Signaling by ROBO receptors (Homo sapiens)

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3, 20, 41, 42, 44...591285337275, 18, 5928525340, 4717, 46502, 192940, 47, 48275329284449nucleoplasmcytosolcytosolnucleoplasmPAK1 PSME2 LHX2,(LHX9):ROBO3geneCXCR4 RPL23 VASP RPL30 RPL39 SLIT2 ROBO1 PAK3 UBA52(1-76) NELL2:ROBO3ATPFAU SLIT2 LHX3 3x4Hyp-3Hyp-GlcGalHyl-COL4A5 RPL26L1 CUL2 SLIT1 MYO9B ROBO2:AKAP5:PPP3CBRAC1:GDPSLIT2 PFN2 PAK5 RPS13 RHO GTPases activatePAKsROBO1,ROBO2PSME3 ROBO3.1 mRNA ROBO1 RPL36 ROBO1 SLIT3 PSMC1 MAGOHB SLIT2:ROBO1:ABL:CAPCXCL12:CXCR4:ROBO1:SLIT2RPS19 EIF4G1 LHX2:ROBO2 geneRPS4Y1 GPC1:HSPGPPP3CB PRKACA DCCCLASP2 RPL39L VASP RPL40 PSMB11 CXCR4 SLIT1:ROBO1:FLRT33x4Hyp-COL4A5 SLIT1 VASP 3x4Hyp-GalHyl-COL4A5 DCC RPL35 PSMD12 RPL41 NCK2ROBO2 MyrG-p-Y419-SRCSLIT1 SLIT3 p-S1330-ROBO3.1 RPS27A(77-156) RPL18 LHX2 NCK2 ROBO3.1:AKAP5:p-T497,T638,S657-PRKCALHX2 PSMA4 CXCR4:CXCL12SLIT2:ROBO1:SRGAPRAC1 COL4A5 EIF4A3 ROBO1:NRP1DAG1(30-653) DAG1(654-895) RHOA ROBO3 genePRKACG ROBO3.2 mRNAROBO2 RPL13A ZSWIM8 ABL2 ROBO1RPL19 LDB1 SOS1 RPS20 NCK1 UBC(77-152) DystroglycanMYO9BRPL38 UBC(153-228) RBX1 RPL10A ROBO1,ROBO2:KeratansulfateUb-ROBO3.1:ZSWIM8-CUL2RPS28 SRGAP2 tRNA Keratan sulfate AKAP5 PPP3CBPSME4 UBB(1-76) RPL32 UBC(77-152) 80S ribosomeRPS10 SLIT1 PAK6 AKAP5 UBB(77-152) PSMD3 SLIT2 RPLP2 RPS6 RPL18A RPL37A RPSA RPS27 NTN1 RPL18 RPL35A RPL17 ELOC ROBO3.1 RPL27A ABL2 RPL15 PSMA8 PRKACG p-T497,T638,S657-PRKCANCK1 ABL1 SLIT2 RPL8 RPS8 RPL6 ROBO3.1:ZSWIM8-CUL2SLIT1:COL4A5RPL21 ISL1 LHX2:ROBO1 geneARHGAP39RPL14 SRGAPRHOA:GTPZSWIM8 p-Y1019-ROBO3.1:DCC:NTN15S rRNA UBC(381-456) RPL34 ROBO1:SLITRPL36AL ROBO2 RPL10L PFNSLIT1:ROBO1,ROBO2ROBO2 RHOA:GDPH2OZSWIM8-CUL2 E3ubiquitin ligaseSOSRPS27A(77-156) LHX2,(LHX9)ROBO3.1 RPS21 RPL3 RPL39 ROBO2,(ROBO1):ROBO3.1RPS11 RPS9 ABL2 3x4Hyp-3Hyp-5Hyl-COL4A5 RPL31 RPS4X LHX4 AKAP5 RPL11 RPS4Y1 eRF3:GDPPSMC5 RPL3L RPL32 RPS21 RPL13A PSMB10 RPSA SLIT2 geneRPL21 NCBP1 GlcGalHyl-COL4A5 ROBO2 SLIT2 RNPS1 3x4Hyp-5Hyl-COL4A5 EVL GSPT1 UPF3A NCK1 ELOB PiRBX1 RPL36A RPS13 CAP2 ROBO3 gene GlcGalHyl-COL4A5 RPL23 SLIT3 RBM8A ADPZSWIM8 FAU PSMA1 FLRT3 CDC42 DAG1(654-895) RPL23A ROBO1 RPL26 ABL1 RPS4Y2 RPS7 ATPROBO2:AKAP5:p-T497,T638,S657-PRKCAETF1 p-T497,T638,S657-PRKCA LHX9 RPS14 ELOB LHX2 CAP1 SLIT2 RPS27L PFN1 RBM8A EVL RPS12 CUL2 RPL18A ROBO2 genePRKAR2A-PKA type IIMAGOH RPL38 ROBO1 UPF2 ROBO3PSMB5 p-Y1073-ROBO1 PSMD2 CDC42:GDPPAK5 ROBO3.1:DCC:NTN1SLIT2 SOS2 RPS15A ROBO1 ROBO3.1ROBO2 gene RHO GTPases ActivateROCKsROBO1 RNPS1 ROBO3.2PSMB2 p-T497,T638,S657-PRKCA ABL2 SLIT2 SLIT2 ROBO1 ROBO1 RPL10L PAK1 RPL26 ROBO2 UBB(1-76) PSME1 USP3328S rRNA ENAH ETF1RPS14 ABL1 SLIT2 tRNAPiRPS3A RPL37 PSMA7 SLIT3CAPROBO2:AKAP5:PRKAR2A-PKA type IIRPL3L H2OABL2 GDP RPS8 RPS4X PSMB7 NCBP1 ROBO1 PSMD5 RPS3A SLIT2:ROBO1:NCKRPL30 UBC(305-380) PSMB3 SLIT1UBB(153-228) SLIT2 RAC1:GTP3x4Hyp-5Hyl-COL4A5 RPS27A(1-76) SLIT2 UBB(77-152) RPL12 p-S1330-ROBO3.1:AKAP5:p-T497,T638,S657-PRKCAGTP NCBP2 AKAP5 3x4Hyp-3Hyp-5Hyl-COL4A5 ABL1 LHX2 SLIT2 PABPC1 RPL29 PSMC2 CLASP2 GTP UBC(457-532) RPLP1 RPS24 RPL22 SLIT2 RPS3 RAC1 EIF4G1PSMC3 ROBO1 geneRPL10A HOXA2MAGOHB H2OPSMD9 UBC(609-684) CAP1 RPL23A SLIT2,(SLIT3):Keratan sulfateROBO2 gene RPL10 RPLP1 RPS27A(1-76) SLIT2(31-1121) PSMA5 CDC42 CASC3 PAK2 GalHyl-COL4A5 RHOA CASC3 RPL24 RPL41 EVL GDP Nonsense-MediatedDecay (NMD)3x4Hyp-3Hyp-COL4A5 RPL39L ROBO2 RPL26L1 NCK2 RPS15 SLIT2:ROBO1:NCK:PAKROBO1 ROBO1 SLIT1:ROBO1PolyUb-ROBO1SLIT1 RPS2 SLIT3 RPL4 SLIT2:ROBO1:Ena/VASPproteinsHeparan sulfate N-acetyl-alpha-D-glucosaminide NCK2 NCK2 UBC(533-608) RPL8 RPL22L1 PSMC6 Ub-ROBO3.1 PRKACA SLIT1:ROBO1,ROBO2:NCK2RPS18 SLIT2,SLIT2 cleavagefragmentsSLIT2 MSI1 PSMF1 PSMA6 COL4A5 RPS3 NCK2 RPS5 PSMB6 ROBO1 SLIT2 ROBO3.1 SLIT1 5S rRNA SRGAP3 PRKAR2A RPS6 RPLP0 RPS24 UBC(153-228) CDC42:GTPUBA52(1-76) CLASP1 UBC(381-456) PFN1 RPL31 CLASPSLIT2UBC(457-532) RPS26 SLIT2:ROBO1:Ena/VASP:PFNCap Binding Complex(CBC)CUL2 UBC(229-304) RPS5 SLIT2,(SLIT3)RPS26 GDP DCC:NTN1RPS9 SRGAP1 ROBO1 LHX3 RPL11 RPL40 UBC(609-684) RPL27A ROBO1 gene UBC(229-304) 5.8S rRNA RPL10 Translated ROBO3.2mRNA in complexwith NMD-initiatingUPF2PSMD7 ROBO1 28S rRNA PAK2 SLIT2 ISL1:LHX3/4:LDB1LHX4 GSPT2 SLIT2 RPL28 UPF3B 3x4Hyp-GalHyl-COL4A5 RPL24 RPL36A SLIT2:p-Y1073-ROBO1:ABLPSMC4 UBC(533-608) ABL1 RPS17 ROBO2 ARHGAP39 PAK6 UPF2 NCK1,NCK2PRKAR2A RPL14 RPS11 UBC(1-76) RPL27 SLIT2(1122-1529)NTN1 RPS7 NRP1RPL13 ROBO1:SLIT2:ARHGAP39ROBO2:AKAP5DCC ATPPSMD6 NTN1 SLIT2:DystroglycanSRGAP1 PSMD11 RPS18 RPL22 ROBO1 GPC1 MAGOH RPL19 Ena/VASP ProteinsDCC ROBO1 RPL34 ROBO1 ROBO3.1:AKAP5RPL37A ROBO3.1 PAK3 RPL5 Ub3x4Hyp-3Hyp-GalHyl-COL4A5 UBC(1-76) Heparan sulfate N-acetyl-alpha-D-glucosaminide LHX2ROBO3.1 mRNA:MSI13x4Hyp-3Hyp-GalHyl-COL4A5 3x4Hyp-GlcGalHyl-COL4A5 ADPROBO3.1 SLIT2(31-1121)ROBO2 PSMD13 GTPRPS4Y2 3x4Hyp-GlcGalHyl-COL4A5 H2ONRP1 SHFM1 SLIT2(1122-1529) ELOC PSMB8 SLIT2 gene GDPAKAP5 SOS1 3x4Hyp-3Hyp-COL4A5 NELL2 GPC1 RPL37 RPS17 SLIT2:ROBO1:ABL:CLASPROBO1 RPLP0 RPS12 SLIT2(1122-1529) PSMB1 ISL1:LHX3/4:LDB1:SLIT2 geneRPL22L1 RPL28 EIF4A3 5.8S rRNA ROBO1 ROBO1 ABLSLIT2 ROBO2:SLIT2ADPRPS2 SLIT2,SLIT2 cleavagefragments:GPC1:HSPGPiFLRT3SLIT2:ROBO1:MYO9B18S rRNA RPS16 5Hyl-COL4A5 Ubp-Y1019-ROBO3.1 ROBO2 RPL4 PSMD10 Keratan sulfateROBO2 3x4Hyp-COL4A5 SLIT2 RPLP2 ROBO3.2 mRNA GSPT2 RPL35A RPS23 SLIT3 PSMD14 SLIT3:ROBO1,ROBO2ELOC RPS29 GDP ELOB RPL36AL RPS25 SLIT1 SLIT2 PSMD4 CAP2 SLIT2:ROBO1:NCK:SOSROBO1:SLIT2RPS15 RPS25 DAG1(30-653) RPL15 DCC ROBO3.1 ROBO3.2 UBC(305-380) LHX9 PABPC15Hyl-COL4A5 RPL27 RPS10 RPL7A PSMD1 RPL5 RPS15A NCBP2 3x4Hyp-3Hyp-GlcGalHyl-COL4A5 GDP DCC:ROBO1:SLITCollagen alpha-5(IV)chainsROBO3.1 ExonJunction:UPF2:UPF3ComplexMSI1p-T497,T638,S657-PRKCA HOXA2 PAK4 RPS28 RPS20 SRGAP3 RPL12 RPL29 CXCL12(22-93) 18S rRNA ROBO3.1 mRNARPL6 PFN2 SRGAP2 RPL35 NELL2AKAP5 GTP UBB(153-228) ROBO2AKAP5 ISL1 PSMA2 GalHyl-COL4A5 RPL7A NCK1 RPL9 RPS23 RPS16 RPL3 CLASP1 RPL7 RPS19 PRKACB SLIT2(31-1121) ENAH RBX1 HOXA2:ROBO2 geneCXCL12(22-93) PSMB9 PRKACB PAK4 26S proteasomeRPS27L PSMA3 Keratan sulfate ROBO1 LDB1 SLIT2:ROBO1:ABLUPF3B ROBO1 RPL9 ROBO1 SOS2 ROBO3.2 GSPT1 RPL7 RPL17 PAKPSMB4 AKAP5RPL13 ENAH ROBO2 RPS29 RPL36 ROBO1 UnidentifiedproteaseROBO2,(ROBO1)RPS27 PSMD8 UPF3A 29372729149, 15, 21, 23, 24, 33...535113, 1416, 3116, 314, 12, 26, 32, 34...6-8, 10, 11, 22...275316, 315316, 3159