Citrate cycle (TCA cycle) (Mycobacterium tuberculosis)

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Glyoxylateicl1acnOxalacetic acidmdhFumarateGlycolysispykAMalatealpha-ketoglutaratePyruvatePhosphoenolpyruvate(PEP)Acetyl-CoAMethylcitratefumCMethylisocitrateCitratesucCkorAIsocitrateSuccinyl-CoAacncitAaceEglcBSuccinateprpCicd12-oxo-2-hydroxyadipate(HOA)GlutamateHydroxylevulinatehoasmezpckApcakorBicd2aceAbaceAasucDdlaTlpdCprpBaceAbaceAaicl1sdhBsdhCsdhAsdhD


Description

The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011]. Source: KEGG (http://www.genome.jp/kegg-bin/highlight_pathway?scale=1.0&map=map00020)

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History

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CompareRevisionActionTimeUserComment
107215view14:31, 17 September 2019MaintBotChEBI identifier normalization
106910view13:38, 17 September 2019MaintBotHMDB identifier normalization
89183view03:50, 23 August 2016AriuttaOntology Term : 'classic metabolic pathway' added !
89182view03:50, 23 August 2016AriuttaOntology Term : 'citric acid cycle pathway' added !
87403view11:05, 22 July 2016MaintBotadded missing graphids
80115view21:07, 7 May 2015Khanspersupdated metabolites
80114view20:54, 7 May 2015Khansperscleanup and connect lines
80112view20:29, 7 May 2015KhanspersReverted to version '21:08, 26 February 2013' by Khanspers
71638view19:33, 17 October 2013MaintBotAutomated update of data sources
71165view07:26, 11 October 2013Mkutmonconnected interactions
69558view20:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
59398view21:08, 26 February 2013MaintBotModified categories
43157view16:46, 3 June 2011Madhunannotate
43156view16:44, 3 June 2011Madhunnnotate
43155view16:41, 3 June 2011Madhunannotation
41494view01:11, 2 March 2011MaintBotRemoved redundant pathway information and comments
40201view16:18, 17 February 2011MadhunNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
2-oxo-2-hydroxyadipate (HOA)Metabolite
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
CitrateMetaboliteHMDB0000094 (HMDB)
FumarateMetaboliteHMDB0000134 (HMDB)
GlutamateMetaboliteCHEBI:18237 (ChEBI)
GlycolysisPathwayWP1567 (WikiPathways)
GlyoxylateMetaboliteHMDB0000119 (HMDB)
HydroxylevulinateMetabolite
IsocitrateMetaboliteHMDB0000193 (HMDB)
MalateMetaboliteHMDB0000744 (HMDB)
MethylcitrateMetaboliteHMDB0000379 (HMDB)
MethylisocitrateMetaboliteHMDB0006471 (HMDB)
Oxalacetic acidMetaboliteHMDB0000223 (HMDB)
Phosphoenolpyruvate (PEP)MetaboliteHMDB0000263 (HMDB)
PyruvateMetaboliteHMDB0000243 (HMDB)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)
aceAa GeneProductRv1915 (TubercuList)
aceAaGeneProductRv1915 (TubercuList)
aceAbGeneProductRv1916 (TubercuList)
aceEGeneProductRv2241 (TubercuList)
acnGeneProductRv1475c (TubercuList)
alpha-ketoglutarateMetaboliteHMDB0061388 (HMDB)
citAGeneProductRv0889c (TubercuList)
dlaTGeneProductRv2215 (TubercuList)
fumCGeneProductRv1098c (TubercuList) PDB No. 3NO9
glcBGeneProductRv1837c (TubercuList)
hoasGeneProductRv1248c (TubercuList)
icd1GeneProductRv3339c (TubercuList)
icd2GeneProductRv0066c (TubercuList)
icl1GeneProductRv0467 (TubercuList)
korAGeneProductRv2455c (TubercuList)
korBGeneProductRv2454c (TubercuList)
lpdCGeneProductRv0462 (TubercuList)
mdhGeneProductRv1240 (TubercuList)
mezGeneProductRv2332 (TubercuList)
pcaGeneProductRv2967c (TubercuList)
pckAGeneProductRv0211 (TubercuList)
prpBGeneProductRv1130 (TubercuList)
prpCGeneProductRv1131 (TubercuList)
pykAGeneProductRv1617 (TubercuList)
sdhAGeneProductRv3318 (TubercuList)
sdhB GeneProductRv3319 (TubercuList)
sdhCGeneProductRv3316 (TubercuList)
sdhDGeneProductRv3317 (TubercuList)
sucCGeneProductRv0951 (TubercuList)
sucDGeneProductRv0952 (TubercuList)

Annotated Interactions

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