DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
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nucleoplasm
mitochondrion
cytosol
CASP8(385-479)
CREBBP
TRIM25
IFIH1
ATP
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3
MV dsRNA intermediate form
MAVS
TRIM25
5'-ppp poly-U/UC RNA variants
MAVS
ATP
CREBBP
IKBKE
IFIH1
TRIM25
RV RNA
TRIM25
NKIRAS2
MAVS
IFIH1
IFIH1
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6
TAX1BP1:TNFAIP3
TRIM25
IRF3
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH
p-4S,T404-IRF3,p-S477,S479-IRF7
TRIM25
TANK
K63polyUb-DDX58
TRAF6
RV RNA
RNF135
ATP
2xviral
dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP
RNF135
K63polyUb-DDX58
MAVS
p-S477,S479-IRF7
K63polyUb-DDX58
Influenza A dsRNA intermediate form
TBK1
HMGB1
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi
EP300
UBC(305-380)
CREBBP
CASP8(375-384)
K63polyUb-DDX58
RIPK1
IFIH1
IFNB1
TRIM25
K63polyUb-DDX58
TRAF2
RNF135
p-5S,T404-IRF3
MV dsRNA intermediate form
p-S477,S479-IRF7
5'-ppp poly-U/UC RNA variants
NFKB1(1-433)
MAVS
PCBP2
MAVS:NLRX1
ISG15
ITCH
IFIH1
TBK1
TBK1/IKKi:SIKE1
IRF3
NLRX1
p-T,4S-IRF3:p-T,4S-IRF3
FADD
CHUK
TRIM25
5'-ppp poly-U/UC RNA variants
ATP
MV dsRNA intermediate form
viral
dsRNA:IFIH1,
2xviral
dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5
IFIH1
MAVS
Influenza A dsRNA intermediate form
MAVS
ATP
IKBKE
TRAF2
RIPK1
CASP10(416-521)
IFIH1
TAX1BP1
RNF135
UBC(533-608)
TANK
IKBKG
UBC(609-684)
TRIM25
UBE2D1
RNF135
MAVS
TRIM25
IFIH1
MV dsRNA intermediate form
Influenza A dsRNA intermediate form
TRIM25
IKBKE
RIPK1
ATP
RV RNA
p-S176,S180-CHUK
MV dsRNA intermediate form
5'-ppp poly-U/UC RNA variants
K63polyUb-TRAF3
Influenza A dsRNA intermediate form
UBE2L6
MAP3K1
UBE2L6
MV dsRNA intermediate form
S100B
RV RNA
CREBBP
PCBP2
UBC(381-456)
IFIH1
ATP
DDX58
TRAF6
IRF3
DDX58
CASP8(1-216)
dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex
p-S32,S36-NFKBIA
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7
TKFC
NFKB1(1-433)
p-4S,T404-IRF3
RELA
IFIH1
5'-ppp poly-U/UC RNA variants
FADD
IRF7
IFIH1
TBK1
EP300
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300
RV RNA
ATP
CHUK
TANK
Influenza A dsRNA intermediate form
ATG5
ATG12
FADD
K48polyUb-DDX58,K48polyUb-IFIH1
VAF/pIRF7:CBP/p300
SAA1(19-122)
CASP10(1-521)
CASP8(1-479),
CASP10(1-521)
DDX58, IFIH1
UBA7
TRAF6
RNF135
FADD
p-S477,S479-IRF7
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219)
ATP
MAVS
DDX58
5'-ppp poly-U/UC RNA variants
NFKB1(1-433),
NFKB2(1-454):RELA
ATP
IKBKB
IFNA
PIN1
p-IRF3 dimer:PIN1
K63polyUb-DDX58
5'-ppp poly-U/UC RNA variants
RNF135
IFN alpha/beta
(IFNA/B)
N-epsilon-(1-(1-carboxy)ethyl)lysine
ATP
p-IRF3:p-IRF3
UBC(457-532)
NKIRAS1
MV dsRNA intermediate form
OTUD5
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7
CHUK:IKBKB:IKBKG
K63polyUb-DDX58
RNF135
ATP
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:TRAF3
5'-ppp poly-U/UC RNA variants
Influenza A dsRNA intermediate form
ISG15:DDX58
conjugate
HERC5
Influenza A dsRNA intermediate form
Influenza A dsRNA intermediate form
MAVS
IFIH1
IFNA genes
FADD
p-2S-IRF7:p-2S-IRF7
RNF135
Influenza A dsRNA intermediate form
NFKBIA
DDX58 ligand
p-S477,S479-IRF7
TAX1BP1
ATP
UBE2K
MV dsRNA intermediate form
K48polyUb-MAVS
Type-I IFN genes
K48polyUb
K63polyUb-TRAF3
EP300
MV dsRNA intermediate form
K63polyUb-DDX58
NLRC5
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521)
VAF (virus-activated
factor)
IFIH1 ligand
FADD
H2O
RV RNA
ATP
IKBKE
MAVS
TRIM25
Influenza A dsRNA intermediate form
RV RNA
Influenza A dsRNA intermediate form
RELA
AGER
TKFC
UBE2L6
RIPK1
RNF125
CHUK
RV RNA
Influenza A dsRNA intermediate form
p-4S,T404-IRF3
RNF135
TRAF6
CBP/p300:pIRF7:pIRF7
VAF/pIRF7:CBP/p300
bound to type I IFN
gene promoter
IFIH1
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK
IFIH1
TRIM25
RV RNA
NKIRAS
ATP
dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12
RNF135
K63polyUb-DDX58
RV RNA
IKBKG
K63polyUb-DDX58
IFIH1
UBC(153-228)
ATG5:ATG12:MAVS
RNF135
RNF135
RIPK1
5'-ppp poly-U/UC RNA variants
SIKE1
DDX58
5'-ppp poly-U/UC RNA variants
K63polyUb-DDX58
IFIH1
IKBKE
TRAF6
Influenza A dsRNA intermediate form
MV dsRNA intermediate form
CASP10(1-219)
CREBBP
MV dsRNA intermediate form
Influenza A dsRNA intermediate form
RV RNA
CHUK:IKBKB:IKBKG
p-S477,S479-IRF7
IRF3-P:IRF7-P
TRIM25
p-T,4S-IRF3:p-T,4S-IRF3
TANK
RV RNA
ITCH
MV dsRNA intermediate form
S100A12
FADD
IFNA genes
p-4S,T404-IRF3
MV dsRNA intermediate form
ATP
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521)
MAP3K1
IRF7
CASP10(1-521)
CASP10(1-521)
K48polyUb-TRAF3
5'-ppp poly-U/UC RNA variants
NFkB inhibitor:NFkB
complex
IFIH1
UBC(229-304)
IFIH1
IKBKG
5'-ppp poly-U/UC RNA variants
5'-ppp poly-U/UC RNA variants
NFkB Complex
NLRC5
MAVS
K48polyUb-RNF125
5'-ppp poly-U/UC RNA variants
K63polyUb-DDX58
UBE2K
IKBKE
TRIM25
IFNB1
UBA52(1-76)
Influenza A dsRNA intermediate form
RV RNA
Ub
NFKB1(1-433)
TRIM25
ISG15:UBEIL/UbcH8:CEB1
RNF135
HERC5
ATP
RV RNA
RV RNA
RNF135
5'-ppp poly-U/UC RNA variants
EP300
TRAF6
p-S19,S23-NFKBIB
TBK1
RV RNA
RIPK1
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS
IFNB1 gene
MV dsRNA intermediate form
ADP
UBB(77-152)
MV dsRNA intermediate form
Influenza A dsRNA intermediate form
TRIM25
IKBKG
Influenza A dsRNA intermediate form
UBB(153-228)
K63polyUb-DDX58
UBE2D2
NFKB2(1-454)
K63polyUb
PCBP2
RNF135,TRIM25
IFIH1
UBE2D2
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:PCBP2
ADP
ISGylated IRF3
RNF135
Influenza A dsRNA intermediate form
CREBBP
EP300
UBE2L6
p-S477,S479-IRF7
MV dsRNA intermediate form
TRIM25
K48polyUb-IFIH1
RNF135
TBK1
EP300
TRAF2
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1
NFKB2(1-454)
NECML
RV RNA
RNF216
p-S477,S479-IRF7
TRIM25
ATG5
UBB(1-76)
TRIM25
MV dsRNA intermediate form
TRIM25
p-4S,T404-IRF3
IKK related kinases
TBK1/IKK epsilon
EP300
TNFAIP3
2x DDX58 ligand:2x
DDX58:2xATP
K63polyUb-TRAF3
SIKE1
ATP
5'-ppp poly-U/UC RNA variants
TRAF2
MAVS
MV dsRNA intermediate form
RV RNA
RV RNA
CASP10(1-219)
K63polyUb-DDX58
RELA
UBE2D1
RPS27A(1-76)
UBA7
K63polyUb-DDX58
RV RNA
TRAF2, TRAF6
CASP8(1-216)
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD
IFIH1
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB
Influenza A dsRNA intermediate form
ATP
p-4S,T404-IRF3
AGER ligands:AGER
Influenza A dsRNA intermediate form
5'-ppp poly-U/UC RNA variants
MAVS
IRF3,IRF7
CASP10(1-219)
CYLD
5'-ppp poly-U/UC RNA variants
Influenza A dsRNA intermediate form
K63polyUb-DDX58
MV dsRNA intermediate form
TRIM25
APP(672-711)
MAVS
IFIH1
Peptide
IKBKE
ATP
unknown ligase
IRF7
CREBBP
Influenza A dsRNA intermediate form
RIPK1
IFIH1
ISG15
IKBKB
viral
dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain
ATG12
ATP
5'-ppp poly-U/UC RNA variants
RNF135
RNF135
IFNB1 gene
5'-ppp poly-U/UC RNA variants
IFNB1 gene
IKBKB
p-5S,T404-IRF3
RNF135
CASP8(1-479)
TRIM25
E2 enzyme (UBE2K,
UbcH5a-c)
TBK1
TNFAIP3
Phospho-NF-kappaB
Inhibitor
TRAF3
K48polyUb
CREBBP,EP300
Influenza A dsRNA intermediate form
TAX1BP1:TNFAIP3:TBK1/IKKi
2xp-S477,S479-IRF7
RV RNA
ATP
IRF3-P:IRF7-P
K63polyUb-TRAF3
p-4S,T404-IRF3
PIN1
DHX58
TRAF2
MAVS
MAVS
p-S477,S479-IRF7
p-4S,T404-IRF3
CASP8(217-374)
RNF135
viral dsRNA:IFIH1
CASP8(1-479)
ATP
p-S477,S479-IRF7
K48polyUb-DDX58
5'-ppp poly-U/UC RNA variants
MAVS
Influenza A dsRNA intermediate form
IFNB1 gene
K63polyUb-DDX58
ADP
ATP
MAVS
UBE2D3
ATP
NLRX1
Influenza A dsRNA intermediate form
p-4S,T404-IRF3
CASP8(1-479)
TBK1
K63polyUb-DDX58
ADP
K63polyUb-DDX58
K63polyUb-DDX58
ATP
K63polyUb-DDX58
MV dsRNA intermediate form
K63polyUb
Influenza A dsRNA intermediate form
K63polyUb-DDX58
MAVS
5'-ppp poly-U/UC RNA variants
RV RNA
RV RNA
IRF7
5'-ppp poly-U/UC RNA variants
viral
dsRNA:IFIH1,
viral
dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon
IFIH1
RNF135
p-S177,S181-IKBKB
p-S477,S479-IRF7
viral
dsRNA:IFIH1,
2xviral
dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP
RV RNA
MV dsRNA intermediate form
MAVS
IFIH1:TKFC
RNF135
ATP
CASP8(1-216)
CASP10(220-415)
TRAF2
NFKB2(1-454)
MV dsRNA intermediate form
UBC(1-76)
p-4S,T404-IRF3
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300:Promotor region of interferon beta
APP(672-713)
5'-ppp poly-U/UC RNA variants
p-4S,T404-IRF3
ISG15
K63polyUb-DDX58
ATP
NFKBIB
RNF125:E2
enzyme
(UBE2K,
UbcH5a-c):K48-polyubiquitin
MV dsRNA intermediate form
UBE2D3
UBC(77-152)
52
52
3, 79, 84
79
3, 79, 84
52
62
12, 53, 57
52
12, 53, 57
41
12, 57
3, 79, 84
3, 79, 84
52
52
3, 79, 84
52
3, 79, 84
3, 79, 84
52
3, 79, 84
3, 79, 84
37
3, 79, 84
52
52
30
52
3, 79, 84
3, 79, 84
3, 79, 84
3, 79, 84
3, 79, 84
52
3, 79, 84
52
52
52
52
52
30
79
79
76
82
52
28, 36
30
52
52
30
52
30
3, 79, 84
3, 79, 84
3, 79, 84
3, 79, 84
37
79
51
52
52
52
52
3, 79, 84
3, 79, 84
30
4, 8, 21, 46, 71...
47
52
3, 79, 84
30
37