DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)

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5, 17, 25, 60, 73...61, 6421, 23, 42, 44, 7053, 723335116, 24, 8213, 47, 6232, 654, 40, 8321, 23, 42, 44, 7040, 7237, 4915, 3550, 663021, 23, 42-44, 706, 27, 39, 577510, 34, 37135819, 268, 71, 72205818, 65, 8516, 24, 824, 41, 47, 54, 8459, 68, 724122, 30, 40, 5228, 55, 6446, 67, 74, 783150, 5615, 3556803115845nucleoplasmcytosolmitochondrionCASP10(220-415)IFIH1 TRIM25 TRIM25 K48polyUb-DDX58,K48polyUb-IFIH1p-S477,S479-IRF7 K63polyUb-DDX58 ATP 5'-ppp poly-U/UC RNA variants MAVS CASP10(1-219) RNF135 TBK1/IKKi:SIKE1IRF3 NLRC5 5'-ppp poly-U/UC RNA variants K63polyUb-DDX58 TAX1BP1:TNFAIP3RV RNA TRIM25 dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANKK63polyUb-DDX58 K63polyUb-DDX58 EP300 ATP MAVS DDX58 ligandTRAF6 p-4S,T404-IRF3 IFNA genes TRAF2 EP300 p-4S,T404-IRF3 ATP TANK 5'-ppp poly-U/UC RNA variants MAVS IKBKB Influenza A dsRNA intermediate form 5'-ppp poly-U/UC RNA variants CHUK:IKBKB:IKBKGdsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1RNF135 K63polyUb-TRAF3 IRF3 MAVS RV RNA AGER TRAF2 RNF135 ATP K63polyUb-TRAF3 K63polyUb-DDX58 Influenza A dsRNA intermediate form UBB(153-228) IFNA genes RV RNA DDX58, IFIH1MV dsRNA intermediate form p-S32,S36-NFKBIA TRIM25 RV RNA K48polyUb-MAVS IFN alpha/beta(IFNA/B)IKBKB IKBKG TANK MAP3K1 ATPviraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVSTRAF2 NKIRAS2 IFNA NLRC5IFIH1 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521)TRIM25 ATG5 RIPK1 p-4S,T404-IRF3 RNF2165'-ppp poly-U/UC RNA variants CASP8(375-384)RNF135 K63polyUb-DDX58 ADPUBC(77-152) CREBBP Influenza A dsRNA intermediate form SAA1(19-122) IFIH1 2xp-S477,S479-IRF7IKBKB IRF3-P:IRF7-PMAVS K48polyUbRV RNA RIPK1 Influenza A dsRNA intermediate form IKBKG MAVS UBA52(1-76) p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKBK63polyUb-DDX58 IFIH1 NLRX1 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7TRIM25 SIKE1ATP UBC(229-304) UBE2D2 RNF135 RNF135 FADD p-S477,S479-IRF7 TBK1 2x DDX58 ligand:2xDDX58:2xATPTBK1 CREBBP Influenza A dsRNA intermediate form MV dsRNA intermediate form ATP RIPK1 K63polyUb-DDX58 RNF135 NFKB1(1-433) PCBP2 UBE2D3 CASP10(1-219) ATP MAVS DAKRV RNA TRIM25 ISG15:DDX58conjugateTNFAIP3 TBK1 5'-ppp poly-U/UC RNA variants IKK related kinasesTBK1/IKK epsilonRNF135 UBE2D2 UBE2D3 Influenza A dsRNA intermediate form IFIH1 viral dsRNA:IFIH1TRIM25 p-IRF3 dimer:PIN1TAX1BP1:TNFAIP3:TBK1/IKKiType-I IFN genesADPInfluenza A dsRNA intermediate form Influenza A dsRNA intermediate form TRIM25 IKBKE 5'-ppp poly-U/UC RNA variants EP300 FADD MV dsRNA intermediate form NFKB1(1-433):NFKB2(1-454):RELAMV dsRNA intermediate form 5'-ppp poly-U/UC RNA variants UBC(305-380) MV dsRNA intermediate form IRF3 AGER ligands:AGERATPMV dsRNA intermediate form CASP10(1-521) ATP Influenza A dsRNA intermediate form ATP IFIH1 ATPviraldsRNA:IFIH1,2xviraldsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATPRNF135 Influenza A dsRNA intermediate form CHUK:IKBKB:IKBKGInfluenza A dsRNA intermediate form UBE2L6 RIPK1H2Op-4S,T404-IRF3 IKBKG RV RNA K63polyUb-DDX58 CASP8(217-374)MV dsRNA intermediate form ATP CHUK ATG12 RNF135 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3TRIM25 OTUD5ATPRV RNA CREBBP CREBBP IKBKE K63polyUb-TRAF3 TRIM25 IFNB1 gene Influenza A dsRNA intermediate form DDX58MV dsRNA intermediate form MV dsRNA intermediate form p-S477,S479-IRF7K63polyUb-DDX58 5'-ppp poly-U/UC RNA variants IFNB1 CREBBP MAVS:NLRX1p-S19,S23-NFKBIB Influenza A dsRNA intermediate form EP300 p-4S,T404-IRF3 ATG12 HERC5 CASP10(1-219) TRIM25 APP(672-713) viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilonIFNB1Influenza A dsRNA intermediate form RV RNA RNF125ATP UBE2K IFIH1 RIPK1 NFKBIA K63polyUb-DDX58 RNF135 IRF7 p-T,4S-IRF3:p-T,4S-IRF3TRAF6 PIN1 TBK1 RNF135 RV RNA Peptide TANKInfluenza A dsRNA intermediate form TAX1BP1 MV dsRNA intermediate form IFIH1 DAK TRAF3 UBE2L6 ATP UBE2K RV RNA ATP CASP8(1-216) ATP CASP8(1-479) K63polyUb-DDX58 CHUK p-S477,S479-IRF7 TRAF6 5'-ppp poly-U/UC RNA variants unknown ligasePhospho-NF-kappaBInhibitorMAP3K1IRF3,IRF7Influenza A dsRNA intermediate form p-S477,S479-IRF7 DDX58 UBB(1-76) NFkB ComplexITCH 5'-ppp poly-U/UC RNA variants EP300 TRAF6 IFIH1 ATP TRAF2 IFIH1 IFIH1 NFKB2(1-454) CREBBP K63polyUb-DDX58CYLDIFIH1 ligandIFIH1 CHUK UBC(533-608) viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADDATP TRAF6 IKBKG ADPTBK1 MAVS UBC(1-76) MAVS MAVS UBC(153-228) NFKB2(1-454) TAX1BP1 N-epsilon-(1-(1-carboxy)ethyl)lysine 5'-ppp poly-U/UC RNA variants K63polyUb-DDX58 p-4S,T404-IRF3 p-S477,S479-IRF7 ISG15 Influenza A dsRNA intermediate form TRIM25 MV dsRNA intermediate form MAVS 5'-ppp poly-U/UC RNA variants SIKE1 TRIM25 APP(672-711) RNF135 RNF135 p-4S,T404-IRF3 p-4S,T404-IRF3 MV dsRNA intermediate form MV dsRNA intermediate form K48polyUb-IFIH1 ATP p-S176,S180-CHUK Influenza A dsRNA intermediate form TRIM25 IFIH1 p-S477,S479-IRF7 MV dsRNA intermediate form p-S477,S479-IRF7 p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300:Promotor region of interferon betaUBE2L6 K63polyUb-DDX58 IKBKE Influenza A dsRNA intermediate form TANK VAF/pIRF7:CBP/p300MV dsRNA intermediate form RPS27A(1-76) IKBKE dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complexp-4S,T404-IRF3,p-S477,S479-IRF75'-ppp poly-U/UC RNA variants UBA7 ITCHRNF135,TRIM25S100A12 p-4S,T404-IRF3 ISG15 IFIH1:DAKNFKB1(1-433) TRAF2 MV dsRNA intermediate form FADD DDX58 RELA ATP UBE2D1 UBC(609-684) 5'-ppp poly-U/UC RNA variants TRIM25 K63polyUb-TRAF3CASP8(385-479)TRAF6 TBK1 IKBKE RV RNA RV RNA RNF135 UBB(77-152) MAVS IRF7p-5S,T404-IRF3 IFIH1 dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKiTRIM25 DHX58Influenza A dsRNA intermediate form p-S477,S479-IRF7 UbK63polyUbRNF135 IFIH1 TBK1 RV RNA CREBBP, EP300NLRX15'-ppp poly-U/UC RNA variants MV dsRNA intermediate form ATP ATG5:ATG12:MAVSK48polyUb-DDX58 TNFAIP3 IFNB1 geneISG15 ATPRV RNA Influenza A dsRNA intermediate form RV RNA IFIH1 p-T,4S-IRF3:p-T,4S-IRF3CASP10(1-521) RV RNA MAVS K63polyUb-DDX58 MV dsRNA intermediate form UBE2L6 K63polyUb-DDX58 IkBs:NFkBADPIFNB1 gene NKIRASTRIM25 Influenza A dsRNA intermediate form dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12S100B IRF7 PIN1MV dsRNA intermediate form 5'-ppp poly-U/UC RNA variants PCBP2 CASP8(1-479) IFIH1 5'-ppp poly-U/UC RNA variants UBC(457-532) K63polyUbATP RELA TRIM25 K63polyUb-DDX58 FADD Influenza A dsRNA intermediate form RNF135 RV RNA IFIH1 MAVS K63polyUb-DDX58 MAVSIFIH1 viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219)MV dsRNA intermediate form Influenza A dsRNA intermediate form ATP K63polyUb-DDX58 ATP CASP8(1-479),CASP10(1-521)RIPK1 K63polyUb-DDX58 CASP8(1-216) MV dsRNA intermediate form CASP10(416-521)TRIM25 2xviraldsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATPRV RNA VAF (virus-activatedfactor)ISG15:UBEIL/UbcH8:CEB1viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:PCBP2p-2S-IRF7:p-2S-IRF7MAVS dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF75'-ppp poly-U/UC RNA variants viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521)viraldsRNA:IFIH1,2xviraldsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5IFIH1 MAVS p-IRF3:p-IRF3RV RNA IFIH1 ATG5 NKIRAS1 HMGB1 RV RNA ISGylated IRF3CASP10(1-521) RIPK1 FADD EP300 p-5S,T404-IRF3 PCBP2MV dsRNA intermediate form Influenza A dsRNA intermediate form RNF135 5'-ppp poly-U/UC RNA variants 5'-ppp poly-U/UC RNA variants FADD RV RNA RNF135 K48polyUb-TRAF3TRIM25 NFKB2(1-454) RNF135 TRIM25 p-S177,S181-IKBKB K63polyUb-DDX58 RV RNA viraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:TRAF3ATP RV RNA NECML MAVS CASP8(1-216) RNF125:E2enzyme(UBE2K,UbcH5a-c):K48-polyubiquitinUBA7 RNF135 5'-ppp poly-U/UC RNA variants IRF3-P:IRF7-PEP300 IKBKE DDX58 IFIH1 p-S477,S479-IRF7 TRIM25 IKBKE Influenza A dsRNA intermediate form UBC(381-456) IFIH1 MAVS CASP8(1-479) TRAF2 IRF7 p-4S,T404-IRF3 MAVS viraldsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomainMV dsRNA intermediate form TRAF2, TRAF6HERC5 CBP/p300:pIRF7:pIRF7IFNB1 gene RNF135 UBE2D1 NFKB1(1-433) K63polyUb-DDX58 5'-ppp poly-U/UC RNA variants 5'-ppp poly-U/UC RNA variants MAVS K48polyUb-RNF125 NFKBIB dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6FADDE2 enzyme (UBE2K,UbcH5a-c)K48polyUbviraldsRNA:IFIH1,viraldsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCHRNF135 VAF/pIRF7:CBP/p300bound to type I IFNgene promoterRELA CREBBP IFIH1 46, 61, 7423646, 61, 7446, 61, 7446, 61, 747, 697646, 61, 747646, 61, 7446, 61, 7446, 61, 747, 69, 806146, 61, 7436146, 61, 747646, 61, 7429, 7976767646, 61, 7476762761, 9, 12, 38, 48...767646, 61, 74767646, 61, 743676767627, 69, 8027646, 61, 747646, 61, 74246, 61, 7446, 61, 742767646, 61, 74617646, 61, 74767676632761446, 61, 746146, 61, 7446, 61, 7435361176