Opioid Signalling (Homo sapiens)

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14, 31, 395340540401, 34, 554, 24, 48, 5118, 33106, 224521, 509, 13, 29254017, 4344, 52403737, 424715, 27, 363012494515465428, 203211, 35, 381916, 5649231040, 41nucleoplasmcytosolendoplasmic reticulum lumenActivated PLC beta1/4ADPPPP3CC GNAI1 (Gialpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)GNB4 H2OADCY7 ADCY5 POMC(237-241) G protein alpha:GTPcomplexPRKACG PDYN(226-230) GNAI1 GNG5 PRKAR1A p-T75-PPP1R1B p-T75,S137-PPP1R1B PPP3CB ITPR:I(1,4,5)P3tetramerADCY2 GNG12 GNGT2 GNAT2 ATPGNAI2 PRKACA ADCY3 G alpha (i): GTPGDP GDP GNB5 GNB4 (Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)ADPp-S505,S727-PLA2G4A ATPGNAI3 PiAdenylate cyclase(Mg2+ cofactor)DAGsADCY8 OPRM1 PPP3CC ADCY3 GDP PPP3R1 GNG13 GNAI1 p-T75,S102,S137-PPP1R1B PRKACA,(PRKACB,PRKACG,PRKX)Mg2+ ADCY3 ADCY8 active PKC (alpha,gamma, delta)GNB2 Mg2+ GNG13 PKA tetramerDARPP-32phosphorylated onT34ITPR3 p-T34-PPP1R1B GNAT3 PPP1R1B Mg2+ PP2A-ABdeltaCcomplexPRKACB GNAI3 GTP Calmodulin:CaMK IVADCY1 GNAI3 H2OGNG3 GNG5 p-T75,S102-PPP1R1B GNB1 ADCY6 Mg2+ GNAT3 activated PDE1A AMPPRKACG cAMP GNAI2 PRKAR2A ITPR1 GNAO1 POMC(237-241) PiADCY5 H2OPOMC(237-267) ADCY9 GNAO1 GNAI1 GTP Mg2+ PPP2CB p-T34,S102-PPP1R1B POMC(237-267) ADCY7 Pip-T75,S102,S137-PPP1R1B PDE1A GNG11 p-T34,T75,S137-PPP1R1B GNGT1 ATPGNB1 Galpha-olf:GDP:Adenylate cyclase (active) complexPPiPiAdenylate cyclase(Mg2+ cofactor)PRKAR1A CALM1 GNAT3 GNG2 GNAI3 GNAI3 GNGT1 ADCY1 GTP ITPR2 GNAI2 ADCY8 GDP PDE1B GNG2 ADCY5 GTPPRKACG PRKACA CAMK4ARAPLC-betaGNAZ ADCY8 ITPR1 GNG4 ADCY4 p-T75,S137-PPP1R1B p-T34,T75-PPP1R1B ADCY1 GNAT3 GNAI3 IP3 receptorhomotetramerGNAO1 GNAI1 GNG7 PDE4A G alpha-olf:GDPcomplexGNAL CALM1 GTP PRKCA GNB5 I(1,4,5)P3 ADCY9 Mg2+ ADCY4 PLCB3 PPP1CAPRKCD ATPGNG13 POMC(237-267) DARPP-32 (and/orphosphorylated)p-T34,S102,S137-PPP1R1B Ca2+ Ca2+ ADCY1 CDK5GNG5 p-S137-PPP1R1B PRKAR2B ATPGNAT2 GNB2 GNGT2 CAMK4 GNGT1 GNG4 GNG5 GNG12 GNAT3 GNAZ ADCY2 ITPR3 PLCB4 Opioid:MOR:Gprotein-GTP complexGNAI1 GNB5 GNG10 PKA catalyticsubunitG-protein beta-gammacomplexCa2+ p-T34,T75,S102-PPP1R1B GNB1 ADCY7 activated PDE1dimersp-S102-PPP1R1B PDYN(226-230) GNAT3 Zn2+ GNB5 GNG7 GNG11 H2OGTP PRKACG PLCB2 GNG2 ADCY1 GNG8 ADPp-T34,T75,S137-PPP1R1B GNAI2 CALM1 POMC(237-241) GNAT1 Ca2+ H2OPRKACB GRK2p-T185,Y187-MAPK1Fe3+ PRKACB ATPPLCB2 p-S102,S137-PPP1R1B GNAI1 GNAI1 PPP3CB GNAI1 PC p-T34,T75-PPP1R1B GDPPhosphorylated (T34)DARPP-32:PP1AADCY2 GNAI3 GNB3 p-S102,S137-PPP1R1B ADCY6 GNG2 Ca2+ GNB4 ADCY4 ADCY6 ADCY6 cAMPGNG3 GNB1 ADCY6 p-S505,S727-PLA2G4APPP2CA PPP2R1A phospho-CaMKIV:CalmodulinPPP1CA OPRM1PDE1C GNAT2 GNAO1 p-S137-PPP1R1B PLCB1 PPP3CA GNB1 I(1,4,5)P3 GNAI2 ADCY2 p-S12,S13-CAMK4 ADCY4 ADCY4 PLA2G4AGNAT3 ADCY2 PRKACB GNAT3 Mg2+ GNAI3 GNAI2 GNAI3 ADCY2 PRKACAGNG11 ADCY7 PRKAR1A G protein alpha:GTPcomplexp-T34,T75,S102,S137-PPP1R1B GNG8 GNAT2 Opioid peptideZn2+ Protein Kinase A,catalytic subunitsATPADCY3 ADCY3 CALM1GNB2 GNG11 ADCY6 CREB1p-T34,T75,S102,S137-PPP1R1B PPP2R1B GNAT3 GNAI2 GNG7 GNG11 p-S29-ADRBK1CALM1:4xCa2+GNG10 PPP3CA GNAI3 AMPGNAI3 Calmodulin:CaMK IVGNGT2 GNG3 Ca2+ GNAT2 Ca2+PRKAR1B PPP3CC PRKACG ADCY6 p-T34,T75,S137-PPP1R1B ITPR1 GNAI3 GNAI3 GNG8 GNAZ ADCY5 ADPGNAI2 PLCB3 PRKACA GNAI1 ADCY1 ADCY6 GNGT1 ADCY2 GNAL GNAI3 GNGT1 PDE 4GNG4 GNG5 GNAI2 p-T34,S137-PPP1R1B ADCY5 GNG7 GNAI2 GNG10 PPP3CB ADPGDP GNG7 GTP ADCY3 GNAO1 ADCY4 CREB1p-T34-PPP1R1B Mn2+ p-S54-PDE4Bp-T34,S102,S137-PPP1R1B ADCY8 GNAT1 GRK2:calmodulinPPiADCY7 POMC(237-241) p-T75,S137-PPP1R1B p-S102-PPP1R1B GNAI2 PRKAR2B p-T75-PPP1R1B ITPR3 ADCY5 NAD+ GNAZ ADCY3 POMC(237-267) GNAL ADPADCY9 PRKACB Ca2+ GNAT1 GNG12 Fe3+ ActivePLA2:phosphatidylcholineADCY7 GNAL ADCY5 p-T34,S137-PPP1R1B PDYN(226-230) activated PDE1C p-T34,T75,S102-PPP1R1B Zn2+ GNAT3 GDP GNG3 ADCY2 p-S133-CREB1 CALM1 GNAI3 ATPGNGT2 Mg2+ ADCY5 GNAT2 ADCY9 GNB2 GNAO1 DARPP-32 (for CDK5phosphorylation)GTP GNG10 p-T34,T75,S137-PPP1R1B ADCY2 GNG2 ADCY9 PPP3CA PRKACA p-T34-PPP1R1B ADCY1 Galpha-olf:GTP:Adenylate cyclase (active) complexGNAL GNAT1 PRKACG CALM1:4xCa2+GNAT3 GDP PP2B catalytic(Fe3+, Zn2+)cAMPPDE4B ADCY6 Opioid:MOR:Gprotein-GDP complexPRKACG GNAI2 GNAI2 GNAL G-protein alpha(i):GDPGNAT2 ADCY5 p-T75,S102-PPP1R1B GNAT1 p-T34,T75-PPP1R1B ADCY3 AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerGNAI1 PRKACA ADCY4 p-T34,T75,S102,S137-PPP1R1B GNAT3 PDE4D ADCY8 ITPR2 Mg2+ OPRM1 ADCY9 ADCY9 p-T75-DARPP32s:PRKACAATP2-LysophosphatidylcholinePDE1 dimersGNG8 I(1,4,5)P3ADCY1 GDPactivated PDE1B GNB4 PI(4,5)P2PPP3 complexGDP Opioid:MORAHCYL1 ADCY7 ADCY4 PLCB1 cAMP:PKA regulatorysubunitGNG10 PRKAR2A PDE4BGTP Ca2+GNAZ GNGT2 ADCY7 GNAI2 Fe3+ p-T75,S102,S137-PPP1R1B GNB3 PKA catalyticsubunitPRKACA GDP ADCY8 ITPR2 GNB2 ADCY8 G protein-GDPcomplexADCY9 p-S133-CREB1GNB5 PRKCG PRKAR2A p-T34,S102-PPP1R1B GTP GNAT3 GNAZ G-protein alpha:GDPPKA tetramer:4xcAMPcAMPADCY1 PKA catalyticsubunitCa2+ ADCY9 GNAO1 ADCY7 GNG13 ADCY2 ADCY9 ADCY7 PRKAR1B GNAO1 ADCY3 GDP PDYN(226-230) p-T34,T75-PPP1R1B GNAZ PDE4C p-T75-DARPP32sGNAT3 GTPGNG4 GNAT1 Mg2+ GNAO1 PLCB4 PCGNAZ GNB4 GNAL GNAI1 p-T34,T75,S102,S137-PPP1R1B p-T34,T75,S102-PPP1R1B PRKAR2B G-protein alpha(i):GTP:AdenylatecyclaseGNG4 GNG8 GNAI1 GNB3 ADCY4 CALM1 Opioid:MOR:G-proteincomplexPOMC(237-241) PRKACA ADCY8 POMC(237-267) CALM1 cAMP Adenylate cyclase(Mg2+ cofactor)ADCY4 p-S133-CREB1PCGNAI1 OPRM1 PPP1R1B p-T34,T75,S102-PPP1R1B PDYN(226-230) GNAT1 GNAZ PRKACB GNAI2 ADCY1 H2OGNG12 PRKAR1B ADCY5 PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaMADCY3 p-S133-CREB1homodimerGNG3 GNAT2 GNAT1 GNB3 GNG12 CALM1 Fe2+ G alpha-olf:GTPPRKACB GTP ADCY8 Adenylate cyclase(Mg2+ cofactor)Ca2+ GNG13 ADCY6 p-T75,S102-PPP1R1B p-T34,S102-PPP1R1B p-T34,S137-PPP1R1B CALM1 p-T75-PPP1R1B GRK2 GNAT2 GNAL H2OG-protein alpha(i/o/z/t) subunitPPP2R5D GNAT1 GNAT3 p-T34,S102,S137-PPP1R1B (Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)GNB3 G alpha-olf:GDPcomplexPiADPOPRM1 PRKACA PRKX CAMK4 G-betagammaGNAI1 282628