Signaling by ROBO receptors (Homo sapiens)

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1, 14, 16, 26, 27, 30...17, 21333317, 21, 344649, 521235, 36, 383336111629, 42cytosolcytosolnucleoplasmnucleoplasmKeratan sulfate 80S ribosomePSMD5 EIF4A3 UBB(153-228) SLIT2:ROBO1:MYO9BCDC42 SLIT2 SRGAP1 RPL41 ROBO1 SLIT2:p-Y1073-ROBO1:ABLSLIT1 SOSAKAP5 SLIT2 RPL26 PAK1 MAGOH ELOC ROBO1 ROBO2 ROBO1,ROBO2:KeratansulfatePAK5 ROBO1 RPL21 RPS8 SLIT2 RPS6 SLIT1 PSMD6 LHX2 ZSWIM8 CAP1 UPF2 RPL39L RPS9 UbPSMA3 RPS26 LHX2 ABL2 LHX2 ROBO3.1 RPL23A SLIT2 RPL22 GlcGalHyl-COL4A5 SLIT1 3x4Hyp-3Hyp-5Hyl-COL4A5 ROBO3SOS2 RPS4Y1 RPS14 RPL4 ROBO1 AKAP5 NTN1 RBX1 RBX1 LHX2,(LHX9)PSMA5 ROBO2 RPL26 ROBO3.2PSMA6 AKAP5 UBC(229-304) RPL22 ARHGAP39 RPLP1 5Hyl-COL4A5 NTN1 RAC1 MYO9B ROBO3.1:AKAP5SOS2 CAP2 RHOA RAC1:GTPPSMD13 CLASP1 UnidentifiedproteaseDCC:ROBO1:SLITRPL39 Ena/VASP ProteinsCDC42 RPL13 SLIT2:ROBO1:Ena/VASP:PFNNCBP2 PAK6 PiPSMD3 RPL15 SLIT1 SLIT2 NCK1 PAK2 p-S1330-ROBO3.1 PSME1 RPL27 COL4A5 RHOA RPL10 RPS27L NCK2 EIF4G1SLIT2(31-1121)ELOB RPL31 PRKAR2A PRKAR2A-PKA type IIPiNCK2SLIT1 CLASP2 Translated ROBO3.2mRNA in complexwith NMD-initiatingUPF2RPL36A SLIT2,(SLIT3):Keratan sulfateRPS8 NCK2 RPL30 Heparan sulfate N-acetyl-alpha-D-glucosaminide Ub-ROBO3.1 SRGAP2 RPS11 RPS27 SLIT2:ROBO1:Ena/VASPproteinsRPL37A PSMA2 3x4Hyp-3Hyp-GlcGalHyl-COL4A5 PRKACB PSMD2 ENAH 18S rRNA SLIT3 EVL SLIT13x4Hyp-3Hyp-GalHyl-COL4A5 LHX2:ROBO1 geneROBO1 SLIT2:ROBO1:ABL:CAPLHX9 p-S1330-ROBO3.1:AKAP5:p-T497,T638,S657-PRKCASLIT3RPS10 CLASP2 RPL38 PAK3 PFNSLIT2:ROBO1:NCKROBO2 PSMB2 RPL26L1 RPS16 RPL31 RPS16 SLIT2(1122-1529)RPS9 SLIT2GTP UPF3B CUL2 RPL32 ABL1 3x4Hyp-GalHyl-COL4A5 RPL13A RPL11 p-Y1019-ROBO3.1:DCC:NTN1RPS23 SRGAP2 UBC(77-152) UBC(381-456) 28S rRNA LHX3 ROBO1:SLITPSME2 ROBO1 RPL19 RPL10 NCK1,NCK2RPL3 RPL24 RPL10A UBB(77-152) SLIT2:ROBO1:ABL:CLASPFAU RPL11 GDPPSMB11 LHX2 ROBO1 UPF2 RPL21 CDC42:GDP5.8S rRNA SOS1 PSME3 SLIT2 RPL5 PAK6 RPS3 ATPROBO2 ROBO1 PFN1 PSMA4 PPP3CB RPS3A RBM8A SLIT2:ROBO1:NCK:SOSPAKPSMD1 H2OABL2 UBC(533-608) PFN2 ROBO2 CXCR4 NELL2SLIT3 PAK5 RPL37 EIF4G1 RPS12 p-T497,T638,S657-PRKCASLIT3 UBC(153-228) GPC1:HSPGPRKACB CASC3 RPS27A(1-76) PSMA1 UBC(609-684) PSMF1 RPS4Y2 RPL39 LHX2CAP2 ROBO1:SLIT2UBC(609-684) RPL4 tRNARPS3 ROBO3.1 RPL27A SHFM1 ROBO3.2 mRNAROBO1 RPL6 GPC1 CXCL12(22-93) RHO GTPases ActivateROCKs3x4Hyp-3Hyp-5Hyl-COL4A5 RPL13 ROBO2,(ROBO1):ROBO3.1RPS4Y2 PSMD12 RPL40 UBC(457-532) PSMB10 NRP1RPS11 UBB(77-152) SLIT2 UBC(381-456) ROBO3.1 mRNA:MSI1RPL17 3x4Hyp-GlcGalHyl-COL4A5 ROBO3.1:DCC:NTN1RPS14 RPS6 NCK2 RPS3A 3x4Hyp-3Hyp-GlcGalHyl-COL4A5 DAG1(654-895) RPS27A(77-156) SLIT3 ADPRPL19 ROBO1 H2OROBO3.1 mRNAROBO3.1 RHO GTPases activatePAKsRPS24 NRP1 RPL39L ETF1 SLIT2 RAC1 RPS27A(77-156) RPS28 SLIT2 ROBO1 RPS17 ROBO1LHX2,(LHX9):ROBO3geneRPLP2 PSMA8 3x4Hyp-3Hyp-COL4A5 3x4Hyp-5Hyl-COL4A5 ADPPSMC4 ETF1RPS27L PSMB5 ELOC RPS29 ROBO3 geneROBO2 PAK4 SLIT2,SLIT2 cleavagefragments:GPC1:HSPGPABPC1 RPL12 PRKAR2A CUL2 RPL10L RPS27A(1-76) SRGAPSLIT2 RPS18 RNPS1 SLIT1:COL4A5RPL34 DCC PSMD8 PSMA7 VASP VASP NCK1 SLIT2 gene RPLP0 EVL LHX4 SLIT2 RPS25 NELL2:ROBO3ELOB RPS20 ROBO1 RPL28 28S rRNA Keratan sulfate3x4Hyp-3Hyp-GalHyl-COL4A5 NCBP2 PAK4 RPL35 RPL23 p-T497,T638,S657-PRKCA SLIT3 RPL18A PSMC6 GTP ABL1 RPS7 SLIT1:ROBO1,ROBO2:NCK2RPS29 MAGOHB ROBO3 gene SLIT2 ROBO3.1SLIT2 PFN2 DCC:NTN1ROBO1 RPL8 MyrG-p-Y419-SRCGlcGalHyl-COL4A5 FLRT3RPS13 RPS21 RPL41 SLIT2,(SLIT3)3x4Hyp-5Hyl-COL4A5 ROBO2 geneNCK1 RPSA ROBO2 ROBO1 RPS20 PSME4 NCK2 NCBP1 RPL28 SLIT2(31-1121) RPL15 RPS2 RPLP2 SOS1 RPS4X SLIT2(1122-1529) ZSWIM8-CUL2 E3ubiquitin ligaseRPSA ROBO1 ROBO1 ROBO1 5Hyl-COL4A5 PSMD9 LDB1 RPS15A RPL9 RPL32 RPL8 ATPPSMB4 ROBO1 gene AKAP5 UBA52(1-76) RPS26 CLASP1 ROBO2:AKAP5PAK2 18S rRNA NTN1 RPL35A RPS15A PSMC1 RPL36A RPL13A 5S rRNA RPL14 3x4Hyp-3Hyp-COL4A5 AKAP5PSMD4 RPL5 ABL2 UBB(153-228) COL4A5 GDP ABL1 RPL12 EVL RPL23 SLIT2 CDC42:GTPMSI1 SLIT2:ROBO1:ABLSLIT2 p-Y1019-ROBO3.1 RNPS1 p-T497,T638,S657-PRKCA UPF3A ROBO2:AKAP5:PPP3CBp-Y1073-ROBO1 RPS5 ROBO3.1 ARHGAP39CXCR4:CXCL12RPS24 ROBO3.2 ROBO1 SRGAP3 USP33RPL36 PSMD10 H2ORPL7A ROBO1 geneAKAP5 RPL35 ROBO1 Ub-ROBO3.1:ZSWIM8-CUL2RPS10 ROBO3.1 UBB(1-76) Nonsense-MediatedDecay (NMD)GTP PABPC1ROBO3.1:AKAP5:p-T497,T638,S657-PRKCAMSI1ROBO1 DAG1(30-653) RPL3L SRGAP3 NCBP1 DCC SLIT2 SLIT2 geneRPS7 ROBO3.1:ZSWIM8-CUL2Heparan sulfate N-acetyl-alpha-D-glucosaminide ENAH RPL36AL HOXA2:ROBO2 geneUBB(1-76) PSMC3 SLIT2 HOXA2UBC(229-304) RPS2 ELOC ROBO2 3x4Hyp-COL4A5 ISL1:LHX3/4:LDB1:SLIT2 geneROBO2 Collagen alpha-5(IV)chainsISL1:LHX3/4:LDB1GPC1 3x4Hyp-COL4A5 RPL22L1 ABL1 LHX9 SLIT3:ROBO1,ROBO2SLIT1:ROBO1:FLRT3PFN1 SLIT2:ROBO1:SRGAPRPS4Y1 GalHyl-COL4A5 SLIT2(31-1121) MAGOH RPS28 SLIT2:DystroglycanUBC(533-608) ZSWIM8 AKAP5 RPS19 ENAH ROBO3.2 ISL1 RPL18 FAU ROBO2ABLROBO1 GSPT2 ROBO1:NRP1PPP3CBRPL7 CASC3 ISL1 NELL2 RPS4X ROBO1 RPL23A ROBO3.1 PRKACG PSMD7 ROBO2,(ROBO1)GDP SLIT2 ABL1 RPL10L RPL18A RPS17 ROBO2:AKAP5:p-T497,T638,S657-PRKCADAG1(654-895) RPL27A UBC(457-532) UBC(1-76) RPL18 PSMD11 HOXA2 ABL2 ROBO1 DCCROBO2 3x4Hyp-GlcGalHyl-COL4A5 tRNA ATPRHOA:GDPRPL35A RPL6 PSMD14 SLIT2(1122-1529) UBC(305-380) RPS23 ROBO3.1 RPL17 SLIT1:ROBO1,ROBO2CAP1 RAC1:GDPEIF4A3 ROBO3.2 mRNA RBM8A ELOB PSMC5 RPL9 UBA52(1-76) SLIT2,SLIT2 cleavagefragmentsRPS27 DystroglycanCLASPSLIT2 RPLP0 RPLP1 UBC(305-380) MAGOHB GTPCap Binding Complex(CBC)RHOA:GTPLDB1 ROBO2 RPL37A PAK1 RPL7A RPS18 UBC(1-76) SLIT2 PSMB1 LHX4 RPL3 ROBO2 gene ROBO3.1 mRNA ABL2 H2Op-T497,T638,S657-PRKCA RPS21 RPL14 UPF3B UPF3A GDP PSMB9 RPS19 RPS15 SLIT2 PiLHX3 CXCL12:CXCR4:ROBO1:SLIT2RPS12 SLIT1 ROBO1,ROBO2PSMC2 RPL30 LHX2:ROBO2 geneGalHyl-COL4A5 RBX1 SLIT1 RPL24 AKAP5 ROBO1:SLIT2:ARHGAP39VASP FLRT3 DCC PSMB6 SLIT2:ROBO1:NCK:PAKRPL40 RPS15 DCC CXCL12(22-93) RPL27 UBC(153-228) ROBO2 RPL10A DAG1(30-653) GDP ROBO1 SRGAP1 UBC(77-152) 26S proteasomeGSPT2 SLIT1:ROBO1ExonJunction:UPF2:UPF3ComplexRPL34 CUL2 ROBO2:AKAP5:PRKAR2A-PKA type IIPSMB3 RPS13 PAK3 ROBO1 5S rRNA CXCR4 PolyUb-ROBO1GDP RPL29 RPL26L1 ZSWIM8 RPL36AL PRKACA Keratan sulfate ROBO2:SLIT2RPL22L1 NCK2 PSMB7 3x4Hyp-GalHyl-COL4A5 RPL7 ADPSLIT2 RPS25 RPL36 UbRPL3L PRKACG NCK1 CAPGSPT1 PSMB8 eRF3:GDPPRKACA GSPT1 RPL37 ROBO2 gene MYO9BRPL38 RPL29 5.8S rRNA RPS5 36556, 50203, 15, 23, 28, 48...6, 50202, 9, 19, 22, 25...6, 5037, 4444820124, 5, 10, 13, 18...6, 50778