Signaling by NTRK1 (TRKA) (Homo sapiens)
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38, 53, 54, 61
7
69
29
74
32
18, 39
31
19
30
15, 23, 44, 56, 57, 66...
21
13
10, 11, 21, 53
25, 28, 48
29
65
31
10, 14, 21
29
31
3, 63
9
5, 36, 64
11, 49
1, 33, 37, 43
47
21, 46
52
68
73
16, 22, 50
12, 50, 57, 75, 77
10, 11, 18, 53
11
2
67
41
5, 64
Golgi lumen
endosome
nucleoplasm
clathrin-coated endocytic vesicle
cytosol
YWHAB
p-S408-MEF2A
ATP
GTP
p-T185,Y187-MAPK1
RAF/MAP kinase
cascade
ADP
MAPK12
ATP
RIT1
NGF
p-6Y-FRS2
NGF
BRAF dimer complex
Activated TrkA
receptor complex
PPP2CB
p-Y419-SRC-1
NGF
ADP
SHC1
H2O
Zn2+
Activated TrkA
receptor complex
ATP
NGF
Active TrkA
receptor:p-FRS2
complex
BRAF
RPS6KA5
RALGDS
NGF
ATP
PPP2R5D
p-Y-SHC1
p-S272,T222,T334-MAPKAPK2
KIDINS220
p-5Y-NTRK1
S-Farn-Me-2xPalmS HRAS
p-S133-CREB1
PP2A-ABdeltaC
complex
ADP
ATP
p-Y-IRS1
GDP
PIK3R2
ADP
p-Y-SHC1
CLTA
RAP1A
RAP1A
CRK
ATP
ADCYAP1(2-742)
Zn2+
GTP
p-4Y-PLCG1
NTRK2
AP2B1
AP2S1
RAP1:GTP:B-Raf
complex
RIT1
Guanine nucleotide
exchange factor
ATP
Phospho-Ribosomal
protein S6 kinase
AP2A1
MAPK3
Ade-Rib:ADORA2A:p-5Y-NTRK1,p-5Y-NTRK2
Active TrkA
receptor:ARMS:Crk
complex
ATP
PLCG1
RAP1:GTP:activated
BRAF dimer:p-2S
MAPK2K:MAPK complex
p-Y-SHC1
AP2A2(1-939)
ATP
p-T202,Y204-MAPK3
PIK3CA
RAP1:GTP
GDP
p-5Y-NTRK1
p-4S,T359,T573-RPS6KA1
RAP1A
Activated
TrkA
receptor
complex:Clathrin-coated vesicle
RAP1A
p-4S,T231,T365-RPS6KA3
p-T185,Y187-MAPK1
NGF
FRS2
ATP
Activated TrkA
receptor:p-SHC
Ribosomal protein S6
kinase
Activated TrkA
receptor complex
NGF
AP2B1
GTP
CRK
DNM1
p-5Y-NTRK1
Phospho-MAP kinase
p38 (Mg2+ cofactor)
RALB
S-Farn-Me-PalmS KRAS4A
p-5Y-NTRK1
p-5Y-NTRK1-1
S-Farn-Me-2xPalmS HRAS
MEF2
YWHAB
p-Y1096-KIDINS220
RIT2
p-T222,S272-MAPKAPK2
IRS2
Ade-Rib
CRKL
GTP
GTP
p-T180,Y182-MAPK11
Zn2+
AP2B1
RIT2
GDP
SHC
p-5Y-NTRK1-1
p-T180,Y182-MAPK11
NGF processing
NTRK1
p-6Y-FRS2
NTRK2
p-S218,S222-MAP2K1
PI3K
GRB2-1
Pi
Activated TrkA
receptor:IRS1/2
AP2S1
ADORA2A
Active
TrkA
receptor:Phospho-ARMS:Crk complex
GDP
MEF2C
NGF
GDP
NGF
p-5Y-NTRK1
AP2M1
Zn2+
p-Y-SHC2
GTP
p-5Y-NTRK1
Activated TrkA
receptor complex
RAPGEF1
GTP
PI(3,4,5)P3
CRK
SHC2
NTRK1
NGF
AP2M1
Active
TrkA
receptor:Phospho-PLCG1 complex
MAPK11
p-S445,T599,S602,S729 BRAF
GDP
GTP
Active
Trk
receptor
complex:RIT/RIN-GTP:B-RAF
YWHAB
PI(4,5)P2
ADP
S-Farn-Me KRAS4B
PIK3CB
p-Y1096-KIDINS220
ADP
KIDINS220
ATP
FRS2
GTP
p-6Y-FRS2
MAPKAP kinase
GTP
AP2S1
MEF2A
p21 RAS:GDP
p-p38 MAPK
alpha/beta
RALA
p-Y-SHC
p-T218,Y220-MAPK7
ADCYAP1(2-742):ADCYAP1R1:p-5Y-NTRK1,p-5Y-NTRK2
p-Y1096-KIDINS220
NGF
ADP
p-5Y-NTRK1
ADP
MAPK3
p-S218,S222-MAP2K1
ADP
VRK3:DUSP3
ATP
p-S,T-BRAF
NTRK2
Active TrkA
receptor:PLCG1
complex
S-Farn-Me-PalmS KRAS4A
p-S445,S729-BRAF
Activated
TrkA
receptor
complex:Clathrin-coated vesicle:dynein:dynactin complex
H2O
MAPK1
CRKL
MAP2K2
IRS1
ADP
Rap1-GTP
complex:BRAF
complex
GTP
p-5Y-NTRK1
MAPK3/MAPK1/MAPK7
dimers
Ade-Rib
AP2A1
p-T,Y MAPK dimers
RPS6KA3
ATP
ADP
p-MEF2
CRK
S-Farn-Me PalmS NRAS
Active TrkA receptor
complex:RIT/RIN-GDP
PIK3R2
YWHAB
p-T,Y MAPKs
Ade-Rib
Zn2+
DAG and IP3
signaling
p-5Y-NTRK1
Zn2+
RAP1:GTP:activated
BRAF
dimer:MAPK2K:MAPK
complex
p-5Y-NTRK1
CLTA
NGF
S-Farn-Me KRAS4B
ADP
ELK1
ATP
p75 NTR
receptor-mediated
signalling
p-5Y-NTRK1
p-S63-ATF1
CLTC
NGF
S-Farn-Me KRAS4B
p-Y-SHC2
MAPKAPK3
ADCYAP1(2-742)
p-T185,Y187-MAPK1
NGF
NGF
ATP
AP2A2(1-939)
BRAF complex
NGF-stimulated
transcription
RAP1A
ADP
RIT1
Active Trk receptor
complex:RIT/RIN-GTP
ADP
Zn2+
GTP
p-T180,Y182-MAPK14
ADP
mature beta-NGF
homodimer
beta-NGF dimer:TrkA
receptor
RAP1A
MAPKAPK2
p-S396-MEF2C
B-RAF
PIK3R1
p-S727-STAT3
YWHAB
Activated TrkA
receptor complex
ATP
SH3GL2
p-S218,S222-MAP2K1
PIK3CB
p-5Y-NTRK1
RAP1A
YWHAB
ADP
NTRK1
Activated
TrkA
receptor
complex:Clathrin-coated vesicle:Endophilin
MAP2K5
YWHAB
RAP1A
NTRK1,2
ADP
p-S445,T599,S602,S729 BRAF
ADP
CRK
Ras-GTP:RalGDS
complex
ADCYAP1(2-742)
RAPGEF1
PLCG1
Pi
NGF
RPS6KA1
PPP2R1B
p-5Y-NTRK1
STAT3
p-Y-SHC3
DUSP4
p-4S,T356,T570-RPS6KA2
GRB2-1:SOS1:p-Y-SHC
S-Farn-Me PalmS NRAS
p-Y-SHC2
DUSP7
PPP2CA
GTP
ATP
p-4Y-PLCG1
CRKL
PIP3 activates AKT
signaling
p-Y-IRS1
DUSP6
S-Farn-Me PalmS NRAS
Rap1-GTP
complex:p-S,T-BRAF
complex
ADP
p-5Y-NTRK1
RAP1A
MAPK7
Zn2+
ATP
ADP
AP2A2(1-939)
RHOA
AP2A1
MAP2K1
NGF
p-S445,S729-BRAF
H2O
p-T202,Y204-MAPK3
MAPK14
p-MAPK3/MAPK1/MAPK7
dimers
RAP1:GDP
SH3GL2
p-5Y-NTRK1-1
RAL-GTP
RPS6KA2
p-S445,T599,S602,S729 BRAF
p-T185,Y187-MAPK1
GTP
Rap1-GDP
p-5Y-NTRK1
SHC3
ERK-specific DUSP
p-Y-IRS2
Active TrkA
receptor:FRS2
complex
RIT2
DNAL4
GDP
DNM2
p-T,Y MAPK dimers
VRK3
MAP kinase p38 (Mg2+
cofactor)
MAPK7
PIK3R1
MAPK3
NGF
MAPK1
Activated
TrkA
receptor:Phospho-IRS1/2
p-S445,T599,S602,S729 BRAF
ATP
GTP
MAP2K1
Mg2+
p-5Y-NTRK2
p-S222,S226-MAP2K2
p-Y-IRS2
Mg2+
NGF
SH3GL2
PIK3CA
RALA
AP2B1
p-5Y-NTRK1
p-T202,Y204-MAPK3
DNM3
GDP
p-S222,S226-MAP2K2
NGF
RAP1A
p-T202,Y204-MAPK3
NGF
Clathrin:AP-2
complex
MAPKs
AP2A1
ADP
NGF
NGF
ADP
p-5Y-NTRK1
p-T185,Y187-MAPK1
ADCYAP1R1
CLTC
PI(3,4,5)P3
NGF
SHC2
ATP
PIK3R2
GTP
p-S212,S360,S376,T581-RPS6KA5
Active
TrkA
receptor:Phospho-ARMS:Crk:C3G complex
ADCYAP1R1
NGF
MAPK1
p-5Y-NTRK1
p-5Y-NTRK1
YWHAB
p-5Y-NTRK1
RALB
GRB2-1
p-5Y-NTRK1
Pi
GDP
p-T180,Y182-MAPK14
p-S,2T-MAPKAPK3
NGF
GTP
GDP
NTRK1
p-2S MAP2K
homo/heterodimers
PIK3CB
ATP
IRS1,2
p-T202,Y204-MAPK3
RIT/RIN-GDP
SHC1
Rap1-GTP complex
GTP
Rap1-GTP
p-Y-IRS1
ATF1
AP2M1
MAP2K
homo/heterodimers
p-5Y-NTRK2
GDP
IRS2
RAP1:GTP:activated
BRAF dimer:p-2S
MAPK2K:p-T,Y MAPK
complex
p21 RAS:GTP
SOS1
SOS1
p-T218,Y220-MAPK7
AP2S1
p-5Y-NTRK1
RIT1
AP2A2(1-939)
Dynamin-1/2/3
IRS1
p-Y-SHC3
RALGDS
CLTA
Zn2+
Phospho-IRS1/2:PI3K(p85:p110)
CREB1
CLTC
ADP
GTP
MAPK3
CRK
RAL-GDP
NGF
AP2M1
S-Farn-Me-PalmS KRAS4A
Activated TrkA
receptor:SHC
ADCYAP1R1
MAPK13
NGF
p-5Y-NTRK1
p-5Y-NTRK1-1
PIK3R1
Ade-Rib:ADORA2A:NTRK1,2
GTP
RAP1A
p-Y-IRS2
BRAF
DUSP3
BRAF
ADCYAP1(2-742):ADCYAP1R1:NTRK1,2
Zn2+
ATP
YWHAB
p-5Y-NTRK1
Zn2+
p-5Y-NTRK1-1
PPP2R1A
p-Y1096-KIDINS220
MAP2K2
p-T218,Y220-MAPK7
ATP
PIK3CA
beta-NGF dimer:TrkA
receptor dimer
SHC3
NGF
NGF
NGF
GRB2-1:SOS1
p-Y-SHC3
Activated
TrkA
receptor:Phospho-IRS1/2:PI3K(p85:p110)
NTRK1
Active
TrkA
receptor:p-FRS2:CRKL:RAPGEF1
p-S222,S226-MAP2K2
CLTA
Active
TrkA
receptor:p-FRS2:CRKL complex
S-Farn-Me-2xPalmS HRAS
RAP1:GTP:activated
BRAF dimer
PIP3:RhoA
BRAF
RAP1A
SRC-1
ADORA2A
RIT2
RHOA
CLTC
p-Y1096-KIDINS220
MAPK1
GTP
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3
ARMS:Crk
CRK
p-4S,T336-ELK1
DUSP3
ADORA2A
GDP
ATP
p-5Y-NTRK1
NTRK1
ADP
26, 59
78
26, 59
10, 27, 58
50, 51, 55
42, 72
4, 6, 17, 20, 24...
8