RNA Polymerase II Transcription (Homo sapiens)

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4823, 3656735630, 67402956408, 8553299, 22, 56, 594017, 21, 40, 54, 57...29171779563, 17, 76, 844, 26, 4717, 814017, 817316, 19, 78, 846532652, 726115, 50566517, 84175617, 81, 865617, 81, 865640, 824, 26, 4760nucleoplasmTAF12 RTF1 GTF2F2 CDK7 POLR2H TAF7 POLR2F TCEB3 POLR2G GTF2H4 SYMPK LSM11 template:capped transcript hybrid POLR2B MAGOHB POLR2L GTF2H1 LEO1 GTF2F1 3'-end cleaved mRNA with spliced exons POLR2D NCBP2 CCNK template DNA:30 nt transcript hybrid CTDP1 p-SUPT5H GTF2H2 NELFA EIF4A3 NELFB TAF5 TAF5 POLR2A POLR2H PPiPOLR2D CTP GTF2A1(275-376) MLLT1 POLR2J CDK7 TAF13 GTP TAF2 POLR2E GTF2F2 TAF10 NTPPOLR2F MAGOH p-SUPT5H TAF6 GTF2H3 TCEB3CL2 upstreammRNAfragment:CPSF:PAP:PABPN1 complexNCBP2 GTP POLR2H POLR2I POLR2A GTF2H4 POLR2I ERCC3 POLR2J TAF4 GTF2H3 CTDP1 POLR2H CSTF3 ERCC2 GTF2F1 CSTF2 EAF1 MNAT1 POLR2H POLR2I GTF2F2 TAF5 POLR2G GTF2H1 TAF4B POLR2A TCEB3CL2 CCNT1 POLR2A CSTF2T EAF2 GTF2BTFIIEGTF2H2 GTF2A2 GTF2F2 GTF2H2 SUPT6H POLR2H CTP SUPT4H1 NELFCD GTF2F2 POLR2A PAF1 TCEB3C LSM10 CCNT1 TAF2 GTF2H5 TCEB2 NCBP1 POLR2G GTF2H3 TAF12 NELFCD CCNH GTF2H5 POLR2B POLR2D GTF2H4 TCEB3CL2 SUPT6H GTF2H5 CF I - 68 kDa subunit POLR2G TAF4 UTP GTF2F2 TAF9B MNAT1 POLR2B TAF9B TCEB3CL2 POLR2C TAF13 NCBP2 CDK7 TAF1 GTF2A2 POLR2I CLP1 CCNH POLR2K GTF2H4 MNAT1 PPiPOLR2F GTF2H1 CCNT1 FIP1L1 TAF1 CPSF1 NTPERCC2 SUPT16H template DNA:30 nt transcript hybrid ERCC2 SUPT16H Early elongationcomplex withhyperphosphorylatedPol II CTDTAF7L POLR2I NELFA NELFE POLR2A CF I - 72 kDa subunit ERCC3 POLR2K POLR2C POLR2B AFF4 RNGTTGTF2H2 RNMT POLR2C UTP SSRP1 CDK9 TCEB1 POLR2L POLR2L CTDP1 TCEA1 NELFA CLP1 POLR2A ATP POLR2E TAF1L POLDIP3 Elongation complexwith separated anduncleavedtranscriptCCNT1 CCNT1 WDR61 MNAT1 TFIIHSSRP1MNAT1 POLR2L POLR2A SSRP1 upstream intronless mRNA fragment GTF2H2 TAF7L GTF2E1 CTR9 TAF15 TAF6 SNRPG EAF1 POLR2I CTP UTP U7 snRNP:ZNF473ATP POLR2E TCEB3B MLLT3 POLR2B RTF1 POLR2L GTF2H5 NCBP2 TAF9B TAF10 TCEB1GTF2H5 GTF2E1 POLR2H template DNA:30 nt transcript hybrid TAF11 NUDT21 GTF2F2 POLR2L POLR2E GTF2H3 GTF2H5 NELF complexRNA Pol II withphosphorylated CTD:CE complex withactivated GTSLBP capped pre-mRNA template DNA:4-9 nucleotide transcript hybrid GTF2A1(275-376) SNRPD3 MLLT3 PAPOLA p-SUPT5H POLR2I GTF2E2 POLR2F ERCC3 POLR2B NELFCD POLR2C FYTTD1 GTP POLR2L POLR2D POLR2E SUPT4H1 NTPATP GTF2F1 GTF2H4 GTF2A1(275-376) ELL GTF2H2 GTF2F2 TAF4 GTF2A2 TAF9 NELFE ATP p-S5-POLR2A p-S5-POLR2A GTF2A1(1-274) TAF4 SUPT4H1 POLR2J Mature Intronless transcript derived Histone mRNA TAF1 TAF9B NELFE CDK9 TAF11 GTF2F2 GTF2H5 DNA containing RNA Polymerase II promoter CDK7 POLR2A p-SUPT5H GTF2E1 RNMTAFF4 NELFCD CDK7 SYMPK TAF11 GTF2B pol IIpromoter:TFIIDcomplexEAF2 CF I - 68 kDa subunit TAF11 TAF6 TAF7L POLR2K SUPT4H1 POLR2F EIF4A3 POLR2C POLR2I THOC7 GTF2A1(275-376) TAF11 POLR2G POLR2L POLR2C CDK9 TCEB3B ELLTCEB3 POLR2D NTPPOLR2F POLR2H CTP POLR2G SYMPK Elongin B:C complexTAF6 DDX39B DNA containing RNA Polymerase II promoter GTF2A1(1-274) RTF1 POLR2F GTF2F2 GTF2B POLR2J POLR2K Aborted elongationcomplex afterarrestPCF11 capped pre-mRNA GTF2H5 CTDP1 TAF7 CSTF3 CLP1 CPSF4 POLR2I NCBP1 POLR2F GTF2H1 POLR2H TAF15 TAF11 POLR2L LEO1 CCNT2 TAF9 RNAPolII(hypophosphorylated) complex bound to DSIF proteinERCC2 POLR2G POLR2J TCEA1 ATPPOLR2H CDC73 SNRPD3 CCNT2 CDK7 ATP POLR2E GTF2H5 template DNA withfirst transcriptdinucleotide,opened to +8positionTAF6 POLR2F TFIIFSNRPE CTDP1 GTF2F2 EAF1 ERCC3 TAF13 TAF1L POLR2E SRSF4 GTF2B NELFE ERCC2 GTP POLR2I TCEB3B GTF2F1 TAF3 GTF2H5 POLR2C TFIIEGTF2H4 POLR2J SRSF5 GTF2H5 CDK9TAF3 TCEB3 ELL POLR2L MLLT1 GTF2H5 GTF2H2 POLR2K TAF11 GTF2F2 DHX38 POLR2J TAF5 GTF2H2 THOC3 TAF5 GTF2F2 GTF2F2 TAF1 TAF10 PiPOLR2I SRRM1 WDR61 TAF12 GTF2H1 SRSF7 CCNH POLR2B hSLU7 CDK9 CTR9 CTR9 TCEB3CL CDK7 POLR2C POLR2B GTF2F1 GTF2F2 GTF2H1 POLR2F SNRPF TCEB2 GTF2H4 POLR2G TBP POLR2F POLR2C U2AF2 CTR9 UPF3B TCEB3CL2 NELFB GTF2A1(1-274) ERCC2 ATP Elongation complexCTP GTF2F1 NELFA POLR2D CPSF2 POLR2D CTP TAF4 POLR2B POLR2L POLR2J TCEB3CL CCNT1 POLR2L GTF2H4 TAF12 EAF2 Template DNA hybrid with phosphodiester-PPi intermediate POLR2D GTF2F1 POLR2G p-S5-POLR2A TCEB3 Elongin Complexpol II transcriptioncomplex containing3 Nucleotide longtranscriptGTF2H1 ZC3H11A POLR2H TAF4 POLR2H pol II transcriptioncomplex containing9 nucleotide longtranscriptCDK7 TAF15 SUPT4H1 POLR2K POLR2J 3' end cleaved,ligated exoncontaining complexPOLR2D SUPT16H SRSF2 TCEB2 NCBP2 GTF2F1 POLR2K TBP TCEA1 CCNT1 POLR2H TCEB3B POLR2C TAF1 NUDT21 GTF2F1 ATP POLR2D NELFA POLR2B POLR2B TAF4B ERCC3 POLR2J POLR2C POLR2K NTPERCC2 POLR2F Capped IntronlessHistonepre-mRNA:CBC:ZFP100ComplexGTF2A1(275-376) TCEB3CL POLR2K CCNK TAF10 GTF2F2 POLR2E TAF3 GTF2H3 PPiTAF9B POLR2F POLR2C ERCC2 Processiveelongation complexNTPTAF9B CTDP1 UTP CASC3 CPSF3 DDX39A CDC73 ERCC2 POLR2F ERCC2 GTF2F2 MNAT1 GTF2E2 NELFE MLLT1 POLR2K p-S2,S5-POLR2A TAF15 GTF2F1 POLR2J POLR2L MNAT1 CCNH SSRP1 ERCC3 GTF2H1 MLLT3 TAF11 TAF1L ATP POLR2J UTP TCEB1 GTF2H4 GTF2H2 RNAPolymeraseIIholoenzymecomplex(hyperphosphorylated)TCEB3B pol II transcriptioncomplex containing4-9 nucleotide longtranscriptPOLR2E TCEB3C GTF2H3 FYTTD1 WDR61 GTF2H2 POLR2K PAF1 CDK7 TAF5 SNRPB CDK7 TAF12 GTF2F1 TCEA1 CF I - 72 kDa subunit GTF2H3 TAF13 LEO1 p-S2,S5-POLR2A GTF2H1 EAF1 CDK7 GTF2F1 POLR2E GTP POLR2E TCEB3B NCBP2 NCBP1 EAF2TAF9 GTF2H4 CTP p-S5-POLR2A MNAT1 CPSF2 NCBP2 GTF2H2 ATP TCEB3CL GTF2E1 Cap Binding Complex(CBC)POLR2E TCEB3 TAF10 POLR2J GTF2F1 NELFCDCSTF1 CPSF4 NELFB pol II openpre-initiationcomplexCTP TCEB3CL PAPOLA POLR2I GTF2H2 ATPNELFCD Capped intronless pre-mRNA POLR2B ERCC2 POLR2L template DNA:4 nucleotide transcript hybrid ERCC3 GTF2A1(1-274) p-SUPT5H TAF15 POLR2B pol II closedpre-initiationcomplexTAF7 POLR2I TAF1L ERCC3 TCEB3B CCNK NCBP1 POLR2J TAF3 GTF2E2 GTF2H1 TAF7 POLR2F POLR2D FIP1L1 POLR2H GTF2H3 POLR2K ERCC2 TCEB3 ATP NELFCD SRSF2 TAF10 NTPPOLR2H NELFB CF I - 68 kDa subunit POLR2B GTF2F2 UTP DNA containing RNA Polymerase II promoter SRSF9 GTF2A1(275-376) SYMPK TAF15 TAF1 MLLT1 POLR2K TAF5 UPF3B THOC7 THOC6 intronless pre-mRNAcleavage complexCTR9 GTF2H4 RBM8A UTP POLR2C CCNT2 TAF9 TAF4 GTF2H1 GTF2F2 SRSF9 POLR2H PPiGTF2H5 TAF1L POLR2A GTF2H3 UTP p-S2,S5-POLR2A CDC73 GTP POLR2J TAF13 SUPT16H Pol II transcriptioncomplex containingtranscript to +30ERCC2 U2AF1L4 ATP GTF2A2 POLR2F POLR2J POLR2H CCNT1 NCBP1 TAF13 TCEB2CCNT1 GTF2H5 POLR2K mRNA with spliced exons TAF9 POLR2D RNAPolII(hypophosphorylated):capped pre-mRNA complexGTF2H2 CCNH GTF2H2 POLR2J POLR2J ALYREF NUDT21 POLR2J SRSF11 TBP POLR2J GTP ZNF473 TAF2 POLR2D NELFE GTP TAF4B TAF10 GTF2H5 POLR2L ATP PPiTCEB3C CCNH POLR2G NCBP1 TAF3 TAF6 CCNH POLR2C POLR2F CTP NCBP1 CCNH TBP GTP downstreamintronless mRNAfragmentPOLR2F TAF6 CDK7 TAF15 POLR2H MNAT1 TAF9B POLR2J POLR2L TCEB3CL2 TBP DNA containing PolII promoter withtranscript with 2or 3 nucleotidesPOLR2B GTF2H5 TAF6 GTF2E2 FACT complexCTDP1 POLR2B TAF3 TCEB3CL RTF1 TCEB3CL GTF2A1(275-376) CCNK TCEB3 CPSF2 GTF2F2 SRSF7 TAF7L GTP POLR2I SRSF5 U2AF1 NCBP1 NCBP2 POLR2H TAF7 CPSF1 CPSF7 POLR2K CCNT1,CCNT2,CCNKGTF2A1(275-376) POLR2C TAF9B IWS1 CSTF2T POLR2F TAF4B GTF2A1(1-274) p-SUPT5H SUPT6H ERCC3 U7 snRNA TAF9B PAF1 POLR2J TAF12 GTF2A1(1-274) Arrested processiveelongation complexTCEB3CL2 TAF5 POLR2G ERCC3 POLR2D CTP GTF2B CDC40 POLR2C TAF10 DNA containing RNA Polymerase II promoter POLR2D CDK9 POLR2C GTF2F2 POLR2E SSRP1 TBP PABPN1 POLR2C GTF2H2 GTF2F1 SSRP1 NELFCD TAF5 GTF2E2 TCEB3C TAF15 POLR2I TAF13 GTF2H4 ATP GTP NTPLUZP4 POLR2D TAF7 DHX38 SLBP CDK7 U7 snRNA NTPTAF6 TAF1 GTF2A1(1-274) ERCC3 MatureIntronlesstranscriptderivedHistonemRNA:SLBP:CBP80:CBP20NELFA TFIIHGTF2F1 POLR2I POLR2H DDX39B CTDP1 NELFB GTF2H1 CPSF7 CCNT2 POLR2I POLR2D POLR2I CCNT2 RTF1 GTF2H2 p-S2,S5-POLR2A POLR2E POLR2K TAF13 POLR2C POLR2K GTF2A2 SNRPF SUPT4H1 GTF2F1 TAF9 POLR2A TAF1L ADPPOLR2E GTF2H2 GTP GTF2A2 LSM11 SNRPG CCNH TAF3 MNAT1 POLR2I THOC2 RNPS1 POLR2C POLR2H POLR2I ERCC2 POLR2J damaged DNAsubstrate:nascentmRNA hybridNELFA IWS1 POLR2G TCEB3C GTF2H1 NELFB ZNF473 TAF1 ERCC3 MLLT1 SRSF6 CLP1 ZC3H11A Intronless Histone pre-mRNA POLR2J GTF2F2 POLR2D Elongating transcript in processive Pol II mediated elongation GenericTranscriptionPathwayCDC73 POLR2F GTF2F2 CDK7 AMPPAF1 PPiPOLR2E TAF2 TAF9 GTF2H1 TAF13 TCEB3CL2 CDC73 TAF7 Pol II transcriptioncomplex with (ser5)phosphorylated CTDcontaining extrudedtranscript to +30POLR2G ERCC2 POLR2F EAF1 GTF2F2 TFIIHCF I - 68 kDa subunit POLR2H CTP GTF2H4 POLR2E P-TEFb complexU2AF2 GTF2E1 p-SUPT5HhSLU7 WDR33 POLR2K TAF9B Open DNA -10 to +2 containing RNA Polymerase II promoter TAF13 POLR2K CCNT2 MNAT1 GTF2A2 GTF2H4 POLR2C Pol II transcriptioncomplex containingextruded transcriptto +30SUPT4H1 PCF11