(77-152) POLR2D CUL4B CCNH damaged DNA with open bubble structure CUL4A POLR2F DDB1 PAR-PARP1 UBC(457-532) UBC(609-684) UBC(609-684) GTF2H5 RBX1 GTF2H2 ZNF830 DDB1 DDB1 POLR2B Ub,SUMO-XPC UBB(77-152) UBC(609-684) CUL4B GTF2H1 POLR2G PPIE CUL4B MNAT1 PAR-PARP2 UBC(229-304) GTF2H2 UBB(153-228) SUMO2 POLR2F XPA ERCC6 POLE3 RAD23A UBC(1-76) UBC(533-608) UBB(153-228) RPS27A(1-76) SSB-dsDNA:trimmed nascent mRNA UBB(77-152) damaged DNA substrate:nascent mRNA hybrid ERCC6 RPS27A(1-76) CUL4B ERCC6 ERCC5 ERCC1:ERCC4CCNH PRPF19 UBC(533-608) CCNH CCNH HMGN1 GTF2H2 UBC(229-304) UBC(457-532) POLR2L CUL4B POLE2 GTF2H1 TCEA1 GTF2H3 POLR2I GTF2H3 UBB(1-76) POLR2J UBC(1-76) UBC(609-684) CUL4A UBA52(1-76) ERCC3 ERCC3 UV-DDB:COP9SignalosomeGTF2H2 ISY1 RPS27A(1-76) CHD1L POLD1 CCNH PAR-PARP1 POLR2J UBA52(1-76) POLR2F UBC(1-76) POLR2I ERCC6 GTF2H5 USP7 XPA POLR2C UBC(381-456) UBC(305-380) POLR2I UBC(153-228) UBC(1-76) UBB(1-76) ISY1 POLR2G ERCC4 PAR-PARP2 UBC(305-380) POLE3 RPS27A(1-76) UBA52(1-76) POLD2 ERCC1 POLR2I UBC(77-152) POLR2L CHD1L RBX1 POLR2L MNAT1 POLE2 POLR2B POLR2E ISY1 UBC(229-304) RFC3 POLR2F POLR2E PAR-PARP1 GTF2H1 UBC(229-304) UBC(77-152) POLD4 UBC(609-684) Ub,p-S2,S5-POLR2A UBB(77-152) GTF2H5 Ub,p-S2,S5-POLR2A RFC1 UBC(305-380) GTF2H2 ERCC4UBB(153-228) POLR2J POLR2F UBC(457-532) POLR2B RPA3 GTF2H1 POLR2E UBB(1-76) RBX1 POLD1 POLR2B CDK7 ERCC2 ERCC3 DDB1 GTF2H4 UBB(153-228) CUL4B POLR2H UBC(229-304) POLD2 POLE dNTPUBC(229-304) RPA1 UBC(77-152) XPA COPS6 ERCC3 Distorted dsDNA PRPF19 RPA1 ZNF830 UBC(153-228) HMGN1 UBE2N UBB(1-76) UVSSA RBX1 RPS27A(1-76) POLR2C ERCC8 RFC4 RBX1 XAB2 UBC(533-608) Ub-XPC UBC(609-684) CUL4A UBB(77-152) RPA1 RPA1 UBA52(1-76) POLR2I TCEA1 p-S2,S5-POLR2A UBB(1-76) COPS6 UBB(1-76) UBC(305-380) POLD1 RPA2 POLE3 UBB(153-228) PRPF19 POLR2L POLR2C UVSSA:USP7CDK7 UBC(77-152) MNAT1 Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2MonoUb-K164-PCNA UBC(305-380) GTF2H1 RFC5 UBC(77-152) PRPF19 UBC(229-304) GTF2H2 XAB2 ACTR8 CDK7 RAD23B UBA52(1-76) GTF2H1 UBC(533-608) UBC(533-608) COPS2 PAR-DDB2 Ub,p-S2,S5-POLR2A GTF2H2 RPS27A(1-76) UBC(533-608) UBB(77-152) RPS27A(1-76) UVSSA POLR2G SUMO3-C93-UBE2I CETN2 UBC(153-228) XAB2 UBB(1-76) RBX1 CUL4A UBC(533-608) Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2GPS1 UBB(153-228) Ub-215-UBC(153-228) UBA52(1-76) MNAT1 GTF2H3 XPA POLR2B POLR2J POLR2B UBB(153-228) CUL4A Distorted dsDNA UBA52(1-76) UBC(229-304) UBC(77-152) UVSSA RFC2 PCNA UBB(153-228) GTF2H1 UBB(1-76) UBA52(1-76) POLR2G XPA PAR-PARP2 damaged DNA with open bubble structure RFC5 RBX1 PPIE UBB(153-228) dsDNA with transcription bubble UBB(153-228) ERCC8:DDB1:CUL4:RBX1RPA3 UBC(77-152) RFC1 UBC(229-304) CUL4A UBB(1-76) RPS27A(1-76) GTF2H5 POLD1 PAR-PARP1 GTF2H3 POLR2J UBC(457-532) PRPF19 PCNA XAB2 CCNH Distorted dsDNA CUL4A RBX1 ERCC4 POLK PCNA RAD23B UBC(305-380) Ub,p-S2,S5-POLR2A CETN2 ERCC3 RFC4 POLD,POLE,POLKINO80E POLR2I GTF2H4 ISY1 ERCC2 UBC(305-380) UBC(305-380) UBC(229-304) UBA52(1-76) UBB(77-152) UBC(1-76) UBB(77-152) CUL4B UBB(77-152) GTF2H2 UBC(153-228) UBC(533-608) GTF2H2 RFC4 RPS27A(1-76) RAD23A POLR2J UBC(77-152) UBC(305-380) POLR2D PPiUBA52(1-76)