TCR signaling (Homo sapiens)

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18, 31, 3694623, 34, 4211, 16, 631, 29442, 3512, 13, 56, 742014, 667, 6717, 6972995, 8, 409493, 37, 57, 68, 7313, 56722229, 459, 3978427910, 15, 24, 59, 7022, 33, 644, 535843, 5116, 63677929977, 7919, 28761, 29, 587841, 50, 52, 7113, 5625-27, 32, 5516, 6342613028nucleoplasmcytosolUb-580-UBC(533-608) HLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DRB1-1 beta chain Antigen HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain p-MAP3K7 p-Y771,Y783,Y1254-PLCG1 ITK UBE2V1 HLA class II histocompatibility antigen, DRB1-13 beta chain PiHLA class II histocompatibility antigen, DRB1-7 beta chain p-Y113,128,145-LCP2 HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DP PSMB8 ATPBCL10 PSMC1 WAS RIPK2HLA class II histocompatibility antigen, DQ beta 2 chain PDPK1 HLA class II histocompatibility antigen, DRB1-16 beta chain SLP-76 bound toGads:LATPAK3 Ub-124-UBC(77-152) PAK3 PIK3R2 p-T184,T187-MAP3K7 HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DRB1-11 beta chain HLA class II histocompatibility antigen, DQ TRAC TRAV19 p-6Y-CD247 CD4 HLA class II histocompatibility antigen, DRB1-11 beta chain p-S552-CARD11 CD3D HLA class II histocompatibility antigen, DRB1-9 beta chain precursor HLA class II histocompatibility antigen, DR beta 5 chain TRAC HLA class II histocompatibility antigen, DR-1 beta chain precursor ADPTRBV12-3 TCRA CD45,CD148TRBC1 GRAP2 p-5Y-LAT GRAP2 ADPK63polyUb-NEMO CHUK HLA class II histocompatibility antigen, DRB1-12 beta chain ATPUb-48-RPS27A(1-76) T-cell receptor alpha chain V region PY14 precursor PSMD12 UBE2N HLA class II histocompatibility antigen, DRB1-8 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain VASP Ena/VASP proteinsp-Y188,Y199-CD3E p-S552-CARD11 HLA class II histocompatibility antigen, DRB1-1 beta chain TRBC1 MALT1 H2OIKBKG p-Y753,Y759,Y1217-PLCG2 SCF-beta-TRCPCD4 HLA class II histocompatibility antigen, DQ K63polyUbNCK1 H2Op-5Y-LAT BTRC ATPHLA class II histocompatibility antigen, DRB1-14 beta chain HLA class II histocompatibility antigen, DRB1-7 beta chain CD3G ITK:p-Y113,128,145-SLP-76:GADS:LATBCL10ATPHLA class II histocompatibility antigen, DRB1-9 beta chain precursor PTPRJ HLA class II histocompatibility antigen, DP alpha chain precursor p-Y394-LCK HLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DQ beta 2 chain ITKHLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-1 beta chain ATPPI(3,4,5)P3 p-5Y-LAT HLA class II histocompatibility antigen, DRB1-10 beta chain TCRB HLA class II histocompatibility antigen, DRB1-13 beta chain TCRA p-5Y-LAT ATPPLCG1 PSMD7 CD3G HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor NFKB1(1-433) HLA class II histocompatibility antigen, DRB1-13 beta chain p-Y160,Y171-CD3G HLA class II histocompatibility antigen, DQ beta 2 chain p-Y90,T538,S676,S695-PRKCQ HLA class II histocompatibility antigen, DRB1-10 beta chain p-S177,S181-IKKB:IKKA:pUb-NEMOHLA class II histocompatibility antigen, DRB1-15 beta chain HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-10 beta chain ADPPAK2 ATPp-Y771,Y783,Y1254-PLCG1 HLA class II histocompatibility antigen, DRB1-7 beta chain PSME4 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor HLA class II histocompatibility antigen, DQ ENAH p-Y188,Y199-CD3E ZAP-70 and ITKtyrosine kinasesTRAV19 p-S552-CARD11 TRBC1 HLA class II histocompatibility antigen, DRB1-15 beta chain HLA class II histocompatibility antigen, DRB1-1 beta chain Ub-352-UBC(305-380) T-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DRB1-15 beta chain PSMD13 PTPRC CD4 Ub-48-UBB(1-76) Antigen HLA class II histocompatibility antigen, DRB1-14 beta chain HLA class II histocompatibility antigen, DRB1-1 beta chain LCP2HLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DQ NCK1 p-S177,S181-IKBKB HLA class II histocompatibility antigen, DRB1-16 beta chain PI(4,5)P2HLA class II histocompatibility antigen, DQ SKP1 Antigen CHUK TAB2/TAK1 complexRELA p-Y113,128,145-LCP2 TRBV12-3 K48-UbRELA HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DP alpha chain precursor TRAC HLA class II histocompatibility antigen, DP alpha chain precursor PLCG1 p-Y315,Y493-ZAP70 ADPTRBV12-3 ATPHLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DR beta 5 chain DAGs p-Y160,Y171-CD3G p-Y160,Y171-CD3G UBE2D1 p-BCL10 p-Y160,Y171-CD3G CD3G p-Y315,Y493-ZAP70 NFKB1(1-433) CD247-1 HLA class II histocompatibility antigen, DRB3-1 beta chain precursor HLA class II histocompatibility antigen, DP PSMA3 HLA class II histocompatibility antigen, DRB1-4 beta chain LATPDK1:PIP2,PIP3TRBV12-3 Antigen-bearing MHCClass II : TCRcomplex:CD4:Lckp-5Y-LAT p-Y90-PKC-theta:DAGGRAP2FYB HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor p-Y394-LCK p-Y149,Y160-CD3D HLA class II histocompatibility antigen, DR beta 4 chain PI(3,4)P2 HLA class II histocompatibility antigen, DRB1-4 beta chain p-Y394-LCK HLA class II histocompatibility antigen, DQ TCRA HLA class II histocompatibility antigen, DRB1-7 beta chain Ub-48-UBC(1-76) PSMA8 p-6Y-CD247 FYBTRBV12-3 p-Y394-LCK HLA class II histocompatibility antigen, DR alpha chain precursor p-Y317-PAG1 PSME3 HLA class II histocompatibility antigen, DRB1-11 beta chain PI(3,4,5)P3 HLA class II histocompatibility antigen, DRB1-8 beta chain PI3KHLA class II histocompatibility antigen, DRB1-15 beta chain TRAC HLA class II histocompatibility antigen, DRB1-8 beta chain TRAV19 HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DRB1-10 beta chain HLA class II histocompatibility antigen, DP alpha chain precursor CUL1 GRAP2 p-Y113,128,145-LCP2 p-Y188,Y199-CD3E ATPDAGs p-Y113,128,145-LCP2 GADS:p-5Y-LATEVL NCK1TRBC1 TAB2 TCRB HLA class II histocompatibility antigen, DR beta 5 chain PI(3,4,5)P3 PSMB5 TRBC1 DAGs HLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DRB1-14 beta chain HLA class II histocompatibility antigen, DRB3-1 beta chain precursor HLA class II histocompatibility antigen, DRB1-12 beta chain TRBV12-3 CSKTCRA Ub-656-UBC(609-684) PI(3,4,5)P3 HLA class II histocompatibility antigen, DR beta 5 chain p-5Y-LAT HLA class II histocompatibility antigen, DRB1-13 beta chain ATPPSMC5 HLA class II histocompatibility antigen, DRB1-4 beta chain PIK3CA HLA class II histocompatibility antigen, DR alpha chain precursor HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DP PLCG1HLA class II histocompatibility antigen, DQ beta 2 chain phosphorylatedPLC-gamma1 bound toSLP-76PIK3CA TAK1/TAB2 complexbound to TRAF6/CBMcomplexPI(3,4)P2p-Y90-PRKCQ p-6Y-CD247 p-Y113,128,145-LCP2 I(1,4,5)P3p-S552-CARD11 PDPK1 TRAC CD4 HLA class II histocompatibility antigen, DRB1-10 beta chain CARMA1 trimerMALT1 trimer boundto Bcl10 and CARMA1trimerATPHLA class II histocompatibility antigen, DR beta 5 chain CD4 PSMD11 HLA class II histocompatibility antigen, DP PI(3,4,5)P3 phosphorylatedPLC-gamma1 bound toLATPSMA5 PLCG1 ADPHLA class II histocompatibility antigen, DRB1-7 beta chain PI(3,4)P2 HLA class II histocompatibility antigen, DQ beta 2 chain IkB(alpha):NF-kBcomplexHLA class II histocompatibility antigen, DRB3-1 beta chain precursor HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DR-1 beta chain precursor CD3D UBE2N:UBE2V1ADPHLA class II histocompatibility antigen, DRB1-1 beta chain PDPK1 p-Y113,128,145-LCP2 PI(3,4,5)P3 p-BCL10HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DQ TRAV19 Ub-276-UBC(229-304) HLA class II histocompatibility antigen, DQ PSMA7 Bcl10 trimer boundto CARMA1 trimerPI(3,4)P2 p-SLP-76:NCK:PAKCD247-1 PI(3,4,5)P3 CD4 Antigen-bearing MHCClass II :TCRcomplex:CD4: Lckphosphorylated atTyr394TRBC1 TCRB HLA class II histocompatibility antigen, DP p-S552-CARD11 GRAP2 p-S552-CARD11 HLA class II histocompatibility antigen, DRB3-1 beta chain precursor Antigen-bearingMHCClassII:TCRcomplex:CD4:p-Lck(Y505)LCP2 PSMF1 PDPK1 IKBKG PTPN22Ub-200-UBB(153-228) HLA class II histocompatibility antigen, DRB1-14 beta chain RELA HLA class II histocompatibility antigen, DQ beta 2 chain CDC34 TRAF6CHUK Ub-TRAF6 trimerbound to CBMcomplexHLA class II histocompatibility antigen, DRB1-14 beta chain HLA class II histocompatibility antigen, DRB1-9 beta chain precursor ADPPIK3R1 p-Y113,128,145-LCP2 PLCG1:p-5Y-LATHLA class II histocompatibility antigen, DRB1-7 beta chain Antigen p-Y317-PAG1HLA class II histocompatibility antigen, DQ H2OPDPK1 PI(4,5)P2HLA class II histocompatibility antigen, DRB1-4 beta chain ZAP-70 bound tophosphorylated ITAMmotifsHLA class II histocompatibility antigen, DRB1-10 beta chain TCRB PSMA4 MALT1 HLA class II histocompatibility antigen, DRB1-16 beta chain PSMB1 HLA class II histocompatibility antigen, DR alpha chain precursor PSMD6 Antigen-bearing MHCClass II :TCRcomplex:CD4: Lckphosphorylated atTyr394MALT1 p-5Y-LAT p-5Y-LAT HLA class II histocompatibility antigen, DQ PSMB3 PI(4,5)P2TRBV12-3 HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DRB1-11 beta chain NFKB1(1-433):RELAHLA class II histocompatibility antigen, DRB1-9 beta chain precursor T-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DR alpha chain precursor PI(3,4)P2 PTPN22 ADPPTPN22:CSKNFKB1(1-433) HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-11 beta chain TCRB RELA RELA HLA class II histocompatibility antigen, DRB1-7 beta chain p-Y113,128,145-SLP-76:GADS:LATZAP70HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DRB1-15 beta chain Ub-504-UBC(457-532) TRAV19 EVL PSMD3 HLA class II histocompatibility antigen, DRB1-8 beta chain p-Y63,Y79,Y110-TRAT1 TCRB HLA class II histocompatibility antigen, DRB1-1 beta chain PSMD9 HLA class II histocompatibility antigen, DRB1-9 beta chain precursor TRBC1 NFKB1(1-433) PI(3,4)P2 Active PKC thetabound to DAGFBXW11 TCRA p-5Y-LAT PIK3CB HLA class II histocompatibility antigen, DRB1-11 beta chain HLA class II histocompatibility antigen, DRB1-9 beta chain precursor PIP3 activates AKTsignalingHLA class II histocompatibility antigen, DRB1-15 beta chain PKC-theta (open):DAGHLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-8 beta chain HLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DRB1-13 beta chain CD4 p-Y149,Y160-CD3D PSMA6 K63polyUbADPMALT1 trimerp-BCL10 PAK1,2,3HLA class II histocompatibility antigen, DRB3-1 beta chain precursor PSMD2 p-Y149,Y160-CD3D p-S552-CARD11 p-Y771,Y783,Y1254-PLCG1PSMD10 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor p-SLP-76:ADAP:Ena/VASPPI(3,4)P2 MALT1 PDPK1 HLA class II histocompatibility antigen, DRB1-11 beta chain HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-9 beta chain precursor PRKCQ PI(3,4)P2 HLA class II histocompatibility antigen, DR alpha chain precursor PSMC3 p-BCL10 HLA class II histocompatibility antigen, DQ ADPHLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-8 beta chain HLA class II histocompatibility antigen, DP ENAH HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor Ub-428-UBC(381-456) HLA class II histocompatibility antigen, DR beta 5 chain PSMB10 p-Y160,Y171-CD3G HLA class II histocompatibility antigen, DRB1-15 beta chain CARMA1 bound to PDK1HLA class II histocompatibility antigen, DRB1-8 beta chain HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DQ beta 2 chain CARD11 HLA class II histocompatibility antigen, DRB1-11 beta chain GRAP2 HLA class II histocompatibility antigen, DRB1-4 beta chain HLA class II histocompatibility antigen, DRB3-1 beta chain precursor PSMD4 PSMC6 HLA class II histocompatibility antigen, DRB3-1 beta chain precursor HLA class II histocompatibility antigen, DRB1-1 beta chain p-6Y-CD247 HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DR beta 4 chain p-S552-CARD11HLA class II histocompatibility antigen, DQ PLC-gamma1 bound toLAT or SLP-76HLA class II histocompatibility antigen, DRB1-9 beta chain precursor HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DP UBE2N Activated ZAP-70p-Y493-ZAP70 HLA class II histocompatibility antigen, DRB1-4 beta chain PRKQC closedconformationPIK3R1 CD3E WASTRAC CD3E PI(3,4)P2 HLA class II histocompatibility antigen, DR beta 4 chain CSK ITK p-Y149,Y160-CD3D HLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DR alpha chain precursor T-cell receptor alpha chain V region PY14 precursor TRAC p-Y113,128,145-LCP2 HLA class II histocompatibility antigen, DR beta 4 chain MALT1 H2OTRBV12-3 PDPK1 HLA class II histocompatibility antigen, DRB3-1 beta chain precursor PSME1 PSMB7 ADPUb-48-UBA52(1-76) HLA class II histocompatibility antigen, DP alpha chain precursor p-SLP-76:ADAPPDPK1 CARD11PI(3,4,5)P3 CSK HLA class II histocompatibility antigen, DRB3-1 beta chain precursor HLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DRB1-11 beta chain HLA class II histocompatibility antigen, DRB1-7 beta chain p-Y505-LCK p-Y771,Y783,Y1254-PLCG1 CD3E ADPAntigen T-cell receptor alpha chain V region PY14 precursor p-S177,S181-IKKB:IKKA:NEMOPI(3,4)P2 PDPK1 UBE2N:UBE2V1p-SLP-76:NCK1:WASPp-4Y-PLCG1 p-Y113,128,145-LCP2 p-S552-CARD11 PAK1 p-Y113,128,145-LCP2 HLA class II histocompatibility antigen, DRB1-9 beta chain precursor HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DQ p-Y394-LCK TRBC1 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor p-Y113,128,145-LCP2 p-SLP-76:NCK1PI(3,4)P2 TCRB HLA class II histocompatibility antigen, DRB1-14 beta chain Activated CARMA1K48PolyUb-K21,22-p-S32,S36-IkBA TCRA p-PLCGNFKB1(1-433) ATPHLA class II histocompatibility antigen, DQB1*0602 beta chain precursor PSMD5 p-Y188,Y199-CD3E CD3G PAK2 K63polyUb-TRAF6 p-4Y-PLCG1 ADPADPPSMC4 TRAV19 HLA class II histocompatibility antigen, DR alpha chain precursor IKBKB ATPPI(3,4,5)P3PSME2 TRAF6 PiPI(3,4,5)P3 H2OTCRB TCRA HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-10 beta chain CD3E TRBV12-3 PSMD1 DAGsATPTRAV19 p-5Y-LAT p-BCL10 K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complexCD101PAK1 HLA class II histocompatibility antigen, DQ p-BCL10 HLA class II histocompatibility antigen, DRB1-15 beta chain PSMB2 UBE2D2,UBE2D1,(CDC34)PI(3,4,5)P3 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor HLA class II histocompatibility antigen, DRB1-14 beta chain NFKBIA TRAC Phosphorylated Bcl10bound to CARMA1 andRIP2ATPp-S32,36-IkB-alpha:NF-kB complexUb-200-UBC(153-228) HLA class II histocompatibility antigen, DRB1-13 beta chain UBE2D2 HLA class II histocompatibility antigen, DR alpha chain precursor TRAV19 p-5Y-LAT Bcl10 bound toCARMA1T-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DR alpha chain precursor 26S proteasomeUb-124-UBB(77-152) p-BCL10 DAGsHLA class II histocompatibility antigen, DRB1-4 beta chain phospho tyrosineZAP-70p-Y149,Y160-CD3D HLA class II histocompatibility antigen, DRB1-10 beta chain HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor PI(3,4,5)P3 p-6Y-CD247 CD4 CD247-1 p-Y394-LCK ADPAntigen GRAP2 HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-14 beta chain p-Y188,Y199-CD3E TRAV19 HLA class II histocompatibility antigen, DP CD4 TRAC PDPK1p-S177,S181-IKBKB TCRA HLA class II histocompatibility antigen, DQ PSMC2 HLA class II histocompatibility antigen, DR beta 4 chain PLCG1:p-3Y-SLP-76:Gads:LATPIK3CB p-S32,S36-NFKBIA HLA class II histocompatibility antigen, DRB1-7 beta chain PSMD8 K63polyUb-TRAF6 HLA class II histocompatibility antigen, DRB1-4 beta chain ZAP70 VASP GRAP2 PDPK1 HLA class II histocompatibility antigen, DR-1 beta chain precursor Csk:p-PAGINPP5Dp-Y113,128,145-LCP2HLA class II histocompatibility antigen, DQ GRAP2 Antigen-bearing MHCClass II: TCR withphosphorylatedITAMs:CD4p-Y63,Y79,Y110-TRAT1PI(3,4)P2 CD3D p-Y394-LCK p-5Y-LATCD3D TCRA PSMA2 Activated PLC gamma1bound to PIP2HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-1 beta chain HLA class II histocompatibility antigen, DR beta 5 chain UBE2V1 HLA class II histocompatibility antigen, DQ NCK1 HLA class II histocompatibility antigen, DRB1-4 beta chain HLA class II histocompatibility antigen, DRB1-10 beta chain p-Y113,128,145-LCP2 PSMB6 GRAP2 T-cell receptor alpha chain V region PY14 precursor TAB2 PDPK1 HLA class II histocompatibility antigen, DRB1-15 beta chain T-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DR-1 beta chain precursor PiFYB HLA class II histocompatibility antigen, DP PI(3,4,5)P3 CHUK:IKBKB:IKBKGPI(4,5)P2 ATPNFKB1(1-433):RELAPSMB11 PSMA1 Antigen TCRB PSMB4 T-cell receptor alpha chain V region PY14 precursor p-S552-CARD11 HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DQ PSMD14 Antigen PIK3R2 HLA class II histocompatibility antigen, DR beta 4 chain SHFM1 LCK PSMB9 Antigen HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 4 chain PTENCD247-1 PIP3, PI(3,4)P2ADPPhosphorylatedPLC-gamma1 bound toLAT or SLP-76PI3K bound to TRATTRBC1 TRAF6 trimer boundto CBM complexHLA class II histocompatibility antigen, DRB1-14 beta chain PI(3,4)P2 77738, 47, 65212148, 75496021216121602149542161, 6248