Signaling by VEGF (Homo sapiens)

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41, 59, 76, 100109, 12171, 9446, 56, 63, 106, 1121134562573, 92, 12926, 9278, 10847113, 1391411564, 98, 13474, 1156117, 67, 104, 12361206165459, 34628723, 103321483374, 11540, 10022, 44, 55, 56, 63...14671, 948, 5049, 57, 823631, 1076512, 11410212546, 14716, 1115, 14, 21, 75, 91...61, 1171013814524, 59, 99, 11872, 881262, 35, 51, 68, 697, 1281, 3, 55, 115, 119...10, 117426229135, 1469029, 1097, 12860, 8228, 74, 14485451108527, 52, 62, 66, 12710119, 89, 1168443774136, 138109endoplasmic reticulum lumennucleoplasmcytosolp-T500,T642,S661-PRKCB PAK1,2,3 dimerNCK2 WASF3 p-S21,Y420-FYN pS-SHB SRC-1 ATPVEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2ITGAV(31-1048) SHB ABI1 ATPVEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1NCK2 p-6Y-VEGFR2 p-S474-AKT2 AXLp-T410,T563-PRKCZ DOCK1 PI(3,4,5)P3 VEGFA PAK2 p-6Y,S732-PTK2 NCK2 beta-catenin SRC-1SRC-1 VEGFA VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2Bp-Y31,Y118-PXN FIGF CAV1 SPHK1p-Y12-BCAR1 VEGFA:p-6Y-VEGFR2:p-SHB:PTK2SRC-1 heme NOX2complex:RAC1:GTPVEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXNADPp-S-AKT:PIP3BCAR1Ca2+ VEGFA-165 Protein kinase Acatalytic subunitp-6Y-VEGFR2 ATPADPp-T507-PRKCD VEGFA-165 ADPPI(4,5)P2PDPK1:PIP3VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK22xPalmC-MyrG-p-S1177-NOS3 VE-cadherin PI(3,4,5)P3 MAPKAP1 p-T305,S472-AKT3 S-Farn-Me-PalmS KRAS4A PAK2 CALM1 ITPR1 p-S,2T-MAPKAPK3 NCK2 eNOS:Caveolin-1:CaM:HSP90VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1SRC-1 ELMO1 VEGFA-165 PAK2 RAC1 NCKAP1L BAIAP2VEGFVEGFA-165 MAPK11 BH4 FMN eNOS:CaM:HSP90:p-AKT1GTP MAPKAP kinaseRHOA:GTPS-Farn-Me PalmS NRAS THEM4 VEGFA-165 HSP90AA1 Ca2+ FMN NADP+2xPalmC-MyrG-NOS3 AKT2 NCK1,NCK2ADPADPPI(3,4,5)P3 PIK3CA p-6Y-VEGFR2 ITGB3 p-S21,Y420-FYN heme PAK2 HSP90AA1 VEGFA dimerADPGTP GTP p-Y31,Y118-PXN NRP2 HSP90AA1 Ca2+ MAPKAPK2 NCKAP1L ADPPIK3CB ADPH+FMN CALM1:4xCa2+VEGFR1 SRC-1 p-6Y-VEGFR2 pS-SHB VEGFA-165 ADPVEGFA-165 p-6Y-VEGFR2 WRC:IRSp53/58:RAC1:GTP:PIP3GDP S-Farn-Me KRAS4B VEGFC SRC-1 SH2D2A p-6Y-VEGFR2 p-S472-AKT3 GTP p-T308,S473-AKT1 VEGFR2 CDC42 VEGFA-165 CAV1 p-Y419-SRC NCKAP1 VEGFA-165 p-S15,S78,S82-HSP27p-6Y-VEGFR2 pS-SHB VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1PAK3 p-Y174-VAV1 PIK3CB p-6Y-VEGFR2 2xPalmC-MyrG-NOS3 DOCK180:ELMO1,ELMO2p-6Y-VEGFR2 PRKACA VE-cadherin-CatenincomplexPI(3,4,5)P3 p-S472-AKT3 Ca2+PXNGDP VEGFA-165 FIGF Zn2+ p-6Y-VEGFR2 p-T180,Y182-MAPK11 SRC-1 pS-SHB VEGFA-165 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXLADMANOX2 complexVEGFA-165 VEGFA-165 FAD VEGFA-165 Zn2+ p-T180,Y182-MAPK14 VEGFAdimer:p-6Y-VEGFR2dimer:PLCG1CALM1 p-6Y-VEGFR2 SRC-1 GTPNRP1p-6Y-VEGFR2 CYFIP1 VEGFAdimer:p-6Y-VEGFR2dimerITGB3 RAC1 ADPCDC42 ATPCRK SRC-1 VEGFA-165 p-4Y-PLCG1 ATPATPVAV1 VEGFA-165 ITGB3 VEGFA-165 GDPp-6Y,S732-PTK2 RHOA VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1VEGFAdimer:p-6Y-VEGFR2dimer:SH2D2AVEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3ABI2 heme TORC2 complexGDP O2.-GTPp-T,p-S-AKTZn2+ VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3KZn2+ FLT4 RASA1:p21RAS:GTP:SPGRAC1 H2Op-T410-PRKCZ CDC42-GDPGTP VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXLAKT3 heme ATPSPG eNOS:Caveolin-1:CaMp-6Y-VEGFR2 Zn2+ PTK2 p-6Y-VEGFR2 p-6Y,S732-PTK2 PDPK1 ADPp-6Y-VEGFR2 p-PKCA,p-PKCB,p-PKCZ,p-PKCDITPR2 VEGFA-165 dimerPGF ADPITGAV(31-1048) p-6Y-VEGFR2 p-S474-AKT2 p-Y173-VAV3 S-Farn-Me-2xPalmS HRAS p-T500-PRKCB p-Y172-VAV2 p-6Y-VEGFR2 p-Y174-VAV1 VEGFA-165 VAV3 ATPHSP27oligomer:F-actinS-Farn-Me KRAS4B GTP NCF2 ATPNCK1 eNOS:CaM:HSP90VEGFC ATPPRKCD RASA1 CRK VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTPPIK3R2 MTOR p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3NRP2:VEGFR1 dimerPTK2p-6Y-VEGFR2 VAV1,2,3RAC1 Ca2+ATPAKT:PIP3:THEM4/TRIB3SRC-1 PI3KDAG:active PKC:Ca+2NRP1 ATPPIK3R2 p-6Y-VEGFR2 CDC42:GTPAKT3 ELMO2 pS-SHB HSP90AA1 pS-SHB NCF4 GTP MAPK14 FAD p-S141,T402-PAK2 SHC2 p-6Y-VEGFR2 L-ArgJUP VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1AKT1 pS-SHB JUP VEGFAdimer:p-6Y-VEGFR2dimerPAK1 p-S21,Y420-FYN O2pS-SHB Zn2+ heme p-6Y-VEGFR2 ATPp-6Y-VEGFR2 CAV1 VEGFA-165 ITPR3 NCKAP1 p-Y419-SRC CALM1 AKT:PIP3ITPR:I(1,4,5)P3tetramerATPCYBA L-CitROCK2 NRP2CTNND1 PI(4,5)P2Ca2+ WASF3 RHOA p-S-AKT:PDPK1:PIP3FLT4PRR5 Activated ROCK2 PLCG1 p-S154,T436-PAK3 PXN CYFIP2 p-S1177-eNOS:CaM:HSP90:p-AKT1RAC1:GTPCALM1 VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2BGTP RHOA:GTP:ROCK1,ROCK2PI(3,4,5)P3ATPTRIB3 GTP VEGFA-165 VEGFA RICTOR CRKp-Y172-VAV2 S-Farn-Me-2xPalmS HRAS FMN pS-SHB PI(3,4,5)P3 p-6Y-VEGFR2 BAIAP2 NCK2 p-S21,Y420-FYN Unknown GEFp-Y172-VAV2 Mg2+ p-Y12-BCAR1 VAV1 ADPBH4PAK3 VEGFAdimer:p-6Y-VEGFR2dimer:SH2D2A:SRC-1ATPheme FMN WASF1 Ca2+ VEGFA-165 PIK3CB VEGFAdimer:p-6Y-VEGFR2dimer:p-4Y-PLCG1p-Y174-VAV1 ADPCALM1 p-6Y-VEGFR2 GTP VEGFA,C,D dimersRAC1 RAC1 PI(3,4,5)P3 NCK1 VEGFR2:VEGFA,C,DADPp-Y397-PTK2 AHCYL1 VEGFA-165 FIGF RAC1:GDPCTNNA1 AAMPPDPK1VEGFR2 PI(3,4,5)P3 VEGFAdimer:p-6Y-VEGFR2dimer:SHBDAGsPIP3:VAV1,2,3p-6Y-VEGFR2 p-6Y-VEGFR2 S-Farn-Me PalmS NRAS ADPI(1,4,5)P3CTNND1 VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTPITPR2 p-T308,S473-AKT1 HSP90AA1 p-Y419-SRC p-S665-VE-cadherin-Catenin complexp-Y419-SRC SHC2p-5Y-PTK2 VEGF dimerp-VAVfamily:PIP3:RAC1:GTPATPVEGFR1 dimer:VEGFA,VEGFB, PGF dimersp-Y397-PTK2 p-Y31,Y118-PXN I(1,4,5)P3 p-Y12-BCAR1 ATPVEGFA-165 WASF1 p-Y397-PTK2 p-S225-SPHK1VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-S21,Y420-FYNNCF2 VEGFB ITPR3 CYFIP2 Ca2+ HSP90AA1p-6Y-VEGFR2 VEGFA-165 MAP kinase p38 (Mg2+cofactor)2xPalmC-MyrG-p-S1177-NOS3 pS-SHB MAPK12 AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerADPNCK1 ITPR3 ADPADPActivated ROCK1 p-6Y-VEGFR2 HSP90AA1 ADPp-T500,T642,S661-PRKCB p-6Y,S732-PTK2 ATPRAF/MAP kinasecascadep-S,T-PAK1,2,3PAK1 ATPp-Y420-FYN VEGFC p-6Y,S732-PTK2 PI(3,4,5)P3 VEGFA-165 PIK3CB ATPSRC-1 ADPNOAKT1 p-5Y-PTK2 ITPR1 p-VAV family:PIP3p-T308,S473-AKT1 GTP p-VAVfamily:PIP3:RAC1:GDPBRK1 ITGB3 PIK3R1 VEGFA-165 2xp-VAVfamily:PIP3:RAC1:GTP:PAK 1-3GTP NCK1 VEGFB FAD CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNHSP90AA1 PAK3 Integrin alphaVbeta3p21 RAS:GTPNCK1 WASF2 HSP90AA1 ROCK1 WASF2 FYNRHOA:GTP:Mg2+:Activated ROCK1,ROCK2VEGFR2p-5Y,S732-PTK2 VEGFR1p-S473-AKT1 ITPR2 SRC-1p-S272,T222,T334-MAPKAPK2 WAVE RegulatoryComplexp-Y174-VAV1 VEGFA p-Y397-PTK2 ATPADPp-6Y-VEGFR2 ATPp-Y173-VAV3 VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1BRK1 VEGFA:p-6Y-VEGFR2:SHC2RAC1 PAK1 ELMO2 PIK3CA SH2D2A ITGAV(31-1048) SRC-1 VEGFB VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1VEGFA-165 p-Y173-VAV3 SH2D2A2xPalmC-MyrG-NOS3 heme ELMO1 PRKACG HSBP1 oligomer p-T497,T638,S657-PRKCA p-Y174-VAV1 GTP PI(3,4,5)P3 VEGFB FIGF p-T497-PRKCA p-6Y-VEGFR2 ADPp-Y173-VAV3 GTP VEGFA-165 PRKACB VAV2 ITGAV(31-1048) VEGFA-165 SH2D2A ROCK1 VEGFC VEGFA-165 p-S141,T402-PAK2 SRC-1ABI1 FAD VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:FYNbeta-catenin RASA1p-6Y-VEGFR2 SRC-1 ATPPIK3R2 NRP1:VEGFR2 dimerATPRAC1:GTPeNOS:Caveolin-1SH2D2A VEGFC,VEGFD dimersp-S473-AKT1 VEGFA,VEGFB,PGFdimersVEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNNADPHNCF1 NCK1 ABI2 HSP90AA1 p-T507,S645,S664-PRKCD CDC42 CYBB p-Y173-VAV3 FIGF FMN VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1PI(3,4,5)P3 heme Phospho-MAP kinasep38 (Mg2+ cofactor)p-6Y-VEGFR2 p-T507,S645,S664-PRKCD VEGFA-165 PGF PI(3,4,5)P3 ITPR1 ADPpS-SHB p-6Y-VEGFR2 O2FYN Mg2+ VEGFA p-T497,T638,S657-PRKCA VEGFA inhibitorsVEGFA-165 p-Y419-SRC VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRKp-T308,S473-AKT1 p-Y772,Y814-AXL FIGF p-6Y-VEGFR2 p-Y772,Y814-AXL PIK3CA NAD+ ATPp-6Y,S732-PTK2 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2VEGFAdimer:p-6Y-VEGFR2dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3KHSP90AA1 AXL S1PCDC42 Ca2+p-6Y-VEGFR2 pS-SHB p-6Y-VEGFR2 p-4Y-PLCG1VEGFA-165 PI(3,4,5)P3PRKCB VEGFA-165 VEGFC AKT2 DAGsADPPIK3R1 BCAR1 SH2D2A p-S144,T423-PAK1 ATPFAD PI(3,4,5)P3 SHBNCK2 CYFIP1 AAMP genePTK2B PIK3CA pS-SHB p-6Y-VEGFR2 ATPCYBB PAK2 CYBA I(1,4,5)P3 p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4FAD PLCG1GTP p-Y172-VAV2 SH2D2A CDC42 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1pS-SHB PTK2BF-actinS-Farn-Me-PalmS KRAS4A PTK2B ADPMLST8 ATPp-Y12-BCAR1 NCF4 p-T309,S474-AKT2 p-T308,S473-AKT1FMN MAPK13 PIK3R1 VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-Y420-FYNSRC-1 VEGFA-165 VEGFA-165 FAD VEGFR1 p-6Y-VEGFR2 BH4 CTNNA1 pS-SHB p-6Y,S732-PTK2 SRC-1 F-actin VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTPCALM1 PRKCZ p-Y772,Y814-AXL ROCK1,ROCK2VEGFA-165 Ca2+ heme pS-SHB HSP90AA1 p-Y130,S141,T402-PAK2 NCK2 ATPSH2D2A HSP90AA1NCF1 HSP90AA1 PDPK1NCK2 PGF NCK2 p-S665-VE-cadherin PAK2 dimerGTP VEGFA-165 ADPp-6Y-VEGFR2 DAGs VEGFAdimer:p-6Y-VEGFR2dimer:PI3KNCK1 IP3 receptorhomotetramerVEGFA VEGFA-165 VEGFR2 VEGFA-165dimer:VEGFR2VEGFR3 dimer:VEGFC,VEGFD dimersCALM1 PAK2 HSP90AA1 p-T410,T563-PRKCZ MAPKAPK3 p-6Y,S732-PTK2 p-6Y-VEGFR2 VEGFA-165 VAV3 VEGFA-165 PIK3R1 RAC1 VEGFC PKCA,PKCB,PKCD,PKCZCAV1VEGFAdimer:p-6Y-VEGFR2dimer:p-S-SHBADPADPGDP2xPalmC-MyrG-NOS3 ADPGDPVEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1PGF ROCK2 PIK3R2 p-VAVfamily:PIP3:RAC1:GTP:PAK 1-3Ca2+ GTPFAD Zn2+ VEGFA p-Y31,Y118-PXN PRKCA VEGFA-165 p-PKCPDPK1 FAD VEGFA-165 Mg2+ p-Y172-VAV2 RHOA NCK1 DOCK1 VEGFA-165dimer:VEGFAinhibitorsHSP90AA1 pS-SHB RAC1 HSP90AA1 p-6Y-VEGFR2 2xPalmC-MyrG-NOS3 p-6Y-VEGFR2 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNVEGFA-165 p-S21,Y420-FYN CALM1VAV2 NCK1 3053, 1148130303039, 1333053, 11411, 13, 18, 37, 48...303093863096, 120, 1323053, 114303081