Homologous recombination (Homo sapiens)

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1Pol-deltaPol-deltaDamaged chromatidSister chromatidMRN complexStrand invasiongamma radiation / genotoxic drugsPol-deltaPOLD3RAD51RAD51BRCA2BRCA2BRCA2RPA1 ?RPA1 ?RPA1 ?NBNRAD52RAD52POLD4RAD51ATMRAD54BMRE11ARAD51BRCA2POLD1RPA1 ?POLD2RAD52RAD50ATMRAD54B


Homologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA.

Source: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, James D. Watson; ''Molecular Biology of the Cell, 4th edition''; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A747#A845, 2002


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118416view14:19, 27 May 2021Marvin M2added isbn
118411view14:16, 27 May 2021EweitzOntology Term : 'homologous recombination pathway of double-strand break repair' added !
106593view19:34, 10 September 2019KhanspersModified description
105617view04:57, 10 August 2019KhanspersModified description
104834view14:07, 20 June 2019IreneHemelChanged undirected interactions in drawing to graphical lines
68935view17:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
59133view22:37, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41086view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
36295view23:20, 17 March 2010KhanspersModified categories
35578view15:25, 12 February 2010ThomasModified description
35566view15:17, 12 February 2010Thomasadded literature
34748view23:01, 13 January 2010KhanspersAdded connectors
34546view20:01, 21 December 2009Khanspersminor changes
31992view13:14, 14 August 2009MaintBotFixed group labels
29610view12:09, 23 May 2009MartijnVanIerselUpdated ensembl references
21069view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Homologous recombination]] moved to [[Pathway:WP186]]: Moved to stable identifier
14599view06:37, 23 May 2008Thomasgrouped complexes, not much to connect here
10356view03:00, 23 January 2008AlexanderPicoModified categories
9585view09:48, 9 January 2008Thomasmade a start with HR pathway

External references


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NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl)
BRCA2GeneProductENSG00000139618 (Ensembl)
MRE11AGeneProductENSG00000020922 (Ensembl)
NBNGeneProductENSG00000104320 (Ensembl)
POLD1GeneProductENSG00000062822 (Ensembl)
POLD2GeneProductENSG00000106628 (Ensembl)
POLD3GeneProductENSG00000077514 (Ensembl)
POLD4GeneProductENSG00000175482 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RAD52GeneProductENSG00000002016 (Ensembl)
RAD54BGeneProductENSG00000197275 (Ensembl)
RPA1 ?GeneProductENSG00000132383 (Ensembl) Type you comment here

Annotated Interactions

No annotated interactions

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