GPCRs, Class A Rhodopsin-like (Mus musculus)

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1, 2Chemokine receptor-likeBradykininPurinoceptorsThyrotropin-releasing hormone & SecretagogueGPR37 / endothelin B-likeOpioidPeptideHormone proteinAPJ likeCannabisC5a anaphylatoxinC-X-C ChemokineRhodopsin VertebrateChemokineMelanocortinNeurotensinAlpha AdrenoceptorsAngiotensinRhodopsin OtherNucleotide-likeC-C ChemokineAmineCCKProstanoid(Rhod)opsinOlfactoryLutropin-choriogonadotropic hormoneOlfactory type 3ProstacyclinProstaglandinFmet-leu-pheVasopressin-likeThyrotropinPlatelet activating factorNeuromedin UEndothelinNeuropeptide YAdrenoceptorsInterleukin-8AdenosineClass A Orphan/otherBeta AdrenoceptorsSomatostatinAcetylcholine (muscarinic)ThromboxaneProteinase activatedThrombinBombesinGalaninFollicle stimulating hormoneHrh2Gabbr1Gpr109bOlfr145Fpr1Cysltr1P2ry6Gpr37Mc3rNpy6rHtr1aAdra2cOlfr155Gpr87Olfr6Olfr955Mc1rTrhr2Agtrl1Olfr937Mc4rOlfr44Olfr926P2ry4Htr1bOlfr144Ccrl2Olfr948Gpr44Bdkrb1Olfr944Olfr148Gpr35Sstr2Ntsr1Gpr37l1Olfr971Olfr711Galr3NmbrP2ry2F2rAgtr1Q9EQ94Gpr27Ccr2FshrAvpCxcr4Agtr2Htr5aTcp10cAdora3P2ry12Ntsr2Blr1SerotoninHistamineOlfr930Olfr703Olfr156Mas1Cxcr3Npy1rGpr63Chrm1Drd4PtgfrOlfr887Olfr49Ptger2Sstr5Olfr894Gpr30Gpr45PtafrCcr8Bdkrb2Ppyr1Sstr4Adrb1Ccbp2Htr1dOlfr943PtgdrCnr1Tbxa2rOlfr959Fpr-rs2Avpr2LhcgrRhoAdra1dMc5rOlfr713Olfr70Olfr876Olfr160Olfr17Olfr710Htr2bOxtrGpr33Olfr242Adra1bP2ry13Olfr1355Gpr12Olfr716Sucnr1Npy5rOlfr945P2ry1Fprl1Opn1mwMelatoninHtr2aFpr-rs3Sstr3Adrb3GrprOlfr707Olfr957Cx3cr1Ccr5Gpr3Olfr27Olfr714Q9EPG0C5r1Ptger3Drd3Htr5bDopamineF2rl2Fpr-rs4Olfr970Ccr1Olfr146Olfr157Hrh1Olfr143Ptger1Cmklr1Mc2rHtr2cOlfr15Olfr968Gpr50Gpr83Olfr151Chrm3Agtr1bOlfr874TshrNmur1Galr2Olfr960Adra1aOlfr715Olfr972Opn4Htr6CckbrOlfr708Olfr893Adora2aOlfr933Olfr701Olfr889Olfr71F2rl1Ccr4Olfr961Mtnr1aOprm1Gpr65Ccr3Adora2bOlfr480OxtGpr19Olfr704Opn3CckarOlfr705Q9EPV1P2ry14Opn1swAdra2bGpr34RrhCcr9Olfr870Sstr1Adrb2TrhrOlfr938Avpr1bGalr1Chrm4Olfr934Olfr888Oprl1Htr7Brs3Adra2aLtb4r1Fpr-rs1Htr1fOprk1Ccr6Olfr954PtgirEdnrbHtr4Olfr706Oprd1F2rl3Ccr1l1RgrNpy2rOlfr749Olfr878Cmkor1Olfr2Il8rbC3ar1Avpr1aCnr2Olfr159Ptger4Olfr16Olfr19Chrm2


Description

This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.

Quality Tags

Ontology Terms

 

Bibliography

  1. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G; ''GPCRDB: an information system for G protein-coupled receptors.''; Nucleic Acids Res, 1998 PubMed Europe PMC
  2. Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines.''; Bioinformatics, 2002 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106862view13:34, 17 September 2019MaintBotHMDB identifier normalization
79710view08:29, 6 April 2015EgonwAdded the two papers cited in the Description.
79709view08:22, 6 April 2015EgonwModified description
79708view08:20, 6 April 2015EgonwAdded the thromboxane ChEBI identifier.
79707view08:19, 6 April 2015EgonwReplaced a gene name with its Entrez Gene identifier.
79706view08:18, 6 April 2015EgonwConverted a label to a metabolite DataNode and converted a few arrows into mim interactions.
78422view10:26, 7 January 2015MaintBotadded missing graphIds
71758view20:22, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
69995view22:29, 11 July 2013MaintBotupdated to 2013 schema
67317view10:36, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
62834view04:52, 3 May 2013MaintBotupdated uniprot data source
41315view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
34575view22:06, 21 December 2009KhanspersModified description
34554view20:23, 21 December 2009KhanspersLayout and added metabolite
34553view20:20, 21 December 2009KhanspersModified description
33379view14:37, 30 November 2009MaintBotRemoved group label
32705view21:10, 1 September 2009MaintBotAdded groups
32704view19:44, 1 September 2009MaintBotAdded groups
32703view19:36, 1 September 2009MaintBotReverted to version '11:30, 14 November 2008' by MaintBot
32359view13:41, 15 August 2009MaintBotFixed text labels
31993view13:14, 14 August 2009MaintBotFixed group labels
31405view20:51, 13 August 2009MaintBotFixed text labels
30903view00:25, 30 July 2009MaintBotConverted from Homo sapiens
21077view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:GPCRDB Class A Rhodopsin-like]] moved to [[Pathway:WP189]]: Moved to stable identifier
10213view18:31, 16 January 2008MaintBotSpecify description
10048view15:05, 11 January 2008MaintBot
8104view13:46, 7 January 2008MaintBot[[Pathway:Mouse:GPCRDB Class A Rhodopsin-like]] moved to [[Pathway:Mus musculus:GPCRDB Class A Rhodopsin-like]]: Renaming species
7417view12:42, 4 November 2007MaintBotAdded categories to GPML
19486view22:19, 22 May 2007BruceConklingpml file for [[Mouse:GPCRDB_Class_A_Rhodopsin-like]]
6445view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:GPCRDB_Class_A_Rhodopsin-like]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Adora2aGeneProduct11540 (Entrez Gene)
Adora2bGeneProduct11541 (Entrez Gene)
Adora3GeneProduct11542 (Entrez Gene)
Adra1aGeneProduct11549 (Entrez Gene)
Adra1bGeneProduct11548 (Entrez Gene)
Adra1dGeneProduct11550 (Entrez Gene)
Adra2aGeneProduct11551 (Entrez Gene)
Adra2bGeneProduct11552 (Entrez Gene)
Adra2cGeneProduct11553 (Entrez Gene)
Adrb1GeneProduct11554 (Entrez Gene)
Adrb2GeneProduct11555 (Entrez Gene)
Adrb3GeneProduct11556 (Entrez Gene)
Agtr1GeneProduct11607 (Entrez Gene)
Agtr1bGeneProduct11608 (Entrez Gene)
Agtr2GeneProduct11609 (Entrez Gene)
Agtrl1GeneProduct23796 (Entrez Gene)
AvpGeneProduct11998 (Entrez Gene)
Avpr1aGeneProduct54140 (Entrez Gene)
Avpr1bGeneProduct26361 (Entrez Gene)
Avpr2GeneProduct12000 (Entrez Gene)
Bdkrb1GeneProduct12061 (Entrez Gene)
Bdkrb2GeneProduct12062 (Entrez Gene)
Blr1GeneProduct12145 (Entrez Gene)
Brs3GeneProduct12209 (Entrez Gene)
C3ar1GeneProduct12267 (Entrez Gene)
C5r1GeneProduct12273 (Entrez Gene)
Ccbp2GeneProduct59289 (Entrez Gene)
CckarGeneProduct12425 (Entrez Gene)
CckbrGeneProduct12426 (Entrez Gene)
Ccr1GeneProduct12768 (Entrez Gene)
Ccr1l1GeneProduct12770 (Entrez Gene)
Ccr2GeneProduct12772 (Entrez Gene)
Ccr3GeneProduct12771 (Entrez Gene)
Ccr4GeneProduct12773 (Entrez Gene)
Ccr5GeneProduct12774 (Entrez Gene)
Ccr6GeneProduct12458 (Entrez Gene)
Ccr8GeneProduct12776 (Entrez Gene)
Ccr9GeneProduct12769 (Entrez Gene)
Ccrl2GeneProduct54199 (Entrez Gene)
Chrm1GeneProduct12669 (Entrez Gene)
Chrm2GeneProduct243764 (Entrez Gene)
Chrm3GeneProduct12671 (Entrez Gene)
Chrm4GeneProduct12672 (Entrez Gene)
Cmklr1GeneProduct14747 (Entrez Gene)
Cmkor1GeneProduct12778 (Entrez Gene)
Cnr1GeneProduct12801 (Entrez Gene)
Cnr2GeneProduct12802 (Entrez Gene)
Cx3cr1GeneProduct13051 (Entrez Gene)
Cxcr3GeneProduct12766 (Entrez Gene)
Cxcr4GeneProduct12767 (Entrez Gene)
Cysltr1GeneProduct58861 (Entrez Gene)
DopamineMetabolite62-31-7 (CAS)
Drd3GeneProduct13490 (Entrez Gene)
Drd4GeneProduct13491 (Entrez Gene)
EdnrbGeneProduct13618 (Entrez Gene)
F2rGeneProduct14062 (Entrez Gene)
F2rl1GeneProduct14063 (Entrez Gene)
F2rl2GeneProduct14064 (Entrez Gene)
F2rl3GeneProduct14065 (Entrez Gene)
Fpr-rs1GeneProduct14288 (Entrez Gene)
Fpr-rs2GeneProduct14289 (Entrez Gene)
Fpr-rs3GeneProduct14290 (Entrez Gene)
Fpr-rs4GeneProduct14291 (Entrez Gene)
Fpr1GeneProduct14293 (Entrez Gene)
Fprl1GeneProduct14294 (Entrez Gene)
FshrGeneProduct14309 (Entrez Gene)
Gabbr1GeneProduct54393 (Entrez Gene)
Galr1GeneProduct14427 (Entrez Gene)
Galr2GeneProduct14428 (Entrez Gene)
Galr3GeneProduct14429 (Entrez Gene)
Gpr109bGeneProduct80885 (Entrez Gene)
Gpr12GeneProduct14738 (Entrez Gene)
Gpr19GeneProduct14760 (Entrez Gene)
Gpr27GeneProduct14761 (Entrez Gene)
Gpr30GeneProduct76854 (Entrez Gene)
Gpr3GeneProduct14748 (Entrez Gene)
Gpr33GeneProduct14762 (Entrez Gene)
Gpr34GeneProduct23890 (Entrez Gene)
Gpr35GeneProduct64095 (Entrez Gene)
Gpr37GeneProduct14763 (Entrez Gene)
Gpr37l1GeneProduct171469 (Entrez Gene)
Gpr44GeneProduct14764 (Entrez Gene)
Gpr45GeneProduct93690 (Entrez Gene)
Gpr50GeneProduct14765 (Entrez Gene)
Gpr63GeneProduct81006 (Entrez Gene)
Gpr65GeneProduct14744 (Entrez Gene)
Gpr83GeneProduct14608 (Entrez Gene)
Gpr87GeneProduct84111 (Entrez Gene)
GrprGeneProduct14829 (Entrez Gene)
HistamineMetabolite51-45-6 (CAS)
Hrh1GeneProduct15465 (Entrez Gene)
Hrh2GeneProduct15466 (Entrez Gene)
Htr1aGeneProduct15550 (Entrez Gene)
Htr1bGeneProduct15551 (Entrez Gene)
Htr1dGeneProduct15552 (Entrez Gene)
Htr1fGeneProduct15557 (Entrez Gene)
Htr2aGeneProduct15558 (Entrez Gene)
Htr2bGeneProduct15559 (Entrez Gene)
Htr2cGeneProduct15560 (Entrez Gene)
Htr4GeneProduct15562 (Entrez Gene)
Htr5aGeneProduct15563 (Entrez Gene)
Htr5bGeneProduct15564 (Entrez Gene)
Htr6GeneProduct15565 (Entrez Gene)
Htr7GeneProduct15566 (Entrez Gene)
Il8rbGeneProduct12765 (Entrez Gene)
LhcgrGeneProduct16867 (Entrez Gene)
Ltb4r1GeneProduct16995 (Entrez Gene)
Mas1GeneProduct17171 (Entrez Gene)
Mc1rGeneProduct17199 (Entrez Gene)
Mc2rGeneProduct17200 (Entrez Gene)
Mc3rGeneProduct17201 (Entrez Gene)
Mc4rGeneProduct17202 (Entrez Gene)
Mc5rGeneProduct17203 (Entrez Gene)
MelatoninMetaboliteHMDB0001389 (HMDB)
Mtnr1aGeneProduct17773 (Entrez Gene)
NmbrGeneProduct18101 (Entrez Gene)
Nmur1GeneProduct14767 (Entrez Gene)
Npy1rGeneProduct18166 (Entrez Gene)
Npy2rGeneProduct18167 (Entrez Gene)
Npy5rGeneProduct18168 (Entrez Gene)
Npy6rGeneProduct18169 (Entrez Gene)
Ntsr1GeneProduct18216 (Entrez Gene)
Ntsr2GeneProduct18217 (Entrez Gene)
Olfr1355GeneProduct404334 (Entrez Gene)
Olfr143GeneProduct258802 (Entrez Gene)
Olfr144GeneProduct257959 (Entrez Gene)
Olfr145GeneProduct258310 (Entrez Gene)
Olfr146GeneProduct258742 (Entrez Gene)
Olfr148GeneProduct258498 (Entrez Gene)
Olfr151GeneProduct406176 (Entrez Gene)
Olfr15GeneProduct18312 (Entrez Gene)
Olfr155GeneProduct29845 (Entrez Gene)
Olfr156GeneProduct29846 (Entrez Gene)
Olfr157GeneProduct29847 (Entrez Gene)
Olfr159GeneProduct29849 (Entrez Gene)
Olfr160GeneProduct80706 (Entrez Gene)
Olfr16GeneProduct18313 (Entrez Gene)
Olfr17GeneProduct18314 (Entrez Gene)
Olfr19GeneProduct18316 (Entrez Gene)
Olfr2GeneProduct18317 (Entrez Gene)
Olfr242GeneProduct406175 (Entrez Gene) ��Ω��Ω258500[L] ��Ω��Ω
Olfr27GeneProduct258826 (Entrez Gene)
Olfr44GeneProduct18343 (Entrez Gene)
Olfr480GeneProduct56861 (Entrez Gene)
Olfr49GeneProduct18348 (Entrez Gene)
Olfr6GeneProduct233670 (Entrez Gene)
Olfr701GeneProduct66786 (Entrez Gene)
Olfr703GeneProduct258589 (Entrez Gene)
Olfr704GeneProductQ9EPF6 (Uniprot-TrEMBL)
Olfr705GeneProduct259034 (Entrez Gene)
Olfr70GeneProduct56014 (Entrez Gene)
Olfr706GeneProduct258350 (Entrez Gene)
Olfr707GeneProduct194433 (Entrez Gene)
Olfr708GeneProduct258173 (Entrez Gene)
Olfr710GeneProduct258594 (Entrez Gene)
Olfr711GeneProduct259037 (Entrez Gene)
Olfr713GeneProduct259036 (Entrez Gene)
Olfr714GeneProduct259035 (Entrez Gene)
Olfr715GeneProduct258776 (Entrez Gene)
Olfr71GeneProduct56015 (Entrez Gene)
Olfr716GeneProduct258597 (Entrez Gene)
Olfr749GeneProduct56858 (Entrez Gene)
Olfr870GeneProduct57251 (Entrez Gene)
Olfr874GeneProduct258882 (Entrez Gene)
Olfr876GeneProduct258883 (Entrez Gene)
Olfr878GeneProduct258794 (Entrez Gene)
Olfr887GeneProduct258415 (Entrez Gene)
Olfr888GeneProduct258416 (Entrez Gene)
Olfr889GeneProduct258475 (Entrez Gene)
Olfr893GeneProduct258333 (Entrez Gene)
Olfr894GeneProduct258868 (Entrez Gene)
Olfr926GeneProduct258811 (Entrez Gene)
Olfr930GeneProduct258269 (Entrez Gene)
Olfr933GeneProduct258433 (Entrez Gene)
Olfr934GeneProduct258434 (Entrez Gene)
Olfr937GeneProduct258431 (Entrez Gene)
Olfr938GeneProduct258430 (Entrez Gene)
Olfr943GeneProduct258323 (Entrez Gene)
Olfr944GeneProduct258500 (Entrez Gene) ��Ω��Ω258500[L] ��Ω��Ω
Olfr945GeneProduct258499 (Entrez Gene)
Olfr948GeneProductQ9EQ95 (Uniprot-TrEMBL)
Olfr954GeneProduct258328 (Entrez Gene)
Olfr955GeneProduct258242 (Entrez Gene)
Olfr957GeneProduct258740 (Entrez Gene)
Olfr959GeneProduct258501 (Entrez Gene)
Olfr960GeneProduct258276 (Entrez Gene)
Olfr961GeneProduct258497 (Entrez Gene)
Olfr968GeneProduct258605 (Entrez Gene) ��Ω��Ω258603[L] ��Ω��Ω
Olfr970GeneProduct258604 (Entrez Gene)
Olfr971GeneProduct258607 (Entrez Gene)
Olfr972GeneProduct258603 (Entrez Gene) ��Ω��Ω258603[L] ��Ω��Ω
Opn1mwGeneProduct14539 (Entrez Gene)
Opn1swGeneProduct12057 (Entrez Gene)
Opn3GeneProduct13603 (Entrez Gene)
Opn4GeneProduct30044 (Entrez Gene)
Oprd1GeneProduct18386 (Entrez Gene)
Oprk1GeneProduct18387 (Entrez Gene)
Oprl1GeneProduct18389 (Entrez Gene)
Oprm1GeneProduct18390 (Entrez Gene)
OxtGeneProduct18429 (Entrez Gene)
OxtrGeneProduct18430 (Entrez Gene)
P2ry1GeneProduct18441 (Entrez Gene)
P2ry12GeneProduct70839 (Entrez Gene)
P2ry13GeneProduct74191 (Entrez Gene)
P2ry14GeneProduct140795 (Entrez Gene)
P2ry2GeneProduct18442 (Entrez Gene)
P2ry4GeneProduct57385 (Entrez Gene)
P2ry6GeneProduct233571 (Entrez Gene)
Ppyr1GeneProduct19065 (Entrez Gene)
PtafrGeneProduct19204 (Entrez Gene)
PtgdrGeneProduct19214 (Entrez Gene)
Ptger1GeneProduct19216 (Entrez Gene)
Ptger2GeneProduct19217 (Entrez Gene)
Ptger3GeneProduct19218 (Entrez Gene)
Ptger4GeneProduct19219 (Entrez Gene)
PtgfrGeneProduct19220 (Entrez Gene)
PtgirGeneProduct19222 (Entrez Gene)
Q9EPG0GeneProductQ9EPG0_MOUSE (Uniprot-TrEMBL)
Q9EPV1GeneProductQ9EPV1 (Uniprot-TrEMBL)
Q9EQ94GeneProductQ9EQ94 (Uniprot-TrEMBL)
RgrGeneProduct57811 (Entrez Gene)
RhoGeneProduct212541 (Entrez Gene)
RrhGeneProduct20132 (Entrez Gene)
SerotoninMetabolite50-67-9 (CAS)
Sstr1GeneProduct20605 (Entrez Gene)
Sstr2GeneProduct20606 (Entrez Gene)
Sstr3GeneProduct20607 (Entrez Gene)
Sstr4GeneProduct20608 (Entrez Gene)
Sstr5GeneProduct20609 (Entrez Gene)
Sucnr1GeneProduct84112 (Entrez Gene)
Tbxa2rGeneProduct21390 (Entrez Gene)
Tcp10cGeneProduct21462 (Entrez Gene)
ThromboxaneMetaboliteCHEBI:26995 (ChEBI)
Trhr2GeneProduct170732 (Entrez Gene)
TrhrGeneProduct22045 (Entrez Gene)
TshrGeneProduct22095 (Entrez Gene)

Annotated Interactions

No annotated interactions

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