Neurotransmitter release cycle (Homo sapiens)

From WikiPathways

Jump to: navigation, search
28, 30, 35, 3861, 25, 40, 462126, 29, 361, 25, 40, 46411, 12, 202, 3415, 3941443, 41, 25, 40, 4313161, 14, 4032, 379, 4526, 29, 3626, 29, 368, 19, 331, 25, 405, 1817, 24, 2726, 29, 3626, 29, 3631clathrin-sculpted glutamate transport vesicle lumenlysosomal lumencytosolclathrin-sculpted monoamine transport vesicle lumenclathrin-coated endocytic vesiclecytosolmitochondrial matrixclathrin-sculpted acetylcholine transport vesicle lumenmitochondrial matrixChoRAB3ASTX1APPFIA2 NH4+SLC18A3BZRAP1 SLC1A6 RAB3A MAOA PPFIA2 RIMS1 SLC17A7 SNAP25ARL6IP5CPLX1NAAA (29-125) SLC18A2 STXBP1-1RIMS1 CPLX1STX1ABZRAP1 VAMP2 NAd ATPSNAP25 PPFIA2 L-GlnSLC1A7 H2OSYN1 H+RIMS1:UNC13B:BZRAP1:Alpha-liprinH+NSTEA-ETA PPFIA3 SNARE complexPPFIA4 CPLX1 Na+SYT1 DDCX BZRAP1 O-acetylcholine PPFIA3 SLC17A7 Docked Noradrenalinloaded synapticvesicleSNAP25PPFIA4 GLS ChoPPFIA1 SNARE complexAcChoVAMP2 MAOA:FADRIMS1:UNC13B:BZRAP1:Alpha-liprinCl-RAB3A PPFIA1 CPLX1SLC38A2GABA synthesis,release, reuptakeand degradationSYN3 RIMS1 RAB3A RIMS1 SLC5A73,4-dihydroxyphenylglycolaldehydeRAB3ASLC18A25HT PPFIA4 BZRAP1 SYN2 NLAU-ETA PPFIA3 RAB3A RAB3ASLC18A2 5HTPPFIA4 STX1A SYN3 5HTRAB3A SNAP25 SLC22A1 DABZRAP1 L-GluPPFIA2 Noradrenalin loadedsynaptic vesicleSNAP25 PPFIA4 APBA1SYN2 STX1A SLC1A1 VAMP2 VAMP2 SYT1 SYN3 SLC18A3 CASKSTX1A Glutamate loadedsynaptic vesicleSynapsinUNC13B PPFIA4 PPFIA2 NOLE-ETA NAAA dimerOCT2ATPCPLX1Docked dopamineloaded synapticvesicleRIMS1 Na+PPFIA1 BZRAP1 LIN7A Na+SYT1SYT1 PPFIA1 SYT1PPFIA4 BZRAP1 SLC22A2 BZRAP1 SNARE complexL-GluSNAP25 SYN3 PPFIA2 VAMP2 K+GLS dimersETAH+AA L-GlnPPFIA3 SNAP25 Cl-SYT1 DARAB3A Ac-CoAOLEA VAMP2 O-acetylcholine RAB3A SYT1CASK VAMP2 CHATLIN7B SYT1 ADPNH3UNC13B Empty GlutamateSynaptic VesicleL-GluUNC13B K+Ca2+PPFIA4 STX1A PALM Na+LIN7A,B,C5HT RAB3A SLC1A3 SLC18A2 PPFIA3 FAsSLC1A2 STXBP1-1UNC13B SNAP25 RIMS1 NAdDA VAMP2 SNAP25 RAB3A H+PPFIA2 SLC18A2 RAB3A SLC22A2H2O2STX1A SLC17A7 SYT1 SLC18A3 LIN7C LIN7:CASK:APBA1PPFIA1 Docked GlutamateLoaded SynapticVesicleSTX1A SYN2 NAd LIN7B STX1A 5HTBZRAP1 VAMP2 PPFIA3 PPFIA1 STXBP1-1 PPFIA2 PPFIA1 L-GlnRIMS1 SYT1 LIN7A STX1AUNC13B RIMS1:UNC13B:BZRAP1:Alpha-liprinSNAP25 VAMP2 ADPSYN1 SYT1SLC18A2 STXBP1-1STX1ADocked acetylcholineloaded SynapticVesicleL-GluSYT1 Na+UNC13BSYN1 RAB3A RIMS1 SLC1A1-3,6,7PiNPALM-ETA SynapsinSNAP25 VAMP2 Serotonin loadedsynaptic vesicleSTX1A PPFIA2 AcChoSNARE complexMYSA RAB3A CPLX1 H+VAMP2 SLC18A2 STX1A RAB3ANa+CPLX1 SNAP25 RIMS1 UNC13B CPLX1SLC18A2SYT1 STX1A SNARE complexSTXBP1-1CPLX1 STX1APPFIA2 H2OSYT1 VAMP2 STXBP1-1 STEA NAEsSTXBP1-1DASLC18A3 SLC18A2Glu STXBP1-1 O2SLC17A7PPFIA4 DA SNAP25PPFIA3 Acetylcholine LoadedSynaptic VesicleSTXBP1-1 UNC13B NAdNARAC-ETA BZRAP1 SYN2 SYT1 LIN7C RAB3ASTXBP1-1 NAAA (126-349) SYN1 UNC13B Docked serotoninloaded synapticvesicleRIMS1:UNC13B:BZRAP1:Alpha-liprinGlu SNAP25NMYS-ETA CoA-SHSYT1SYT1 UNC13B PPFIA3 Dopamine loadedsynaptic vesicleCPLX1 PPFIA1 H2OPPFIA1 GLS2 PPFIA3 VAMP2 PPFIA4 PPFIA3 VAMP2 RIMS1:UNC13B:BZRAP1:Alpha-liprinUNC13B H+SLC18A2VAMP2 SNAP25FAD PPFIA1 VAMP2 RIMS1 Empty AcetylcholineSynaptic VesicleSLC18A3APBA1 22, 42777722, 42722, 42722, 427722, 427710, 23


Description

Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 112310
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Mahajan, SS

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Toonen RF, de Vries KJ, Zalm R, Südhof TC, Verhage M.; ''Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.''; PubMed Europe PMC
  2. Iioka H, Moriyama I, Kyuma M, Ito K, Amasaki M, Ichijo M.; ''[Studies on L-glutamate transport mechanism in human placental trophoblast microvilli membrane vesicles].''; PubMed Europe PMC
  3. Melone M, Varoqui H, Erickson JD, Conti F.; ''Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex.''; PubMed Europe PMC
  4. Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, Kavanaugh M, Edwards RH.; ''Glutamine uptake by neurons: interaction of protons with system a transporters.''; PubMed Europe PMC
  5. Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH.; ''Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.''; PubMed Europe PMC
  6. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H.; ''Cloning and characterization of two human polyspecific organic cation transporters.''; PubMed Europe PMC
  7. Mueller HT, Borg JP, Margolis B, Turner RS.; ''Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.''; PubMed Europe PMC
  8. Quesada AR, Sanchez-Jimenez F, Perez-Rodriguez J, Marquez J, Medina MA, Nuñez de Castro I.; ''Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells.''; PubMed Europe PMC
  9. Surratt CK, Persico AM, Yang XD, Edgar SR, Bird GS, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR.; ''A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs.''; PubMed Europe PMC
  10. Buddhala C, Hsu CC, Wu JY.; ''A novel mechanism for GABA synthesis and packaging into synaptic vesicles.''; PubMed Europe PMC
  11. Zhou Y, Danbolt NC.; ''Glutamate as a neurotransmitter in the healthy brain.''; PubMed Europe PMC
  12. Jen JC, Wan J, Palos TP, Howard BD, Baloh RW.; ''Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures.''; PubMed Europe PMC
  13. Toussaint JL, Geoffroy V, Schmitt M, Werner A, Garnier JM, Simoni P, Kempf J.; ''Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.''; PubMed Europe PMC
  14. Dulubova I, Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J.; ''Munc18-1 binds directly to the neuronal SNARE complex.''; PubMed Europe PMC
  15. Tsuboi K, Sun YX, Okamoto Y, Araki N, Tonai T, Ueda N.; ''Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase.''; PubMed Europe PMC
  16. Erickson JD, Varoqui H, Schäfer MK, Modi W, Diebler MF, Weihe E, Rand J, Eiden LE, Bonner TI, Usdin TB.; ''Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus.''; PubMed Europe PMC
  17. Henry JP, Botton D, Sagne C, Isambert MF, Desnos C, Blanchard V, Raisman-Vozari R, Krejci E, Massoulie J, Gasnier B.; ''Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules.''; PubMed Europe PMC
  18. Takamori S, Rhee JS, Rosenmund C, Jahn R.; ''Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons.''; PubMed Europe PMC
  19. Elgadi KM, Meguid RA, Qian M, Souba WW, Abcouwer SF.; ''Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing.''; PubMed Europe PMC
  20. Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD.; ''Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18.''; PubMed Europe PMC
  21. Butz S, Okamoto M, Südhof TC.; ''A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.''; PubMed Europe PMC
  22. Sun L, Bittner MA, Holz RW.; ''Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells.''; PubMed Europe PMC
  23. Bak LK, Schousboe A, Waagepetersen HS.; ''The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.''; PubMed Europe PMC
  24. Rilstone JJ, Alkhater RA, Minassian BA.; ''Brain dopamine-serotonin vesicular transport disease and its treatment.''; PubMed Europe PMC
  25. Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC.; ''Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.''; PubMed Europe PMC
  26. Stein A, Radhakrishnan A, Riedel D, Fasshauer D, Jahn R.; ''Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids.''; PubMed Europe PMC
  27. Johnson RG.; ''Accumulation of biological amines into chromaffin granules: a model for hormone and neurotransmitter transport.''; PubMed Europe PMC
  28. Sudhof TC.; ''The synaptic vesicle cycle.''; PubMed Europe PMC
  29. Barclay JW, Craig TJ, Fisher RJ, Ciufo LF, Evans GJ, Morgan A, Burgoyne RD.; ''Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.''; PubMed Europe PMC
  30. Edwards RH.; ''The neurotransmitter cycle and quantal size.''; PubMed Europe PMC
  31. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA.; ''Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.''; PubMed Europe PMC
  32. Apparsundaram S, Ferguson SM, George AL, Blakely RD.; ''Molecular cloning of a human, hemicholinium-3-sensitive choline transporter.''; PubMed Europe PMC
  33. Gómez-Fabre PM, Aledo JC, Del Castillo-Olivares A, Alonso FJ, Núñez De Castro I, Campos JA, Márquez J.; ''Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase.''; PubMed Europe PMC
  34. de Vrij W, Bulthuis RA, van Iwaarden PR, Konings WN.; ''Mechanism of L-glutamate transport in membrane vesicles from Bacillus stearothermophilus.''; PubMed Europe PMC
  35. Becherer U, Rettig J.; ''Vesicle pools, docking, priming, and release.''; PubMed Europe PMC
  36. Martens S, Kozlov MM, McMahon HT.; ''How synaptotagmin promotes membrane fusion.''; PubMed Europe PMC
  37. Okuda T, Haga T.; ''Functional characterization of the human high-affinity choline transporter.''; PubMed Europe PMC
  38. Schoch S, Gundelfinger ED.; ''Molecular organization of the presynaptic active zone.''; PubMed Europe PMC
  39. Hong SB, Li CM, Rhee HJ, Park JH, He X, Levy B, Yoo OJ, Schuchman EH.; ''Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein.''; PubMed Europe PMC
  40. Riento K, Galli T, Jansson S, Ehnholm C, Lehtonen E, Olkkonen VM.; ''Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells.''; PubMed Europe PMC
  41. Michaelson DM, Angel I.; ''Determination of delta pH in cholinergic synaptic vesicles: its effect on storage and release of acetylcholine.''; PubMed Europe PMC
  42. Sun L, Bittner MA, Holz RW.; ''Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.''; PubMed Europe PMC
  43. Binda F, Dipace C, Bowton E, Robertson SD, Lute BJ, Fog JU, Zhang M, Sen N, Colbran RJ, Gnegy ME, Gether U, Javitch JA, Erreger K, Galli A.; ''Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.''; PubMed Europe PMC
  44. Takamori S, Riedel D, Jahn R.; ''Immunoisolation of GABA-specific synaptic vesicles defines a functionally distinct subset of synaptic vesicles.''; PubMed Europe PMC
  45. Gopalakrishnan A, Sievert M, Ruoho AE.; ''Identification of the substrate binding region of vesicular monoamine transporter-2 (VMAT-2) using iodoaminoflisopolol as a novel photoprobe.''; PubMed Europe PMC
  46. Augustin I, Rosenmund C, Südhof TC, Brose N.; ''Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.''; PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
101217view11:11, 1 November 2018ReactomeTeamreactome version 66
100755view20:36, 31 October 2018ReactomeTeamreactome version 65
100299view19:13, 31 October 2018ReactomeTeamreactome version 64
99845view15:57, 31 October 2018ReactomeTeamreactome version 63
99402view14:34, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99093view12:39, 31 October 2018ReactomeTeamreactome version 62
94499view09:05, 14 September 2017Mkutmonreactome version 61
88044view13:39, 25 July 2016RyanmillerOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
88043view13:38, 25 July 2016RyanmillerOntology Term : 'signaling pathway' added !
86606view09:22, 11 July 2016ReactomeTeamreactome version 56
83254view10:32, 18 November 2015ReactomeTeamVersion54
81364view12:53, 21 August 2015ReactomeTeamVersion53
76832view08:05, 17 July 2014ReactomeTeamFixed remaining interactions
76536view11:51, 16 July 2014ReactomeTeamFixed remaining interactions
75869view09:52, 11 June 2014ReactomeTeamRe-fixing comment source
75569view10:37, 10 June 2014ReactomeTeamReactome 48 Update
74924view13:45, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74568view08:36, 30 April 2014ReactomeTeamReactome46
42089view21:56, 4 March 2011MaintBotAutomatic update
39897view05:55, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3,4-dihydroxyphenylglycolaldehydeMetaboliteCHEBI:27852 (ChEBI)
5HT MetaboliteCHEBI:28790 (ChEBI)
5HTMetaboliteCHEBI:28790 (ChEBI)
AA MetaboliteCHEBI:15843 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
APBA1 ProteinQ02410 (Uniprot-TrEMBL)
APBA1ProteinQ02410 (Uniprot-TrEMBL)
ARL6IP5ProteinO75915 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
AcChoMetaboliteCHEBI:15355 (ChEBI)
Acetylcholine Loaded Synaptic VesicleComplexR-HSA-264786 (Reactome)
BZRAP1 ProteinO95153 (Uniprot-TrEMBL)
CASK ProteinO14936 (Uniprot-TrEMBL)
CASKProteinO14936 (Uniprot-TrEMBL)
CHATProteinP28329 (Uniprot-TrEMBL)
CPLX1 ProteinO14810 (Uniprot-TrEMBL)
CPLX1ProteinO14810 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
ChoMetaboliteCHEBI:15354 (ChEBI)
Cl-MetaboliteCHEBI:17996 (ChEBI)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
DA MetaboliteCHEBI:18243 (ChEBI)
DAMetaboliteCHEBI:18243 (ChEBI)
DDCX MetaboliteCHEBI:30805 (ChEBI)
Docked Glutamate

Loaded Synaptic

Vesicle
ComplexR-HSA-210458 (Reactome) Glutamate synaptic vesicle contains Rab3 ( GTPase), synaptobrevin/VAMP ( V-SNARE), VGLUT1 (Glutamate transporter) and synpatotagmin which is beleived to be a Ca2+ sensor and plays a role in the synaptic vesicle fusion process.
Docked Noradrenalin

loaded synaptic

vesicle
ComplexR-HSA-374939 (Reactome)
Docked acetylcholine

loaded Synaptic

Vesicle
ComplexR-HSA-372534 (Reactome) Acetylcholine synaptic vesicle contains Rab3 ( GTPase), synaptobrevin/VAMP ( V-SNARE), VGLUT1 (Glutamate transporter) and synpatotagmin which is beleived to be a Ca2+ sensor and plays a role in the synaptic vesicle fusion process.
Docked dopamine

loaded synaptic

vesicle
ComplexR-HSA-380573 (Reactome)
Docked serotonin

loaded synaptic

vesicle
ComplexR-HSA-380900 (Reactome)
Dopamine loaded synaptic vesicleComplexR-HSA-380575 (Reactome)
ETAMetaboliteCHEBI:16000 (ChEBI)
Empty Acetylcholine Synaptic VesicleComplexR-HSA-210372 (Reactome)
Empty Glutamate Synaptic VesicleComplexR-HSA-264795 (Reactome)
FAD MetaboliteCHEBI:16238 (ChEBI)
FAsComplexR-ALL-6803778 (Reactome)
GABA synthesis,

release, reuptake

and degradation
PathwayR-HSA-888590 (Reactome) GABA is a major inhibitory neurotransmitter in the mammalian central nervous system. GABA modulates neuronal excitability throughout the nervous system. Disruption of GABA neurotransmission leads to many neurological diseases including epilepsy and a general anxiety disorder. GABA is synthesized by two distinct enzymes GAD67 and GAD65 that differ in their cellular localization, functional properties and co-factor requirements. GABA synthesized by GAD65 is used for neurotransmission whereas GABA synthesized by GAD67 is used for processes other than neurotransmission such as synaptogenesis and protection against neuronal injury. GABA is loaded into synaptic vesicle with the help of vesicular inhibitory amino acid transporter or VGAT. GAD65 and VGAT are functionally linked at the synaptic vesicle membrane and GABA synthesized by GAD65 is preferentially loaded into the synaptic vesicle over GABA synthesized in cytoplasm by GAD67.The GABA loaded synaptic vesicles are docked at the plasma membrane with the help of the SNARE complexes and primed by interplay between various proteins including Munc18, complexin etc. Release of GABA loaded synaptic vesicle is initiated by the arrival of action potential at the presynaptic bouton and opening of N or P/Q voltage gated Ca2+ channels. Ca2+ influx results in Ca2+ binding by synaptobrevin, which is a part of the SNARE complex that also includes SNAP25 and syntaxin, leading to synaptic vesicle fusion. Release of GABA in the synaptic cleft leads to binding of GABA by the GABA receptors and post ligand binding events.
GLS ProteinO94925 (Uniprot-TrEMBL)
GLS dimersComplexR-HSA-507859 (Reactome)
GLS2 ProteinQ9UI32 (Uniprot-TrEMBL)
Glu MetaboliteCHEBI:29985 (ChEBI)
Glutamate loaded synaptic vesicleComplexR-HSA-210380 (Reactome)
H+MetaboliteCHEBI:15378 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
K+MetaboliteCHEBI:29103 (ChEBI)
L-GlnMetaboliteCHEBI:58359 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
LIN7:CASK:APBA1ComplexR-HSA-5336456 (Reactome)
LIN7A ProteinO14910 (Uniprot-TrEMBL)
LIN7A,B,CComplexR-HSA-5336428 (Reactome)
LIN7B ProteinQ9HAP6 (Uniprot-TrEMBL)
LIN7C ProteinQ9NUP9 (Uniprot-TrEMBL)
MAOA ProteinP21397 (Uniprot-TrEMBL)
MAOA:FADComplexR-HSA-141332 (Reactome)
MYSA MetaboliteCHEBI:28875 (ChEBI)
NAAA (126-349) ProteinQ02083 (Uniprot-TrEMBL)
NAAA (29-125) ProteinQ02083 (Uniprot-TrEMBL)
NAAA dimerComplexR-HSA-6803758 (Reactome)
NAEsComplexR-ALL-6803725 (Reactome)
NARAC-ETA MetaboliteCHEBI:2700 (ChEBI)
NAd MetaboliteCHEBI:18357 (ChEBI)
NAdMetaboliteCHEBI:18357 (ChEBI)
NH3MetaboliteCHEBI:16134 (ChEBI)
NH4+MetaboliteCHEBI:28938 (ChEBI)
NLAU-ETA MetaboliteCHEBI:85263 (ChEBI)
NMYS-ETA MetaboliteCHEBI:85262 (ChEBI)
NOLE-ETA MetaboliteCHEBI:71466 (ChEBI)
NPALM-ETA MetaboliteCHEBI:71464 (ChEBI)
NSTEA-ETA MetaboliteCHEBI:85299 (ChEBI)
Na+MetaboliteCHEBI:29101 (ChEBI)
Noradrenalin loaded synaptic vesicleComplexR-HSA-374911 (Reactome)
O-acetylcholine MetaboliteCHEBI:15355 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
OCT2ComplexR-HSA-2901780 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
OLEA MetaboliteCHEBI:16196 (ChEBI)
PALM MetaboliteCHEBI:15756 (ChEBI)
PPFIA1 ProteinQ13136 (Uniprot-TrEMBL)
PPFIA2 ProteinO75334 (Uniprot-TrEMBL)
PPFIA3 ProteinO75145 (Uniprot-TrEMBL)
PPFIA4 ProteinO75335 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RAB3A ProteinP20336 (Uniprot-TrEMBL) Rab3A, located in the synaptic vesicle membrane, interacts with RIM ( Rab3A interacting Molecule) and with Doc2. These interactions are beleived to initiate the process of priming which precedes the fuison of the synaptic vesicle with the plasma membrane.
RAB3AProteinP20336 (Uniprot-TrEMBL) Rab3A, located in the synaptic vesicle membrane, interacts with RIM ( Rab3A interacting Molecule) and with Doc2. These interactions are beleived to initiate the process of priming which precedes the fuison of the synaptic vesicle with the plasma membrane.
RIMS1 ProteinQ86UR5 (Uniprot-TrEMBL)
RIMS1:UNC13B:BZRAP1:Alpha-liprinComplexR-HSA-210374 (Reactome) Rab3A, located in the synaptic vesicle membrane, interacts with RIM ( Rab3A interacting Molecule) and with Doc2. These interactions are beleived to initiate the process of priming which precedes the fuison of the synaptic vesicle with the plasma membrane.
SLC17A7 ProteinQ9P2U7 (Uniprot-TrEMBL)
SLC17A7ProteinQ9P2U7 (Uniprot-TrEMBL)
SLC18A2 ProteinQ05940 (Uniprot-TrEMBL)
SLC18A2ProteinQ05940 (Uniprot-TrEMBL)
SLC18A3 ProteinQ16572 (Uniprot-TrEMBL)
SLC18A3ProteinQ16572 (Uniprot-TrEMBL)
SLC1A1 ProteinP43005 (Uniprot-TrEMBL)
SLC1A1-3,6,7ComplexR-HSA-210358 (Reactome)
SLC1A2 ProteinP43004 (Uniprot-TrEMBL)
SLC1A3 ProteinP43003 (Uniprot-TrEMBL)
SLC1A6 ProteinP48664 (Uniprot-TrEMBL)
SLC1A7 ProteinO00341 (Uniprot-TrEMBL)
SLC22A1 ProteinO15245 (Uniprot-TrEMBL)
SLC22A2 ProteinO15244 (Uniprot-TrEMBL)
SLC22A2ProteinO15244 (Uniprot-TrEMBL)
SLC38A2ProteinQ96QD8 (Uniprot-TrEMBL)
SLC5A7ProteinQ9GZV3 (Uniprot-TrEMBL)
SNAP25 ProteinP60880 (Uniprot-TrEMBL)
SNAP25ProteinP60880 (Uniprot-TrEMBL)
SNARE complexComplexR-HSA-210441 (Reactome)
STEA MetaboliteCHEBI:9254 (ChEBI)
STX1A ProteinQ16623 (Uniprot-TrEMBL)
STX1AProteinQ16623 (Uniprot-TrEMBL)
STXBP1-1 ProteinP61764-1 (Uniprot-TrEMBL) Munc 18 interacts with syntaxin in the plasma membrane, with Mint (Munc 18 interacting) which in turn interacts with CASK and neurexins. Munc18 also interacts with granulophilin. Granulophilin is interacts simultaneously with syntaxin and Munc18. These interactions are believed to be involved in the docking of the synaptic vesicle to the plasma membrane. However, the sequence of events is unclear.
STXBP1-1ProteinP61764-1 (Uniprot-TrEMBL) Munc 18 interacts with syntaxin in the plasma membrane, with Mint (Munc 18 interacting) which in turn interacts with CASK and neurexins. Munc18 also interacts with granulophilin. Granulophilin is interacts simultaneously with syntaxin and Munc18. These interactions are believed to be involved in the docking of the synaptic vesicle to the plasma membrane. However, the sequence of events is unclear.
SYN1 ProteinP17600 (Uniprot-TrEMBL)
SYN2 ProteinQ92777 (Uniprot-TrEMBL)
SYN3 ProteinO14994 (Uniprot-TrEMBL)
SYT1 ProteinP21579 (Uniprot-TrEMBL)
SYT1ProteinP21579 (Uniprot-TrEMBL)
Serotonin loaded synaptic vesicleComplexR-HSA-380903 (Reactome)
SynapsinComplexR-HSA-380576 (Reactome)
UNC13B ProteinO14795 (Uniprot-TrEMBL)
UNC13BProteinO14795 (Uniprot-TrEMBL)
VAMP2 ProteinP63027 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
3,4-dihydroxyphenylglycolaldehydeArrowR-HSA-374909 (Reactome)
5HTArrowR-HSA-380586 (Reactome)
5HTArrowR-HSA-380901 (Reactome)
5HTR-HSA-380586 (Reactome)
ADPArrowR-HSA-349520 (Reactome)
ADPArrowR-HSA-374916 (Reactome)
APBA1R-HSA-5336443 (Reactome)
ARL6IP5TBarR-HSA-210404 (Reactome)
ATPR-HSA-349520 (Reactome)
ATPR-HSA-374916 (Reactome)
Ac-CoAR-HSA-264622 (Reactome)
AcChoArrowR-HSA-264622 (Reactome)
AcChoArrowR-HSA-372529 (Reactome)
AcChoR-HSA-264615 (Reactome)
Acetylcholine Loaded Synaptic VesicleArrowR-HSA-264615 (Reactome)
Acetylcholine Loaded Synaptic VesicleR-HSA-372505 (Reactome)
Acetylcholine Loaded Synaptic Vesiclemim-catalysisR-HSA-372505 (Reactome)
CASKR-HSA-5336443 (Reactome)
CHATmim-catalysisR-HSA-264622 (Reactome)
CPLX1ArrowR-HSA-210430 (Reactome)
CPLX1ArrowR-HSA-372529 (Reactome)
CPLX1ArrowR-HSA-374899 (Reactome)
CPLX1ArrowR-HSA-380869 (Reactome)
CPLX1ArrowR-HSA-380901 (Reactome)
CPLX1R-HSA-210426 (Reactome)
CPLX1R-HSA-372505 (Reactome)
CPLX1R-HSA-374922 (Reactome)
CPLX1R-HSA-380574 (Reactome)
CPLX1R-HSA-380905 (Reactome)
Ca2+ArrowR-HSA-210430 (Reactome)
ChoArrowR-HSA-429594 (Reactome)
ChoR-HSA-264622 (Reactome)
ChoR-HSA-429594 (Reactome)
Cl-ArrowR-HSA-429594 (Reactome)
Cl-R-HSA-429594 (Reactome)
CoA-SHArrowR-HSA-264622 (Reactome)
DAArrowR-HSA-372542 (Reactome)
DAArrowR-HSA-380869 (Reactome)
DAR-HSA-372542 (Reactome)
Docked Glutamate

Loaded Synaptic

Vesicle
ArrowR-HSA-210426 (Reactome)
Docked Glutamate

Loaded Synaptic

Vesicle
R-HSA-210430 (Reactome)
Docked Glutamate

Loaded Synaptic

Vesicle
mim-catalysisR-HSA-210430 (Reactome)
Docked Noradrenalin

loaded synaptic

vesicle
ArrowR-HSA-374922 (Reactome)
Docked Noradrenalin

loaded synaptic

vesicle
R-HSA-374899 (Reactome)
Docked Noradrenalin

loaded synaptic

vesicle
mim-catalysisR-HSA-374899 (Reactome)
Docked acetylcholine

loaded Synaptic

Vesicle
ArrowR-HSA-372505 (Reactome)
Docked acetylcholine

loaded Synaptic

Vesicle
R-HSA-372529 (Reactome)
Docked acetylcholine

loaded Synaptic

Vesicle
mim-catalysisR-HSA-372529 (Reactome)
Docked dopamine

loaded synaptic

vesicle
ArrowR-HSA-380574 (Reactome)
Docked dopamine

loaded synaptic

vesicle
R-HSA-380869 (Reactome)
Docked dopamine

loaded synaptic

vesicle
mim-catalysisR-HSA-380869 (Reactome)
Docked serotonin

loaded synaptic

vesicle
ArrowR-HSA-380905 (Reactome)
Docked serotonin

loaded synaptic

vesicle
R-HSA-380901 (Reactome)
Docked serotonin

loaded synaptic

vesicle
mim-catalysisR-HSA-380901 (Reactome)
Dopamine loaded synaptic vesicleR-HSA-380574 (Reactome)
Dopamine loaded synaptic vesiclemim-catalysisR-HSA-380574 (Reactome)
ETAArrowR-HSA-6803753 (Reactome)
Empty Acetylcholine Synaptic VesicleR-HSA-264615 (Reactome)
Empty Glutamate Synaptic VesicleR-HSA-210444 (Reactome)
Empty Glutamate Synaptic Vesiclemim-catalysisR-HSA-210444 (Reactome)
FAsArrowR-HSA-6803753 (Reactome)
GLS dimersmim-catalysisR-HSA-70609 (Reactome)
Glutamate loaded synaptic vesicleArrowR-HSA-210444 (Reactome)
Glutamate loaded synaptic vesicleR-HSA-210426 (Reactome)
Glutamate loaded synaptic vesiclemim-catalysisR-HSA-210426 (Reactome)
H+ArrowR-HSA-210404 (Reactome)
H+ArrowR-HSA-264615 (Reactome)
H+ArrowR-HSA-349520 (Reactome)
H+ArrowR-HSA-374916 (Reactome)
H+R-HSA-210404 (Reactome)
H+R-HSA-264615 (Reactome)
H+R-HSA-349520 (Reactome)
H+R-HSA-374916 (Reactome)
H2O2ArrowR-HSA-374909 (Reactome)
H2OR-HSA-374909 (Reactome)
H2OR-HSA-6803753 (Reactome)
H2OR-HSA-70609 (Reactome)
K+ArrowR-HSA-210404 (Reactome)
K+R-HSA-210404 (Reactome)
L-GlnArrowR-HSA-212642 (Reactome)
L-GlnArrowR-HSA-212651 (Reactome)
L-GlnR-HSA-212642 (Reactome)
L-GlnR-HSA-212651 (Reactome)
L-GlnR-HSA-70609 (Reactome)
L-GluArrowR-HSA-210404 (Reactome)
L-GluArrowR-HSA-210430 (Reactome)
L-GluArrowR-HSA-212658 (Reactome)
L-GluArrowR-HSA-70609 (Reactome)
L-GluR-HSA-210404 (Reactome)
L-GluR-HSA-210444 (Reactome)
L-GluR-HSA-212658 (Reactome)
LIN7:CASK:APBA1ArrowR-HSA-380574 (Reactome)