TCR signaling (Homo sapiens)

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40, 44, 471418687, 9, 39, 72, 7527, 29, 30, 37, 5241, 743, 6721707173, 778, 325336, 43, 6621, 6210703, 6773, 7763, 691025, 38262, 33, 34, 56, 651210, 20, 593, 45, 57, 6761722, 2446, 61324, 16, 35, 54718, 194263707028, 76618708, 18, 3211, 4948, 701, 17, 6413, 73, 7762705526nucleoplasmcytosolHLA class II histocompatibility antigen, DRB1-11 beta chain p-BCL10 ATPp-5Y-LAT HLA class II histocompatibility antigen, DQ TRBC1 HLA class II histocompatibility antigen, DQ K63polyUb-NEMO Csk:p-PAGHLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DRB1-9 beta chain precursor PIP3 activates AKTsignalingHLA class II histocompatibility antigen, DRB3-1 beta chain precursor p-S552-CARD11MALT1 trimer boundto Bcl10 and CARMA1trimerPSMB7 PSMB9 HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DR beta 4 chain Bcl10 bound toCARMA1Ub-200-UBB(153-228) PI(4,5)P2 PSMA7 HLA class II histocompatibility antigen, DRB1-14 beta chain TCRA HLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DRB3-1 beta chain precursor PDPK1 PI(3,4)P2 HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DQ beta 2 chain ATPPTENTAB2 ADPPDPK1 p-Y493-ZAP70 T-cell receptor alpha chain V region PY14 precursor PSMD7 PSMB11 HLA class II histocompatibility antigen, DQ beta 2 chain ADPp-Y317-PAG1IkB(alpha):NF-kBcomplexPIK3R2 PDK1:PIP2,PIP3HLA class II histocompatibility antigen, DR alpha chain precursor HLA class II histocompatibility antigen, DRB1-14 beta chain CD3D RIPK2PSMC5 Pip-Y90-PKC-theta:DAGHLA class II histocompatibility antigen, DRB1-1 beta chain PSMA8 NFKB1(1-433) Antigen HLA class II histocompatibility antigen, DQ beta 2 chain p-Y63,Y79,Y110-TRAT1 HLA class II histocompatibility antigen, DR beta 4 chain p-5Y-LAT DAGs PIK3CA HLA class II histocompatibility antigen, DRB1-1 beta chain PSMA2 SLP-76 bound toGads:LATp-6Y-CD247-1 PDPK1 K63polyUbp-S32,S36-NFKBIA HLA class II histocompatibility antigen, DRB1-14 beta chain TCRB HLA class II histocompatibility antigen, DP TRAV19 PI(3,4)P2 UBE2N HLA class II histocompatibility antigen, DP HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DR alpha chain precursor K63polyUbHLA class II histocompatibility antigen, DRB1-11 beta chain WAS HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-4 beta chain ITK:p-Y113,128,145-SLP-76:GADS:LATHLA class II histocompatibility antigen, DR alpha chain precursor HLA class II histocompatibility antigen, DRB1-10 beta chain p-Y315,Y493-ZAP70 HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1-1 beta chain H2Op-BCL10 HLA class II histocompatibility antigen, DRB1-4 beta chain HLA class II histocompatibility antigen, DP alpha chain precursor TRBV12-3 p-S32,36-IkB-alpha:NF-kB complexHLA class II histocompatibility antigen, DR beta 5 chain CD4 TRBV12-3 BCL10 HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DQ beta 2 chain PI(3,4)P2 HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DR beta 4 chain T-cell receptor alpha chain V region PY14 precursor CD4 PI(3,4,5)P3 HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-9 beta chain precursor p-Y505-LCK HLA class II histocompatibility antigen, DRB1-14 beta chain p-5Y-LAT BTRC CHUK TRAC p-Y771,Y783,Y1254-PLCG1 HLA class II histocompatibility antigen, DRB1-8 beta chain p-Y149,Y160-CD3D HLA class II histocompatibility antigen, DQ p-MAP3K7 GRAP2 TCRA PSMB3 p-Y113,128,145-LCP2 RELA HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DQ ITK PSME3 CD4 HLA class II histocompatibility antigen, DR alpha chain precursor ADPHLA class II histocompatibility antigen, DRB1-10 beta chain HLA class II histocompatibility antigen, DRB1-15 beta chain ADPHLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-1 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain TAK1/TAB2 complexbound to TRAF6/CBMcomplexPhosphorylated Bcl10bound to CARMA1 andRIP2DAGsCHUK HLA class II histocompatibility antigen, DR alpha chain precursor PDPK1 HLA class II histocompatibility antigen, DRB1-1 beta chain HLA class II histocompatibility antigen, DRB3-1 beta chain precursor phosphorylatedPLC-gamma1 bound toLATp-S552-CARD11 TRBC1 TRBV12-3 TRAC PAK3 K48PolyUb-K21,22-p-S32,S36-IkBA HLA class II histocompatibility antigen, DRB1-8 beta chain H2OCD247-1 ZAP-70 bound tophosphorylated ITAMmotifsPDPK1 HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1-12 beta chain Antigen-bearing MHCClass II: TCR withphosphorylatedITAMs:CD4PSMA4 TCRA p-4Y-PLCG1 HLA class II histocompatibility antigen, DRB1-1 beta chain p-S552-CARD11 HLA class II histocompatibility antigen, DRB1-4 beta chain GRAP2 PLCG1 PKC-theta (open):DAGUBE2D2 HLA class II histocompatibility antigen, DQ VASP HLA class II histocompatibility antigen, DQ beta 2 chain H2OTCRB ADPp-Y394-LCK PSMB1 HLA class II histocompatibility antigen, DP HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain PSME1 HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DRB1-12 beta chain PI3K bound to TRATPSMC4 NCK1 NFKBIA PSMC2 Ub-48-RPS27A(1-76) PAK3 HLA class II histocompatibility antigen, DRB1-15 beta chain p-Y113,128,145-LCP2 TRBC1 PAK2 TRBV12-3 p-Y113,128,145-LCP2 PI(3,4,5)P3 HLA class II histocompatibility antigen, DRB1-8 beta chain HLA class II histocompatibility antigen, DQ NFKB1(1-433) Ub-428-UBC(381-456) Activated CARMA1p-Y771,Y783,Y1254-PLCG1 HLA class II histocompatibility antigen, DRB1-9 beta chain precursor HLA class II histocompatibility antigen, DRB1-4 beta chain PDPK1PI(3,4,5)P3 Pip-S552-CARD11 GRAP2 TRAC PIK3CB HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-9 beta chain precursor p-Y160,Y171-CD3G Ub-200-UBC(153-228) TCRB CSK p-Y113,128,145-LCP2 Ub-580-UBC(533-608) HLA class II histocompatibility antigen, DRB1-14 beta chain PIK3CB Ena/VASP proteinsp-BCL10HLA class II histocompatibility antigen, DQ CD3E PSMD9 p-5Y-LAT K48-UbHLA class II histocompatibility antigen, DR-1 beta chain precursor TRBV12-3 PLCG1:p-5Y-LATHLA class II histocompatibility antigen, DP p-Y149,Y160-CD3D p-S552-CARD11 HLA class II histocompatibility antigen, DRB1-7 beta chain TCRA HLA class II histocompatibility antigen, DR beta 4 chain TRBC1 HLA class II histocompatibility antigen, DRB1-14 beta chain PSMD10 ADPPIP3, PI(3,4)P2TRBC1 p-Y113,128,145-LCP2 SHFM1 p-Y317-PAG1 p-5Y-LAT CD3G NFKB1(1-433) PIK3CA HLA class II histocompatibility antigen, DRB1-12 beta chain ATPUb-124-UBC(77-152) TRAC GRAP2 TCRB PI(3,4,5)P3 HLA class II histocompatibility antigen, DRB1-13 beta chain p-Y394-LCK PSMD12 MALT1 HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DRB1-13 beta chain p-SLP-76:NCK:PAKPSMB8 HLA class II histocompatibility antigen, DP PI(3,4,5)P3 NCK1 PSMB4 CHUK Activated ZAP-70ATPCSKGRAP2 HLA class II histocompatibility antigen, DRB3-1 beta chain precursor FYB PLC-gamma1 bound toLAT or SLP-76Antigen TRBC1 CDC34 TRAF6UBE2N:UBE2V1p-S177,S181-IKKB:IKKA:pUb-NEMOHLA class II histocompatibility antigen, DRB1-11 beta chain CD4 FYB HLA class II histocompatibility antigen, DRB1-12 beta chain p-Y394-LCK Antigen Ub-48-UBC(1-76) p-SLP-76:NCK1HLA class II histocompatibility antigen, DRB1-15 beta chain p-BCL10 p-S177,S181-IKBKB K63polyUb-TRAF6 p-Y315,Y493-ZAP70 PI(4,5)P2p-Y188,Y199-CD3E PI(3,4,5)P3 IKBKB T-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor HLA class II histocompatibility antigen, DRB1-7 beta chain PI(3,4)P2 TRBC1 CD3D TRAC TRAC HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DP HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor ENAH TCRB PI(3,4)P2 Ub-TRAF6 trimerbound to CBMcomplexHLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DRB1-11 beta chain CD3E p-5Y-LAT p-5Y-LAT CD4 MALT1 p-6Y-CD247-1 HLA class II histocompatibility antigen, DR alpha chain precursor CD3D HLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DRB1-4 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain HLA class II histocompatibility antigen, DRB1-16 beta chain CD3D HLA class II histocompatibility antigen, DRB1-10 beta chain Ub-48-UBA52(1-76) MALT1 PSMD1 HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DQ PTPN22:CSKAntigen TRBV12-3 HLA class II histocompatibility antigen, DP PiRELA PSMC3 Active PKC thetabound to DAGSKP1 p-BCL10 HLA class II histocompatibility antigen, DRB1-11 beta chain TRAC p-Y160,Y171-CD3G PI(3,4)P2 GRAP2BCL10HLA class II histocompatibility antigen, DQ PhosphorylatedPLC-gamma1 bound toLAT or SLP-76Ub-352-UBC(305-380) PI(3,4,5)P3PSMA3 HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DRB1-11 beta chain HLA class II histocompatibility antigen, DP alpha chain precursor TRBV12-3 H2Op-Y771,Y783,Y1254-PLCG1 PSMD11 ADPPSMB6 HLA class II histocompatibility antigen, DRB1-1 beta chain PI(4,5)P2HLA class II histocompatibility antigen, DRB1-4 beta chain HLA class II histocompatibility antigen, DR beta 4 chain PAK1 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor HLA class II histocompatibility antigen, DR beta 5 chain p-Y394-LCK ATPAntigen p-T184,T187-MAP3K7 PLCG1:p-3Y-SLP-76:Gads:LATATPHLA class II histocompatibility antigen, DQ beta 2 chain p-Y113,128,145-LCP2 PI(3,4)P2 PRKCQ PSMC1 HLA class II histocompatibility antigen, DR-1 beta chain precursor CD3E Ub-48-UBB(1-76) p-5Y-LAT PDPK1 p-Y771,Y783,Y1254-PLCG1GRAP2 CUL1 IKBKG ATPHLA class II histocompatibility antigen, DRB1-15 beta chain UBE2V1 TRAC PDPK1 ADPPTPRC p-Y113,128,145-LCP2 PI(3,4)P2 HLA class II histocompatibility antigen, DRB1-9 beta chain precursor NFKB1(1-433):RELAPSMD5 HLA class II histocompatibility antigen, DRB1-12 beta chain NFKB1(1-433) p-S177,S181-IKKB:IKKA:NEMOCARD11HLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DRB3-1 beta chain precursor CARMA1 trimerATPT-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DRB1-12 beta chain p-Y113,128,145-LCP2GRAP2 HLA class II histocompatibility antigen, DP alpha chain precursor Antigen-bearing MHCClass II :TCRcomplex:CD4: Lckphosphorylated atTyr394HLA class II histocompatibility antigen, DQ HLA class II histocompatibility antigen, DRB1-9 beta chain precursor FBXW11 ADPDAGs p-Y188,Y199-CD3E p-Y149,Y160-CD3D HLA class II histocompatibility antigen, DP alpha chain precursor CD4 HLA class II histocompatibility antigen, DQ MALT1 T-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DR alpha chain precursor UBE2D2,UBE2D1,(CDC34)TRAC TRAF6 trimer boundto CBM complexp-Y113,128,145-SLP-76:GADS:LATPLCG1 TRAF6 ATPTRBV12-3 NFKB1(1-433) p-Y160,Y171-CD3G p-Y394-LCK PLCG1ATPPSME4 PLCG1 HLA class II histocompatibility antigen, DRB1-7 beta chain NCK1p-S552-CARD11 p-5Y-LAT ATPHLA class II histocompatibility antigen, DRB1-9 beta chain precursor PI(3,4,5)P3 HLA class II histocompatibility antigen, DQ TAB2 CD4 DAGsEVL DAGs HLA class II histocompatibility antigen, DR alpha chain precursor TRAV19 TRBC1 PSMA6 PI(3,4)P2 p-Y160,Y171-CD3G ITKCD45,CD148PSMC6 CD3E HLA class II histocompatibility antigen, DRB1-10 beta chain PSMD6 PI(3,4)P2 p-6Y-CD247-1 PI(3,4)P2 PSMD2 HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DQ GRAP2 HLA class II histocompatibility antigen, DRB3-1 beta chain precursor TRAV19 CSK CD247-1 HLA class II histocompatibility antigen, DP alpha chain precursor T-cell receptor alpha chain V region PY14 precursor UBE2V1 H2OHLA class II histocompatibility antigen, DP HLA class II histocompatibility antigen, DRB1-14 beta chain PIK3R2 Antigen HLA class II histocompatibility antigen, DRB1-13 beta chain EVL HLA class II histocompatibility antigen, DRB1-1 beta chain HLA class II histocompatibility antigen, DRB1-9 beta chain precursor HLA class II histocompatibility antigen, DRB1-13 beta chain SCF-beta-TRCPPI(3,4,5)P3 p-6Y-CD247-1 PSMD3 Antigen PTPN22ATPHLA class II histocompatibility antigen, DRB1-14 beta chain HLA class II histocompatibility antigen, DRB1-11 beta chain p-Y90-PRKCQ HLA class II histocompatibility antigen, DRB1-12 beta chain p-Y394-LCK p-Y188,Y199-CD3E PI(3,4)P2 HLA class II histocompatibility antigen, DRB1-14 beta chain TCRB PIK3R1 ADPHLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DR-1 beta chain precursor phospho tyrosineZAP-70HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DRB1-15 beta chain HLA class II histocompatibility antigen, DP alpha chain precursor HLA class II histocompatibility antigen, DRB1-15 beta chain MALT1 trimerATPLCK HLA class II histocompatibility antigen, DQ PSMB10 ATPp-Y160,Y171-CD3G PIK3R1 PDPK1 Antigen K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complexCD4 p-5Y-LAT TRAV19 PSME2 p-Y113,128,145-LCP2 INPP5DHLA class II histocompatibility antigen, DR beta 5 chain CD247-1 p-5Y-LATp-6Y-CD247-1 I(1,4,5)P3Activated PLC gamma1bound to PIP2K63polyUb-TRAF6 PDPK1 TCRB PI(4,5)P2TCRA HLA class II histocompatibility antigen, DRB1-15 beta chain HLA class II histocompatibility antigen, DRB3-1 beta chain precursor HLA class II histocompatibility antigen, DRB1-12 beta chain HLA class II histocompatibility antigen, DRB1-11 beta chain CD4 p-Y113,128,145-LCP2 IKBKG HLA class II histocompatibility antigen, DR-1 beta chain precursor HLA class II histocompatibility antigen, DR beta 5 chain PAK1,2,3HLA class II histocompatibility antigen, DRB1-7 beta chain PDPK1 p-Y149,Y160-CD3D ZAP-70 and ITKtyrosine kinasesUb-656-UBC(609-684) TRBC1 TAB2/TAK1 complexCD247-1 T-cell receptor alpha chain V region PY14 precursor LCP2HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DP phosphorylatedPLC-gamma1 bound toSLP-76TRAV19 p-Y113,128,145-LCP2 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor CD3G PDPK1 LCP2 PAK2 p-Y188,Y199-CD3E HLA class II histocompatibility antigen, DRB1-9 beta chain precursor HLA class II histocompatibility antigen, DRB3-1 beta chain precursor Ub-504-UBC(457-532) HLA class II histocompatibility antigen, DRB1-4 beta chain CD101p-S177,S181-IKBKB UBE2D1 HLA class II histocompatibility antigen, DRB3-1 beta chain precursor CHUK:IKBKB:IKBKGTCRB p-SLP-76:ADAPPSMD4 PSMB2 TCRA ADPPAK1 HLA class II histocompatibility antigen, DRB1-7 beta chain PI(3,4,5)P3 p-Y113,128,145-LCP2 GADS:p-5Y-LATCD3G Antigen-bearing MHCClass II :TCRcomplex:CD4: Lckphosphorylated atTyr394Antigen-bearing MHCClass II : TCRcomplex:CD4:Lckp-Y188,Y199-CD3E UBE2N HLA class II histocompatibility antigen, DR alpha chain precursor NCK1 p-Y394-LCK TRAV19 HLA class II histocompatibility antigen, DRB1-10 beta chain HLA class II histocompatibility antigen, DRB1-12 beta chain 26S proteasomeUb-276-UBC(229-304) HLA class II histocompatibility antigen, DRB1-10 beta chain HLA class II histocompatibility antigen, DQ ATPFYBVASP CARD11 ADPATPLATPI(3,4,5)P3 HLA class II histocompatibility antigen, DR beta 4 chain TRBV12-3 WASADPHLA class II histocompatibility antigen, DQ p-BCL10 HLA class II histocompatibility antigen, DRB1-10 beta chain PI(3,4)P2HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DRB1-16 beta chain GRAP2 p-SLP-76:ADAP:Ena/VASPTCRA HLA class II histocompatibility antigen, DRB1-16 beta chain ADPPI(3,4,5)P3 p-Y63,Y79,Y110-TRAT1RELA HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor HLA class II histocompatibility antigen, DRB1-4 beta chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1-15 beta chain Antigen-bearingMHCClassII:TCRcomplex:CD4:p-Lck(Y505)p-S552-CARD11 p-Y90,T538,S676,S695-PRKCQ ITK HLA class II histocompatibility antigen, DRB1-10 beta chain Antigen TCRA p-Y149,Y160-CD3D PSMA5 HLA class II histocompatibility antigen, DRB1-15 beta chain T-cell receptor alpha chain V region PY14 precursor HLA class II histocompatibility antigen, DRB1-7 beta chain HLA class II histocompatibility antigen, DRB1-11 beta chain ENAH HLA class II histocompatibility antigen, DR-1 beta chain precursor Ub-124-UBB(77-152) UBE2N:UBE2V1PSMF1 PI3KHLA class II histocompatibility antigen, DRB1-10 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain MALT1 p-Y113,128,145-LCP2 PSMD13 HLA class II histocompatibility antigen, DRB1-13 beta chain HLA class II histocompatibility antigen, DQ PSMB5 PRKQC closedconformationCARMA1 bound to PDK1ADPHLA class II histocompatibility antigen, DRB1-7 beta chain p-5Y-LAT ADPp-BCL10 RELA TCRB PSMA1 CD3G HLA class II histocompatibility antigen, DRB1-1 beta chain p-S552-CARD11 HLA class II histocompatibility antigen, DQ PSMD14 T-cell receptor alpha chain V region PY14 precursor PTPRJ p-S552-CARD11 PI(3,4,5)P3 HLA class II histocompatibility antigen, DRB1-7 beta chain RELA HLA class II histocompatibility antigen, DRB1-16 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain HLA class II histocompatibility antigen, DQ PSMD8 ZAP70 TRAV19 HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor p-S552-CARD11 TRAV19 NFKB1(1-433):RELAHLA class II histocompatibility antigen, DQB1*0602 beta chain precursor Bcl10 trimer boundto CARMA1 trimerTRAV19 PTPN22 HLA class II histocompatibility antigen, DRB1-7 beta chain p-SLP-76:NCK1:WASPHLA class II histocompatibility antigen, DRB1-8 beta chain ZAP70HLA class II histocompatibility antigen, DRB1-4 beta chain TCRA 15152369621215151258605, 31, 502351, 60151515