Signaling by EGFR (Homo sapiens)

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18, 49, 94, 972326, 921078, 808, 7251, 68742542100675125625, 732, 29, 546667, 7928, 69, 7140, 98464, 9237, 573034, 39, 8919, 37, 57, 5811, 7031, 961262, 9923478, 7286861293359066355, 777621, 53360867, 15, 6517, 34, 898341, 48, 55, 57, 58, 8820, 7416, 44, 46, 6232, 5216, 44, 46, 6211, 7025plasma membraneplasma membraneplasma membranecytosolplasma membraneRPS27A(1-76) p-6Y-EGFR RPS27A(1-76) EGFR L747_T751delinsP ADPp-Y371-CBL UBC(457-532) EGFR A289D GRB2-1 EPN1 PTPN317-DMAG EGFR D770_N771insNPH Resistantligand-responsiveEGFR mutantsEGF UBC(609-684) UBA52(1-76) EGFR R108K EGF CDC42 PI(3,4,5)P3 UBC(609-684) Reversible EGFR-specific TKIs Beta-Pix:CDC42:GTPEGF:p-6Y-EGFR:GRB2:GAB1EGFR L747_P753delinsS CBL HGS PLCG1EGFR E746_A750del;T790M p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR STAM UBC(153-228) EGFR L747_T751del p-Y371-CBL EPN1 PTPN12EGFR R108K EGF EGF p-Y349,Y350-SHC1 ATPEGFR M766_A767insASV EGF:p-6Y-EGFR dimerGRB2:GAB1,GRB2:GAB1:PIP3EGFR D770_N771insNPH EGFR L747_P753delinsS UBC(153-228) Cetuximab EGFR A289T EGFR D770_N771insNPG p-Y371-CBL EGF UBB(153-228) EGFR E746_T751delinsA EGFR E746_A750del;T790M SH3KBP1 EGFR G719C ADAM:Zn2+UBC(457-532) EGFR E746_A750del EGFR L858R EGF EGFR D770_N771insNPG EGF:p-EGFR dimerdephosphorylated atY1148 (Y1172)CDC37 PLCG1 HSP90AA1 EGF:p-6Y-EGFR:p-Y371-CBLLigand-responsive EGFR mutants sensitive to non-covalent TKIs SH3KBP1 EGFR G719C UBC(609-684) ADAM12 EGFR D770_N771insNPG UBC(305-380) UBC(77-152) UBC(533-608) EGFR D770_N771insNPG EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85EGFR L747_P753delinsS UBC(1-76) SH3KBP1 UBC(609-684) STAM2 UBC(381-456) PiEGFR:CetuximabIPI-504 PiPTPN11 EGF GRB2-1 EGFR L858R EGF:Ub-p-6Y-EGFR:p-Y371-CBLUBC(153-228) EGFR G719C UBC(457-532) GRB2-1 SH3GL2 EGFR A289V Geldanamycin EGFR T263P Covalent EGFRtyrosine kinaseinhibitorsUBC(305-380) UBB(1-76) ADPEGF:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15SH3GL1 p-6Y-EGFR EGFR L747_A750delinsP UBC(609-684) UBC(533-608) EGFR G719C UBC(457-532) Ligand-responsive EGFR mutants resistant to non-covalent TKIs SPRY1 H2OUBC(305-380) CetuximabUBC(305-380) RPS27A(1-76) EGFR T263P UBC(609-684) EGFR L858R;T790M UBB(77-152) H2OGRB2-1EGF p-6Y-EGFR EGFR G719S EGF:p-6Y-EGFR:SHC1HSP90AA1 HSP90AA1 EGFR T263P GTP p-6Y-EGFR CSKGRB2-1 Irreversible anti-EGFRplus TKIs UBC(229-304) MyrG,p-Y530-SRC EGF:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1GDP ARHGEF7 PIP3 activates AKTsignalingEGFR E746_A750del;T790M EGFR L858R;T790M EGFRvIIISPRY2 EGFR L747_T751del GDPSH3GL3 EGFR L747_S752del SH3GL1 EGF p-6Y-EGFR UBB(1-76) EPN1 EPS15 EGFR A289V EGF UBC(533-608) HGS p-6Y-EGFR UBC(229-304) EGFR UbEGFR L747_T751del EGF UBC(229-304) EGFR E746_A750del HSP90AA1 UBB(77-152) SPRY1 UBC(153-228) SH3GL1 SOS1 HSP90AA1 GRB2-1 EGF GTP p-6Y-EGFR p-6Y-EGFR EGF EGFR E746_S752delinsV EGFR L858R;T790M EGFR E746_T751delinsA EGFR A289D SH3GL1 ARHGEF7 ATPGRB2-1 RAF/MAP kinasecascadeEGFR M766_A767insASV p-6Y-EGFR EPS15 PIK3CA:PIK3R1SH3GL3 p-6Y-EGFR UBC(77-152) p-5Y-GAB1 GRB2-1 Herbimycin A EGFR D770_N771insNPH EPN1 STAM UBC(229-304) EGFR D770_N771insNPG HSP90AA1 EGFR M766_A767insASV UBB(1-76) EGFR E746_S752delinsV PI(3,4,5)P3 Ligand-responsiveEGFRmutants:HSP90:CDC37GAB1 Irreversible EGFR-specific TKIs p-Y371-CBL EGFR R108K SH3GL1 SHC1 EGF UBB(153-228) GTP GRB2-1 CDC37 p-Y-PXN EGFR L747_A750delinsP UBB(77-152) EPS15 EGFR E746_S752delinsV GRB2-1 PiEGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2UBC(381-456) EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15UBC(229-304) UBC(153-228) LRIG1EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTPUBB(153-228) SHC1UBB(153-228) SH3GL2 EGFR L858R;T790M EGFR L861Q UBC(1-76) CIN85:endophilinCDC37 UBC(77-152) EGFRvIIImutant:HSP90:CDC37SH3GL3 CDC37 SOS1EGFR E746_S752delinsV EGFR G719A Ub-Beta-Pix:CDC42:GTPUbPI(3,4,5)P3 PI(3,4,5)P3 EPS15L1 SH3GL2 GRB2-1 UBC(229-304) UBC(153-228) GAB1 PIK3CA Active dimers ofligand-responsiveEGFR mutantsEGFR A289V GRB2-1 GRB2-1GRB2-1 GRB2-1 HSP90AA1 EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAMEGF UBC(77-152) STAM2 KRAS CDC37 EGFR EGF:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2H2OUbEGFR D770_N771insNPH H2OEGFR G719A p-Y627,Y659-GAB1 UBB(77-152) ADAM17 EGFR R108K CDC37 EGFR L747_T751delinsP BenzoquinoidansamycinsZn2+ HRAS EGFR D770_N771insNPH RPS27A(1-76) UBC(609-684) EGFR p-6Y-EGFR HSP90:BenzoquinoidansamycinsUBB(1-76) UBC(457-532) HSP90AA1 STAM UBC(381-456) p-6Y-EGFR ATPEGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2CDC37 EGFR G719C HSP90AA1 CBL:SPRY1/2UBB(1-76) EPN1 IPI-504 EGFR A289T EGF PiEGFR V738_K739insKIPVAI UBC(305-380) p-Y371-CBL UBC(1-76) CBL SH3KBP1 EGFR G719S EGF EGFR T263P GRB2-1 CSK p-6Y-EGFR EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilinp-6Y-EGFR UBC(381-456) EPS15L1 EGFR L747_T751del PiEGFR M766_A767insASV EGFR E746_T751delinsA 17-AAG PI(4,5)P2 UbUBC(229-304) H2OSH3GL2 Sensitiveligand-responsiveEGFRmutants:Non-covalent EGFR TKIsARHGEF7 EGFR L747_S752del RPS27A(1-76) UBC(381-456) PTPRKHSP90AA1 EGFR L858R UBC(77-152) EGFR E746_T751delinsA EGF EPS15L1 UBB(1-76) EGFR A289T UBA52(1-76) SH3GL2 p-Y371-CBL UBC(381-456) EGFR A289V GRB2-1 EGFR G719C 17-AAG PIK3CA PI(3,4,5)P3STAM EGFR G719S EGFR L861Q ADPp-6Y-EGFR p-6Y-EGFR EGF UBC(77-152) p-5Y-GAB1 UBB(77-152) UBB(1-76) EGFR G719A CBL CBL p-5Y-GAB1 SH3GL1 EGF EGFR G719S ARHGEF7 STAM GTP Resistantligand-responsiveEGFRmutants:CovalentEGFR TKIsEGFR A289T EGFR G598V SH3GL2 GRB2-1 EGF EGFR E746_A750del UBC(457-532) p-4Y-PLCG1UBC(153-228) EGF:p-6Y-EGFR:p-Y371-CBL:GRB2CDC42 Reversible anti-EGFRplus TKIs EGFR L747_T751delinsP p-6Y-EGFR EGFR T263P UBC(609-684) PI(4,5)P2 DAG and IP3signalingp-Y349,Y350-SHC1 CDC37 EGF:EGFR dimerGTP CBL EGFR D770_N771insNPH p-Y371-CBL SH3KBP1 EGFR M766_A767insASV EGFR E746_A750del;T790M EGFR V738_K739insKIPVAI EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1EGF SH3GL1 UBC(153-228) UBC(229-304) PTPN11 EGFR G598V p-Y850 EPS15 EGF UBA52(1-76) EGF EGFR L747_T751delinsP EGFR A289D RPS27A(1-76) PIK3R1 Irreversible EGFR-specific TKIs EGFR M766_A767insASV HGS p-6Y-EGFR GAB1EPS15 Pro-EGFSH3GL3 H2OUBC(457-532) STAM p-Y-PXN:CSK:MyrG,p-Y530-SRCEGFR G719A KRAS EGFSTAM2 GRB2:GAB1UBC(1-76) EGF:EGFRDimer:Covalent EGFRTKIsEGF:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2EGF UBC(381-456) SH3GL3 EGFR L747_P753delinsS ARHGEF7 UBC(1-76) UBB(77-152) EGFR L861Q ADPCDC42 UBB(153-228) GTPHGS EGFR L858R;T790M UBB(77-152) SOS1 SRC-1Herbimycin A ADPEGF:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15CBL EGF:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1UBA52(1-76) PIK3R1 SH3KBP1 CDC37 EGFR G598V GRB2-1:SOS1EGFR G719S GRB2-1 UBB(77-152) UBB(153-228) SPRY1/2EGFR L858R;T790M EGFR L747_S752del p-Y371-CBL EGFR G598V EGFR E746_S752delinsV PI(3,4,5)P3 UBA52(1-76) EGF EGF STAM2 EGFR E746_A750del;T790M EGFR A289D EGFR V738_K739insKIPVAI EGFR L858R;T790M EGF:p-6Y-EGFR:GRB2:SOS1EGFRvIII mutantdimerUBC(381-456) Reversible EGFR-specific TKIs UBC(609-684) PTPN11STAM2 HRAS EPS15L1EGFR L747_P753delinsS p-Y55-SPRY2 GRB2-1 EGFR G719S EPN1EGFR V738_K739insKIPVAI SH3GL3 SH3GL1 UBC(533-608) GRB2-1 PI(3,4,5)P3 Ub-SH3KBP1 EGFR D770_N771insNPG MyrG-SRC EGF UBC(609-684) UBC(1-76) CDC42 Irreversible anti-EGFRplus TKIs Geldanamycin EGFR L747_A750delinsP EGF:EGFRHGS UBC(457-532) PI(3,4,5)P3 EGFR V738_K739insKIPVAI EGF:p-6Y-EGFR:CBLGRB2-1 p-Y371-CBL EGFR G598V EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3KEGFR R108K UbEGFR E746_A750del EGF EGFR E746_T751delinsA UBB(1-76) UBB(153-228) NRAS CBL EPS15L1 UBC(1-76) UBC(305-380) RPS27A(1-76) ADAM10(215-824) GAB1 UbEGF p-6Y-EGFR SH3GL3 p-6Y-EGFR UBB(1-76) EGFR G598V HGS EGF UBC(77-152) CBL:Beta-Pix:CDC42:GTPIrreversible EGFR-specific TKIs UBC(533-608) EGFR L747_S752del p-Y371-CBL EGFR L747_T751delinsP UBC(381-456) 17-DMAG EGFR L858R p-6Y-EGFR GRB2:GAB1:PIP3EGF:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2RPS27A(1-76) CDC37 ATPp-Y371-CBL SH3KBP1 EGF SPRY2 UBC(457-532) p-Y371-CBL Irreversible anti-EGFRplus TKIs HSP90EGFR E746_A750del p-Y53-SPRY1 p-6Y-EGFR HSP90AA1 GTP PAG1EGFR A289T UBC(77-152) EGFR p-6Y-EGFR ATPEGF CBL:GRB2UBC(229-304) EGFR V738_K739insKIPVAI SPRY1 UBC(533-608) SPRY2 EGFR R108K ATPEGFR L858R EGF EGFR E746_S752delinsV UBC(77-152) UBC(305-380) EGFRp-5Y-GAB1 UBC(305-380) SPRY1/2UBC(153-228) UBC(533-608) EGF:p-6Y-EGFR:PLCG1EGF:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2UBC(533-608) EGF p-6Y-EGFR CDC37p-6Y-EGFR SPRY2 EGFR L747_A750delinsP ADPEPS15 CBLUBC(457-532) EGF EGF ADPEGFR L747_A750delinsP EGFR E746_A750del;T790M EGFR L747_P753delinsS ADPEGFR E746_A750del EGFR A289D HSP90AA1 EGFR T263P PI(3,4,5)P3 EGFRvIII p-6Y-EGFR p21 RAS:GTPUBC(1-76) UBC(77-152) UBB(77-152) EGFR M766_A767insASV ATPReversible anti-EGFRplus TKIs GRB2-1 EGFR E746_A750del;T790M EGFR L861Q RPS27A(1-76) EGFR A289V EGF GAB1 SOS1 PiSPRY1 EGFR L861Q p-Y55-SPRY2 UBB(77-152) EGFR L861Q ATPUBA52(1-76) EGF:Ligand-responsive EGFR mutants dimerEGF:p-6Y-EGFR:CBL:GRB2EPS15L1 Non-covalent EGFRtyrosine kinaseinhibitorsp-4Y-EGFR EGFR L858R PI(4,5)P2CDC42 PXN:MyrG-SRCEGF EGFR A289D UBC(1-76) UBC(229-304) RPS27A(1-76) UBC(533-608) EGFR A289V p21 RAS:GDPUBB(153-228) EGFR L747_T751del p-Y53-SPRY1 p-6Y-EGFR p-6Y-EGFR EGFR L747_A750delinsP EGFR D770_N771insNPH UBB(153-228) UBB(153-228) EGFR G719A UBA52(1-76) NRAS UBC(381-456) UBC(533-608) EGFR L747_T751delinsP SH3GL2 EGFR L747_S752del p-Y317-PAG1UBC(1-76) EGFR L747_S752del PI(4,5)P2p-Y55-SPRY2EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAMEGFR A289T EPS15:HGS:STAMp-4Y-PLCG1 STAM2 CDC37 Ligand-responsiveEGFR mutants dimerUBA52(1-76) UBA52(1-76) UBB(1-76) PXN SH3GL2 EGFR L747_T751del UBC(153-228) UBC(305-380) EGFR G719A EGFR E746_T751delinsA PTPN11 UBC(305-380) EGFR V738_K739insKIPVAI UBA52(1-76) SH3GL3 EGF:p-6Y-EGFR:p-Y349,350-SHC1EGFRvIII Ligand-responsiveEGFR mutantsEGFR D770_N771insNPG EGF:Ligand-responsive EGFR mutants:HSP90:CDC378181626262624562, 8245, 82816244, 453861454362458181858145, 82816281626262, 8145814562, 8243454362, 828162, 824545, 828144, 454581624345818181431, 5, 9, 13, 14, 22...624344, 454543624562, 815443626182, 8444, 4544, 458181816245, 8227, 8662, 8162, 818343624343298145, 8262, 82814545, 826262, 81436245, 828144, 4581818162, 8262, 8262, 8162