RNA Polymerase II Transcription (Homo sapiens)
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30, 67
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29
17
17
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56
3, 17, 76, 84
4, 26, 47
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40
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16, 19, 78, 84
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32
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15, 50
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4, 26, 47
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nucleoplasm
TAF12
RTF1
GTF2F2
CDK7
POLR2H
TAF7
POLR2F
TCEB3
POLR2G
GTF2H4
SYMPK
LSM11
template:capped transcript hybrid
POLR2B
MAGOHB
POLR2L
GTF2H1
LEO1
GTF2F1
3'-end cleaved mRNA with spliced exons
POLR2D
NCBP2
CCNK
template DNA:30 nt transcript hybrid
CTDP1
p-SUPT5H
GTF2H2
NELFA
EIF4A3
NELFB
TAF5
TAF5
POLR2A
POLR2H
PPi
POLR2D
CTP
GTF2A1(275-376)
MLLT1
POLR2J
CDK7
TAF13
GTP
TAF2
POLR2E
GTF2F2
TAF10
NTP
POLR2F
MAGOH
p-SUPT5H
TAF6
GTF2H3
TCEB3CL2
upstream
mRNA
fragment:CPSF:PAP:PABPN1 complex
NCBP2
GTP
POLR2H
POLR2I
POLR2A
GTF2H4
POLR2I
ERCC3
POLR2J
TAF4
GTF2H3
CTDP1
POLR2H
CSTF3
ERCC2
GTF2F1
CSTF2
EAF1
MNAT1
POLR2H
POLR2I
GTF2F2
TAF5
POLR2G
GTF2H1
TAF4B
POLR2A
TCEB3CL2
CCNT1
POLR2A
CSTF2T
EAF2
GTF2B
TFIIE
GTF2H2
GTF2A2
GTF2F2
GTF2H2
SUPT6H
POLR2H
CTP
SUPT4H1
NELFCD
GTF2F2
POLR2A
PAF1
TCEB3C
LSM10
CCNT1
TAF2
GTF2H5
TCEB2
NCBP1
POLR2G
GTF2H3
TAF12
NELFCD
CCNH
GTF2H5
POLR2B
POLR2D
GTF2H4
TCEB3CL2
SUPT6H
GTF2H5
CF I - 68 kDa subunit
POLR2G
TAF4
UTP
GTF2F2
TAF9B
MNAT1
POLR2B
TAF9B
TCEB3CL2
POLR2C
TAF13
NCBP2
CDK7
TAF1
GTF2A2
POLR2I
CLP1
CCNH
POLR2K
GTF2H4
MNAT1
PPi
POLR2F
GTF2H1
CCNT1
FIP1L1
TAF1
CPSF1
NTP
ERCC2
SUPT16H
template DNA:30 nt transcript hybrid
ERCC2
SUPT16H
Early elongation
complex with
hyperphosphorylated
Pol II CTD
TAF7L
POLR2I
NELFA
NELFE
POLR2A
CF I - 72 kDa subunit
ERCC3
POLR2K
POLR2C
POLR2B
AFF4
RNGTT
GTF2H2
RNMT
POLR2C
UTP
SSRP1
CDK9
TCEB1
POLR2L
POLR2L
CTDP1
TCEA1
NELFA
CLP1
POLR2A
ATP
POLR2E
TAF1L
POLDIP3
Elongation complex
with separated and
uncleaved
transcript
CCNT1
CCNT1
WDR61
MNAT1
TFIIH
SSRP1
MNAT1
POLR2L
POLR2A
SSRP1
upstream intronless mRNA fragment
GTF2H2
TAF7L
GTF2E1
CTR9
TAF15
TAF6
SNRPG
EAF1
POLR2I
CTP
UTP
U7 snRNP:ZNF473
ATP
POLR2E
TCEB3B
MLLT3
POLR2B
RTF1
POLR2L
GTF2H5
NCBP2
TAF9B
TAF10
TCEB1
GTF2H5
GTF2E1
POLR2H
template DNA:30 nt transcript hybrid
TAF11
NUDT21
GTF2F2
POLR2L
POLR2E
GTF2H3
GTF2H5
NELF complex
RNA Pol II with
phosphorylated CTD:
CE complex with
activated GT
SLBP
capped pre-mRNA
template DNA:4-9 nucleotide transcript hybrid
GTF2A1(275-376)
SNRPD3
MLLT3
PAPOLA
p-SUPT5H
POLR2I
GTF2E2
POLR2F
ERCC3
POLR2B
NELFCD
POLR2C
FYTTD1
GTP
POLR2L
POLR2D
POLR2E
SUPT4H1
NTP
ATP
GTF2F1
GTF2H4
GTF2A1(275-376)
ELL
GTF2H2
GTF2F2
TAF4
GTF2A2
TAF9
NELFE
ATP
p-S5-POLR2A
p-S5-POLR2A
GTF2A1(1-274)
TAF4
SUPT4H1
POLR2J
Mature Intronless transcript derived Histone mRNA
TAF1
TAF9B
NELFE
CDK9
TAF11
GTF2F2
GTF2H5
DNA containing RNA Polymerase II promoter
CDK7
POLR2A
p-SUPT5H
GTF2E1
RNMT
AFF4
NELFCD
CDK7
SYMPK
TAF11
GTF2B
pol II
promoter:TFIID
complex
EAF2
CF I - 68 kDa subunit
TAF11
TAF6
TAF7L
POLR2K
SUPT4H1
POLR2F
EIF4A3
POLR2C
POLR2I
THOC7
GTF2A1(275-376)
TAF11
POLR2G
POLR2L
POLR2C
CDK9
TCEB3B
ELL
TCEB3
POLR2D
NTP
POLR2F
POLR2H
CTP
POLR2G
SYMPK
Elongin B:C complex
TAF6
DDX39B
DNA containing RNA Polymerase II promoter
GTF2A1(1-274)
RTF1
POLR2F
GTF2F2
GTF2B
POLR2J
POLR2K
Aborted elongation
complex after
arrest
PCF11
capped pre-mRNA
GTF2H5
CTDP1
TAF7
CSTF3
CLP1
CPSF4
POLR2I
NCBP1
POLR2F
GTF2H1
POLR2H
TAF15
TAF11
POLR2L
LEO1
CCNT2
TAF9
RNA
Pol
II
(hypophosphorylated) complex bound to DSIF protein
ERCC2
POLR2G
POLR2J
TCEA1
ATP
POLR2H
CDC73
SNRPD3
CCNT2
CDK7
ATP
POLR2E
GTF2H5
template DNA with
first transcript
dinucleotide,
opened to +8
position
TAF6
POLR2F
TFIIF
SNRPE
CTDP1
GTF2F2
EAF1
ERCC3
TAF13
TAF1L
POLR2E
SRSF4
GTF2B
NELFE
ERCC2
GTP
POLR2I
TCEB3B
GTF2F1
TAF3
GTF2H5
POLR2C
TFIIE
GTF2H4
POLR2J
SRSF5
GTF2H5
CDK9
TAF3
TCEB3
ELL
POLR2L
MLLT1
GTF2H5
GTF2H2
POLR2K
TAF11
GTF2F2
DHX38
POLR2J
TAF5
GTF2H2
THOC3
TAF5
GTF2F2
GTF2F2
TAF1
TAF10
Pi
POLR2I
SRRM1
WDR61
TAF12
GTF2H1
SRSF7
CCNH
POLR2B
hSLU7
CDK9
CTR9
CTR9
TCEB3CL
CDK7
POLR2C
POLR2B
GTF2F1
GTF2F2
GTF2H1
POLR2F
SNRPF
TCEB2
GTF2H4
POLR2G
TBP
POLR2F
POLR2C
U2AF2
CTR9
UPF3B
TCEB3CL2
NELFB
GTF2A1(1-274)
ERCC2
ATP
Elongation complex
CTP
GTF2F1
NELFA
POLR2D
CPSF2
POLR2D
CTP
TAF4
POLR2B
POLR2L
POLR2J
TCEB3CL
CCNT1
POLR2L
GTF2H4
TAF12
EAF2
Template DNA hybrid with phosphodiester-PPi intermediate
POLR2D
GTF2F1
POLR2G
p-S5-POLR2A
TCEB3
Elongin Complex
pol II transcription
complex containing
3 Nucleotide long
transcript
GTF2H1
ZC3H11A
POLR2H
TAF4
POLR2H
pol II transcription
complex containing
9 nucleotide long
transcript
CDK7
TAF15
SUPT4H1
POLR2K
POLR2J
3' end cleaved,
ligated exon
containing complex
POLR2D
SUPT16H
SRSF2
TCEB2
NCBP2
GTF2F1
POLR2K
TBP
TCEA1
CCNT1
POLR2H
TCEB3B
POLR2C
TAF1
NUDT21
GTF2F1
ATP
POLR2D
NELFA
POLR2B
POLR2B
TAF4B
ERCC3
POLR2J
POLR2C
POLR2K
NTP
ERCC2
POLR2F
Capped Intronless
Histone
pre-mRNA:CBC:ZFP100
Complex
GTF2A1(275-376)
TCEB3CL
POLR2K
CCNK
TAF10
GTF2F2
POLR2E
TAF3
GTF2H3
PPi
TAF9B
POLR2F
POLR2C
ERCC2
Processive
elongation complex
NTP
TAF9B
CTDP1
UTP
CASC3
CPSF3
DDX39A
CDC73
ERCC2
POLR2F
ERCC2
GTF2F2
MNAT1
GTF2E2
NELFE
MLLT1
POLR2K
p-S2,S5-POLR2A
TAF15
GTF2F1
POLR2J
POLR2L
MNAT1
CCNH
SSRP1
ERCC3
GTF2H1
MLLT3
TAF11
TAF1L
ATP
POLR2J
UTP
TCEB1
GTF2H4
GTF2H2
RNA
Polymerase
II
holoenzyme
complex
(hyperphosphorylated)
TCEB3B
pol II transcription
complex containing
4-9 nucleotide long
transcript
POLR2E
TCEB3C
GTF2H3
FYTTD1
WDR61
GTF2H2
POLR2K
PAF1
CDK7
TAF5
SNRPB
CDK7
TAF12
GTF2F1
TCEA1
CF I - 72 kDa subunit
GTF2H3
TAF13
LEO1
p-S2,S5-POLR2A
GTF2H1
EAF1
CDK7
GTF2F1
POLR2E
GTP
POLR2E
TCEB3B
NCBP2
NCBP1
EAF2
TAF9
GTF2H4
CTP
p-S5-POLR2A
MNAT1
CPSF2
NCBP2
GTF2H2
ATP
TCEB3CL
GTF2E1
Cap Binding Complex
(CBC)
POLR2E
TCEB3
TAF10
POLR2J
GTF2F1
NELFCD
CSTF1
CPSF4
NELFB
pol II open
pre-initiation
complex
CTP
TCEB3CL
PAPOLA
POLR2I
GTF2H2
ATP
NELFCD
Capped intronless pre-mRNA
POLR2B
ERCC2
POLR2L
template DNA:4 nucleotide transcript hybrid
ERCC3
GTF2A1(1-274)
p-SUPT5H
TAF15
POLR2B
pol II closed
pre-initiation
complex
TAF7
POLR2I
TAF1L
ERCC3
TCEB3B
CCNK
NCBP1
POLR2J
TAF3
GTF2E2
GTF2H1
TAF7
POLR2F
POLR2D
FIP1L1
POLR2H
GTF2H3
POLR2K
ERCC2
TCEB3
ATP
NELFCD
SRSF2
TAF10
NTP
POLR2H
NELFB
CF I - 68 kDa subunit
POLR2B
GTF2F2
UTP
DNA containing RNA Polymerase II promoter
SRSF9
GTF2A1(275-376)
SYMPK
TAF15
TAF1
MLLT1
POLR2K
TAF5
UPF3B
THOC7
THOC6
intronless pre-mRNA
cleavage complex
CTR9
GTF2H4
RBM8A
UTP
POLR2C
CCNT2
TAF9
TAF4
GTF2H1
GTF2F2
SRSF9
POLR2H
PPi
GTF2H5
TAF1L
POLR2A
GTF2H3
UTP
p-S2,S5-POLR2A
CDC73
GTP
POLR2J
TAF13
SUPT16H
Pol II transcription
complex containing
transcript to +30
ERCC2
U2AF1L4
ATP
GTF2A2
POLR2F
POLR2J
POLR2H
CCNT1
NCBP1
TAF13
TCEB2
CCNT1
GTF2H5
POLR2K
mRNA with spliced exons
TAF9
POLR2D
RNA
Pol
II
(hypophosphorylated):capped pre-mRNA complex
GTF2H2
CCNH
GTF2H2
POLR2J
POLR2J
ALYREF
NUDT21
POLR2J
SRSF11
TBP
POLR2J
GTP
ZNF473
TAF2
POLR2D
NELFE
GTP
TAF4B
TAF10
GTF2H5
POLR2L
ATP
PPi
TCEB3C
CCNH
POLR2G
NCBP1
TAF3
TAF6
CCNH
POLR2C
POLR2F
CTP
NCBP1
CCNH
TBP
GTP
downstream
intronless mRNA
fragment
POLR2F
TAF6
CDK7
TAF15
POLR2H
MNAT1
TAF9B
POLR2J
POLR2L
TCEB3CL2
TBP
DNA containing Pol
II promoter with
transcript with 2
or 3 nucleotides
POLR2B
GTF2H5
TAF6
GTF2E2
FACT complex
CTDP1
POLR2B
TAF3
TCEB3CL
RTF1
TCEB3CL
GTF2A1(275-376)
CCNK
TCEB3
CPSF2
GTF2F2
SRSF7
TAF7L
GTP
POLR2I
SRSF5
U2AF1
NCBP1
NCBP2
POLR2H
TAF7
CPSF1
CPSF7
POLR2K
CCNT1,CCNT2,CCNK
GTF2A1(275-376)
POLR2C
TAF9B
IWS1
CSTF2T
POLR2F
TAF4B
GTF2A1(1-274)
p-SUPT5H
SUPT6H
ERCC3
U7 snRNA
TAF9B
PAF1
POLR2J
TAF12
GTF2A1(1-274)
Arrested processive
elongation complex
TCEB3CL2
TAF5
POLR2G
ERCC3
POLR2D
CTP
GTF2B
CDC40
POLR2C
TAF10
DNA containing RNA Polymerase II promoter
POLR2D
CDK9
POLR2C
GTF2F2
POLR2E
SSRP1
TBP
PABPN1
POLR2C
GTF2H2
GTF2F1
SSRP1
NELFCD
TAF5
GTF2E2
TCEB3C
TAF15
POLR2I
TAF13
GTF2H4
ATP
GTP
NTP
LUZP4
POLR2D
TAF7
DHX38
SLBP
CDK7
U7 snRNA
NTP
TAF6
TAF1
GTF2A1(1-274)
ERCC3
Mature
Intronless
transcript
derived
Histone
mRNA:SLBP:CBP80:CBP20
NELFA
TFIIH
GTF2F1
POLR2I
POLR2H
DDX39B
CTDP1
NELFB
GTF2H1
CPSF7
CCNT2
POLR2I
POLR2D
POLR2I
CCNT2
RTF1
GTF2H2
p-S2,S5-POLR2A
POLR2E
POLR2K
TAF13
POLR2C
POLR2K
GTF2A2
SNRPF
SUPT4H1
GTF2F1
TAF9
POLR2A
TAF1L
ADP
POLR2E
GTF2H2
GTP
GTF2A2
LSM11
SNRPG
CCNH
TAF3
MNAT1
POLR2I
THOC2
RNPS1
POLR2C
POLR2H
POLR2I
ERCC2
POLR2J
damaged DNA
substrate:nascent
mRNA hybrid
NELFA
IWS1
POLR2G
TCEB3C
GTF2H1
NELFB
ZNF473
TAF1
ERCC3
MLLT1
SRSF6
CLP1
ZC3H11A
Intronless Histone pre-mRNA
POLR2J
GTF2F2
POLR2D
Elongating transcript in processive Pol II mediated elongation
Generic
Transcription
Pathway
CDC73
POLR2F
GTF2F2
CDK7
AMP
PAF1
PPi
POLR2E
TAF2
TAF9
GTF2H1
TAF13
TCEB3CL2
CDC73
TAF7
Pol II transcription
complex with (ser5)
phosphorylated CTD
containing extruded
transcript to +30
POLR2G
ERCC2
POLR2F
EAF1
GTF2F2
TFIIH
CF I - 68 kDa subunit
POLR2H
CTP
GTF2H4
POLR2E
P-TEFb complex
U2AF2
GTF2E1
p-SUPT5H
hSLU7
WDR33
POLR2K
TAF9B
Open DNA -10 to +2 containing RNA Polymerase II promoter
TAF13
POLR2K
CCNT2
MNAT1
GTF2A2
GTF2H4
POLR2C
Pol II transcription
complex containing
extruded transcript
to +30
SUPT4H1
PCF11