Phenylalanine Biosynthesis (Saccharomyces cerevisiae)

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1-4Phenylpyruvatewater2-oxoglutarateARO7L-alanineprephenateARO8carbon dioxideL-glutamatechorismateARO9PHA2L-phenylalaninepyruvate


Biosynthesis of the aromatic amino acids phenylalanine, tyrosine, and tryptophan proceeds via a common pathway to chorismate, at which point the pathway branches (CITS:[Jones][1943992]). One branch proceeds to phenylalanine and tyrosine, and the other to tryptophan (CITS:[Jones]). The phenylalanine and tyrosine branch has one reaction in common, rearrangement of chorismate to prephenate, at which point, the pathway branches again to either phenylalanine or tyrosine (CITS:[1943992])). S. cerevisiae, similar to E. coli, synthesize phenylalanine and tyrosine via the intermediate 4-hydroxyphenylpyruvate and phenylpyruvate, respectively, while some other organisms synthesize them via arogenate (CITS:[1943992]). Aromatic amino acid biosynthesis in S. cerevisiae is controlled by a combination of feedback inhibition, activation of enzyme activity, and regulation of enzyme synthesis (CITS:[Jones][1943992]). The carbon flow through the pathways is regulated primarily at the initial step and the branching points by the terminal end-products. The initial step of chorismate biosynthesis can be catalyzed by two isoenzymes Aro3p or Aro4p, whereby Aro3p is inhibited by phenylalanine, and Aro4p by tyrosine (CITS:[Jones][1943992]). The first step in the phenylalanine-tyrosine branch is feedback inhibited by tyrosine and activated by tryptophan (CITS:[1943992]). The transcriptional activator GCN4 regulates most of the genes encoding for the aromatic amino acid biosynthetic enzymes; however, no GCN4 regulation was found for ARO7 of the phenylalanine and tyrosine and branch, TYR1 of the tyrosine branch, or TRP1 of the tryptophan branch (CITS:[1943992]).

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  1. Urrestarazu A, Vissers S, Iraqui I, Grenson M; ''Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination.''; Mol Gen Genet, 1998 PubMed Europe PMC
  2. Iraqui I, Vissers S, Cartiaux M, Urrestarazu A; ''Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily.''; Mol Gen Genet, 1998 PubMed Europe PMC
  3. Braus GH; ''Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.''; Microbiol Rev, 1991 PubMed Europe PMC
  4. Schnappauf G, Krappmann S, Braus GH; ''Tyrosine and tryptophan act through the same binding site at the dimer interface of yeast chorismate mutase.''; J Biol Chem, 1998 PubMed Europe PMC


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107249view14:34, 17 September 2019MaintBotChEBI identifier normalization
96393view09:53, 12 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
92986view18:02, 21 July 2017Khanspersupdated connections, nodes and overall layout
92985view17:51, 21 July 2017KhanspersModified description
92984view17:51, 21 July 2017Khanspersremoved GenMAPP notes
92912view07:52, 17 July 2017DeSlTrying to upload; new ChEBi iso CAS for chorismate
69817view14:35, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69617view20:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67591view11:30, 26 June 2013DdiglesOntology Term : 'phenylalanine biosynthetic pathway' added !
41851view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
36651view22:39, 9 April 2010MaintBotDescription and bibliography added from SGD
21087view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Phenylalanine Biosynthesis]] moved to [[Pathway:WP194]]: Moved to stable identifier
12810view08:03, 17 May 2008MaintBotautomated metabolite conversion
8873view14:11, 7 January 2008MaintBotAdded to category $category
8871view14:11, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
ARO7GeneProductS000006264 (SGD)
ARO8GeneProductS000003170 (SGD)
ARO9GeneProductS000001179 (SGD)
L-alanineMetaboliteCHEBI:16977 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-phenylalanineMetaboliteCHEBI:17295 (ChEBI)
PHA2GeneProductS000005260 (SGD)
PhenylpyruvateMetaboliteCHEBI:30851 (ChEBI)
carbon dioxideMetaboliteCHEBI:16526 (ChEBI)
chorismateMetaboliteCHEBI:17333 (ChEBI)
prephenateMetabolite126-49-8 (CAS)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
waterMetaboliteCHEBI:15377 (ChEBI)

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