Protein folding (Homo sapiens)

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7, 16, 2215, 218, 10, 14, 15188, 1014, 258, 10, 1514, 252, 3, 6, 9, 11...148, 10, 15, 268, 10, 158, 154181912, 24cytosolUnfolded CCNE p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADPTUBB4B unfolded CCT8 TUBA1C folding intermediate p-S18,S19,S20,S25-PDCL GNG3 PiGNG12 CCT8 GNAI1 CCT4 ADPPartially folded GNB3 TUBB4B folding intermediate Unfolded GNB3 TUBB4A folding intermediate TCP1 GNG4 TUBB6 RGS7 RGS7,RGS9,(RGS6,RGS11)Unfolded GNB5 CCT3 TUBA3E unfolded TBCB Unfolded GNB2 TUBB6 folding intermediate TUBA4B folding intermediate TCP1 CCT6A TCP1 CCT3 CCT8 TUBA1C unfolded CCT5 CCT8 TUBAL3 folding intermediate CCT4 GTP TUBB1 TUBA4A unfolded TUBA3C/3D unfolded Cofactor B:GTP-alphatubulinPFDN2 ATPGNB3 G-protein alpha(i/o/z/t) subunitADP TBCBTUBA4A PFDN6 VBP1 ADPTUBB1 unfolded GNG3 TUBA1C unfolded CCT2 TUBB3 folding intermediate GNG12 Unfolded GNB3 FBXW10 TUBB6 folding intermediate RGS11 TBCA CCT2 Partially folded GNB1 CCT6B FBXW5 TUBA3E folding intermediate TUBA8 TUBB3 unfolded GTP TUBA8 folding intermediate CCT6B TUBB4A unfolded CCT4 CCT/TRiC:ATP:unfolded tubulin complexUnfolded GNB5 unfolded CCT/TRiCsubstratecandidatesCCT7 ATPGNG12 CCT4 TBCE TUBB4A unfolded Unfolded GNB3 CCT3 CCT4 GNB4 GNG11 GNB1 LONP2 TCP1 TCP1 CCT3 ADP ADP PFDN4 GNGT1 GNG10 CCT7 CCT8 FBXW2 GNB2 TCP1 GNG8 alpha-betaheterodimerCCT2 CCT5 TUBA1A folding intermediate ATPCCT8 TUBA8 folding intermediate TUBB4B unfolded CCT8 XRN2 Unfolded GNB4 TUBB3 unfolded CCT5 GNG7 CCT7 GTP TUBAL3 folding intermediate RGS9 PiCCT7 Unfolded GNB1 p-S18,S19,S20,S25-PDCLp-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADPTUBA1A CCT2 Partially folded GNB4 TUBA1C folding intermediate ADPCCT6B betatubulin:GTP:CofactorD:alphatubulin:GTP:Cofactor ETUBB4B unfolded TUBA3C/3D folding intermediate Unfolded GNB2 TUBA3E folding intermediate CCT3 FBXO6 beta-tubulin folding intermediate GNB5 TUBB4B unfolded TUBB2A unfolded Unfolded HDAC3 CCT7 TUBB6 unfolded TBCC GNB1 TUBA1B folding intermediate TUBAL3 GNAO1 FBXW10 TBCACCT4 TUBA1A folding intermediate TUBA1B folding intermediate TUBB2A folding intermediate SKIV2L CCT2 TUBB2B folding intermediate ADP TUBA1B folding intermediate GNG11 TUBA8 folding intermediate p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADPCCT3 GNB5:CCT/TRiC:ADPTCP1 TUBA8 unfolded PartiallyfoldedG-proteinbetasubunit:CCT/TRiC:ADPp-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunitCCT6B PFDN2 TCP1 Partially folded GNB2 TUBA4A unfolded Unfolded TP53 TUBAL3 folding intermediate TUBA1C folding intermediate CCT6A TUBB3 folding intermediate GNG13 FBXO4 NOP56 CCT6A GNG7 GNB2 TUBA4A folding intermediate Partially folded GNB3 CCT5 TUBA3C/3D unfolded ADP CCT7 TCP1 CCT4 TUBB2A unfolded TUBB6 folding intermediate TUBA3C/3D folding intermediate TUBA3C/3D unfolded TCP1 RGS9 Unfolded WRAP53 RGS11 TUBB2A GNGT2 GTP TUBA4A unfolded AP3M1 CCT2 TUBB2B unfolded TCP1 GNGT1 TUBA1A unfolded GNAT1 CCT7 TUBA3C/3D folding intermediate Partially folded GNB5 TUBB2B unfolded CCT2 TBCD tubulin-GTP foldingintermediateTUBB1 folding intermediate CCT2 TUBA1A folding intermediate TCP1 CCT5 TUBB2B folding intermediate Partially folded GNB2 AP3M1 G-protein gammasubunitCCT3 RGS11 RGS7 Unfolded G-proteinbeta subunitGNG7 TUBAL3 folding intermediate CCT6B PiUnfolded ACTB CCT6A GTP TUBB2A folding intermediate ADP TUBB4B folding intermediate FBXW7 ARFGEF2 ATPGTP:beta-tubulinfoldingintermediateTUBA1C unfolded CSNK2A2 GNGT2 CCT4 TUBA1B unfolded actin/tubulin-boundCCT/TRiC:ADPFBXW5 CCT7 GTPTUBB3 unfolded Casein kinase IIPiGNGT2 p-S18,S19,S20,S25-PDCL CCT5 GNG4 GNB4 TUBB4A folding intermediate TUBA1A folding intermediate ADPRGS6 CCT5 GNG2 TUBB2B folding intermediate TBCECCT3 GNAT2 GNB4 GNG2 TUBB2A folding intermediate TUBA4B folding intermediate TUBB6 unfolded CCT/TRiC:ADP:actinFBXL5 GNAO1 CCT6A FBXW9 GNB5:(RGS7,RGS9,(RGS6,RGS11))CCT8 Unfolded STAT3 GNAT3 TUBA4A unfolded FBXL5 Unfolded GNB1 TUBB3 folding intermediate GNB2 CCT5 TUBA3C/3D unfolded TUBB6 folding intermediate TUBB4B folding intermediate alpha-tubulin folding intermediate CCT3 Partially folded GNB2 CSNK2A1 CCT8 FKBP9 CCT2 TUBA4B unfolded UnfoldedG-proteinbetasubunit:CCT/TRiC:ATPTUBB2B folding intermediate CCT4 TUBB4A folding intermediate CCT7 CCT4 TUBA1B unfolded CCT5 CCT4 CCT8 CCT/TRiC:ADP:Sphingosine kinase 1GNG5 CCT6A TUBA4B KIFC3-2 TBCCTUBA4A folding intermediate Unfolded HDAC3 TUBB6 folding intermediate GNG3 TUBB2B folding intermediate CCT7 CCT2 FBXW9 CCT8 CCT5 CCT5 TUBA1B folding intermediate TUBB1 folding intermediate Unfolded WRAP53 beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor CCCT5 CCT8 TUBB3 unfolded Cofactor D:GTP:betatubulinTUBA4A unfolded TUBB4B Unfolded GBA cofactorA:GTP:beta-tubulinfoldingintermediateCCT6A Unfolded GNB4 GNG13 ARFGEF2 ARL2CCT3 Unfolded GBA CCT2 GTP CCT7 TUBB2B USP11 TUBA3C/3D folding intermediate Unfolded GNB4 TUBA1B GTP-alpha-tubulinfoldingintermediateTUBA4B folding intermediate TUBB2B unfolded Unfolded GNB2 ACTB(1-375)ADP GNG2 CCT3 GNB3 Unfolded ACTB TUBAL3 unfolded KIFC3-2 CCT6A CCT6B TUBA1B folding intermediate FBXL3 ADP RGS6 FBXW2 TUBA3E folding intermediate CSNK2B XRN2 TUBA1C unfolded TCP1 CCT3 GNB1 CCT7 FBXW4 CCT6A CCT6A GNGT1 Partially folded GNB4 CCT8 GNAZ RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADPCCT/TRiC:ADP:non-native tubulinGNB3 TCP1 CCT6B G-proteinheterotrimerTUBB3 folding intermediate Partially folded GNB3 ADP TUBA8 folding intermediate GNAT1 Partially folded GNB5 Unfolded TP53 CCT6B TUBB2A unfolded GNG8 p-S18,S19,S20,S25-PDCL CCT3 TUBA3E unfolded CCT6B Cofactor E:GTP-alphatubulin foldingTUBA3C/3D unfolded CCT/TRiC:ATP:actinCCT6A CCT2 CCT6A TUBB4A CCT8 GNB5 CCT6A GNAI3 TUBA3E folding intermediate TUBB3 folding intermediate Unfolded ACTB CCT5 TUBA8 unfolded FBXO6 ADP TUBB3 p-S18,S19,S20,S25-PDCL:G-protein beta 1-4:gamma complexSPHK1TUBB4A unfolded Partially folded GNB5 GTP TUBA4A folding intermediate TUBA4A folding intermediate CCT/TRiC:ADPTUBA3E Unfolded GNB1 TUBA4B folding intermediate TUBA3C/3D folding intermediate TUBA1C folding intermediate Partially folded GNB1 TCP1 TUBA3C/3D ATP PFDN1 TUBB6 unfolded TUBB3 unfolded SPHK1 TBCDunfoldedactin/tubulinGNAI3 TUBB1 folding intermediate RGS7 TUBB2A unfolded PFDN4 CCT4 GNG13 TUBA4B folding intermediate CCT6B CCT6B CCT3 TUBB4A unfolded TUBA1C Unfolded GAPDHS FBXW4 TUBB4A folding intermediate TBCE KIF13A Unfolded GNB5 CCT4 TUBB2B unfolded FBXW7 CCT5 Unfolded CCNE CCT2 p-S18,S19,S20,S25-PDCL LONP2 TUBA1C unfolded GNG4 TUBB2B unfolded TBCE ADP PFDN6 UnfoldedG-proteinbetasubunit:CCT/TRiC:ADPCCT5 CCT4 PFDN5 TUBB1 unfolded Unfolded STAT3 CCT3 GNAT3 CCT7 TUBB4A folding intermediate Unfolded DCAF7 TUBAL3 unfolded TUBB4B folding intermediate CCT7 RGS6 TUBB1 unfolded CCT6A TUBA1C folding intermediate TUBA3E folding intermediate CCT8 USP11 Partially folded GNB4 TUBA8 folding intermediate FBXO4 TUBA1A unfolded GNG11 PDCLTUBA1A unfolded TUBB6 unfolded GNAI1 TBCD CCT5 GNG8 CCT2 Unfolded ACTB GNG5 GNAZ GNG10 TUBB1 unfolded TUBB1 unfolded Partially folded GNB1 CCT8 p-S18,S19,S20,S25-PDCL TBCD RGS9 KIF13A SKIV2L GTP TCP1 TUBA4A folding intermediate GNAI2 CCT6A TUBB4B folding intermediate TUBB4B unfolded ATP PFDN1 TUBB2A folding intermediate CCT6B CCT4 CCT6B GNG10 Prefoldin-associatedactin/tubulinTUBA1A unfolded CCT6A ADP CCT6B CCT7 GNAT2 GNB5 CCT2 CCT3 TUBB2A folding intermediate CCT7 Unfolded GAPDHS TUBAL3 folding intermediate FKBP9 PrefoldinTUBB6 unfolded TUBA1A folding intermediate GTP CCT6B VBP1 TUBA4B unfolded TUBB4A unfolded TUBA1A unfolded TUBB1 folding intermediate CCT2 CCT/TRiC:substratecomplexPFDN5 Unfolded DCAF7 GTP NOP56 Unfolded ACTB TUBB1 folding intermediate ADP ATP FBXL3 TUBB2A unfolded GNAI2 GNG5 CCT4 CCT6B 15142, 3, 6, 9, 11...1, 5, 16158, 10, 151411