Signaling by NTRK1 (TRKA) (Homo sapiens)

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38, 53, 54, 6176929743218, 3931193015, 23, 44, 56, 57, 66...211310, 11, 21, 5325, 28, 4829653110, 14, 2129313, 6395, 36, 6411, 491, 33, 37, 434721, 4652687316, 22, 5012, 50, 57, 75, 7710, 11, 18, 5311267415, 64Golgi lumenendosomenucleoplasmclathrin-coated endocytic vesiclecytosolYWHAB p-S408-MEF2A ATPGTPp-T185,Y187-MAPK1 RAF/MAP kinasecascadeADPMAPK12 ATPRIT1 NGF p-6Y-FRS2 NGF BRAF dimer complexActivated TrkAreceptor complexPPP2CB p-Y419-SRC-1NGF ADPSHC1 H2OZn2+ Activated TrkAreceptor complexATPNGF Active TrkAreceptor:p-FRS2complexBRAF RPS6KA5RALGDS NGF ATPPPP2R5D p-Y-SHC1 p-S272,T222,T334-MAPKAPK2 KIDINS220 p-5Y-NTRK1 S-Farn-Me-2xPalmS HRAS p-S133-CREB1PP2A-ABdeltaCcomplexADPATPp-Y-IRS1 GDPPIK3R2 ADPp-Y-SHC1 CLTA RAP1A RAP1A CRK ATPADCYAP1(2-742) Zn2+ GTPp-4Y-PLCG1NTRK2 AP2B1 AP2S1 RAP1:GTP:B-RafcomplexRIT1 Guanine nucleotideexchange factorATPPhospho-Ribosomalprotein S6 kinaseAP2A1 MAPK3 Ade-Rib:ADORA2A:p-5Y-NTRK1,p-5Y-NTRK2Active TrkAreceptor:ARMS:CrkcomplexATPPLCG1 RAP1:GTP:activatedBRAF dimer:p-2SMAPK2K:MAPK complexp-Y-SHC1 AP2A2(1-939) ATPp-T202,Y204-MAPK3 PIK3CA RAP1:GTPGDPp-5Y-NTRK1 p-4S,T359,T573-RPS6KA1 RAP1A ActivatedTrkAreceptorcomplex:Clathrin-coated vesicleRAP1A p-4S,T231,T365-RPS6KA3 p-T185,Y187-MAPK1 NGF FRS2 ATPActivated TrkAreceptor:p-SHCRibosomal protein S6kinaseActivated TrkAreceptor complexNGF AP2B1 GTPCRK DNM1 p-5Y-NTRK1 Phospho-MAP kinasep38 (Mg2+ cofactor)RALB S-Farn-Me-PalmS KRAS4A p-5Y-NTRK1 p-5Y-NTRK1-1 S-Farn-Me-2xPalmS HRAS MEF2YWHAB p-Y1096-KIDINS220 RIT2 p-T222,S272-MAPKAPK2IRS2 Ade-RibCRKLGTPGTP p-T180,Y182-MAPK11 Zn2+ AP2B1 RIT2 GDP SHCp-5Y-NTRK1-1 p-T180,Y182-MAPK11 NGF processingNTRK1p-6Y-FRS2 NTRK2 p-S218,S222-MAP2K1 PI3KGRB2-1 PiActivated TrkAreceptor:IRS1/2AP2S1 ADORA2A ActiveTrkAreceptor:Phospho-ARMS:Crk complexGDPMEF2C NGF GDPNGF p-5Y-NTRK1 AP2M1 Zn2+ p-Y-SHC2 GTPp-5Y-NTRK1 Activated TrkAreceptor complexRAPGEF1 GTP PI(3,4,5)P3 CRK SHC2 NTRK1 NGF AP2M1 ActiveTrkAreceptor:Phospho-PLCG1 complexMAPK11 p-S445,T599,S602,S729 BRAF GDP GTP ActiveTrkreceptorcomplex:RIT/RIN-GTP:B-RAFYWHAB PI(4,5)P2ADPS-Farn-Me KRAS4B PIK3CB p-Y1096-KIDINS220 ADPKIDINS220 ATPFRS2GTP p-6Y-FRS2 MAPKAP kinaseGTPAP2S1 MEF2A p21 RAS:GDPp-p38 MAPKalpha/betaRALA p-Y-SHCp-T218,Y220-MAPK7ADCYAP1(2-742):ADCYAP1R1:p-5Y-NTRK1,p-5Y-NTRK2p-Y1096-KIDINS220 NGF ADPp-5Y-NTRK1 ADPMAPK3 p-S218,S222-MAP2K1 ADPVRK3:DUSP3ATPp-S,T-BRAF NTRK2 Active TrkAreceptor:PLCG1complexS-Farn-Me-PalmS KRAS4A p-S445,S729-BRAF ActivatedTrkAreceptorcomplex:Clathrin-coated vesicle:dynein:dynactin complexH2OMAPK1 CRKL MAP2K2 IRS1 ADPRap1-GTPcomplex:BRAFcomplexGTP p-5Y-NTRK1 MAPK3/MAPK1/MAPK7dimersAde-Rib AP2A1 p-T,Y MAPK dimersRPS6KA3 ATPADPp-MEF2CRK S-Farn-Me PalmS NRAS Active TrkA receptorcomplex:RIT/RIN-GDPPIK3R2 YWHAB p-T,Y MAPKsAde-Rib Zn2+ DAG and IP3signalingp-5Y-NTRK1 Zn2+ RAP1:GTP:activatedBRAFdimer:MAPK2K:MAPKcomplexp-5Y-NTRK1 CLTA NGF S-Farn-Me KRAS4B ADPELK1ATPp75 NTRreceptor-mediatedsignallingp-5Y-NTRK1 p-S63-ATF1CLTC NGF S-Farn-Me KRAS4B p-Y-SHC2 MAPKAPK3 ADCYAP1(2-742)p-T185,Y187-MAPK1 NGF NGF ATPAP2A2(1-939) BRAF complexNGF-stimulatedtranscriptionRAP1A ADPRIT1 Active Trk receptorcomplex:RIT/RIN-GTPADPZn2+ GTP p-T180,Y182-MAPK14 ADPmature beta-NGFhomodimerbeta-NGF dimer:TrkAreceptorRAP1A MAPKAPK2 p-S396-MEF2C B-RAFPIK3R1 p-S727-STAT3YWHAB Activated TrkAreceptor complexATPSH3GL2p-S218,S222-MAP2K1 PIK3CB p-5Y-NTRK1 RAP1A YWHAB ADPNTRK1 ActivatedTrkAreceptorcomplex:Clathrin-coated vesicle:EndophilinMAP2K5YWHAB RAP1A NTRK1,2ADPp-S445,T599,S602,S729 BRAF ADPCRK Ras-GTP:RalGDScomplexADCYAP1(2-742) RAPGEF1PLCG1PiNGF RPS6KA1 PPP2R1B p-5Y-NTRK1 STAT3p-Y-SHC3 DUSP4 p-4S,T356,T570-RPS6KA2 GRB2-1:SOS1:p-Y-SHCS-Farn-Me PalmS NRAS p-Y-SHC2 DUSP7 PPP2CA GTP ATPp-4Y-PLCG1 CRKL PIP3 activates AKTsignalingp-Y-IRS1 DUSP6 S-Farn-Me PalmS NRAS Rap1-GTPcomplex:p-S,T-BRAFcomplexADPp-5Y-NTRK1 RAP1A MAPK7Zn2+ ATPADPAP2A2(1-939) RHOA AP2A1 MAP2K1 NGF p-S445,S729-BRAF H2Op-T202,Y204-MAPK3 MAPK14 p-MAPK3/MAPK1/MAPK7dimersRAP1:GDPSH3GL2 p-5Y-NTRK1-1 RAL-GTPRPS6KA2 p-S445,T599,S602,S729 BRAF p-T185,Y187-MAPK1 GTP Rap1-GDPp-5Y-NTRK1 SHC3 ERK-specific DUSPp-Y-IRS2 Active TrkAreceptor:FRS2complexRIT2 DNAL4GDPDNM2 p-T,Y MAPK dimersVRK3 MAP kinase p38 (Mg2+cofactor)MAPK7 PIK3R1 MAPK3 NGF MAPK1 ActivatedTrkAreceptor:Phospho-IRS1/2p-S445,T599,S602,S729 BRAF ATPGTP MAP2K1 Mg2+ p-5Y-NTRK2 p-S222,S226-MAP2K2 p-Y-IRS2 Mg2+ NGF SH3GL2 PIK3CA RALA AP2B1 p-5Y-NTRK1 p-T202,Y204-MAPK3 DNM3 GDP p-S222,S226-MAP2K2 NGF RAP1A p-T202,Y204-MAPK3 NGF Clathrin:AP-2complexMAPKsAP2A1 ADPNGF NGF ADPp-5Y-NTRK1 p-T185,Y187-MAPK1 ADCYAP1R1 CLTC PI(3,4,5)P3NGF SHC2 ATPPIK3R2 GTP p-S212,S360,S376,T581-RPS6KA5ActiveTrkAreceptor:Phospho-ARMS:Crk:C3G complexADCYAP1R1NGF MAPK1 p-5Y-NTRK1 p-5Y-NTRK1 YWHAB p-5Y-NTRK1 RALB GRB2-1 p-5Y-NTRK1 PiGDP p-T180,Y182-MAPK14 p-S,2T-MAPKAPK3 NGF GTP GDPNTRK1 p-2S MAP2Khomo/heterodimersPIK3CB ATPIRS1,2p-T202,Y204-MAPK3 RIT/RIN-GDPSHC1 Rap1-GTP complexGTP Rap1-GTPp-Y-IRS1 ATF1AP2M1 MAP2Khomo/heterodimersp-5Y-NTRK2 GDP IRS2 RAP1:GTP:activatedBRAF dimer:p-2SMAPK2K:p-T,Y MAPKcomplexp21 RAS:GTPSOS1 SOS1 p-T218,Y220-MAPK7AP2S1 p-5Y-NTRK1 RIT1 AP2A2(1-939) Dynamin-1/2/3IRS1 p-Y-SHC3 RALGDSCLTA Zn2+ Phospho-IRS1/2:PI3K(p85:p110)CREB1CLTC ADPGTP MAPK3 CRK RAL-GDPNGF AP2M1 S-Farn-Me-PalmS KRAS4A Activated TrkAreceptor:SHCADCYAP1R1 MAPK13 NGF p-5Y-NTRK1 p-5Y-NTRK1-1 PIK3R1 Ade-Rib:ADORA2A:NTRK1,2GTP RAP1A p-Y-IRS2 BRAF DUSP3 BRAF ADCYAP1(2-742):ADCYAP1R1:NTRK1,2Zn2+ ATPYWHAB p-5Y-NTRK1 Zn2+ p-5Y-NTRK1-1 PPP2R1A p-Y1096-KIDINS220 MAP2K2 p-T218,Y220-MAPK7 ATPPIK3CA beta-NGF dimer:TrkAreceptor dimerSHC3 NGF NGF NGF GRB2-1:SOS1p-Y-SHC3 ActivatedTrkAreceptor:Phospho-IRS1/2:PI3K(p85:p110)NTRK1 ActiveTrkAreceptor:p-FRS2:CRKL:RAPGEF1p-S222,S226-MAP2K2 CLTA ActiveTrkAreceptor:p-FRS2:CRKL complexS-Farn-Me-2xPalmS HRAS RAP1:GTP:activatedBRAF dimerPIP3:RhoABRAF RAP1A SRC-1ADORA2A RIT2 RHOACLTC p-Y1096-KIDINS220 MAPK1 GTP p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3ARMS:CrkCRK p-4S,T336-ELK1DUSP3 ADORA2AGDP ATPp-5Y-NTRK1 NTRK1 ADP26, 597826, 5910, 27, 5850, 51, 5542, 724, 6, 17, 20, 24...8