Signaling by NTRK1 (Homo sapiens)
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38, 53, 54, 61
29
31
74
30
15, 23, 44, 56, 57, 66...
21, 46
11, 49
47
13
5, 36, 64
31
73
16, 22, 50
29
25, 28, 48
52
65
2
32
31
19
9
3, 63
10, 14, 21
7
5, 64
11
41
12, 50, 57, 75, 77
1, 33, 37, 43
29
69
21
18, 39
68
10, 11, 18, 53
67
10, 11, 21, 53
clathrin-coated endocytic vesicle
Golgi lumen
cytosol
nucleoplasm
endosome
NGF
p-p38 MAPK
alpha/beta
p-5Y-NTRK1
p-T202,Y204-MAPK3
DUSP3
p-5Y-NTRK1
DUSP4
PIK3R2
PIK3R2
p-Y-IRS2
NTRK1
RIT1
ATP
GDP
p-5Y-NTRK1
ADP
p-Y1096-KIDINS220
p-S272,T222,T334-MAPKAPK2
RAP1:GTP
p-5Y-NTRK1
p-S727-STAT3
NGF
GDP
GTP
NGF
ATP
CREB1
ADP
MAPK1
ATP
p21 RAS:GDP
ADP
MAP kinase p38 (Mg2+
cofactor)
AP2A1
MAPKs
Activated TrkA
receptor complex
NGF
p-Y1096-KIDINS220
RALB
Active TrkA
receptor:ARMS:Crk
complex
p-S218,S222-MAP2K1
p-T180,Y182-MAPK11
ADP
S-Farn-Me-2xPalmS HRAS
RAP1A
CLTA
NGF
YWHAB
PI(4,5)P2
p-T218,Y220-MAPK7
RHOA
MAPKAPK3
GDP
RALGDS
DNM3
PIK3CA
ADP
p-5Y-NTRK1-1
p-Y-SHC2
Activated TrkA
receptor complex
RAP1A
GTP
S-Farn-Me-2xPalmS HRAS
Zn2+
Activated TrkA
receptor:p-SHC
Zn2+
AP2A2(1-939)
p-T185,Y187-MAPK1
ELK1
ATP
NGF
NGF
ATP
GTP
BRAF dimer complex
RIT1
p-2S MAP2K
homo/heterodimers
GTP
YWHAB
BRAF
Ade-Rib:ADORA2A:NTRK1,2
GDP
MAPK1
RPS6KA2
MAP2K1
Phospho-MAP kinase
p38 (Mg2+ cofactor)
RAP1:GDP
ADP
ADP
NGF-stimulated
transcription
ADCYAP1(2-742)
GTP
GTP
Activated TrkA
receptor:IRS1/2
p-5Y-NTRK1
Active TrkA
receptor:PLCG1
complex
AP2M1
GRB2-1:SOS1:p-Y-SHC
S-Farn-Me-PalmS KRAS4A
p-MAPK3/MAPK1/MAPK7
dimers
ADP
RAL-GDP
RALA
Pi
VRK3
YWHAB
CLTA
p-S,2T-MAPKAPK3
p-T202,Y204-MAPK3
NGF
Activated TrkA
receptor:SHC
AP2A1
p-T,Y MAPK dimers
Ade-Rib
Active TrkA receptor
complex:RIT/RIN-GDP
CRK
ATP
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3
ATP
RHOA
p-4S,T336-ELK1
MAPKAP kinase
SOS1
Activated TrkA
receptor complex
Ade-Rib:ADORA2A:p-5Y-NTRK1,p-5Y-NTRK2
SH3GL2
PI(3,4,5)P3
p-S133-CREB1
p-S396-MEF2C
MAPK3
GTP
Zn2+
p-S218,S222-MAP2K1
ADP
PIP3 activates AKT
signaling
RALB
GTP
p-5Y-NTRK1-1
YWHAB
GTP
PPP2R1B
Ras-GTP:RalGDS
complex
p-5Y-NTRK1
p-Y-IRS2
p-S445,T599,S602,S729 BRAF
Zn2+
YWHAB
Phospho-Ribosomal
protein S6 kinase
YWHAB
ARMS:Crk
p-Y1096-KIDINS220
YWHAB
ADP
beta-NGF dimer:TrkA
receptor dimer
p-T185,Y187-MAPK1
p-T185,Y187-MAPK1
DNAL4
RAL-GTP
p-T202,Y204-MAPK3
NGF
YWHAB
GDP
RAP1A
MAPK1
NGF
NGF
AP2A1
p-4S,T356,T570-RPS6KA2
MAP2K
homo/heterodimers
PIK3CA
p-T180,Y182-MAPK14
ADORA2A
RAP1A
NGF
p-T,Y MAPK dimers
RIT1
GDP
p-5Y-NTRK1
PIK3CB
CRKL
Active
TrkA
receptor:p-FRS2:CRKL:RAPGEF1
p-5Y-NTRK1-1
RIT2
MAP2K2
MAPK3
BRAF
NGF
PIK3CA
DNM1
Zn2+
AP2B1
DAG and IP3
signaling
RAPGEF1
SH3GL2
p-5Y-NTRK1-1
CRK
GTP
p-S,T-BRAF
SHC1
p-Y-SHC2
p-Y419-SRC-1
Phospho-IRS1/2:PI3K(p85:p110)
p-5Y-NTRK1
PIK3CB
S-Farn-Me-PalmS KRAS4A
p-Y-SHC3
ADP
p75 NTR
receptor-mediated
signalling
p-S445,S729-BRAF
PI3K
ADCYAP1(2-742):ADCYAP1R1:p-5Y-NTRK1,p-5Y-NTRK2
p-5Y-NTRK1
ADCYAP1(2-742)
H2O
ADCYAP1R1
ADP
MAP2K5
p-6Y-FRS2
NGF
NTRK1
ATP
SOS1
Rap1-GTP
complex:p-S,T-BRAF
complex
S-Farn-Me PalmS NRAS
CRKL
Active TrkA
receptor:p-FRS2
complex
ATP
SHC2
NGF
GTP
p-Y1096-KIDINS220
MAPK11
IRS2
p-S445,T599,S602,S729 BRAF
ERK-specific DUSP
NGF
GDP
CRK
p-T222,S272-MAPKAPK2
RAP1A
Ribosomal protein S6
kinase
ADP
SHC
p-5Y-NTRK2
p-5Y-NTRK1
p-5Y-NTRK1
MAPK7
NTRK1
IRS1,2
IRS2
p-Y-SHC3
p-S222,S226-MAP2K2
ATP
Dynamin-1/2/3
Active
Trk
receptor
complex:RIT/RIN-GTP:B-RAF
p-Y-SHC1
MEF2A
CRK
RAP1:GTP:activated
BRAF dimer:p-2S
MAPK2K:MAPK complex
RAP1A
Zn2+
MAPK3/MAPK1/MAPK7
dimers
ATP
ADCYAP1(2-742):ADCYAP1R1:NTRK1,2
AP2A2(1-939)
RIT2
RAP1:GTP:activated
BRAF dimer
GTP
YWHAB
Rap1-GTP
complex:BRAF
complex
Activated
TrkA
receptor:Phospho-IRS1/2:PI3K(p85:p110)
Rap1-GTP complex
PIK3R1
FRS2
ATP
RAP1:GTP:activated
BRAF dimer:p-2S
MAPK2K:p-T,Y MAPK
complex
IRS1
ATP
FRS2
p-T218,Y220-MAPK7
PIK3R1
ATP
p-5Y-NTRK1
p-S408-MEF2A
ADP
p-T,Y MAPKs
AP2M1
p-5Y-NTRK1
p-S445,T599,S602,S729 BRAF
p-T185,Y187-MAPK1
Activated
TrkA
receptor
complex:Clathrin-coated vesicle
ADCYAP1R1
p-5Y-NTRK2
ATP
Active
TrkA
receptor:p-FRS2:CRKL complex
KIDINS220
SH3GL2
DNM2
MAP2K2
BRAF
GTP
ATP
CLTA
p-T180,Y182-MAPK11
RAP1A
VRK3:DUSP3
NTRK1
MAPKAPK2
ADP
RALGDS
Zn2+
S-Farn-Me KRAS4B
Activated
TrkA
receptor
complex:Clathrin-coated vesicle:dynein:dynactin complex
p-Y-SHC1
Zn2+
NGF processing
p-MEF2
SHC2
Activated TrkA
receptor complex
CLTC
p-5Y-NTRK1
ATP
RAP1A
GRB2-1:SOS1
RAP1A
Pi
p-5Y-NTRK1
Activated TrkA
receptor complex
AP2A1
DUSP3
PLCG1
p-Y1096-KIDINS220
NGF
ATP
beta-NGF dimer:TrkA
receptor
NGF
AP2A2(1-939)
ATF1
SHC3
MEF2C
p-5Y-NTRK1
AP2S1
NGF
AP2M1
p-T218,Y220-MAPK7
NGF
p-5Y-NTRK1
Active
TrkA
receptor:Phospho-ARMS:Crk complex
NTRK1
AP2M1
GTP
p-5Y-NTRK1
MAPK12
RPS6KA1
p-S222,S226-MAP2K2
RPS6KA5
Mg2+
CLTA
ADP
ADORA2A
S-Farn-Me-PalmS KRAS4A
NTRK2
ADORA2A
RAF/MAP kinase
cascade
ATP
NGF
RALA
CRK
GTP
BRAF
PPP2CB
GTP
AP2B1
Active Trk receptor
complex:RIT/RIN-GTP
p-Y-SHC
SRC-1
Activated
TrkA
receptor
complex:Clathrin-coated vesicle:Endophilin
GRB2-1
ADCYAP1(2-742)
RAP1:GTP:B-Raf
complex
Ade-Rib
p-S445,T599,S602,S729 BRAF
BRAF complex
RAP1A
ATP
NTRK2
ADCYAP1R1
CRKL
p-Y-IRS1
NTRK1
GTP
Zn2+
Mg2+
Zn2+
IRS1
S-Farn-Me KRAS4B
GDP
SHC1
ADP
S-Farn-Me-2xPalmS HRAS
NGF
GDP
mature beta-NGF
homodimer
p-S63-ATF1
p-5Y-NTRK1
p-5Y-NTRK1
ADP
GDP
AP2B1
Clathrin:AP-2
complex
S-Farn-Me PalmS NRAS
MAPK14
AP2S1
MAP2K1
ADP
NGF
PIK3CB
PIP3:RhoA
Pi
p-Y-IRS1
p-6Y-FRS2
Active TrkA
receptor:FRS2
complex
RIT/RIN-GDP
GTP
PPP2R1A
ATP
p21 RAS:GTP
GDP
p-S212,S360,S376,T581-RPS6KA5
PIK3R1
p-5Y-NTRK1-1
p-5Y-NTRK1
p-4Y-PLCG1
p-Y-SHC1
AP2S1
NGF
B-RAF
p-S222,S226-MAP2K2
p-4Y-PLCG1
RAP1:GTP:activated
BRAF
dimer:MAPK2K:MAPK
complex
NGF
PIK3R2
GRB2-1
NTRK2
MAPK7
Rap1-GTP
GTP
GTP
RAP1A
PP2A-ABdeltaC
complex
ATP
DUSP6
p-5Y-NTRK1
AP2A2(1-939)
p-T180,Y182-MAPK14
ADP
ADP
NGF
p-T185,Y187-MAPK1
RIT2
NGF
PLCG1
p-5Y-NTRK1
GTP
CLTC
p-4S,T359,T573-RPS6KA1
CRK
ADP
RIT1
p-5Y-NTRK1
CRK
p-6Y-FRS2
ADP
S-Farn-Me KRAS4B
GDP
S-Farn-Me PalmS NRAS
p-5Y-NTRK1
H2O
p-4S,T231,T365-RPS6KA3
Active
TrkA
receptor:Phospho-ARMS:Crk:C3G complex
NTRK1,2
H2O
ATP
p-S218,S222-MAP2K1
MEF2
NGF
STAT3
RIT2
CLTC
KIDINS220
AP2S1
MAPK3
Rap1-GDP
ADP
Guanine nucleotide
exchange factor
p-T202,Y204-MAPK3
Activated
TrkA
receptor:Phospho-IRS1/2
PPP2R5D
RAP1A
NGF
PI(3,4,5)P3
MAPK3
ATP
p-Y-SHC3
DUSP7
RPS6KA3
p-S445,S729-BRAF
Active
TrkA
receptor:Phospho-PLCG1 complex
MAPK13
AP2B1
NGF
Ade-Rib
p-Y-IRS1
p-T202,Y204-MAPK3
Zn2+
p-Y-IRS2
CLTC
RAPGEF1
SHC3
MAPK1
PPP2CA
p-Y-SHC2
NGF
4, 6, 17, 20, 24...
10, 27, 58
50, 51, 55
42, 72
26, 59
78
26, 59
8