DNA Replication (Caenorhabditis elegans)

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4. Switching of origins to post-replicative stateOrc5Mcm7ADPRFC Heteropentamer:RNA primer-DNA primerGTPMcm6Orc4DNA polymerase alpha: primase: origin complexOrc2RFC36RFC38Mcm 4,6,7 trimer forms and associatesDNA polymerase alpha: primase: origin complexp49RFC Heteropentamer:RNA primer-DNA primer:Orc3RFC140Orc2Phosphorylated Orc1Orc complexUbiquitinMcm7Mcm10Mcm2Cdt1Orc3dGTPCdc6Ubiquitinated Orc1with the replication forkProcessive complexCdt1Mcm2ATPPre-replicative complexCdc6p70aRFC37CTPRFC40RNA primer-DNA primerOrc complex5. Leading/lagging strand synthesisGemininCdt1p581. Assembly of the pre-replicative complexRNA PrimerRNA primer-DNA primerOrc3DNA PolymeraseUbiquitinPre-replicative complexCdt1ATPMcm4Orc2Orc complexCdc6Mcm6p180Phosphorylation of Mcm 2-7 complexATPOrc ComplexPhosphorylated Cdc63. DNA replication initiationATPDegraded by proteasome in cytosolOrc complexOrc5Mcm5Mcm3PrimasedUTPCdt1Cdc6Orc4RNA primer-DNA primer:origin duplex:PCNAUTPADPOrc3Mcm3Orc5Orc2dCTPMcm4Orc1OriginUbiquitinated Cdc6dATP2. Activation of the pre-replicative complexMcm5PCNA homotrimerDegraded by proteasome in cytosolF33H2.5F10C2.4mcm-7F08B4.5ARPAY47D3A.28RFC4cdc-6CDT1RPA3POLD3RPA2ubq-2PCNAORC3Lorc-2POLD4mcm-3POLD2RPA4Y39A1A.12CDC46pri-1mcm-4ORC6Lrfc-3F34D10.2ASKCDK2RPA1ORC5LGMNNpri-2CDC7mcm-2div-1rfc-2ORC4Lrfc-1Y47D3A.29mcm-6ubq-1


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
ATPMetaboliteCHEBI:15422 (ChEBI)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
CTPMetaboliteCHEBI:17677 (ChEBI)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
GTPMetaboliteCHEBI:15996 (ChEBI)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
UTPMetaboliteCHEBI:15713 (ChEBI)
UbiquitinProtein
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetaboliteCHEBI:16284 (ChEBI)
dCTPMetaboliteCHEBI:16311 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)
dUTPMetaboliteCHEBI:17625 (ChEBI)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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