Signaling by NTRK1 (TRKA) (Homo sapiens)

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25, 26, 55, 573816366, 43161418, 27514846411223447, 461147161418, 27, 302, 9, 50393728524554145640Golgi lumencytosolendosomeclathrin-coated endocytic vesiclenucleoplasmPIK3R1 p-5Y-NTRK1 PIK3CA Zn2+ CRK p-S272,T222,T334-MAPKAPK2 Rap1-GTPcomplex:p-S,T-BRAFcomplexATPAP2A1 p-5Y-NTRK1 SH3GL2 FRS2 NGF PIK3CB GDPATPGuanine nucleotideexchange factorADCYAP1R1 p-Y-IRS2 p-Y-SHCNGF RAL-GTPADPCRK GDPGRB2-1:SOS1PLCG1 NGF p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3MAPK7p-5Y-NTRK1 GTPActiveTrkAreceptor:p-FRS2:CRKL complexNGF ATPCLTA PIP3 activates AKTsignalingNGF p-T180,Y182-MAPK11 ADCYAP1(2-742):ADCYAP1R1:NTRK1,2RAP1A NGF p-5Y-NTRK1 p-4S,T231,T365-RPS6KA3 GDP PI3KADPActive Trk receptorcomplex:RIT/RIN-GTPGDP ActivatedTrkAreceptorcomplex:Clathrin-coated vesicleGRB2-1 PIK3R2 BRAF p-p38 MAPKalpha/betaATF1AP2S1 Rap1-GTPcomplex:BRAFcomplexRAP1:GTP:B-Rafcomplexp-Y-SHC3 GTPRAP1A ADPZn2+ MAPKAPK3 PIK3R1 NGF p-4S,T336-ELK1p-T202,Y204-MAPK3 CREB1MAP kinase p38 (Mg2+cofactor)RALGDS ADPADCYAP1(2-742):ADCYAP1R1:p-5Y-NTRK1,p-5Y-NTRK2SRC-1RAP1A ActiveTrkAreceptor:Phospho-ARMS:Crk complexAP2M1 p-4Y-PLCG1 PIK3R2 Zn2+ ADPAP2A1 p-T202,Y204-MAPK3 RALB beta-NGF dimer:TrkAreceptor dimerPip-5Y-NTRK1 RAP1A Rap1-GDPAP2A1 HRAS RALA AP2B1 Zn2+ Ribosomal protein S6kinaseGTPCLTC p-5Y-NTRK1-1 AP2A2(1-939) Mg2+ AP2B1 SHC3 BRAF p-Y-SHC1 ActivatedTrkAreceptor:Phospho-IRS1/2:PI3K(p85:p110)Activated TrkAreceptor:SHCCRK PIK3CA p-4S,T356,T570-RPS6KA2 MAPKAP kinasemature beta-NGFhomodimerBRAF GDPActivated TrkAreceptor complexActiveTrkAreceptor:Phospho-PLCG1 complexAP2A2(1-939) p-6Y-FRS2 MEF2H2ONGF ATPERK-specific DUSPNGF p-Y-IRS1 NGF p-Y-IRS1 p-Y1096-KIDINS220 CLTA Ade-RibCRKL VRK3 PIK3CA RIT2 p-Y1096-KIDINS220 Phospho-IRS1/2:PI3K(p85:p110)ADCYAP1(2-742)ADPRIT2 GDP ADORA2A p-5Y-NTRK1 p-S727-STAT3p-S445,S729-BRAF RHOANGF ADORA2Ap-S445,S729-BRAF p-5Y-NTRK1 ADPp-S396-MEF2C p-T180,Y182-MAPK14 MEF2A ATPDynamin-1/2/3SHC3 IRS2 IRS2 MAPK7 CLTC p-5Y-NTRK1 p-Y-SHC2 SH3GL2SHC2 CLTA RIT1 CRK AP2B1 p-6Y-FRS2 Activated TrkAreceptor complexActive TrkA receptorcomplex:RIT/RIN-GDPATPp-Y1096-KIDINS220 NGF PPP2CA NTRK1ATPMAPK3/MAPK1/MAPK7dimersRAP1A Active TrkAreceptor:p-FRS2complexAde-Rib:ADORA2A:p-5Y-NTRK1,p-5Y-NTRK2DUSP6 ADCYAP1(2-742) p-Y-IRS1 H2OCRK RIT1 ActiveTrkAreceptor:p-FRS2:CRKL:RAPGEF1p-5Y-NTRK1 Active TrkAreceptor:FRS2complexp-5Y-NTRK1 GTP DNM1 STAT3AP2A2(1-939) ATPNRAS p-5Y-NTRK1 DUSP3 PPP2R5D GTP p-T218,Y220-MAPK7IRS1 ATPADPCRK NGF ActiveTrkAreceptor:Phospho-ARMS:Crk:C3G complexRap1-GTPAde-Rib:ADORA2A:NTRK1,2Activated TrkAreceptor complexp-S,2T-MAPKAPK3 NGF CLTC ADPNRAS Zn2+ p-S133-CREB1BRAF PI(4,5)P2YWHAB GTP ADPp-5Y-NTRK1 SHC2 PLCG1p-5Y-NTRK2 SHC1 Rap1-GTP complexVRK3:DUSP3RAP1A H2OGTP SH3GL2 RPS6KA5ADPRAP1:GDPDNM2 GTPADCYAP1R1 NGF processingp-5Y-NTRK2 HRAS GTP p-Y-SHC3 BRAF complexGTP p-4S,T359,T573-RPS6KA1 DUSP4 RPS6KA1 DNAL4p-5Y-NTRK1 KIDINS220 GTP RPS6KA2 Activated TrkAreceptor:IRS1/2AP2B1 KRAS RIT/RIN-GDPPIK3R2 GDPADPNGF p-5Y-NTRK1-1 Ade-Rib Phospho-Ribosomalprotein S6 kinaseActivated TrkAreceptor complexNGF RAPGEF1 SHC1 ATPDNM3 p-Y-SHC2 Activated TrkAreceptor complexPPP2R1A NGF NGF Zn2+ NTRK1,2p-5Y-NTRK1 ATPRas-GTP:RalGDScomplexRAL-GDPADORA2A p-S212,S360,S376,T581-RPS6KA5YWHAB Zn2+ RIT2 ATPNTRK2 HRAS ActivatedTrkAreceptor:Phospho-IRS1/2CRKL RPS6KA3 p-T185,Y187-MAPK1 CRK ADPATPYWHAB p-5Y-NTRK1 p-5Y-NTRK1-1 p-T218,Y220-MAPK7ADPNGF PIK3R1 ATPDUSP7 p-5Y-NTRK1 MAPKAPK2 RHOA GRB2-1 p-Y-SHC3 p-Y419-SRC-1ADPp-T222,S272-MAPKAPK2RAP1A RIT2 p-MAPK3/MAPK1/MAPK7dimersp21 RAS:GDPp-5Y-NTRK1-1 p-S408-MEF2A ActiveTrkreceptorcomplex:RIT/RIN-GTP:B-RAFp-Y-SHC1 RALA ARMS:CrkATPp-Y1096-KIDINS220 ActivatedTrkAreceptorcomplex:Clathrin-coated vesicle:dynein:dynactin complexRALB Phospho-MAP kinasep38 (Mg2+ cofactor)NTRK1 Mg2+ PIK3CB NTRK1 NTRK1 ActivatedTrkAreceptorcomplex:Clathrin-coated vesicle:Endophilinp-Y1096-KIDINS220 AP2A2(1-939) ADPp-5Y-NTRK1 p-S,T-BRAF FRS2NTRK2 NGF p-Y-SHC1 RALGDSPP2A-ABdeltaCcomplexRIT1 GTP NTRK1 p-T218,Y220-MAPK7 ADPp-5Y-NTRK1 KRAS p-6Y-FRS2 SHCNTRK1 MAP2K5AP2M1 GDPPPP2R1B p-T180,Y182-MAPK14 MEF2C NRAS GDP CLTA GTP NGF MAPK14 RAF/MAP kinasecascadeNGF PI(3,4,5)P3ADPAde-Rib GDP GTPNGF CRKLp-5Y-NTRK1 ADCYAP1R1GRB2-1:SOS1:p-Y-SHCGDPp-S63-ATF1p-5Y-NTRK1 ATPp-4Y-PLCG1p-5Y-NTRK1 RAP1:GTPActive TrkAreceptor:ARMS:CrkcomplexActivated TrkAreceptor:p-SHCp-5Y-NTRK1 BRAF dimer complexGTPp-Y-IRS2 p-MEF2AP2S1 YWHAB YWHAB RAPGEF1KIDINS220 Clathrin:AP-2complexADPPIP3:RhoANGF PPP2CB p-T185,Y187-MAPK1 IRS1,2AP2M1 MAPK13 AP2S1 ATPAP2S1 PI(3,4,5)P3 NGF p75 NTRreceptor-mediatedsignallingActive TrkAreceptor:PLCG1complexNGF p-5Y-NTRK1 ATPNGF ADPGDP IRS1 p-5Y-NTRK1 ATPNGF MAPK12 p-5Y-NTRK1 p-5Y-NTRK1-1 CLTC p-T,Y MAPK dimersp-T180,Y182-MAPK11 MAPK3 ATPAP2A1 NGF PiRIT1 ELK1DUSP3 ADCYAP1(2-742) MAPK11 B-RAFPIK3CB KRAS NGF ADPMAPK1 RAP1A GTP GTP beta-NGF dimer:TrkAreceptorAP2M1 p-Y-IRS2 Pip21 RAS:GTPSOS1 DAG and IP3signalingNTRK2 NGF ATPp-Y-SHC2 SOS1 32, 341, 534, 5, 8, 10, 13...3, 22, 24202932, 34