Signaling by NTRK1 (Homo sapiens)

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38, 53, 54, 612931743015, 23, 44, 56, 57, 66...21, 4611, 4947135, 36, 64317316, 22, 502925, 28, 485265232311993, 6310, 14, 2175, 64114112, 50, 57, 75, 771, 33, 37, 4329692118, 396810, 11, 18, 536710, 11, 21, 53clathrin-coated endocytic vesicleGolgi lumencytosolnucleoplasmendosomeNGF p-p38 MAPKalpha/betap-5Y-NTRK1 p-T202,Y204-MAPK3 DUSP3 p-5Y-NTRK1 DUSP4 PIK3R2 PIK3R2 p-Y-IRS2 NTRK1 RIT1 ATPGDP p-5Y-NTRK1 ADPp-Y1096-KIDINS220 p-S272,T222,T334-MAPKAPK2 RAP1:GTPp-5Y-NTRK1 p-S727-STAT3NGF GDPGTPNGF ATPCREB1ADPMAPK1 ATPp21 RAS:GDPADPMAP kinase p38 (Mg2+cofactor)AP2A1 MAPKsActivated TrkAreceptor complexNGF p-Y1096-KIDINS220 RALB Active TrkAreceptor:ARMS:Crkcomplexp-S218,S222-MAP2K1 p-T180,Y182-MAPK11 ADPS-Farn-Me-2xPalmS HRAS RAP1A CLTA NGF YWHAB PI(4,5)P2p-T218,Y220-MAPK7 RHOA MAPKAPK3 GDP RALGDSDNM3 PIK3CA ADPp-5Y-NTRK1-1 p-Y-SHC2 Activated TrkAreceptor complexRAP1A GTPS-Farn-Me-2xPalmS HRAS Zn2+ Activated TrkAreceptor:p-SHCZn2+ AP2A2(1-939) p-T185,Y187-MAPK1 ELK1ATPNGF NGF ATPGTP BRAF dimer complexRIT1 p-2S MAP2Khomo/heterodimersGTPYWHAB BRAF Ade-Rib:ADORA2A:NTRK1,2GDP MAPK1 RPS6KA2 MAP2K1 Phospho-MAP kinasep38 (Mg2+ cofactor)RAP1:GDPADPADPNGF-stimulatedtranscriptionADCYAP1(2-742) GTP GTP Activated TrkAreceptor:IRS1/2p-5Y-NTRK1 Active TrkAreceptor:PLCG1complexAP2M1 GRB2-1:SOS1:p-Y-SHCS-Farn-Me-PalmS KRAS4A p-MAPK3/MAPK1/MAPK7dimersADPRAL-GDPRALA PiVRK3 YWHAB CLTA p-S,2T-MAPKAPK3 p-T202,Y204-MAPK3 NGF Activated TrkAreceptor:SHCAP2A1 p-T,Y MAPK dimersAde-Rib Active TrkA receptorcomplex:RIT/RIN-GDPCRK ATPp-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3ATPRHOAp-4S,T336-ELK1MAPKAP kinaseSOS1 Activated TrkAreceptor complexAde-Rib:ADORA2A:p-5Y-NTRK1,p-5Y-NTRK2SH3GL2 PI(3,4,5)P3p-S133-CREB1p-S396-MEF2C MAPK3 GTP Zn2+ p-S218,S222-MAP2K1 ADPPIP3 activates AKTsignalingRALB GTP p-5Y-NTRK1-1 YWHAB GTP PPP2R1B Ras-GTP:RalGDScomplexp-5Y-NTRK1 p-Y-IRS2 p-S445,T599,S602,S729 BRAF Zn2+ YWHAB Phospho-Ribosomalprotein S6 kinaseYWHAB ARMS:Crkp-Y1096-KIDINS220 YWHAB ADPbeta-NGF dimer:TrkAreceptor dimerp-T185,Y187-MAPK1 p-T185,Y187-MAPK1 DNAL4RAL-GTPp-T202,Y204-MAPK3 NGF YWHAB GDPRAP1A MAPK1 NGF NGF AP2A1 p-4S,T356,T570-RPS6KA2 MAP2Khomo/heterodimersPIK3CA p-T180,Y182-MAPK14 ADORA2A RAP1A NGF p-T,Y MAPK dimersRIT1 GDP p-5Y-NTRK1 PIK3CB CRKL ActiveTrkAreceptor:p-FRS2:CRKL:RAPGEF1p-5Y-NTRK1-1 RIT2 MAP2K2 MAPK3 BRAF NGF PIK3CA DNM1 Zn2+ AP2B1 DAG and IP3signalingRAPGEF1SH3GL2 p-5Y-NTRK1-1 CRK GTP p-S,T-BRAF SHC1 p-Y-SHC2 p-Y419-SRC-1Phospho-IRS1/2:PI3K(p85:p110)p-5Y-NTRK1 PIK3CB S-Farn-Me-PalmS KRAS4A p-Y-SHC3 ADPp75 NTRreceptor-mediatedsignallingp-S445,S729-BRAF PI3KADCYAP1(2-742):ADCYAP1R1:p-5Y-NTRK1,p-5Y-NTRK2p-5Y-NTRK1 ADCYAP1(2-742)H2OADCYAP1R1 ADPMAP2K5p-6Y-FRS2 NGF NTRK1 ATPSOS1 Rap1-GTPcomplex:p-S,T-BRAFcomplexS-Farn-Me PalmS NRAS CRKLActive TrkAreceptor:p-FRS2complexATPSHC2 NGF GTP p-Y1096-KIDINS220 MAPK11 IRS2 p-S445,T599,S602,S729 BRAF ERK-specific DUSPNGF GDPCRK p-T222,S272-MAPKAPK2RAP1A Ribosomal protein S6kinaseADPSHCp-5Y-NTRK2 p-5Y-NTRK1 p-5Y-NTRK1 MAPK7 NTRK1 IRS1,2IRS2 p-Y-SHC3 p-S222,S226-MAP2K2 ATPDynamin-1/2/3ActiveTrkreceptorcomplex:RIT/RIN-GTP:B-RAFp-Y-SHC1 MEF2A CRK RAP1:GTP:activatedBRAF dimer:p-2SMAPK2K:MAPK complexRAP1A Zn2+ MAPK3/MAPK1/MAPK7dimersATPADCYAP1(2-742):ADCYAP1R1:NTRK1,2AP2A2(1-939) RIT2 RAP1:GTP:activatedBRAF dimerGTP YWHAB Rap1-GTPcomplex:BRAFcomplexActivatedTrkAreceptor:Phospho-IRS1/2:PI3K(p85:p110)Rap1-GTP complexPIK3R1 FRS2ATPRAP1:GTP:activatedBRAF dimer:p-2SMAPK2K:p-T,Y MAPKcomplexIRS1 ATPFRS2 p-T218,Y220-MAPK7PIK3R1 ATPp-5Y-NTRK1 p-S408-MEF2A ADPp-T,Y MAPKsAP2M1 p-5Y-NTRK1 p-S445,T599,S602,S729 BRAF p-T185,Y187-MAPK1 ActivatedTrkAreceptorcomplex:Clathrin-coated vesicleADCYAP1R1p-5Y-NTRK2 ATPActiveTrkAreceptor:p-FRS2:CRKL complexKIDINS220 SH3GL2DNM2 MAP2K2 BRAF GTPATPCLTA p-T180,Y182-MAPK11 RAP1A VRK3:DUSP3NTRK1MAPKAPK2 ADPRALGDS Zn2+ S-Farn-Me KRAS4B ActivatedTrkAreceptorcomplex:Clathrin-coated vesicle:dynein:dynactin complexp-Y-SHC1 Zn2+ NGF processingp-MEF2SHC2 Activated TrkAreceptor complexCLTC p-5Y-NTRK1 ATPRAP1A GRB2-1:SOS1RAP1A Pip-5Y-NTRK1 Activated TrkAreceptor complexAP2A1 DUSP3 PLCG1 p-Y1096-KIDINS220 NGF ATPbeta-NGF dimer:TrkAreceptorNGF AP2A2(1-939) ATF1SHC3 MEF2C p-5Y-NTRK1 AP2S1 NGF AP2M1 p-T218,Y220-MAPK7NGF p-5Y-NTRK1 ActiveTrkAreceptor:Phospho-ARMS:Crk complexNTRK1 AP2M1 GTP p-5Y-NTRK1 MAPK12 RPS6KA1 p-S222,S226-MAP2K2 RPS6KA5Mg2+ CLTA ADPADORA2A S-Farn-Me-PalmS KRAS4A NTRK2 ADORA2ARAF/MAP kinasecascadeATPNGF RALA CRK GTP BRAF PPP2CB GTP AP2B1 Active Trk receptorcomplex:RIT/RIN-GTPp-Y-SHCSRC-1ActivatedTrkAreceptorcomplex:Clathrin-coated vesicle:EndophilinGRB2-1 ADCYAP1(2-742) RAP1:GTP:B-RafcomplexAde-Rib p-S445,T599,S602,S729 BRAF BRAF complexRAP1A ATPNTRK2 ADCYAP1R1 CRKL p-Y-IRS1 NTRK1 GTP Zn2+ Mg2+ Zn2+ IRS1 S-Farn-Me KRAS4B GDPSHC1 ADPS-Farn-Me-2xPalmS HRAS NGF GDP mature beta-NGFhomodimerp-S63-ATF1p-5Y-NTRK1 p-5Y-NTRK1 ADPGDPAP2B1 Clathrin:AP-2complexS-Farn-Me PalmS NRAS MAPK14 AP2S1 MAP2K1 ADPNGF PIK3CB PIP3:RhoAPip-Y-IRS1 p-6Y-FRS2 Active TrkAreceptor:FRS2complexRIT/RIN-GDPGTP PPP2R1A ATPp21 RAS:GTPGDP p-S212,S360,S376,T581-RPS6KA5PIK3R1 p-5Y-NTRK1-1 p-5Y-NTRK1 p-4Y-PLCG1p-Y-SHC1 AP2S1 NGF B-RAFp-S222,S226-MAP2K2 p-4Y-PLCG1 RAP1:GTP:activatedBRAFdimer:MAPK2K:MAPKcomplexNGF PIK3R2 GRB2-1 NTRK2 MAPK7Rap1-GTPGTPGTP RAP1A PP2A-ABdeltaCcomplexATPDUSP6 p-5Y-NTRK1 AP2A2(1-939) p-T180,Y182-MAPK14 ADPADPNGF p-T185,Y187-MAPK1 RIT2 NGF PLCG1p-5Y-NTRK1 GTPCLTC p-4S,T359,T573-RPS6KA1 CRK ADPRIT1 p-5Y-NTRK1 CRK p-6Y-FRS2 ADPS-Farn-Me KRAS4B GDPS-Farn-Me PalmS NRAS p-5Y-NTRK1 H2Op-4S,T231,T365-RPS6KA3 ActiveTrkAreceptor:Phospho-ARMS:Crk:C3G complexNTRK1,2H2OATPp-S218,S222-MAP2K1 MEF2NGF STAT3RIT2 CLTC KIDINS220 AP2S1 MAPK3 Rap1-GDPADPGuanine nucleotideexchange factorp-T202,Y204-MAPK3 ActivatedTrkAreceptor:Phospho-IRS1/2PPP2R5D RAP1A NGF PI(3,4,5)P3 MAPK3 ATPp-Y-SHC3 DUSP7 RPS6KA3 p-S445,S729-BRAF ActiveTrkAreceptor:Phospho-PLCG1 complexMAPK13 AP2B1 NGF Ade-Ribp-Y-IRS1 p-T202,Y204-MAPK3 Zn2+ p-Y-IRS2 CLTC RAPGEF1 SHC3 MAPK1 PPP2CA p-Y-SHC2 NGF 4, 6, 17, 20, 24...10, 27, 5850, 51, 5542, 7226, 597826, 598