Response to elevated platelet cytosolic Ca2+ (Homo sapiens)

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9151841814181612181467124, 5, 12endoplasmic reticulum lumenplatelet alpha granule lumenplatelet dense granule lumenlysosomal lumencytosolsecretory granulePro-EGF TF CFD GAS6(39-691) Ca2+ PCDH7 MANF FLNA VWF(23-763) PDGF dimer CLEC3B SERPINF2 LGALS3BP MANF GTPBP2 CFL1 ISLR ALB ALDOA Protein Kinase C,conventionalp-STXBP3Mg2+ SEPP1 TUBA4A PFN1 FAM49B TLN1 CAP1 LAMP2 CD109 TIMP3 STXBP3PCYOX1L ITGB3 APOA1(25-266) NHLRC2 RAB27B HRG WDR1 APOA1(25-266) CHID1 Pro-EGF PF4(32-101) ADP APOH CLU(23-449) CD63 SERPINA3 HABP4 Platelet densegranule contentAlpha actinins GTP SCG3 PF4(48-101) STXBP2 SYTL4 ITGA2B(32-1039) PSAP,CHID1CYB5R1 PLG(1-810) APP(18-770) FGB(31-491) POTEKP 4xPalmC-CD36 PSAP(60-142) PHACTR2 FGA(20-866) PCYOX1L TUBA4A GAS6(39-691) SRGN SPARC ITIH4 CTSW MMRN1(20-1228) factor V PLEK SERPINA1 PSOLA1 CD9 TIMP1 HGF(32-494) PRKCG APLP2 SYTL4 Mg2+ ATP APOH ADP LGALS3BP SPP2 FAM3C HGF(495-728) OLA1 GDP QSOX1 BRPF3 TIMP1 TMSB4X ADPRAB27B Ca2+ Platelet releasatesecretory granuleproteinsTAGLN2 PPBP(35-128) LHFPL2 ORM1 APP(18-770) VTI1B TAGLN2 VCL 11xCbxE-PROS1 ITIH3 PSAP,CHID1ECM1 ENDOD1 ENDOD1 AHSG STX4HSPA5DAGTOR4A SERPINA3 Platelet alphagranule contentsPFN1 THBS1 TGF beta A2M ORM2 TEX264 TMX3 SERPING1 GTPBP2 Insulin-like growth factors PRKCG KNG1(19-644) MAGED2 ITGA2B(32-?) 5HT LEFTY2(22-366) SPP2 11xCbxE-PROS1 SEPP1 HSPA5TTN Pi CHID1 CFL1 A1BG SERPINA4 Platelet releasate(inferred)cytosolic proteinsp-STX4FERMT3 FLNA VEGFs Platelet densegranule membranecomponentsA2M SELP TMSB4X TIMP3 WDR1 LY6G6F SCCPDH Platelet densegranule membranecomponentsPLEK CALUFAM49B CALM1 NHLRC2 PRKCB Platelet releasatecytosolic proteinsITGB3(27-?) factor XIII A chain FGG HABP4 Activatedconventionalprotein kinase CPlatelet releasatecytosolic proteinsADPSPARC PECAM1 GTP ORM1 SOD1 ANXA5 SCG3 SERPINF2 TTN ATP SELP ISLR PF4(32-101) FGG CD109 ALDOA VEGFs DAG AHSG PPi SRGN TEX264 PPBP(55-128) CDC37L1 5HT FERMT3 Pi PRKCB SOD1 PPBP(35-128) Platelet densegranule contentCLU(23-449) TMX3 Factor VIII precursor LY6G6F PPIA SCCPDH PRKCA PDGF dimer A1BG ABCC4ECM1 Platelet alphagranule membranecomponents that arereleased ondegranulationMAGED2 POTEKP ORM2 factor V STXBP2 HGF(32-494) CTSW SELP QSOX1 CLEC3B Ca2+ PSAP(60-142) PPBP(55-128) CFD PPi APOOL VCL PS MMRN1(20-1228) CYB5R1 Platelet alphagranule contentsPHACTR2 FN1(32-2386) SERPINA4 Platelet releasatesecretory granuleproteinsRARRES2 APOOL TGF beta SERPINA1 CD9 TOR4A CDC37L1 SERPINE1 ATPFAM3C HGF(495-728) TLN1 Insulin-like growth factors ITIH4 PCDH7 CALM1 F13A1(1-731) Platelet alphagranule membranecomponents that arereleased ondegranulationLHFPL2 BRPF3 CD36 Ca2+HRG VTI1B CD63 PECAM1 RARRES2 FGB(31-491) Alpha actinins SELP ADPFN1(32-2386) LAMP2 ALB(19-609) CALUGDP SERPING1 ANXA5 PRKCA Platelet releasate(inferred)cytosolic proteinsKNG1(19-644) Coagulation factor VIII precursor APLP2 PLG(20-810) CAP1 SERPINE1 PPIA ITIH3 PF4(48-101) THBS1 VWF(23-763) apoTF FGA(20-866) 21038, 111718313118


Description

Activation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium and activation of Protein Kinase C (PKC). Phospholipase C cleaves the phosphodiester bond in PIP2 to form 1,2 Diacylglycerol (DAG) and 1,4,5-inositol trisphosphate (IP3). IP3 opens Ca2+ channels in the platelet dense tubular system, raising intracellular Ca2+ levels. DAG is a second messenger that regulates a family of Ser/Thr kinases consisting of PKC isozymes (Nishizuka 1995). DAG achieves activation of PKC isozymes by increasing their affinity for phospholipid. Most PKC enzymes are also calcium-dependent, so their activation is in synergy with the rise in intracellular Ca2+. Platelets contain several PKC isoforms that can be activated by DAG and/or Ca2+ (Chang 1997). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 76005
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: de Bono, Bernard

Quality Tags

Ontology Terms

 

Bibliography

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  1. Iwamoto R, Higashiyama S, Mitamura T, Taniguchi N, Klagsbrun M, Mekada E.; ''Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.''; PubMed Europe PMC
  2. Ichinose A, Hendrickson LE, Fujikawa K, Davie EW.; ''Amino acid sequence of the a subunit of human factor XIII.''; PubMed Europe PMC
  3. DiScipio RG, Davie EW.; ''Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma.''; PubMed Europe PMC
  4. Harrison P, Cramer EM.; ''Platelet alpha-granules.''; PubMed Europe PMC
  5. Wijten P, van Holten T, Woo LL, Bleijerveld OB, Roest M, Heck AJ, Scholten A.; ''High precision platelet releasate definition by quantitative reversed protein profiling--brief report.''; PubMed Europe PMC
  6. Oancea E, Meyer T.; ''Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.''; PubMed Europe PMC
  7. Chung SH, Polgar J, Reed GL.; ''Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.''; PubMed Europe PMC
  8. Al Hawas R, Ren Q, Ye S, Karim ZA, Filipovich AH, Whiteheart SW.; ''Munc18b/STXBP2 is required for platelet secretion.''; PubMed Europe PMC
  9. Walker TR, Watson SP.; ''Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets.''; PubMed Europe PMC
  10. Tolmachova T, Abrink M, Futter CE, Authi KS, Seabra MC.; ''Rab27b regulates number and secretion of platelet dense granules.''; PubMed Europe PMC
  11. Houng A, Polgar J, Reed GL.; ''Munc18-syntaxin complexes and exocytosis in human platelets.''; PubMed Europe PMC
  12. Gogstad GO, Hagen I, Korsmo R, Solum NO.; ''Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.''; PubMed Europe PMC
  13. Tao N, Wagner SJ, Lublin DM.; ''CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.''; PubMed Europe PMC
  14. Fukami MH.; ''Isolation of dense granules from human platelets.''; PubMed Europe PMC
  15. Reed GL, Houng AK, Fitzgerald ML.; ''Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.''; PubMed Europe PMC
  16. Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK.; ''The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage.''; PubMed Europe PMC
  17. Ross D, Joyner WL.; ''Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells.''; PubMed Europe PMC
  18. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB.; ''Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.''; PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
101397view11:28, 1 November 2018ReactomeTeamreactome version 66
100935view21:04, 31 October 2018ReactomeTeamreactome version 65
100472view19:38, 31 October 2018ReactomeTeamreactome version 64
100017view16:21, 31 October 2018ReactomeTeamreactome version 63
99570view14:54, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99193view12:43, 31 October 2018ReactomeTeamreactome version 62
93756view13:34, 16 August 2017ReactomeTeamreactome version 61
93276view11:19, 9 August 2017ReactomeTeamreactome version 61
86355view09:16, 11 July 2016ReactomeTeamreactome version 56
85040view08:26, 10 April 2016EgonwThis is even more accurate.
84779view09:41, 20 March 2016EgonwFixed the ChEBI IDs (removed the R-HSA prefix).
83141view10:08, 18 November 2015ReactomeTeamVersion54
81485view13:01, 21 August 2015ReactomeTeamVersion53
76962view08:24, 17 July 2014ReactomeTeamFixed remaining interactions
76667view12:03, 16 July 2014ReactomeTeamFixed remaining interactions
75996view10:05, 11 June 2014ReactomeTeamRe-fixing comment source
75699view11:03, 10 June 2014ReactomeTeamReactome 48 Update
75055view13:56, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74699view08:46, 30 April 2014ReactomeTeamReactome46
68987view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
45238view18:17, 7 October 2011KhanspersOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
45046view19:05, 6 October 2011ThomasOntology Term : 'platelet' added !
42119view21:58, 4 March 2011MaintBotAutomatic update
39929view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11xCbxE-PROS1 ProteinP07225 (Uniprot-TrEMBL)
4xPalmC-CD36 ProteinP16671 (Uniprot-TrEMBL)
5HT MetaboliteCHEBI:28790 (ChEBI)
A1BG ProteinP04217 (Uniprot-TrEMBL)
A2M ProteinP01023 (Uniprot-TrEMBL)
ABCC4ProteinO15439 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHSG ProteinP02765 (Uniprot-TrEMBL)
ALB ProteinP02768 (Uniprot-TrEMBL)
ALB(19-609) ProteinP02768 (Uniprot-TrEMBL)
ALDOA ProteinP04075 (Uniprot-TrEMBL)
ANXA5 ProteinP08758 (Uniprot-TrEMBL)
APLP2 ProteinQ06481 (Uniprot-TrEMBL)
APOA1(25-266) ProteinP02647 (Uniprot-TrEMBL)
APOH ProteinP02749 (Uniprot-TrEMBL)
APOOL ProteinQ6UXV4 (Uniprot-TrEMBL)
APP(18-770) ProteinP05067 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Activated

conventional

protein kinase C
ComplexR-HSA-139830 (Reactome)
Alpha actinins R-HSA-349778 (Reactome)
Alpha actinins R-HSA-349780 (Reactome)
BRPF3 ProteinQ9ULD4 (Uniprot-TrEMBL)
CALM1 ProteinP0DP23 (Uniprot-TrEMBL)
CALUProteinO43852 (Uniprot-TrEMBL)
CAP1 ProteinQ01518 (Uniprot-TrEMBL)
CD109 ProteinQ6YHK3 (Uniprot-TrEMBL)
CD36 ProteinP16671 (Uniprot-TrEMBL)
CD63 ProteinP08962 (Uniprot-TrEMBL)
CD9 ProteinP21926 (Uniprot-TrEMBL)
CDC37L1 ProteinQ7L3B6 (Uniprot-TrEMBL)
CFD ProteinP00746 (Uniprot-TrEMBL)
CFL1 ProteinP23528 (Uniprot-TrEMBL)
CHID1 ProteinQ9BWS9 (Uniprot-TrEMBL)
CLEC3B ProteinP05452 (Uniprot-TrEMBL)
CLU(23-449) ProteinP10909 (Uniprot-TrEMBL)
CTSW ProteinP56202 (Uniprot-TrEMBL)
CYB5R1 ProteinQ9UHQ9 (Uniprot-TrEMBL)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Coagulation factor VIII precursor ProteinP00451 (Uniprot-TrEMBL)
DAG MetaboliteCHEBI:17815 (ChEBI)
DAGMetaboliteCHEBI:17815 (ChEBI)
ECM1 ProteinQ16610 (Uniprot-TrEMBL)
ENDOD1 ProteinO94919 (Uniprot-TrEMBL)
F13A1(1-731) ProteinP00488 (Uniprot-TrEMBL)
FAM3C ProteinQ92520 (Uniprot-TrEMBL)
FAM49B ProteinQ9NUQ9 (Uniprot-TrEMBL)
FERMT3 ProteinQ86UX7 (Uniprot-TrEMBL)
FGA(20-866) ProteinP02671 (Uniprot-TrEMBL)
FGB(31-491) ProteinP02675 (Uniprot-TrEMBL)
FGG ProteinP02679 (Uniprot-TrEMBL)
FLNA ProteinP21333 (Uniprot-TrEMBL)
FN1(32-2386) ProteinP02751 (Uniprot-TrEMBL)
Factor VIII precursor ProteinP00451 (Uniprot-TrEMBL)
GAS6(39-691) ProteinQ14393 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPBP2 ProteinQ9BX10 (Uniprot-TrEMBL)
HABP4 ProteinQ5JVS0 (Uniprot-TrEMBL)
HGF(32-494) ProteinP14210 (Uniprot-TrEMBL)
HGF(495-728) ProteinP14210 (Uniprot-TrEMBL)
HRG ProteinP04196 (Uniprot-TrEMBL)
HSPA5ProteinP11021 (Uniprot-TrEMBL)
ISLR ProteinO14498 (Uniprot-TrEMBL)
ITGA2B(32-1039) ProteinP08514 (Uniprot-TrEMBL)
ITGA2B(32-?) ProteinP08514 (Uniprot-TrEMBL)
ITGB3 ProteinP05106 (Uniprot-TrEMBL)
ITGB3(27-?) ProteinP05106 (Uniprot-TrEMBL)
ITIH3 ProteinQ06033 (Uniprot-TrEMBL)
ITIH4 ProteinQ14624 (Uniprot-TrEMBL)
Insulin-like growth factors R-HSA-3006323 (Reactome)
Insulin-like growth factors R-HSA-3006324 (Reactome)
KNG1(19-644) ProteinP01042 (Uniprot-TrEMBL)
LAMP2 ProteinP13473 (Uniprot-TrEMBL)
LEFTY2(22-366) ProteinO00292 (Uniprot-TrEMBL)
LGALS3BP ProteinQ08380 (Uniprot-TrEMBL)
LHFPL2 ProteinQ6ZUX7 (Uniprot-TrEMBL)
LY6G6F ProteinQ5SQ64 (Uniprot-TrEMBL)
MAGED2 ProteinQ9UNF1 (Uniprot-TrEMBL)
MANF ProteinP55145 (Uniprot-TrEMBL)
MMRN1(20-1228) ProteinQ13201 (Uniprot-TrEMBL)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NHLRC2 ProteinQ8NBF2 (Uniprot-TrEMBL)
OLA1 ProteinQ9NTK5 (Uniprot-TrEMBL)
ORM1 ProteinP02763 (Uniprot-TrEMBL)
ORM2 ProteinP19652 (Uniprot-TrEMBL)
PCDH7 ProteinO60245 (Uniprot-TrEMBL)
PCYOX1L ProteinQ8NBM8 (Uniprot-TrEMBL)
PDGF dimer R-HSA-184197 (Reactome)
PDGF dimer R-HSA-184202 (Reactome)
PECAM1 ProteinP16284 (Uniprot-TrEMBL)
PF4(32-101) ProteinP02776 (Uniprot-TrEMBL)
PF4(48-101) ProteinP02776 (Uniprot-TrEMBL)
PFN1 ProteinP07737 (Uniprot-TrEMBL)
PHACTR2 ProteinO75167 (Uniprot-TrEMBL)
PLEK ProteinP08567 (Uniprot-TrEMBL)
PLG(1-810) ProteinP00747 (Uniprot-TrEMBL)
PLG(20-810) ProteinP00747 (Uniprot-TrEMBL)
POTEKP ProteinQ9BYX7 (Uniprot-TrEMBL)
PPBP(35-128) ProteinP02775 (Uniprot-TrEMBL)
PPBP(55-128) ProteinP02775 (Uniprot-TrEMBL)
PPIA ProteinP62937 (Uniprot-TrEMBL)
PPi MetaboliteCHEBI:29888 (ChEBI)
PRKCA ProteinP17252 (Uniprot-TrEMBL)
PRKCB ProteinP05771 (Uniprot-TrEMBL)
PRKCG ProteinP05129 (Uniprot-TrEMBL)
PS MetaboliteCHEBI:18303 (ChEBI)
PSAP(60-142) ProteinP07602 (Uniprot-TrEMBL)
PSAP,CHID1ComplexR-HSA-8862963 (Reactome)
PSAP,CHID1ComplexR-HSA-8862989 (Reactome)
PSMetaboliteCHEBI:18303 (ChEBI)
Pi MetaboliteCHEBI:18367 (ChEBI)
Platelet alpha granule contentsComplexR-HSA-481003 (Reactome)
Platelet alpha granule contentsComplexR-HSA-481033 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
ComplexR-HSA-964721 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
ComplexR-HSA-964722 (Reactome)
Platelet dense granule contentComplexR-HSA-481002 (Reactome)
Platelet dense granule contentComplexR-HSA-481030 (Reactome)
Platelet dense

granule membrane

components
ComplexR-HSA-481004 (Reactome)
Platelet dense

granule membrane

components
ComplexR-HSA-481006 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
ComplexR-HSA-482764 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
ComplexR-HSA-482774 (Reactome)
Platelet releasate cytosolic proteinsComplexR-HSA-482768 (Reactome)
Platelet releasate cytosolic proteinsComplexR-HSA-482771 (Reactome)
Platelet releasate

secretory granule

proteins
ComplexR-HSA-482765 (Reactome)
Platelet releasate

secretory granule

proteins
ComplexR-HSA-482769 (Reactome)
Pro-EGF ProteinP01133 (Uniprot-TrEMBL)
Protein Kinase C, conventionalComplexR-HSA-114528 (Reactome) These PKC isoforms are activated by PS in a Ca2+-dependent manner; they also bind DAG, which both increases the specificity of the enzyme for PS and also shifts the affinity for Ca2+ into the physiological range. They are targets of the tumour-promoting phorbol ester PMA, which activates these enzymes by eliminating the requirement for DAG and decreasing the concentration of Ca2+ needed for activation.
QSOX1 ProteinO00391 (Uniprot-TrEMBL)
RAB27B ProteinO00194 (Uniprot-TrEMBL)
RARRES2 ProteinQ99969 (Uniprot-TrEMBL)
SCCPDH ProteinQ8NBX0 (Uniprot-TrEMBL)
SCG3 ProteinQ8WXD2 (Uniprot-TrEMBL)
SELP ProteinP16109 (Uniprot-TrEMBL)
SEPP1 ProteinP49908 (Uniprot-TrEMBL)
SERPINA1 ProteinP01009 (Uniprot-TrEMBL)
SERPINA3 ProteinP01011 (Uniprot-TrEMBL)
SERPINA4 ProteinP29622 (Uniprot-TrEMBL)
SERPINE1 ProteinP05121 (Uniprot-TrEMBL)
SERPINF2 ProteinP08697 (Uniprot-TrEMBL)
SERPING1 ProteinP05155 (Uniprot-TrEMBL)
SOD1 ProteinP00441 (Uniprot-TrEMBL)
SPARC ProteinP09486 (Uniprot-TrEMBL)
SPP2 ProteinQ13103 (Uniprot-TrEMBL)
SRGN ProteinP10124 (Uniprot-TrEMBL)
STX4ProteinQ12846 (Uniprot-TrEMBL)
STXBP2 ProteinQ15833 (Uniprot-TrEMBL)
STXBP3ProteinO00186 (Uniprot-TrEMBL)
SYTL4 ProteinQ96C24 (Uniprot-TrEMBL)
TAGLN2 ProteinP37802 (Uniprot-TrEMBL)
TEX264 ProteinQ9Y6I9 (Uniprot-TrEMBL)
TF ProteinP02787 (Uniprot-TrEMBL)
TGF beta R-HSA-114507 (Reactome)
TGF beta R-HSA-114657 (Reactome)
THBS1 ProteinP07996 (Uniprot-TrEMBL)
TIMP1 ProteinP01033 (Uniprot-TrEMBL)
TIMP3 ProteinP35625 (Uniprot-TrEMBL)
TLN1 ProteinQ9Y490 (Uniprot-TrEMBL)
TMSB4X ProteinP62328 (Uniprot-TrEMBL)
TMX3 ProteinQ96JJ7 (Uniprot-TrEMBL)
TOR4A ProteinQ9NXH8 (Uniprot-TrEMBL)
TTN ProteinQ8WZ42 (Uniprot-TrEMBL)
TUBA4A ProteinP68366 (Uniprot-TrEMBL)
VCL ProteinP18206 (Uniprot-TrEMBL)
VEGFs R-HSA-139882 (Reactome)
VEGFs R-HSA-139884 (Reactome)
VTI1B ProteinQ9UEU0 (Uniprot-TrEMBL)
VWF(23-763) ProteinP04275 (Uniprot-TrEMBL)
WDR1 ProteinO75083 (Uniprot-TrEMBL)
apoTF ProteinP02787 (Uniprot-TrEMBL)
factor V ProteinP12259 (Uniprot-TrEMBL)
factor XIII A chain ProteinP00488 (Uniprot-TrEMBL)
p-STX4ProteinQ12846 (Uniprot-TrEMBL)
p-STXBP3ProteinO00186 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ABCC4mim-catalysisR-HSA-429157 (Reactome)
ADPArrowR-HSA-114683 (Reactome)
ADPArrowR-HSA-114684 (Reactome)
ADPArrowR-HSA-429157 (Reactome)
ADPR-HSA-429157 (Reactome)
ATPR-HSA-114683 (Reactome)
ATPR-HSA-114684 (Reactome)
Activated

conventional

protein kinase C
ArrowR-HSA-114553 (Reactome)
Activated

conventional

protein kinase C
mim-catalysisR-HSA-114683 (Reactome)
Activated

conventional

protein kinase C
mim-catalysisR-HSA-114684 (Reactome)
CALUArrowR-HSA-350745 (Reactome)
CALUR-HSA-350745 (Reactome)
Ca2+R-HSA-114553 (Reactome)
DAGArrowR-HSA-114553 (Reactome)
DAGR-HSA-114553 (Reactome)
HSPA5ArrowR-HSA-351323 (Reactome)
HSPA5R-HSA-351323 (Reactome)
PSAP,CHID1ArrowR-HSA-351341 (Reactome)
PSAP,CHID1R-HSA-351341 (Reactome)
PSR-HSA-114553 (Reactome)
Platelet alpha granule contentsArrowR-HSA-481007 (Reactome)
Platelet alpha granule contentsR-HSA-481007 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
ArrowR-HSA-481044 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
R-HSA-481044 (Reactome)
Platelet dense granule contentArrowR-HSA-481009 (Reactome)
Platelet dense granule contentR-HSA-481009 (Reactome)
Platelet dense

granule membrane

components
ArrowR-HSA-481010 (Reactome)
Platelet dense

granule membrane

components
R-HSA-481010 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
ArrowR-HSA-482775 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
R-HSA-482775 (Reactome)
Platelet releasate cytosolic proteinsArrowR-HSA-482772 (Reactome)
Platelet releasate cytosolic proteinsR-HSA-482772 (Reactome)
Platelet releasate

secretory granule

proteins
ArrowR-HSA-482770 (Reactome)
Platelet releasate

secretory granule

proteins
R-HSA-482770 (Reactome)
Protein Kinase C, conventionalR-HSA-114553 (Reactome)
R-HSA-114553 (Reactome) The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling.
R-HSA-114683 (Reactome) At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Platelet SEC1 protein' are present. At the end of this reaction, 1 molecule of 'Phosphorylated platelet SEC1 protein', and 1 molecule of 'ADP' are present.

This reaction is mediated by the 'calcium-dependent protein kinase C activity' of 'Activated Ca++ and DAG dependent PKC'.

R-HSA-114684 (Reactome) At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Syntaxin 4' are present. At the end of this reaction, 1 molecule of 'Phosphorylated syntaxin 4', and 1 molecule of 'ADP' are present.

This reaction is mediated by the 'calcium-dependent protein kinase C activity' of 'Activated Ca++ and DAG dependent PKC'.

R-HSA-350745 (Reactome) After Platelet activation 'Calumenin' from the endoplasmic reticulum lumen is released in to the extracellular platelet releasate.
R-HSA-351323 (Reactome) After Platelet activation '78 kDa glucose-regulated protein' from the endoplasmic reticulum lumen is released in to the extracellular platelet releasate.
R-HSA-351341 (Reactome) After Platelet activation 'Proactivator polypeptide' from the lysosomal lumen is released in to the extracellular platelet releasate.
R-HSA-429157 (Reactome) ABCC4 (Multidrug resistance protein 4 /MOAT-B) is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, capable of pumping a wide variety of endogenous and xenobiotic anionic compounds out of the cell. ABCC4 also transports molecules involved in cellular signalling, including cyclic nucleotides, eicosanoids, urate and conjugated steroids. ABCC4 has a dual localisation in polarised cells that suggests a key function in cellular protection and extracellular signalling pathways. It is also highly expressed on platelet dense granule membranes where it is believed to contribute to the accumulation of dense granule content.
R-HSA-481007 (Reactome) Alpha granules contain mainly polypeptides such as fibrinogen, von Willebrand factor, growth factors and protease inhibitors that supplement thrombin generation at the site of injury. In addtion to their role in hemostasis, platelets also contain angiogenesis stimulators and inhibitors (Italiano et al. 2008).
R-HSA-481009 (Reactome) ADP is the most important constituent of dense granules, essential for recruiting platelets to the site of vascular injury. Other components include ATP, Ca++, GDP, GTP, Mg++, orthophospate, pyrophosphate, and serotonin.
R-HSA-481010 (Reactome) Constituents of the platelet dense granule membrane are incorporated into the platelet membrane following exocytosis of granule content.
R-HSA-481044 (Reactome) Constituents of the platelet alpha granule membrane are incorporated into the platelet membrane following exocytosis of granule content.
R-HSA-482770 (Reactome) Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.
R-HSA-482772 (Reactome) Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.
R-HSA-482775 (Reactome) Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.
STX4R-HSA-114684 (Reactome)
STXBP3R-HSA-114683 (Reactome)
p-STX4ArrowR-HSA-114684 (Reactome)
p-STXBP3ArrowR-HSA-114683 (Reactome)
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