Signaling by VEGF (Homo sapiens)

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22, 64, 110, 1389013415, 33, 50, 71, 78117, 144132, 140846045, 91446927, 7612169131254710, 37, 87, 11366, 74, 133, 138162510310910945, 9112113623, 6872, 12763, 12611872, 1275993102, 1239, 100140528376, 976526, 30, 12946, 891, 642, 11635, 36, 12234, 12559123104, 14273, 76, 112117693, 70, 79, 108, 14313527, 76101, 115102, 1395218, 114, 1261093919, 2890164114, 53, 59, 61, 675425517, 1314, 51, 56, 77, 88...1023, 27, 48, 49, 57...75, 13026, 10538, 58, 12824, 27, 48, 62, 80...101, 109141nucleoplasmendoplasmic reticulum lumencytosolp-Y31,Y118-PXN heme p-6Y,S732-PTK2 PXN AXL VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2GDPTHEM4 NCF1 pS-SHB p-S21,Y420-FYN p-6Y-VEGFR2 ITPR2 p-S15,S78,S82-HSP27RHOA p-T308,S473-AKT1 VEGFA-165 p-6Y-VEGFR2 NCK2 PIK3CB p-T497,T638,S657-PRKCA PDPK1eNOS:Caveolin-1Ca2+ ATPp-T180,Y182-MAPK11 VEGFA-165 PI(4,5)P2HSP90AA1ATPITPR3 p-6Y-VEGFR2 FMN p-6Y-VEGFR2 VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2VEGFB p-S21,Y420-FYN S-Farn-Me PalmS NRAS SRC-1 VEGFROCK1,ROCK2VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1VEGFA dimerVAV1,2,3p-Y172-VAV2 CAV1 ATPp-T,p-S-AKTp-S1177-eNOS:CaM:HSP90:p-AKT1:BH4PIK3CB GDP NCK1 p-5Y-PTK2 ADPp-6Y,S732-PTK2 PAK1 PKCA,PKCB,PKCD,PKCZPDPK1 GTP PI(3,4,5)P3 PI(3,4,5)P3 p-Y173-VAV3 IP3 receptorhomotetramerVEGFA:p-6Y-VEGFR2:p-SHB:PTK2NADPHp-Y420-FYN RAC1 AKT2 Ca2+VAV1 VEGFA ADPSH2D2A VEGFA-165 WRC:IRSp53/58:RAC1:GTP:PIP3NCK1 VE-cadherin eNOS:Caveolin-1:CaM:HSP90AXLGTP NCKAP1 p-6Y-VEGFR2 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1PI(3,4,5)P3 MAPK11 VEGFA-165 GTP p-Y31,Y118-PXN ATPATPATPPTK2B NCF4 VEGFA-165 ITPR2 SH2D2A PI(3,4,5)P3 ADPADPp-S474-AKT2 VEGFAdimer:p-6Y-VEGFR2dimer:p-4Y-PLCG1O2GTP Ca2+ ATPPLCG1RHOA:GTPCa2+ ADPFMN ATPNCF4 Unknown GEFNCK1 CYFIP2 VEGFA:p-6Y-VEGFR2:SHC2ATPHSP90AA1 FYNATPActivated ROCK1 p-S473-AKT1 AKT2 PGF pS-SHB p-6Y-VEGFR2 p-VAVfamily:PIP3:RAC1:GTPVEGFA-165 VEGFA-165 VEGFA-165 SRC-1p-S,T-PAK1,2,3NCK2 VEGFA-165 PIK3CA VEGFA-165 PRKCB AAMP genep-T500,T642,S661-PRKCB ROCK2 VEGFC PIK3R2 p-Y12-BCAR1 NCK1 ADPheme VEGFC VEGFR2 heme p-6Y-VEGFR2 CYBB FAD ADPATPVEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2Bp-Y174-VAV1 VEGFAdimer:p-6Y-VEGFR2dimer:PI3KAKT:PIP3:THEM4/TRIB3VEGFA-165 SRC-1 p-T305,S472-AKT3 VEGFA-165 SRC-1 p-Y174-VAV1 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1NCKAP1 PGF VEGFR1 dimer:VEGFA,VEGFB, PGF dimersSRC-1 GTP pS-SHB ATPNOX2complex:RAC1:GTPATPRAC1 ADPHSP90AA1 p-6Y-VEGFR2 VEGFA-165 PAK3 HSP90AA1 p-6Y-VEGFR2 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1p-6Y,S732-PTK2 2xPalmC-MyrG-NOS3 VEGFC NRP1:VEGFR2 dimerHSP90AA1 p-Y772,Y814-AXL p-6Y-VEGFR2 AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerITGAV(31-1048) RAC1 p-6Y-VEGFR2 GTP SRC-1 PAK2 dimerVEGFR2PI(3,4,5)P3 PI(3,4,5)P3 p-6Y-VEGFR2 p-VAVfamily:PIP3:RAC1:GDPp-Y173-VAV3 p-6Y-VEGFR2 SHB NCK1 heme VEGFA-165 HSP27oligomer:F-actinNOSHC2p-5Y,S732-PTK2 Mg2+ S-Farn-Me KRAS4B PGF ADPRAC1:GDPPI3KFAD p-Y397-PTK2 p-Y772,Y814-AXL p-Y31,Y118-PXN SRC-1 p-Y130,S141,T402-PAK2 p-6Y-VEGFR2 p-6Y,S732-PTK2 PIK3CB VEGFA-165 Mg2+ CALM1 VEGFA-165 PAK2 NRP1VEGFR1 ADPPIK3R1 ATPCa2+ ATPpS-SHB SHC2 p-6Y-VEGFR2 BRK1 DAGsVEGFR2 RAC1:GTPADPPXNMAPKAPK2 p-S665-VE-cadherin CDC42 ELMO2 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL2xp-VAVfamily:PIP3:RAC1:GTP:PAK 1-3GDPp-Y419-SRC SRC-1PI(3,4,5)P3BCAR1MAPKAPK3 CDC42 CAV1 VEGFA-165 Protein kinase Acatalytic subunitADPVAV2 AKT3 SRC-1 PI(3,4,5)P3 NOX2 complexp-Y419-SRC GTPNCF2 GTP FAD SRC-1 MAP kinase p38 (Mg2+cofactor)ELMO1 PRKCA p-Y12-BCAR1 S1PVE-cadherin-CatenincomplexROCK2 p-6Y-VEGFR2 MTOR pS-SHB FLT4 p-T410,T563-PRKCZ FAD VEGFA-165dimer:VEGFR2CYFIP1 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXLNCK2 ITPR1 DAGs VEGFA-165 p-Y397-PTK2 p-Y772,Y814-AXL p-S473-AKT1 CDC42-GDPI(1,4,5)P3 p-Y172-VAV2 PAK3 VEGFA inhibitorsRAC1 VEGFAdimer:p-6Y-VEGFR2dimer:SHBFIGF BAIAP2 p-T410,T563-PRKCZ p-Y419-SRC HSP90AA1RAC1 p-T308,S473-AKT1PIK3CA BH4 WASF2 SPHK1p-S-AKT:PIP3VEGFA-165 p-VAVfamily:PIP3:RAC1:GTP:PAK 1-3Zn2+ RAC1:GTPp-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3ELMO2 VEGFA-165 CDC42 VEGFA-165 ATPpS-SHB p-T308,S473-AKT1 Ca2+ NCK2 WASF3 ADPSRC-1 ATPCRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNp-T497-PRKCA S-Farn-Me PalmS NRAS Ca2+ PAK2 VEGFAdimer:p-6Y-VEGFR2dimer:SH2D2AVEGFR3 dimer:VEGFC,VEGFD dimersFMN PI(3,4,5)P3 RASA1 p-T180,Y182-MAPK14 p-6Y-VEGFR2 ITGB3 p-Y173-VAV3 SPG HSBP1 oligomer Activated ROCK2 ATPCa2+ CYFIP2 p-T497,T638,S657-PRKCA VEGFC p-T500,T642,S661-PRKCB PI(3,4,5)P3 VEGFA-165 VEGFA Zn2+ p-6Y-VEGFR2 p-6Y-VEGFR2 VAV1 RAC1 p-Y419-SRC FAD GTP p-S21,Y420-FYN pS-SHB CAV1VEGFR1p-T309,S474-AKT2 RAC1 PTK2B VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTPPLCG1 PI(3,4,5)P3 L-ArgVEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2GTP ABI1 p-S665-VE-cadherin-Catenin complexATPVEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNELMO1 p-S21,Y420-FYN p-T308,S473-AKT1 ROCK1 beta-catenin NCK1 p-6Y-VEGFR2 GTP ATPSRC-1 p-6Y-VEGFR2 ATPAKT1 p-T308,S473-AKT1 p-VAV family:PIP3heme p-6Y-VEGFR2 FIGF DOCK1 H2OHSP90AA1 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNPDPK1 VEGFA-165 ADPPAK2 pS-SHB Zn2+ SRC-1 PIK3R2 VAV3 p-Y173-VAV3 p-6Y-VEGFR2 p-T507,S645,S664-PRKCD p-4Y-PLCG1 TORC2 complexCALM1VEGFR1 S-Farn-Me-PalmS KRAS4A VEGFAdimer:p-6Y-VEGFR2dimerATPp-S1177-eNOS:CaM:HSP90:p-AKT1eNOS:Caveolin-1:CaMRHOA WASF1 RAC1 VEGFAdimer:p-6Y-VEGFR2dimerHSP90AA1 p-S474-AKT2 FAD SH2D2A VEGFR2:VEGFA,C,DIntegrin alphaVbeta3ATPO2RASA1:p21RAS:GTP:SPGS-Farn-Me-PalmS KRAS4A NCK2 p-S21,Y420-FYN HSP90AA1 VEGFA-165 PIK3R1 ADPCDC42 HSP90AA1 heme PRKACG 2xPalmC-MyrG-p-S1177-NOS3 RHOA AHCYL1 SH2D2A VEGFA-165 PRKACB ATPp-S472-AKT3 NCK2 NAD+ VEGFB PAK3 GTP VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTPVAV2 HSP90AA1 CALM1 NRP2 FIGF NCK1,NCK2CYBB ATPJUP FIGF AKT3 p21 RAS:GTPATPDAG:active PKC:Ca+2PIK3CB p-S272,T222,T334-MAPKAPK2 ITPR2 VEGFA-165 SH2D2AADPp-Y419-SRC pS-SHB pS-SHB VEGFA VEGFA-165 p-6Y,S732-PTK2 ATPVEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1VEGFB CAV1 ADPPAK2 WAVE RegulatoryComplexZn2+ CRKBRK1 pS-SHB p-6Y-VEGFR2 VEGFA-165 dimerp-Y174-VAV1 CALM1 p-S225-SPHK1PI(3,4,5)P3 VEGFAdimer:p-6Y-VEGFR2dimer:SH2D2A:SRC-1ADPVEGFC PIK3CA ABI2 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRKS-Farn-Me KRAS4B p-PKCA,p-PKCB,p-PKCZ,p-PKCDPIK3R1 CALM1 ITGB3 VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1VEGFA-165 p-6Y,S732-PTK2 p-6Y-VEGFR2 CALM1 p-S144,T423-PAK1 p-6Y-VEGFR2 NCK1 VEGFA-165 NCKAP1L NCK2 ADPheme p-5Y-PTK2 HSP90AA1 ITPR1 GDP p-6Y-VEGFR2 ITPR3 RASA1PDPK1:PIP3p-Y172-VAV2 F-actinCTNNA1 GTPFMN NRP1 FMN ADPCa2+PI(3,4,5)P3 L-CitHSP90AA1 GDPVEGFA SH2D2A p-PKCMAPK13 pS-SHB VAV3 CALM1 GTP p-Y173-VAV3 Phospho-MAP kinasep38 (Mg2+ cofactor)SRC-1VEGFA-165 NCK2 FMN ADPVEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:FYNITGB3 WASF2 pS-SHB PTK2BGDP BH4 VEGFA-165 VEGFA-165 PAK1 MLST8 p-4Y-PLCG1NCF2 p-T500-PRKCB ADPDOCK180:ELMO1,ELMO2beta-catenin PTK2TRIB3 PRR5 p-T507,S645,S664-PRKCD S-Farn-Me-2xPalmS HRAS I(1,4,5)P3NRP2RHOA:GTP:Mg2+:Activated ROCK1,ROCK2FAD PI(4,5)P2JUP VEGFC HSP90AA1 p-6Y-VEGFR2 eNOS:CaM:HSP90:p-AKT1FAD VEGFA,C,D dimersFIGF CTNNA1 pS-SHB ABI2 VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3pS-SHB ADPp-6Y-VEGFR2 PRKCZ p-6Y-VEGFR2 VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-Y420-FYNeNOS:CaM:HSP90MAPKAP kinaseVEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1VEGFA-165 ATPp-S-AKT:PDPK1:PIP3CYBA p-Y12-BCAR1 FYN ITPR3 Zn2+ Ca2+ ADPGTP CTNND1 ITGB3 Mg2+ SRC-1 VEGFA FIGF p-6Y-VEGFR2 BAIAP2Zn2+ SRC-1 VEGFAdimer:p-6Y-VEGFR2dimer:PLCG1VEGFA-165dimer:VEGFAinhibitorsp-6Y,S732-PTK2 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3KF-actin GTP NCK1 PIK3R2 VEGF dimerNRP2:VEGFR1 dimerp-Y174-VAV1 NCKAP1L VEGFA-165 p-S141,T402-PAK2 RHOA:GTP:ROCK1,ROCK2FLT4SHBPIK3CA p-6Y-VEGFR2 RAF/MAP kinasecascadeVEGFA-165 SH2D2A VEGFAdimer:p-6Y-VEGFR2dimer:p-S-SHBPIP3:VAV1,2,3p-Y397-PTK2 p-Y172-VAV2 FAD ADPNCK2 2xPalmC-MyrG-p-S1177-NOS3 ITGAV(31-1048) ROCK1 heme VEGFR2 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXNPTK2 HSP90AA1 VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2BCa2+CYBA p-6Y-VEGFR2 I(1,4,5)P3 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1CDC42:GTPp-6Y-VEGFR2 CALM1:4xCa2+p-Y31,Y118-PXN VEGFA-165 PRKCD RICTOR VEGFA-165 CRK VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-S21,Y420-FYNMAPKAP1 p-S141,T402-PAK2 AAMPFMN VEGFA-165 AKT:PIP3p-T507-PRKCD ADPDOCK1 p-6Y-VEGFR2 NCF1 GTP p-6Y,S732-PTK2 p-S,2T-MAPKAPK3 O2.-HSP90AA1 p-Y12-BCAR1 VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTPPIK3R1 GTPPAK1 VEGFA-165 CRK ITPR:I(1,4,5)P3tetramerPGF p-6Y-VEGFR2 H+S-Farn-Me-2xPalmS HRAS PAK2 Zn2+ p-Y174-VAV1 PIK3R2 ADPp-6Y-VEGFR2 p-6Y-VEGFR2 p-Y172-VAV2 NCK1 HSP90AA1 DAGsPAK1,2,3 dimerVEGFA,VEGFB,PGFdimersVEGFB heme 2xPalmC-MyrG-NOS3 PAK2 p-Y397-PTK2 CALM1 VEGFA-165 SH2D2A WASF3 RAC1 p-T410-PRKCZ AKT1 VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1p-S154,T436-PAK3 CDC42 p-6Y-VEGFR2 2xPalmC-MyrG-NOS3 2xPalmC-MyrG-NOS3 PRKACA BH4SRC-1 PDPK1pS-SHB ITPR1 2xPalmC-MyrG-NOS3 ATPpS-SHB VEGFA-165 ITGAV(31-1048) ADPBCAR1 p-6Y-VEGFR2 CTNND1 VEGFA ITGAV(31-1048) MAPK12 GTP ADMAVEGFA p-S472-AKT3 CYFIP1 ATPNADP+VEGFA-165 MAPK14 VEGFC,VEGFD dimersVEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1ADPVEGFAdimer:p-6Y-VEGFR2dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3KABI1 p-6Y-VEGFR2 VEGFA-165 VEGFA-165 PI(3,4,5)P3SRC-1 p-6Y-VEGFR2 WASF1 ADP321191191191198, 11, 29, 31, 54...40, 89122021, 99, 11140, 8911911911911940, 8911943, 14811911920