Semaphorin interactions (Homo sapiens)

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2, 16, 39, 46, 50119, 24, 3417, 2911, 325838, 41, 47, 48581042, 5721, 30815, 307, 13, 35, 37, 5514, 4918, 473, 15, 5420263, 15, 23, 545, 6, 36, 52, 539, 454422, 27, 5131, 5612, 19, 404, 19, 285425, 4311, 32, 33cytosolcytosolcytosolcytosolcytosolRRAS SEMA3A Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sp-Y-PLXNA2 SEMA4A TREM2 GTPFES HSP90AA1,HSP90AB1GTP Active LIMK1SEMA4D:ERBB2:p-Y-PLXNB1:RND1RHOB SEMA4D PLXNA4 PLXND1 MyrG-CDK5R1(2-307) FYN GTP ARHGEF11,ARHGEF12RHOC PLXNA3 DPYSL2 PLXNA3 HSP90AA1 RAC1 MET HSP90AA1 PLXNA2 p-Y-PLXNA3 ATPGTP MYL12B p-S522-DPYSL3 p-T509,T514,S518,S522-DPYSL2 MYH11 p-Y-PLXNA3 p-T508-LIMK1 RHOA:GTPPlexin-B1:ErbB2ERBB2 CDK5:p35Plexin-B1:MetNRP1:PlexinA1-4:FARP2:FYNLIM Kinasesp-S154,T436-PAK3 SEMA6ARHOA p-S,T508-LIMK1 PLXNA2 RHOA Sema3A:NRP-1:pPlexin-A:Fyn:FesSEMA6A RAC1:GTPSEMA4Ap-Y-PLXNB1 MYH14 SEMA3A PLXNC1FESp-T19,S20-MRLC-smooth muscle/non-muscle myosin IIp-T505-LIMK2 SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35SEMA3A ROCK2 SEMA3A GTP MET FYN p-S544-DPYSL4 Sema3A:NP-1:Plexin-A:Fes:CRMPPTPRC p-LIMKp-Y15-CDK5 ITGB1 RND1 SEMA6DR-Ras-GTPpLIMK dimer:HSP-90ADPADPSEMA4D ARHGEF11 PLXNA3 p-Y-PLXNA1 p-Y-PLXNA4 MET GTP p-S522-DPYSL2 SEMA4D ARHGEF11 PLXNA3 ATPH2OPTPRCSema3A dimerPAK1,2,3 dimerCRMP's tetramersSEMA5A PLXNA3 ITGA1 TREM2 Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAKp-Y-PLXNA2 ADPPiSEMA3A PLXNA4 p-Y-PLXNA4 RAC1 p-Y-PLXNA4 SEMA4DGTP SEMA4D PAK2 p-Y-DPYSL3 p-Y-PLXNA3 Smoothmuscle/non-musclemyosin IISema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sFARP2:PIP5KIgammaSEMA7A:PLXNC1SEMA4D:CD72FYN PLXNA2 SEMA4D RND1 NRP1 MYL6 MET RAC1 LIMK2 PLXNA4 GTP ADPRND1 NRP1 TLN1 ARHGEF12 PLXNA4 p-Y15-CDK5 SEMA3A PAK1 Integrin alpha1beta1p-Y-PLXNA2 PAK3 ATPRHOC PLXNA4 p-Y-PLXNB1 SEMA7AADPGDP NRP1 PLXNB3RHOA p-Y-PLXNA1 R-Ras-GDPp-S522-CRMP1 PAK3 p-S534-DPYSL5 PLXNA2 SEMA4D FARP2p-T509,T514,S518,S522-DPYSL3 FYN FYN RAC1 p-T508-LIMK1 FYN MYL6 CD72SEMA5A:PLXNB3p-S,T508-LIMK1 FES PLXNA3 RND1 MyrG-CDK5R1(2-307) TYROBP PLXNA2 GDP PLXNB1 PLXNA1 p-Y-PLXNB1 GSK3BPLXNA1 RHOB FYN MYH10 NRP1 ADPPLXND1RAC1:GTPRHOC RHOA ADPSEMA3Ep-T19,S20-MYL12B p-Y-PLXNA2 RAC1 FES PLXNC1 LIMK1p-Y-PLXNA4 SEMA4D:MET:p-Y-PLXNB1:RND1:GTPROCK1,ROCK2p-Y-PLXNB1 p-Y-PLXNA1 GTP GDP SEMA4D PLXNA2 Plexin-A1-4:FYNSEMA7A RND1:GTPNRP1 p-Y-PLXNA1 PiSEMA5Ap-Y-PLXNB1 p-Y-PLXNB1 PLXNB3 p-Y-PLXNA1 PLXNB1 FES SEMA7A RRAS Sema3A dimerSEMA3A:PLXND1p-T509,T514,S518,S522-CRMP1 GTP GDPR-Ras-GTPp-S544-DPYSL4 RND1 RHOA/B/C:GTPPLXNA1:TREM2:DAP12NRP1 MYH11 PLXNA2,PLXNA4PLXNA4 SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12GTP PLXNA1 LIMK1 p-Y-DPYSL2 SEMA4D:ERBB2:p-Y-PLXNB1MET RAC1 NRP1 MYH14 GTP PLXNA1 p-Y15-CDK5 p-Y-PLXNA2 ERBB2 FARP2 RHOA:GDPADPGTPADPPLXNA4 GTP p-Y-CRMP1 SEMA3A FES ATPCDK5 PAK1 PAK2 RhoA,B,C:GDPTLN1PIP5K1gamma:Talin-1p-Y-PLXNA1 RAC1 SEMA4D GDPp-Y-PLXNA4 FARP2 GTP p-T19,S20-MYL9 SEMA4D PLXND1RRAS ATPDPYSL4 p-S3-CFL1 PLXNA4 PLXNA2 ITGB1 Sema3A:Nrp-1:PlexinA:Fynp-S144,T423-PAK1 Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAKPLXNA3 NRP1 MyrG-CDK5R1(2-307) PLXNA4 p-Y-DPYSL5 ROCK1 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1ATPATPNRP1:PlexinA1-4:FYNPIP5K1C PLXNA1 ATPRND1 GTP SEMA3A ROCK1 MyrG-CDK5R1(2-307) NRP1 Sema4D:pPlexin-B1:Met:RAC1-GTPp-Y-PLXNA3 PLXNA2 ATPp-T508-LIMK1RND1:GTPSEMA4D dimerNRP1SEMA3E GDP MYL9 SEMA3A SEMA4D:MET:p-Y-PLXNB1SEMA4D:PTPRCFYN GTP ATPRAC1:GDPNRP1 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPSEMA4A:PLXND1FYN PLXNA1 CFL1FES PAK1,2,3SEMA3A ATPARHGAP35 SEMA4D dimerPLXNA3 SEMA3A PLXNA2 PLXNA1 ATPNRP1 Sema3A:Nrp-1:PlexinA:FynHSP90AB1 NRP1 p-Y-PLXNA2 p-Y-PLXNA3 ROCK2 PLXNA1 ERBB2 ADPADPGTP pCofilin: ActiveLIMK-1PLXNA4 FYN PAK1 RHOB ADPp-Y-DPYSL4 p-S534-DPYSL5 ARHGEF12 SEMA6D FYN RHOA TYROBP SEMA6D:PLXNA1:TREM2:DAP12SEMA7A:Integrinalpha1beta1MYH9 CRMP1 PLXNA1 PLXNA1 DPYSL3 ITGA1 FYN PAK2 DPYSL5 ARHGAP35CD72 ERBB2 MYH10 MYH9 ActivatedROCK:RhoA/B/C:GTPp-Y-PLXNA4 GDP FYN PAK3 SEMA6A:PLXNA2,PLXNA4HSP90AB1 p-Y-PLXNB1 PLXNA2 NRP1 SEMA4D PIP5K1C R-Ras-GDPADPFYN p-S141,T402-PAK2 p-Y-PLXNA3 ATPPiRND1 PLXND1 RRAS RAC1 Sema3A:Nrp-1:PlexinA:Fyn:pCdk5SEMA4D SEMA3A SEMA3A


Description

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 373755
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Garapati, Phani Vijay

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
101466view11:33, 1 November 2018ReactomeTeamreactome version 66
101004view21:12, 31 October 2018ReactomeTeamreactome version 65
100540view19:46, 31 October 2018ReactomeTeamreactome version 64
100088view16:31, 31 October 2018ReactomeTeamreactome version 63
99638view15:02, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99241view12:44, 31 October 2018ReactomeTeamreactome version 62
94051view13:54, 16 August 2017ReactomeTeamreactome version 61
93678view11:30, 9 August 2017ReactomeTeamreactome version 61
86802view09:26, 11 July 2016ReactomeTeamreactome version 56
83271view10:36, 18 November 2015ReactomeTeamVersion54
81381view12:54, 21 August 2015ReactomeTeamVersion53
76850view08:07, 17 July 2014ReactomeTeamFixed remaining interactions
76554view11:54, 16 July 2014ReactomeTeamFixed remaining interactions
75887view09:54, 11 June 2014ReactomeTeamRe-fixing comment source
75587view10:42, 10 June 2014ReactomeTeamReactome 48 Update
74942view13:47, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74586view08:38, 30 April 2014ReactomeTeamReactome46
45022view18:42, 6 October 2011ThomasOntology Term : 'signaling pathway' added !
42123view21:58, 4 March 2011MaintBotAutomatic update
39933view05:57, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARHGAP35 ProteinQ9NRY4 (Uniprot-TrEMBL)
ARHGAP35ProteinQ9NRY4 (Uniprot-TrEMBL)
ARHGEF11 ProteinO15085 (Uniprot-TrEMBL)
ARHGEF11,ARHGEF12ComplexR-HSA-416544 (Reactome)
ARHGEF12 ProteinQ9NZN5 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Activated ROCK:RhoA/B/C:GTPComplexR-HSA-422483 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
CD72 ProteinP21854 (Uniprot-TrEMBL)
CD72ProteinP21854 (Uniprot-TrEMBL)
CDK5 ProteinQ00535 (Uniprot-TrEMBL)
CDK5:p35ComplexR-HSA-421107 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRMP's tetramersComplexR-HSA-399843 (Reactome)
CRMP1 ProteinQ14194 (Uniprot-TrEMBL)
DPYSL2 ProteinQ16555 (Uniprot-TrEMBL)
DPYSL3 ProteinQ14195 (Uniprot-TrEMBL)
DPYSL4 ProteinO14531 (Uniprot-TrEMBL)
DPYSL5 ProteinQ9BPU6 (Uniprot-TrEMBL)
ERBB2 ProteinP04626 (Uniprot-TrEMBL)
FARP2 ProteinO94887 (Uniprot-TrEMBL)
FARP2:PIP5KIgammaComplexR-HSA-399839 (Reactome)
FARP2ProteinO94887 (Uniprot-TrEMBL)
FES ProteinP07332 (Uniprot-TrEMBL)
FESProteinP07332 (Uniprot-TrEMBL)
FYN ProteinP06241 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GSK3BProteinP49841 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HSP90AA1 ProteinP07900 (Uniprot-TrEMBL)
HSP90AA1,HSP90AB1ComplexR-HSA-419619 (Reactome)
HSP90AB1 ProteinP08238 (Uniprot-TrEMBL)
ITGA1 ProteinP56199 (Uniprot-TrEMBL)
ITGB1 ProteinP05556 (Uniprot-TrEMBL)
Integrin alpha1beta1ComplexR-HSA-215982 (Reactome)
LIM KinasesComplexR-HSA-419708 (Reactome)
LIMK1 ProteinP53667 (Uniprot-TrEMBL)