Response to elevated platelet cytosolic Ca ions (Homo sapiens)

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11332, 14, 17107931717612310lysosomal lumencytosolplatelet alpha granule lumenplatelet dense granule lumensecretory granuleendoplasmic reticulum lumenAPP(18-770) FAM3C ORM1 TMSB4X LEFTY2(22-366) TLN1 APOOL Alpha actinins TEX264 Ca2+CLU(23-449) HGF(495-728) QSOX1 NHLRC2 CFD CAP1 LY6G6F PF4(48-101) SRGN ATPCa2+ PSAP(60-142) Platelet alphagranule contentsCDC37L1 PHACTR2 Protein Kinase C,conventionalSEPP1 OLA1 p-STXBP3VWF(23-763) PPBP(55-128) Factor VIII precursor PDGF dimer ORM2 ECM1 VCL ALB ITGB3 5HT Pi PPi TF Insulin-like growth factors CAP1 SERPINE1 TIMP3 Platelet densegranule contentAHSG Activatedconventionalprotein kinase CWDR1 CYB5R1 ITIH4 p-STX4TGF beta APOOL ECM1 ADP PSAP,CHID1CYB5R1 FLNA ADP HABP4 BRPF3 LY6G6F PCYOX1L Platelet releasatesecretory granuleproteinsVEGFs TAGLN2 Mg2+ SERPINF2 RAB27B CD9 PRKCG F13A1(1-731) PCDH7 HGF(495-728) 11xCbxE-PROS1 PRKCA Ca2+ WDR1 CLEC3B LAMP2 THBS1 SPP2 GAS6(39-691) FGG GDP FGA(20-866) SOD1 DAG SYTL4 Coagulation factor VIII precursor PHACTR2 ITGB3(27-?) factor XIII A chain Platelet releasate(inferred)cytosolic proteinsPlatelet releasatesecretory granuleproteinsPRKCB ABCC4ITGA2B(32-1039) CD36 TEX264 HSPA5MAGED2 FLNA TMSB4X PPBP(55-128) TUBA4A PPBP(35-128) PCYOX1L APOA1(25-266) GDP SERPINA3 TGF beta Platelet releasate(inferred)cytosolic proteinsCLU(23-449) FAM49B THBS1 APOA1(25-266) SERPINA1 ALDOA ORM2 factor V TMX3 STX4Alpha actinins SRGN STXBP2 LHFPL2 GTP A2M ORM1 SCG3 VWF(23-763) PF4(32-101) OLA1 GTPBP2 TIMP3 CLEC3B RARRES2 ISLR BRPF3 PPIA SPP2 MANF SELP LGALS3BP SERPINA3 11xCbxE-PROS1 VTI1B ENDOD1 PPIA SPARC ATP SERPINA1 ITIH3 SPARC Platelet alphagranule membranecomponents that arereleased ondegranulationPPBP(35-128) SELP SERPING1 PECAM1 GTP KNG1(19-644) ALB(19-609) Platelet releasatecytosolic proteinsInsulin-like growth factors CHID1 ADPITIH3 FERMT3 Platelet densegranule membranecomponentsSCCPDH CALUADPPlatelet alphagranule contentsSCCPDH STXBP2 LHFPL2 CTSW MMRN1(20-1228) PLEK RARRES2 CDC37L1 SYTL4 Pro-EGF GAS6(39-691) CALM1 ANXA5 CFL1 CHID1 ADPSCG3 APOH SOD1 FAM49B SERPINE1 ALDOA KNG1(19-644) PLG(20-810) FERMT3 TIMP1 HRG MAGED2 PSAP(60-142) CFL1 FGB(31-491) TTN SELP SERPINA4 POTEKP A1BG PF4(32-101) SELP APLP2 PDGF dimer VCL GTPBP2 TOR4A FGA(20-866) FGG VTI1B LGALS3BP HGF(32-494) CD63 HSPA5AHSG PECAM1 SEPP1 TIMP1 SERPINA4 factor V Platelet densegranule membranecomponentsA1BG ITGA2B(32-?) PPi PS CTSW FGB(31-491) Pro-EGF Ca2+ TMX3 PRKCA TUBA4A CD9 MANF PLEK Platelet densegranule contentTOR4A DAGSTXBP3PCDH7 Pi PLG(1-810) CALM1 FN1(32-2386) 4xPalmC-CD36 TTN SERPINF2 CD109 SERPING1 HRG ENDOD1 TLN1 ITIH4 ATP TAGLN2 CD109 ISLR FN1(32-2386) APLP2 FAM3C PRKCB Platelet releasatecytosolic proteinsPFN1 HGF(32-494) MMRN1(20-1228) A2M CD63 5HT PF4(48-101) PSAPOH APP(18-770) ANXA5 CALUHABP4 CFD PRKCG VEGFs QSOX1 Mg2+ NHLRC2 PFN1 apoTF Platelet alphagranule membranecomponents that arereleased ondegranulationLAMP2 POTEKP RAB27B PSAP,CHID115, 16818313535412


Description

Activation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium and activation of Protein Kinase C (PKC). Phospholipase C cleaves the phosphodiester bond in PIP2 to form 1,2 Diacylglycerol (DAG) and 1,4,5-inositol trisphosphate (IP3). IP3 opens Ca2+ channels in the platelet dense tubular system, raising intracellular Ca2+ levels. DAG is a second messenger that regulates a family of Ser/Thr kinases consisting of PKC isozymes (Nishizuka 1995). DAG achieves activation of PKC isozymes by increasing their affinity for phospholipid. Most PKC enzymes are also calcium-dependent, so their activation is in synergy with the rise in intracellular Ca2+. Platelets contain several PKC isoforms that can be activated by DAG and/or Ca2+ (Chang 1997). View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 76005
Reactome-version 
Reactome version: 75
Reactome Author 
Reactome Author: de Bono, Bernard

Quality Tags

Ontology Terms

 

Bibliography

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  1. Oancea E, Meyer T.; ''Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.''; PubMed Europe PMC Scholia
  2. Harrison P, Cramer EM.; ''Platelet alpha-granules.''; PubMed Europe PMC Scholia
  3. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB.; ''Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.''; PubMed Europe PMC Scholia
  4. Ross D, Joyner WL.; ''Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells.''; PubMed Europe PMC Scholia
  5. DiScipio RG, Davie EW.; ''Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma.''; PubMed Europe PMC Scholia
  6. Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK.; ''The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage.''; PubMed Europe PMC Scholia
  7. Reed GL, Houng AK, Fitzgerald ML.; ''Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.''; PubMed Europe PMC Scholia
  8. Iwamoto R, Higashiyama S, Mitamura T, Taniguchi N, Klagsbrun M, Mekada E.; ''Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.''; PubMed Europe PMC Scholia
  9. Chung SH, Polgar J, Reed GL.; ''Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.''; PubMed Europe PMC Scholia
  10. Fukami MH.; ''Isolation of dense granules from human platelets.''; PubMed Europe PMC Scholia
  11. Walker TR, Watson SP.; ''Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets.''; PubMed Europe PMC Scholia
  12. Tao N, Wagner SJ, Lublin DM.; ''CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.''; PubMed Europe PMC Scholia
  13. Tolmachova T, Abrink M, Futter CE, Authi KS, Seabra MC.; ''Rab27b regulates number and secretion of platelet dense granules.''; PubMed Europe PMC Scholia
  14. Wijten P, van Holten T, Woo LL, Bleijerveld OB, Roest M, Heck AJ, Scholten A.; ''High precision platelet releasate definition by quantitative reversed protein profiling--brief report.''; PubMed Europe PMC Scholia
  15. Al Hawas R, Ren Q, Ye S, Karim ZA, Filipovich AH, Whiteheart SW.; ''Munc18b/STXBP2 is required for platelet secretion.''; PubMed Europe PMC Scholia
  16. Houng A, Polgar J, Reed GL.; ''Munc18-syntaxin complexes and exocytosis in human platelets.''; PubMed Europe PMC Scholia
  17. Gogstad GO, Hagen I, Korsmo R, Solum NO.; ''Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.''; PubMed Europe PMC Scholia
  18. Ichinose A, Hendrickson LE, Fujikawa K, Davie EW.; ''Amino acid sequence of the a subunit of human factor XIII.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123617view08:20, 7 August 2022EgonwModified title
114827view16:32, 25 January 2021ReactomeTeamReactome version 75
113273view11:34, 2 November 2020ReactomeTeamReactome version 74
112485view15:44, 9 October 2020ReactomeTeamReactome version 73
101397view11:28, 1 November 2018ReactomeTeamreactome version 66
100935view21:04, 31 October 2018ReactomeTeamreactome version 65
100472view19:38, 31 October 2018ReactomeTeamreactome version 64
100017view16:21, 31 October 2018ReactomeTeamreactome version 63
99570view14:54, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99193view12:43, 31 October 2018ReactomeTeamreactome version 62
93756view13:34, 16 August 2017ReactomeTeamreactome version 61
93276view11:19, 9 August 2017ReactomeTeamreactome version 61
86355view09:16, 11 July 2016ReactomeTeamreactome version 56
85040view08:26, 10 April 2016EgonwThis is even more accurate.
84779view09:41, 20 March 2016EgonwFixed the ChEBI IDs (removed the R-HSA prefix).
83141view10:08, 18 November 2015ReactomeTeamVersion54
81485view13:01, 21 August 2015ReactomeTeamVersion53
76962view08:24, 17 July 2014ReactomeTeamFixed remaining interactions
76667view12:03, 16 July 2014ReactomeTeamFixed remaining interactions
75996view10:05, 11 June 2014ReactomeTeamRe-fixing comment source
75699view11:03, 10 June 2014ReactomeTeamReactome 48 Update
75055view13:56, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74699view08:46, 30 April 2014ReactomeTeamReactome46
68987view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
45238view18:17, 7 October 2011KhanspersOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
45046view19:05, 6 October 2011ThomasOntology Term : 'platelet' added !
42119view21:58, 4 March 2011MaintBotAutomatic update
39929view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11xCbxE-PROS1 ProteinP07225 (Uniprot-TrEMBL)
4xPalmC-CD36 ProteinP16671 (Uniprot-TrEMBL)
5HT MetaboliteCHEBI:28790 (ChEBI)
A1BG ProteinP04217 (Uniprot-TrEMBL)
A2M ProteinP01023 (Uniprot-TrEMBL)
ABCC4ProteinO15439 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:456216 (ChEBI)
ADPMetaboliteCHEBI:456216 (ChEBI)
AHSG ProteinP02765 (Uniprot-TrEMBL)
ALB ProteinP02768 (Uniprot-TrEMBL)
ALB(19-609) ProteinP02768 (Uniprot-TrEMBL)
ALDOA ProteinP04075 (Uniprot-TrEMBL)
ANXA5 ProteinP08758 (Uniprot-TrEMBL)
APLP2 ProteinQ06481 (Uniprot-TrEMBL)
APOA1(25-266) ProteinP02647 (Uniprot-TrEMBL)
APOH ProteinP02749 (Uniprot-TrEMBL)
APOOL ProteinQ6UXV4 (Uniprot-TrEMBL)
APP(18-770) ProteinP05067 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:30616 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
Activated

conventional

protein kinase C
ComplexR-HSA-139830 (Reactome)
Alpha actinins R-HSA-349778 (Reactome)
Alpha actinins R-HSA-349780 (Reactome)
BRPF3 ProteinQ9ULD4 (Uniprot-TrEMBL)
CALM1 ProteinP0DP23 (Uniprot-TrEMBL)
CALUProteinO43852 (Uniprot-TrEMBL)
CAP1 ProteinQ01518 (Uniprot-TrEMBL)
CD109 ProteinQ6YHK3 (Uniprot-TrEMBL)
CD36 ProteinP16671 (Uniprot-TrEMBL)
CD63 ProteinP08962 (Uniprot-TrEMBL)
CD9 ProteinP21926 (Uniprot-TrEMBL)
CDC37L1 ProteinQ7L3B6 (Uniprot-TrEMBL)
CFD ProteinP00746 (Uniprot-TrEMBL)
CFL1 ProteinP23528 (Uniprot-TrEMBL)
CHID1 ProteinQ9BWS9 (Uniprot-TrEMBL)
CLEC3B ProteinP05452 (Uniprot-TrEMBL)
CLU(23-449) ProteinP10909 (Uniprot-TrEMBL)
CTSW ProteinP56202 (Uniprot-TrEMBL)
CYB5R1 ProteinQ9UHQ9 (Uniprot-TrEMBL)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Coagulation factor VIII precursor ProteinP00451 (Uniprot-TrEMBL)
DAG MetaboliteCHEBI:17815 (ChEBI)
DAGMetaboliteCHEBI:17815 (ChEBI)
ECM1 ProteinQ16610 (Uniprot-TrEMBL)
ENDOD1 ProteinO94919 (Uniprot-TrEMBL)
F13A1(1-731) ProteinP00488 (Uniprot-TrEMBL)
FAM3C ProteinQ92520 (Uniprot-TrEMBL)
FAM49B ProteinQ9NUQ9 (Uniprot-TrEMBL)
FERMT3 ProteinQ86UX7 (Uniprot-TrEMBL)
FGA(20-866) ProteinP02671 (Uniprot-TrEMBL)
FGB(31-491) ProteinP02675 (Uniprot-TrEMBL)
FGG ProteinP02679 (Uniprot-TrEMBL)
FLNA ProteinP21333 (Uniprot-TrEMBL)
FN1(32-2386) ProteinP02751 (Uniprot-TrEMBL)
Factor VIII precursor ProteinP00451 (Uniprot-TrEMBL)
GAS6(39-691) ProteinQ14393 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPBP2 ProteinQ9BX10 (Uniprot-TrEMBL)
HABP4 ProteinQ5JVS0 (Uniprot-TrEMBL)
HGF(32-494) ProteinP14210 (Uniprot-TrEMBL)
HGF(495-728) ProteinP14210 (Uniprot-TrEMBL)
HRG ProteinP04196 (Uniprot-TrEMBL)
HSPA5ProteinP11021 (Uniprot-TrEMBL)
ISLR ProteinO14498 (Uniprot-TrEMBL)
ITGA2B(32-1039) ProteinP08514 (Uniprot-TrEMBL)
ITGA2B(32-?) ProteinP08514 (Uniprot-TrEMBL)
ITGB3 ProteinP05106 (Uniprot-TrEMBL)
ITGB3(27-?) ProteinP05106 (Uniprot-TrEMBL)
ITIH3 ProteinQ06033 (Uniprot-TrEMBL)
ITIH4 ProteinQ14624 (Uniprot-TrEMBL)
Insulin-like growth factors R-HSA-3006323 (Reactome)
Insulin-like growth factors R-HSA-3006324 (Reactome)
KNG1(19-644) ProteinP01042 (Uniprot-TrEMBL)
LAMP2 ProteinP13473 (Uniprot-TrEMBL)
LEFTY2(22-366) ProteinO00292 (Uniprot-TrEMBL)
LGALS3BP ProteinQ08380 (Uniprot-TrEMBL)
LHFPL2 ProteinQ6ZUX7 (Uniprot-TrEMBL)
LY6G6F ProteinQ5SQ64 (Uniprot-TrEMBL)
MAGED2 ProteinQ9UNF1 (Uniprot-TrEMBL)
MANF ProteinP55145 (Uniprot-TrEMBL)
MMRN1(20-1228) ProteinQ13201 (Uniprot-TrEMBL)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NHLRC2 ProteinQ8NBF2 (Uniprot-TrEMBL)
OLA1 ProteinQ9NTK5 (Uniprot-TrEMBL)
ORM1 ProteinP02763 (Uniprot-TrEMBL)
ORM2 ProteinP19652 (Uniprot-TrEMBL)
PCDH7 ProteinO60245 (Uniprot-TrEMBL)
PCYOX1L ProteinQ8NBM8 (Uniprot-TrEMBL)
PDGF dimer R-HSA-184197 (Reactome)
PDGF dimer R-HSA-184202 (Reactome)
PECAM1 ProteinP16284 (Uniprot-TrEMBL)
PF4(32-101) ProteinP02776 (Uniprot-TrEMBL)
PF4(48-101) ProteinP02776 (Uniprot-TrEMBL)
PFN1 ProteinP07737 (Uniprot-TrEMBL)
PHACTR2 ProteinO75167 (Uniprot-TrEMBL)
PLEK ProteinP08567 (Uniprot-TrEMBL)
PLG(1-810) ProteinP00747 (Uniprot-TrEMBL)
PLG(20-810) ProteinP00747 (Uniprot-TrEMBL)
POTEKP ProteinQ9BYX7 (Uniprot-TrEMBL)
PPBP(35-128) ProteinP02775 (Uniprot-TrEMBL)
PPBP(55-128) ProteinP02775 (Uniprot-TrEMBL)
PPIA ProteinP62937 (Uniprot-TrEMBL)
PPi MetaboliteCHEBI:29888 (ChEBI)
PRKCA ProteinP17252 (Uniprot-TrEMBL)
PRKCB ProteinP05771 (Uniprot-TrEMBL)
PRKCG ProteinP05129 (Uniprot-TrEMBL)
PS MetaboliteCHEBI:18303 (ChEBI)
PSAP(60-142) ProteinP07602 (Uniprot-TrEMBL)
PSAP,CHID1ComplexR-HSA-8862963 (Reactome)
PSAP,CHID1ComplexR-HSA-8862989 (Reactome)
PSMetaboliteCHEBI:18303 (ChEBI)
Pi MetaboliteCHEBI:43474 (ChEBI)
Platelet alpha granule contentsComplexR-HSA-481003 (Reactome)
Platelet alpha granule contentsComplexR-HSA-481033 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
ComplexR-HSA-964721 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
ComplexR-HSA-964722 (Reactome)
Platelet dense granule contentComplexR-HSA-481002 (Reactome)
Platelet dense granule contentComplexR-HSA-481030 (Reactome)
Platelet dense

granule membrane

components
ComplexR-HSA-481004 (Reactome)
Platelet dense

granule membrane

components
ComplexR-HSA-481006 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
ComplexR-HSA-482764 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
ComplexR-HSA-482774 (Reactome)
Platelet releasate cytosolic proteinsComplexR-HSA-482768 (Reactome)
Platelet releasate cytosolic proteinsComplexR-HSA-482771 (Reactome)
Platelet releasate

secretory granule

proteins
ComplexR-HSA-482765 (Reactome)
Platelet releasate

secretory granule

proteins
ComplexR-HSA-482769 (Reactome)
Pro-EGF ProteinP01133 (Uniprot-TrEMBL)
Protein Kinase C, conventionalComplexR-HSA-114528 (Reactome) These PKC isoforms are activated by PS in a Ca2+-dependent manner; they also bind DAG, which both increases the specificity of the enzyme for PS and also shifts the affinity for Ca2+ into the physiological range. They are targets of the tumour-promoting phorbol ester PMA, which activates these enzymes by eliminating the requirement for DAG and decreasing the concentration of Ca2+ needed for activation.
QSOX1 ProteinO00391 (Uniprot-TrEMBL)
RAB27B ProteinO00194 (Uniprot-TrEMBL)
RARRES2 ProteinQ99969 (Uniprot-TrEMBL)
SCCPDH ProteinQ8NBX0 (Uniprot-TrEMBL)
SCG3 ProteinQ8WXD2 (Uniprot-TrEMBL)
SELP ProteinP16109 (Uniprot-TrEMBL)
SEPP1 ProteinP49908 (Uniprot-TrEMBL)
SERPINA1 ProteinP01009 (Uniprot-TrEMBL)
SERPINA3 ProteinP01011 (Uniprot-TrEMBL)
SERPINA4 ProteinP29622 (Uniprot-TrEMBL)
SERPINE1 ProteinP05121 (Uniprot-TrEMBL)
SERPINF2 ProteinP08697 (Uniprot-TrEMBL)
SERPING1 ProteinP05155 (Uniprot-TrEMBL)
SOD1 ProteinP00441 (Uniprot-TrEMBL)
SPARC ProteinP09486 (Uniprot-TrEMBL)
SPP2 ProteinQ13103 (Uniprot-TrEMBL)
SRGN ProteinP10124 (Uniprot-TrEMBL)
STX4ProteinQ12846 (Uniprot-TrEMBL)
STXBP2 ProteinQ15833 (Uniprot-TrEMBL)
STXBP3ProteinO00186 (Uniprot-TrEMBL)
SYTL4 ProteinQ96C24 (Uniprot-TrEMBL)
TAGLN2 ProteinP37802 (Uniprot-TrEMBL)
TEX264 ProteinQ9Y6I9 (Uniprot-TrEMBL)
TF ProteinP02787 (Uniprot-TrEMBL)
TGF beta R-HSA-114507 (Reactome)
TGF beta R-HSA-114657 (Reactome)
THBS1 ProteinP07996 (Uniprot-TrEMBL)
TIMP1 ProteinP01033 (Uniprot-TrEMBL)
TIMP3 ProteinP35625 (Uniprot-TrEMBL)
TLN1 ProteinQ9Y490 (Uniprot-TrEMBL)
TMSB4X ProteinP62328 (Uniprot-TrEMBL)
TMX3 ProteinQ96JJ7 (Uniprot-TrEMBL)
TOR4A ProteinQ9NXH8 (Uniprot-TrEMBL)
TTN ProteinQ8WZ42 (Uniprot-TrEMBL)
TUBA4A ProteinP68366 (Uniprot-TrEMBL)
VCL ProteinP18206 (Uniprot-TrEMBL)
VEGFs R-HSA-139882 (Reactome)
VEGFs R-HSA-139884 (Reactome)
VTI1B ProteinQ9UEU0 (Uniprot-TrEMBL)
VWF(23-763) ProteinP04275 (Uniprot-TrEMBL)
WDR1 ProteinO75083 (Uniprot-TrEMBL)
apoTF ProteinP02787 (Uniprot-TrEMBL)
factor V ProteinP12259 (Uniprot-TrEMBL)
factor XIII A chain ProteinP00488 (Uniprot-TrEMBL)
p-STX4ProteinQ12846 (Uniprot-TrEMBL)
p-STXBP3ProteinO00186 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ABCC4mim-catalysisR-HSA-429157 (Reactome)
ADPArrowR-HSA-114683 (Reactome)
ADPArrowR-HSA-114684 (Reactome)
ADPArrowR-HSA-429157 (Reactome)
ADPR-HSA-429157 (Reactome)
ATPR-HSA-114683 (Reactome)
ATPR-HSA-114684 (Reactome)
Activated

conventional

protein kinase C
ArrowR-HSA-114553 (Reactome)
Activated

conventional

protein kinase C
mim-catalysisR-HSA-114683 (Reactome)
Activated

conventional

protein kinase C
mim-catalysisR-HSA-114684 (Reactome)
CALUArrowR-HSA-350745 (Reactome)
CALUR-HSA-350745 (Reactome)
Ca2+R-HSA-114553 (Reactome)
DAGArrowR-HSA-114553 (Reactome)
DAGR-HSA-114553 (Reactome)
HSPA5ArrowR-HSA-351323 (Reactome)
HSPA5R-HSA-351323 (Reactome)
PSAP,CHID1ArrowR-HSA-351341 (Reactome)
PSAP,CHID1R-HSA-351341 (Reactome)
PSR-HSA-114553 (Reactome)
Platelet alpha granule contentsArrowR-HSA-481007 (Reactome)
Platelet alpha granule contentsR-HSA-481007 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
ArrowR-HSA-481044 (Reactome)
Platelet alpha

granule membrane components that are released on

degranulation
R-HSA-481044 (Reactome)
Platelet dense granule contentArrowR-HSA-481009 (Reactome)
Platelet dense granule contentR-HSA-481009 (Reactome)
Platelet dense

granule membrane

components
ArrowR-HSA-481010 (Reactome)
Platelet dense

granule membrane

components
R-HSA-481010 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
ArrowR-HSA-482775 (Reactome)
Platelet releasate

(inferred)

cytosolic proteins
R-HSA-482775 (Reactome)
Platelet releasate cytosolic proteinsArrowR-HSA-482772 (Reactome)
Platelet releasate cytosolic proteinsR-HSA-482772 (Reactome)
Platelet releasate

secretory granule

proteins
ArrowR-HSA-482770 (Reactome)
Platelet releasate

secretory granule

proteins
R-HSA-482770 (Reactome)
Protein Kinase C, conventionalR-HSA-114553 (Reactome)
R-HSA-114553 (Reactome) The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling.
R-HSA-114683 (Reactome) At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Platelet SEC1 protein' are present. At the end of this reaction, 1 molecule of 'Phosphorylated platelet SEC1 protein', and 1 molecule of 'ADP' are present.

This reaction is mediated by the 'calcium-dependent protein kinase C activity' of 'Activated Ca++ and DAG dependent PKC'.

R-HSA-114684 (Reactome) At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Syntaxin 4' are present. At the end of this reaction, 1 molecule of 'Phosphorylated syntaxin 4', and 1 molecule of 'ADP' are present.

This reaction is mediated by the 'calcium-dependent protein kinase C activity' of 'Activated Ca++ and DAG dependent PKC'.

R-HSA-350745 (Reactome) After Platelet activation 'Calumenin' from the endoplasmic reticulum lumen is released in to the extracellular platelet releasate.
R-HSA-351323 (Reactome) After Platelet activation '78 kDa glucose-regulated protein' from the endoplasmic reticulum lumen is released in to the extracellular platelet releasate.
R-HSA-351341 (Reactome) After Platelet activation 'Proactivator polypeptide' from the lysosomal lumen is released in to the extracellular platelet releasate.
R-HSA-429157 (Reactome) ABCC4 (Multidrug resistance protein 4 /MOAT-B) is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, capable of pumping a wide variety of endogenous and xenobiotic anionic compounds out of the cell. ABCC4 also transports molecules involved in cellular signalling, including cyclic nucleotides, eicosanoids, urate and conjugated steroids. ABCC4 has a dual localisation in polarised cells that suggests a key function in cellular protection and extracellular signalling pathways. It is also highly expressed on platelet dense granule membranes where it is believed to contribute to the accumulation of dense granule content.
R-HSA-481007 (Reactome) Alpha granules contain mainly polypeptides such as fibrinogen, von Willebrand factor, growth factors and protease inhibitors that supplement thrombin generation at the site of injury. In addtion to their role in hemostasis, platelets also contain angiogenesis stimulators and inhibitors (Italiano et al. 2008).
R-HSA-481009 (Reactome) ADP is the most important constituent of dense granules, essential for recruiting platelets to the site of vascular injury. Other components include ATP, Ca++, GDP, GTP, Mg++, orthophospate, pyrophosphate, and serotonin.
R-HSA-481010 (Reactome) Constituents of the platelet dense granule membrane are incorporated into the platelet membrane following exocytosis of granule content.
R-HSA-481044 (Reactome) Constituents of the platelet alpha granule membrane are incorporated into the platelet membrane following exocytosis of granule content.
R-HSA-482770 (Reactome) Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.
R-HSA-482772 (Reactome) Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.
R-HSA-482775 (Reactome) Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate.
STX4R-HSA-114684 (Reactome)
STXBP3R-HSA-114683 (Reactome)
p-STX4ArrowR-HSA-114684 (Reactome)
p-STXBP3ArrowR-HSA-114683 (Reactome)
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