DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)

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2, 11, 29, 44, 61...753, 26, 43, 84345, 31, 5574, 839, 15, 24, 35, 6020, 39, 4063425318, 58, 739, 15, 24, 35, 6014, 865113, 64, 6916, 20, 7219, 20633819, 22, 6520, 8049, 66, 864554, 825, 794819, 25, 45, 56671, 10, 23, 8554, 827176368, 756, 32, 34, 65, 6964626218, 58, 7359, 70, 789, 15, 24, 35, 60...33, 50, 5927, 68nucleoplasmmitochondrioncytosolCASP8(385-479)CREBBP TRIM25 IFIH1 ATP viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3MV dsRNA intermediate form MAVS TRIM25 5'-ppp poly-U/UC RNA variants MAVS ATP CREBBP IKBKE IFIH1 TRIM25 RV RNA TRIM25 NKIRAS2 MAVS IFIH1 IFIH1 dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6TAX1BP1:TNFAIP3TRIM25 IRF3 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCHp-4S,T404-IRF3,p-S477,S479-IRF7TRIM25 TANK K63polyUb-DDX58 TRAF6 RV RNA RNF135 ATP2xviraldsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATPRNF135 K63polyUb-DDX58 MAVS p-S477,S479-IRF7 K63polyUb-DDX58 Influenza A dsRNA intermediate form TBK1 HMGB1 dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKiEP300 UBC(305-380) CREBBP CASP8(375-384)K63polyUb-DDX58 RIPK1IFIH1 IFNB1TRIM25 K63polyUb-DDX58 TRAF2 RNF135 p-5S,T404-IRF3 MV dsRNA intermediate form p-S477,S479-IRF7 5'-ppp poly-U/UC RNA variants NFKB1(1-433) MAVS PCBP2 MAVS:NLRX1ISG15 ITCH IFIH1 TBK1 TBK1/IKKi:SIKE1IRF3 NLRX1 p-T,4S-IRF3:p-T,4S-IRF3FADD CHUK TRIM25 5'-ppp poly-U/UC RNA variants ATP MV dsRNA intermediate form viraldsRNA:IFIH1,2xviraldsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5IFIH1 MAVS Influenza A dsRNA intermediate form MAVS ATPIKBKE TRAF2 RIPK1 CASP10(416-521)IFIH1 TAX1BP1 RNF135 UBC(533-608) TANKIKBKG UBC(609-684) TRIM25 UBE2D1 RNF135 MAVS TRIM25 IFIH1 MV dsRNA intermediate form Influenza A dsRNA intermediate form TRIM25 IKBKE RIPK1 ATP RV RNA p-S176,S180-CHUK MV dsRNA intermediate form 5'-ppp poly-U/UC RNA variants K63polyUb-TRAF3 Influenza A dsRNA intermediate form UBE2L6 MAP3K1 UBE2L6 MV dsRNA intermediate form S100B RV RNA CREBBP PCBP2 UBC(381-456) IFIH1 ATP DDX58 TRAF6 IRF3 DDX58CASP8(1-216) dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complexp-S32,S36-NFKBIA viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7TKFC NFKB1(1-433) p-4S,T404-IRF3 RELA IFIH1 5'-ppp poly-U/UC RNA variants FADD IRF7 IFIH1 TBK1 EP300 p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300RV RNA ATP CHUK TANK Influenza A dsRNA intermediate form ATG5 ATG12 FADD K48polyUb-DDX58,K48polyUb-IFIH1VAF/pIRF7:CBP/p300SAA1(19-122) CASP10(1-521) CASP8(1-479),CASP10(1-521)DDX58, IFIH1UBA7 TRAF6 RNF135 FADDp-S477,S479-IRF7 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219)ATP MAVS DDX58 5'-ppp poly-U/UC RNA variants NFKB1(1-433),NFKB2(1-454):RELAATP IKBKB IFNA PIN1 p-IRF3 dimer:PIN1K63polyUb-DDX58 5'-ppp poly-U/UC RNA variants RNF135 IFN alpha/beta(IFNA/B)N-epsilon-(1-(1-carboxy)ethyl)lysine ATP p-IRF3:p-IRF3UBC(457-532) NKIRAS1 MV dsRNA intermediate form OTUD5dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7CHUK:IKBKB:IKBKGK63polyUb-DDX58 RNF135 ATP viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:TRAF35'-ppp poly-U/UC RNA variants Influenza A dsRNA intermediate form ISG15:DDX58conjugateHERC5 Influenza A dsRNA intermediate form Influenza A dsRNA intermediate form MAVS IFIH1 IFNA genes FADD p-2S-IRF7:p-2S-IRF7RNF135 Influenza A dsRNA intermediate form NFKBIA DDX58 ligandp-S477,S479-IRF7 TAX1BP1 ATP UBE2K MV dsRNA intermediate form K48polyUb-MAVS Type-I IFN genesK48polyUbK63polyUb-TRAF3EP300 MV dsRNA intermediate form K63polyUb-DDX58 NLRC5viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521)VAF (virus-activatedfactor)IFIH1 ligandFADD H2ORV RNA ATP IKBKE MAVS TRIM25 Influenza A dsRNA intermediate form RV RNA Influenza A dsRNA intermediate form RELA AGER TKFCUBE2L6 RIPK1 RNF125CHUK RV RNA Influenza A dsRNA intermediate form p-4S,T404-IRF3 RNF135 TRAF6 CBP/p300:pIRF7:pIRF7VAF/pIRF7:CBP/p300bound to type I IFNgene promoterIFIH1 dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANKIFIH1 TRIM25 RV RNA NKIRASATP dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12RNF135 K63polyUb-DDX58 RV RNA IKBKG K63polyUb-DDX58 IFIH1 UBC(153-228) ATG5:ATG12:MAVSRNF135 RNF135 RIPK1 5'-ppp poly-U/UC RNA variants SIKE1DDX58 5'-ppp poly-U/UC RNA variants K63polyUb-DDX58 IFIH1 IKBKE TRAF6 Influenza A dsRNA intermediate form MV dsRNA intermediate form CASP10(1-219) CREBBP MV dsRNA intermediate form Influenza A dsRNA intermediate form RV RNA CHUK:IKBKB:IKBKGp-S477,S479-IRF7 IRF3-P:IRF7-PTRIM25 p-T,4S-IRF3:p-T,4S-IRF3TANK RV RNA ITCHMV dsRNA intermediate form S100A12 FADD IFNA genes p-4S,T404-IRF3 MV dsRNA intermediate form ATP viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521)MAP3K1IRF7CASP10(1-521) CASP10(1-521) K48polyUb-TRAF35'-ppp poly-U/UC RNA variants NFkB inhibitor:NFkBcomplexIFIH1 UBC(229-304) IFIH1 IKBKG 5'-ppp poly-U/UC RNA variants 5'-ppp poly-U/UC RNA variants NFkB ComplexNLRC5 MAVS K48polyUb-RNF125 5'-ppp poly-U/UC RNA variants K63polyUb-DDX58 UBE2K IKBKE TRIM25 IFNB1 UBA52(1-76) Influenza A dsRNA intermediate form RV RNA UbNFKB1(1-433) TRIM25 ISG15:UBEIL/UbcH8:CEB1RNF135 HERC5 ATP RV RNA RV RNA RNF135 5'-ppp poly-U/UC RNA variants EP300 TRAF6 p-S19,S23-NFKBIB TBK1 RV RNA RIPK1 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVSIFNB1 gene MV dsRNA intermediate form ADPUBB(77-152) MV dsRNA intermediate form Influenza A dsRNA intermediate form TRIM25 IKBKG Influenza A dsRNA intermediate form UBB(153-228) K63polyUb-DDX58 UBE2D2 NFKB2(1-454) K63polyUbPCBP2RNF135,TRIM25IFIH1 UBE2D2 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:PCBP2ADPISGylated IRF3RNF135 Influenza A dsRNA intermediate form CREBBP EP300 UBE2L6 p-S477,S479-IRF7 MV dsRNA intermediate form TRIM25 K48polyUb-IFIH1 RNF135 TBK1 EP300 TRAF2 dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1NFKB2(1-454) NECML RV RNA RNF216p-S477,S479-IRF7TRIM25 ATG5 UBB(1-76) TRIM25 MV dsRNA intermediate form TRIM25 p-4S,T404-IRF3 IKK related kinasesTBK1/IKK epsilonEP300 TNFAIP3 2x DDX58 ligand:2xDDX58:2xATPK63polyUb-TRAF3 SIKE1 ATP 5'-ppp poly-U/UC RNA variants TRAF2 MAVS MV dsRNA intermediate form RV RNA RV RNA CASP10(1-219) K63polyUb-DDX58 RELA UBE2D1 RPS27A(1-76) UBA7 K63polyUb-DDX58 RV RNA TRAF2, TRAF6CASP8(1-216) viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADDIFIH1 IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKBInfluenza A dsRNA intermediate form ATP p-4S,T404-IRF3 AGER ligands:AGERInfluenza A dsRNA intermediate form 5'-ppp poly-U/UC RNA variants MAVS IRF3,IRF7CASP10(1-219) CYLD5'-ppp poly-U/UC RNA variants Influenza A dsRNA intermediate form K63polyUb-DDX58 MV dsRNA intermediate form TRIM25 APP(672-711) MAVS IFIH1 Peptide IKBKE ATP unknown ligaseIRF7 CREBBP Influenza A dsRNA intermediate form RIPK1 IFIH1 ISG15 IKBKB viraldsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomainATG12 ATP 5'-ppp poly-U/UC RNA variants RNF135 RNF135 IFNB1 gene 5'-ppp poly-U/UC RNA variants IFNB1 gene IKBKB p-5S,T404-IRF3 RNF135 CASP8(1-479) TRIM25 E2 enzyme (UBE2K,UbcH5a-c)TBK1 TNFAIP3 Phospho-NF-kappaBInhibitorTRAF3 K48polyUbCREBBP,EP300Influenza A dsRNA intermediate form TAX1BP1:TNFAIP3:TBK1/IKKi2xp-S477,S479-IRF7RV RNA ATP IRF3-P:IRF7-PK63polyUb-TRAF3 p-4S,T404-IRF3 PIN1DHX58TRAF2 MAVSMAVS p-S477,S479-IRF7 p-4S,T404-IRF3 CASP8(217-374)RNF135 viral dsRNA:IFIH1CASP8(1-479) ATPp-S477,S479-IRF7 K48polyUb-DDX58 5'-ppp poly-U/UC RNA variants MAVS Influenza A dsRNA intermediate form IFNB1 geneK63polyUb-DDX58ADPATP MAVS UBE2D3 ATP NLRX1Influenza A dsRNA intermediate form p-4S,T404-IRF3 CASP8(1-479) TBK1 K63polyUb-DDX58 ADPK63polyUb-DDX58 K63polyUb-DDX58 ATPK63polyUb-DDX58 MV dsRNA intermediate form K63polyUbInfluenza A dsRNA intermediate form K63polyUb-DDX58 MAVS 5'-ppp poly-U/UC RNA variants RV RNA RV RNA IRF7 5'-ppp poly-U/UC RNA variants viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilonIFIH1 RNF135 p-S177,S181-IKBKB p-S477,S479-IRF7 viraldsRNA:IFIH1,2xviraldsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATPRV RNA MV dsRNA intermediate form MAVS IFIH1:TKFCRNF135 ATPCASP8(1-216) CASP10(220-415)TRAF2 NFKB2(1-454) MV dsRNA intermediate form UBC(1-76) p-4S,T404-IRF3 p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300:Promotor region of interferon betaAPP(672-713) 5'-ppp poly-U/UC RNA variants p-4S,T404-IRF3 ISG15 K63polyUb-DDX58 ATP NFKBIB RNF125:E2enzyme(UBE2K,UbcH5a-c):K48-polyubiquitinMV dsRNA intermediate form UBE2D3 UBC(77-152) 52523, 79, 84793, 79, 84526212, 53, 575212, 53, 574112, 573, 79, 843, 79, 8452523, 79, 84523, 79, 843, 79, 84523, 79, 843, 79, 84373, 79, 84525230523, 79, 843, 79, 843, 79, 843, 79, 843, 79, 84523, 79, 84525252525230797976825228, 363052523052303, 79, 843, 79, 843, 79, 843, 79, 84377951525252523, 79, 843, 79, 84304, 8, 21, 46, 71...47523, 79, 843037