Signaling by EGFR (Homo sapiens)

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18, 49, 94, 978625, 736355, 77105664, 9286603020, 748, 7219, 37, 57, 5816, 44, 46, 6225121002316, 44, 46, 6231, 96934902528, 69, 7111, 7011, 7051, 687462, 9917, 34, 89423752, 29, 5434, 39, 8962332, 5276351267, 798, 727, 15, 6521, 53126637, 5778, 806834741, 48, 55, 57, 58, 8826, 9240, 9886plasma membraneplasma membranecytosolplasma membraneplasma membraneUBA52(1-76) EGFR E746_A750del UBC(1-76) EGFR A289D p-Y53-SPRY1 UBC(229-304) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR UBC(457-532) EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15EGFR G719A PIK3R1 GRB2:GAB1UBB(1-76) EGFR A289T UBC(1-76) EGFRvIII UbEGFR A289T UBB(1-76) UBC(305-380) SPRY1/2EGFR E746_A750del;T790M H2Op-Y371-CBL CDC37 EGFR G719C EGFEGF p-Y371-CBL p-6Y-EGFR EGFR L858R GAB1SH3GL1 EGF SH3GL3 UBC(381-456) EGFR:CetuximabUBC(305-380) p-6Y-EGFR EGFR E746_S752delinsV EGF EGFR R108K ATPSH3KBP1 Zn2+ EPN1 EGFR A289V CDC37 RPS27A(1-76) PXN:MyrG-SRCEGF:Ub-p-6Y-EGFR:p-Y371-CBLADPUBC(77-152) HRAS p-6Y-EGFR Resistantligand-responsiveEGFRmutants:CovalentEGFR TKIsCDC42 UBC(1-76) EGFR A289V EPS15 H2Op-Y55-SPRY2 HSP90AA1 EPN1UBC(381-456) UBB(77-152) p-6Y-EGFR EGFR E746_A750del;T790M UBC(381-456) EGF:p-6Y-EGFR:p-Y371-CBLGRB2-1 UBC(77-152) EGF p-6Y-EGFR Irreversible anti-EGFRplus TKIs EGFR E746_S752delinsV UBC(77-152) EGF ATPp-Y349,Y350-SHC1 UBB(1-76) EGFR L747_P753delinsS p-Y371-CBL EGFR L858R;T790M EGFR M766_A767insASV EGFR L747_T751delinsP UBC(77-152) IPI-504 PXN PTPN11 p-Y53-SPRY1 EGFR L747_A750delinsP Irreversible EGFR-specific TKIs Herbimycin AEGFRvIII EGFR G598V STAM 17-AAG UBB(153-228) EGFR E746_A750del CBL EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAMGTP GRB2-1 EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3KEGF p-6Y-EGFR PIK3CA:PIK3R1UBC(609-684) EGFEGF p-5Y-GAB1 UBC(381-456) PiGRB2-1:SOS1EGFR E746_T751delinsA EGFR M766_A767insASV p-6Y-EGFR H2OSTAM2 EGFR R108K UBB(153-228) UBC(229-304) EGF UBC(229-304) PIP3 activates AKTsignalingUBC(381-456) SH3GL2 GAB1 UBB(153-228) EGF HSP90AA1 EGFR L747_S752del GRB2-1 EGFR L858R SPRY1 EGFR L861Q UBC(609-684) RPS27A(1-76) EGFR L747_T751del EGFR G719S p-Y371-CBL GRB2:GAB1,GRB2:GAB1:PIP3UBC(229-304) UBB(77-152) p-Y-PXN:CSK:MyrG,p-Y530-SRCSHC1BenzoquinoidansamycinsPTPRKPI(3,4,5)P3 EGF GAB1 EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTPEGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2EGFR V738_K739insKIPVAI HSP90AA1 HSP90AA1 p21 RAS:GDPUBA52(1-76) PI(4,5)P2p-Y371-CBL p-6Y-EGFR EGFR A289V GTPUBC(77-152) EGF:p-6Y-EGFR:GRB2:GAB1EPS15 EGF STAM2 SH3GL2 EGF EGF NRAS PI(4,5)P2PI(3,4,5)P3 UBC(457-532) EGFR E746_A750del;T790M SH3GL2 SH3GL1 EGFR L747_A750delinsP GRB2-1 Geldanamycin PI(3,4,5)P3 HGS SH3KBP1 EGF ADAM:Zn2+EGF UBC(305-380) RPS27A(1-76) p-Y371-CBL p-6Y-EGFR GRB2-1 EGFR L747_A750delinsP EGF EGFR PiEGFR A289D UBB(77-152) EGFR D770_N771insNPG p-6Y-EGFR EGF:p-6Y-EGFR:CBL:GRB2ADPp-6Y-EGFR UBC(609-684) RAF/MAP kinasecascadeEGF:p-6Y-EGFR dimerEGFR A289D EGFR V738_K739insKIPVAI EGFR L747_T751del p-6Y-EGFR EGF EGFR L858R GRB2:GAB1:PIP3EGF UBC(153-228) UBC(1-76) EGFR G719C GDPEGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:EndophilinSPRY2 EPN1 p-Y371-CBL CBL UBB(1-76) Irreversible EGFR-specific TKIs Herbimycin A HSP90AA1 GRB2-1 ARHGEF7 UBA52(1-76) EGFR G719C UBC(305-380) EGFR E746_A750del ARHGEF7 EGFR L747_P753delinsS EPN1 EGFR L858R;T790M EGF:p-6Y-EGFR:p-Y349,350-SHC1CDC42 CBL EGFR L747_A750delinsP HGS UBC(533-608) EPS15L1 ARHGEF7 UBC(305-380) p-6Y-EGFR EGF:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1UBC(609-684) GTP ARHGEF7 EGFR E746_T751delinsA SH3GL2 EGFR D770_N771insNPG H2OHSP90:BenzoquinoidansamycinsSH3GL2 RPS27A(1-76) CBLSPRY1 EGFR R108K SH3KBP1 HSP90AA1 EPS15L1 UBB(77-152) EGF:p-EGFR dimerdephosphorylated atY1148 (Y1172)UBB(153-228) EGFR L747_S752del GRB2-1 UBC(381-456) EGFR L747_P753delinsS EGFRvIII mutantdimerEGFR L858R;T790M GRB2-1 SPRY2 EGFR V738_K739insKIPVAI EGFR G719C EGFR R108K UBC(77-152) UBC(77-152) GAB1 p-Y850 EPS15 UbUBC(533-608) EGF:p-6Y-EGFR:SHC1EGFR A289T UBB(1-76) EGFR M766_A767insASV EGFR G719C EGFR E746_S752delinsV GRB2-1p-Y371-CBL EGF:p-6Y-EGFR:PLCG1UBA52(1-76) ATPLigand-responsive EGFR mutants resistant to non-covalent TKIs UBC(153-228) p-6Y-EGFR GAB1 EGFR L858R Beta-Pix:CDC42:GTPUBC(77-152) UBC(457-532) Resistantligand-responsiveEGFR mutantsPI(4,5)P2 EGFR L747_S752del p-6Y-EGFR EPN1 GRB2-1 UBB(153-228) EPS15 GRB2-1 UBC(609-684) EGFR L747_A750delinsP CIN85:endophilinEGFR D770_N771insNPH p-Y627,Y659-GAB1 KRAS UBB(153-228) Ligand-responsiveEGFR mutants dimerp-Y55-SPRY2 EGFR L747_P753delinsS PIK3CA MyrG,p-Y530-SRC Sensitiveligand-responsiveEGFRmutants:Non-covalent EGFR TKIsEGFR L747_T751delinsP UBA52(1-76) EGF:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2PI(3,4,5)P3 EGFR L858R;T790M UBC(533-608) UBB(153-228) p-6Y-EGFR p21 RAS:GTPUBB(153-228) UBC(533-608) CBL:GRB2UbPI(4,5)P2 STAM2 PTPN11 CDC37 Covalent EGFRtyrosine kinaseinhibitorsUBC(1-76) EGF:p-6Y-EGFR:GRB2:SOS1PiEGFR L747_S752del p-6Y-EGFR UBC(457-532) CBL Ub-SH3KBP1 GRB2-1 EGFR R108K EGFR G719S p-6Y-EGFR UBC(77-152) EGFR A289D UBC(533-608) EGFR D770_N771insNPG EGFR G719S SH3GL3 ATPPIK3CA EGFR E746_T751delinsA HGS UBC(457-532) CetuximabReversible EGFR-specific TKIs EGFR E746_A750del;T790M EGFR G719A EGFR E746_S752delinsV p-6Y-EGFR CBL Reversible anti-EGFRplus TKIs DAG and IP3signalingSHC1 UBC(457-532) EGFRvIIImutant:HSP90:CDC37PTPN3UBC(77-152) SH3GL3 SOS1 EGFR L858R PI(3,4,5)P3 RPS27A(1-76) EGFR L858R;T790M Ligand-responsive EGFR mutants sensitive to non-covalent TKIs MyrG-SRC EGF p-4Y-PLCG1 EGFR A289T EGFR L861Q UBC(1-76) CBL:SPRY1/2ADAM12 SH3GL2 KRAS LRIG1EGFR D770_N771insNPH EGFR G598V STAM2 EGFR E746_A750del;T790M UBC(381-456) UBC(305-380) EGFR 17-DMAG UBC(305-380) EGF EGFR V738_K739insKIPVAI ADPUBC(229-304) EGFR D770_N771insNPG UBC(229-304) NRAS SOS1UBA52(1-76) EGFR L747_S752del EGFR E746_A750del;T790M EGF:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15EGFR V738_K739insKIPVAI GRB2-1 EGF:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2EGFR L861Q UBC(153-228) EGFR G719A UBC(1-76) p-6Y-EGFR SOS1 p-6Y-EGFR CDC42 EPS15 EGF UbEGFR L858R UBC(305-380) p-Y-PXN CDC37 EGFR E746_T751delinsA HGS Ub-Beta-Pix:CDC42:GTPEGFRSTAM EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAMEGFR M766_A767insASV Irreversible anti-EGFRplus TKIs PLCG1EGFR E746_T751delinsA STAM UBB(153-228) UBC(381-456) Reversible anti-EGFRplus TKIs HSP90AA1 EGFR L747_T751delinsP UbEGF:Ligand-responsive EGFR mutants:HSP90:CDC37UBB(77-152) Geldanamycin PiHSP90PI(3,4,5)P3 UBC(609-684) EGFR V738_K739insKIPVAI EGFR A289V UBC(153-228) p-Y349,Y350-SHC1 UBC(229-304) EGFR G598V UBC(229-304) 17-AAG ATPADAM17 EGF:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1p-Y371-CBL EPS15 EGF EGFR L861Q SOS1 EGFR G719A SRC-1PIK3R1 HSP90AA1 EGF EGFR L747_P753delinsS CDC37 EGFR T263P p-Y371-CBL SPRY2 Reversible EGFR-specific TKIs GRB2-1 EGFR G719S PLCG1 EPS15L1 UBC(609-684) EGF GRB2-1 IPI-504 EGFR G719S p-5Y-GAB1 GRB2-1EGF:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2Active dimers ofligand-responsiveEGFR mutantsUBC(533-608) UBC(457-532) EGF:p-6Y-EGFR:CBLUBB(77-152) UBB(1-76) CDC37 EGFR G719C GTP p-Y55-SPRY2EGFR T263P CDC42 EPS15L1GRB2-1 EGFR E746_A750del RPS27A(1-76) EGFR T263P EGFR D770_N771insNPH p-Y371-CBL UBC(533-608) SH3GL1 p-6Y-EGFR UBC(381-456) EGFR V738_K739insKIPVAI p-5Y-GAB1 EGFR L861Q EGFR L747_T751delinsP RPS27A(1-76) EGF:EGFRDimer:Covalent EGFRTKIsp-6Y-EGFR CDC37 GDP Cetuximab UBC(229-304) HSP90AA1 UBC(1-76) EGFR A289T EGFR R108K STAM EGF ADPADAM10(215-824) PiGRB2-1 STAM2 UBA52(1-76) SH3KBP1 EGF p-Y317-PAG1PTPN11EGF GTP EGFR A289T GRB2-1 UBC(153-228) SH3GL1 EGFR L747_S752del PTPN12UBC(153-228) EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1EGF EGF UBC(153-228) UBC(533-608) EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2UBB(77-152) EGFR D770_N771insNPH UBC(533-608) HGS UBA52(1-76) p-Y371-CBL UBB(1-76) EGFR G598V EGFR L747_A750delinsP EGFR E746_A750del;T790M EGF SH3GL1 EGFR E746_A750del HSP90AA1 ADPUBC(457-532) Irreversible EGFR-specific TKIs EGFR E746_S752delinsV EGF:EGFREGFR A289D EGFR M766_A767insASV EGFR D770_N771insNPH EGFR STAM p-6Y-EGFR EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85SH3GL1 SH3GL3 UBB(77-152) EGFR M766_A767insASV RPS27A(1-76) Ligand-responsiveEGFR mutantsCSK EGFR A289V H2OEGF EGFR G598V PI(3,4,5)P3 ADPEGFR G719S SPRY1 UBC(153-228) EGF CDC37 RPS27A(1-76) EGFR L747_T751del EGFR G598V SH3KBP1 EGFR L747_T751delinsP EGFR L747_T751delinsP UBC(1-76) ARHGEF7 UBA52(1-76) EGF:Ligand-responsive EGFR mutants dimerSTAM EGFR HGS EGFR M766_A767insASV PTPN11 CBL EGFR T263P Pro-EGFEGFR A289D SH3GL1 H2OUBC(381-456) EGFR L747_P753delinsS UBC(609-684) EGFR L747_T751del p-5Y-GAB1 CDC37 EPN1 PI(3,4,5)P3EPS15L1 EGFR D770_N771insNPH EGF EGFR L858R;T790M EGFR L861Q EGFR E746_S752delinsV EGFR L858R;T790M SH3KBP1 EGF SH3GL1 SH3GL3 UBC(1-76) EGF EGFR D770_N771insNPH UBC(153-228) SH3KBP1 HRAS EGFR G719A UBA52(1-76) EGFR D770_N771insNPG p-6Y-EGFR UBB(1-76) SH3GL2 SPRY1 17-DMAG STAM2 EGF:p-6Y-EGFR:p-Y371-CBL:GRB2UBC(609-684) EGFR D770_N771insNPG PI(3,4,5)P3 EGFR L747_T751del EGFR L747_T751del UBC(609-684) GRB2-1 GRB2-1 EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15SPRY1/2CDC37 UBC(457-532) UbCSKUBB(77-152) ATPGRB2-1 p-6Y-EGFR ADPSH3GL3 Non-covalent EGFRtyrosine kinaseinhibitorsUBB(1-76) UBC(305-380) PiCBL:Beta-Pix:CDC42:GTPSH3GL3 UBC(229-304) GRB2-1 UBC(153-228) UBC(305-380) EGFR E746_T751delinsA EGFR A289V SPRY2 p-4Y-EGFR ATPp-4Y-PLCG1UBB(153-228) EGFR E746_A750del EGF Ligand-responsiveEGFRmutants:HSP90:CDC37CBL CDC37EPS15:HGS:STAMEGF CDC37 p-6Y-EGFR EGFRvIIIRPS27A(1-76) UBB(1-76) SH3GL3 EPS15L1 SH3GL2 ADPEGFR G719A p-6Y-EGFR ATPHSP90AA1 PAG1UBC(533-608) CDC42 EGF:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2GTP EGF:EGFR dimerEGF Irreversible anti-EGFRplus TKIs UBB(77-152) GTP EGFR T263P EGFR T263P UBC(457-532) EGFR D770_N771insNPG HSP90AA1 6145, 82818345384562, 8181818182, 84434343626244, 4545, 82454562, 824544, 458162, 82438145, 82814362, 824345, 82434345, 8262854545, 824362, 816244, 456245818161456281818162, 8127, 8662, 8244, 458162, 8281454381628162, 828145431, 5, 9, 13, 14, 22...44, 4562818145, 826281816243546262, 81818145456262, 82622944, 45626262628162, 816262, 81