Cholesterol Biosynthesis Pathway (Homo sapiens)

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1CholesterolSQLEHMG-CoAMevalonic acid-5PSC4MOLLanosterinSC5DLMevalonic acid 5-pyrophosphateCYP51A1Mevalonic acidNSDHLDHCR7LSSMVKFatty Acid Beta OxidationSqualeneisopentenyl pyrophosphateHMGCS1Dimethylallyl pyrophosphatefarnesyl pyrophosphateIDI1FDFT1LathosterolHMGCRPMVKMVD7-Dehydrocholesterol(S)-2,3-EpoxysqualeneAcetyl-CoAFDPSGeranyl-PPFDPS


Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia

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Ontology Terms



  1. Porter FD; ''Malformation syndromes due to inborn errors of cholesterol synthesis.''; J Clin Invest, 2002 PubMed


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102317view07:56, 20 December 2018FehrhartChanged title due to overlap with Reactome pathway
101819view10:05, 10 November 2018EgonwReplaced a wrong CAS number of with right ChEBI identifier.
98746view21:23, 3 October 2018Khanspersupdated pathway node
91292view19:13, 23 January 2017KhanspersQuick edit to datanode annotation or property
90349view01:29, 6 November 2016AlexanderPicofixed width on metabolites
90348view01:25, 6 November 2016AlexanderPicoFixed pathway node and conversion interactions
90347view01:12, 6 November 2016AlexanderPicoupdated group type
90344view01:00, 6 November 2016AlexanderPicofixed IPP reactions
81059view14:15, 19 July 2015EgonwAdded a reference for the cholestorol synthesis track.
78758view12:57, 23 January 2015Bart SmeetsPeriodical save, work in progress
78708view01:36, 17 January 2015AndtheWingsModified title
78107view14:04, 3 December 2014Bart Smeetsremoved SREBF1/2, these regulate nearly all enzymes in this pathway.. better to leave them out entirely than to make it seem that HMGCS1 and HMGCR are their only targets
78106view13:48, 3 December 2014Bart Smeetschanged all catalytic reactions to the appropriate MIM interaction
69902view19:29, 11 July 2013AlexanderPicoModified title
68019view07:45, 29 June 2013EgonwAdded a missing metabolite identifier.
63163view20:24, 8 May 2013MaintBotUpdating gpml version
59219view20:13, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
59147view03:03, 22 February 2013MaintBotModified title
44991view14:36, 6 October 2011MartijnVanIerselOntology Term : 'cholesterol biosynthetic pathway' added !
43562view21:55, 29 June 2011Samuel SklarSREBP added
41229view23:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
35133view13:55, 11 February 2010ThomasModified description
35132view13:53, 11 February 2010Thomasremoved genmapp comments
35131view13:52, 11 February 2010Thomasadded references
34473view18:34, 10 December 2009MaintBotAutomatic update of empty xrefs
31995view13:15, 14 August 2009MaintBotFixed group labels
21093view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cholesterol Biosynthesis]] moved to [[Pathway:WP197]]: Moved to stable identifier
14362view15:13, 22 May 2008Pahlesfor some metabolites the type was unknown
14346view13:51, 22 May 2008Pahlesreactions connected
14344view13:40, 22 May 2008PahlesPeriodical save, work in progress
14338view13:29, 22 May 2008Pahlesmetabolites added
14336view13:28, 22 May 2008PahlesPeriodical save, work in progress
14329view13:18, 22 May 2008PahlesPeriodical save, work in progress
14324view13:08, 22 May 2008PahlesPeriodical save, work in progress
14318view12:57, 22 May 2008PahlesPeriodical save, work in progress
13048view11:11, 17 May 2008MaintBotautomated metabolite conversion
7954view13:46, 7 January 2008MaintBot[[Pathway:Human:Cholesterol Biosynthesis]] moved to [[Pathway:Homo sapiens:Cholesterol Biosynthesis]]: Renaming species
7601view16:03, 18 December 2007MaintBotfixed category names
7334view12:42, 4 November 2007MaintBotAdded categories to GPML
19405view22:17, 22 May 2007N.Manteigpml file for [[Human:Cholesterol_Biosynthesis]]
6302view22:17, 22 May 2007M.Liebermangpml file for [[Human:Cholesterol_Biosynthesis]]

External references


View all...
NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetaboliteCHEBI:15441 (ChEBI)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
CYP51A1GeneProduct1595 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
DHCR7GeneProduct1717 (Entrez Gene)
Dimethylallyl pyrophosphateMetabolite358-72-5 (CAS)
FDFT1GeneProduct2222 (Entrez Gene)
FDPSGeneProduct2224 (Entrez Gene)
Fatty Acid Beta OxidationPathwayWP143 (WikiPathways)
Geranyl-PPMetabolite6699-20-3 (CAS)
HMG-CoAMetaboliteHMDB01375 (HMDB)
HMGCRGeneProduct3156 (Entrez Gene)
HMGCS1GeneProduct3157 (Entrez Gene)
IDI1GeneProduct3422 (Entrez Gene)
LSSGeneProduct4047 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
LathosterolMetabolite80-99-9 (CAS)
MVDGeneProduct4597 (Entrez Gene)
MVKGeneProduct4598 (Entrez Gene)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
Mevalonic acidMetabolite150-97-0 (CAS)
NSDHLGeneProduct50814 (Entrez Gene) NAD(P) dependent steroid dehydrogenase-like
PMVKGeneProduct10654 (Entrez Gene)
SC4MOLGeneProduct6307 (Entrez Gene)
SC5DLGeneProduct6309 (Entrez Gene)
SQLEGeneProduct6713 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)

Annotated Interactions

No annotated interactions

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