Mitotic G1 phase and G1/S transition (Homo sapiens)

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6, 10, 22, 42, 43, 76...401675512053, 147554012015962, 108, 22572, 83, 2258, 10966, 16623, 2396758, 99, 111, 122, 176...62, 108, 22514, 51, 168, 23767147, 22672, 225404012034, 190, 2101523718, 20, 29, 49, 71...120402616495, 2259021240, 12081225, 2274072, 2251591641846572, 222, 2251536, 76, 80, 161, 17512053, 120, 147214112, 14467122, 20434, 3717, 50, 85, 101, 116...157, 22521412040, 119, 131, 225153120, 224, 225, 22721241, 107, 16210254225119, 131, 22526152, 22528, 72, 22518, 29, 49, 71, 73...28, 72, 22595, 102, 225137, 184191224168, 188, 24346, 58, 99, 111, 158...1202790, 120168, 18817312, 16, 44, 45, 73...6723757, 6049, 57, 59, 71, 110...120105, 178, 24323, 159, 23979, 147, 226157, 22522, 42, 43, 176, 203...10152, 22552, 118, 199, 232cytosolnucleoplasmCCNA2 RBL2 p-T356-RB1 MCM4 TFDP2 ORC2 LIN37 LIN9 PSMA4 SKP1 TFDP1 LIN54 PRIM2 MYBL2 gene PPP2R1B p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B)PCNA gene MCM2-7CyclinE/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1BLIN37 CUL1 CDT1 MCM3 p-T356-RB1 PSMB9 E2F1:TFDP1,TFDP2:CDC6 geneUBA52(1-76) TFDP2 PPP2CA CCNE2 CDKN1C ORC1 CDK6 p-S788-RB1 CDKN1C CCND1 ORC1 p-T369,S640,S964,S975-RBL1CCNE1 CDK4,CDK6:CCNDCCND1 MCM6 RBL1 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 geneE2F4 UBC(457-532) POLA1 geneRBBP4 ORC6 E2F4 CDC45 gene GMNN p-T177-CDK6 ORC2 CCNE1 CDK2 RBL2 MCM10 TFDP1 E2F1 TK1 geneTOP2A geneUBC(457-532) POLA2 PSMD8 UBC(381-456) PSME1 CDK2 CCNE1 Cyclin B:CDK1CDKN1B CDK2 PP2Ap-Y88-CDKN1B CDKN1C PiTFDP2 TFDP2 POLE4 CCNE2 RBL2 CCND2 p-T187-CDKN1B MCM4 p-S28-LIN52 CCND2 E2F4 Ub-p-T401,S672,1035-RBL2HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CDK1 geneFBXO5TFDP2 ORC3 p-T187-CDKN1B CCNA1 DHFR geneTFDP2 CCND1 CUL1:SKP1:SKP2:CKS1BRBBP4 TFDP2 MCM10 POLE MCM4 E2F1:TFDP1,TFDP2:CCNA1 geneLIN54 TFDP1 TFDP2 TFDP2 CDKN1B E2F5 TFDP2 p-T187-CDKN1B PCNA gene p-S807-RB1 LIN9 CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)CDT1 ATPMCM5 CDK1 geneCDC45 geneSKP2 CCNEDBF4 ORC3 CDKN1A E2F4 UBC(305-380) UBC(1-76) RPA1 CDK6 TFDP2 RBL1 UBC(1-76) CDKN2D CCNE2 CDK:DDK:MCM10:activepre-replicativecomplex:CDC45E2F4:TFDP1,TFDP2E2F1:TFDP1,TFDP2:ORC1 geneCUL1 CCNE2 UBC(381-456) MCM5 UBC(305-380) E2F5 ADPCCND3 p-T,p-S-AKTLIN9 Senescence-Associated Secretory Phenotype (SASP)CDK1CDC25A gene TOP2Ap-T401,S672,S1035-RBL2 MCM4 CCNE2 CCNE1 CCNA2 POLE3 DBF4 E2F3 UbMCM5 HDAC1 MCM5 TFDP1 CCND2 UBC(457-532) UBC(77-152) LIN54 origin of replication HDAC1 FBXO5 geneE2F1 gene TFDP1 CUL1:SKP1:SKP2E2F5 p-T-CDKN1A/BORC5 Cyclin E:p-CDK2PSMD2 MCM3 TFDP2 TFDP1 Oxidative StressInduced SenescenceDREAM complex:CDC6geneDNA primer TFDP2 p-S608-RB1 CDC6 E2F4 E2F5 origin of replication E2F4 HDAC1 ORC6 LIN9 p-S230-RB1 RNA primer-DNAprimer:originduplex with DNAdamageRBBP4 TFDP2 RBL1 TFDP2 CDK2 CDT1 geneUBB(153-228) PiTFDP1 RBL1MCM3 p-Y77-CDKN1A TFDP2 UBC(533-608) ATPPSME2 CCNH CCNE1 CCNE2 CyclinB:CDK1:ORC:originof replicationCCNE:CDK2PSMC5 PSMA6 UBC(533-608) RBL2 E2F4,E2F5:TFDP1,TFDP2CDKN1A PRIM1 UBC(609-684) RBBP4 PSMB6 ATPCyclin E:p-T160-CDK2E2F1:TFDP1,TFDP2:FBXO5 genePSMA7 LIN54 MCM6 TFDP1 E2F3 CDKN2D TK1 gene RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2TFDP1 p-Y397-LYN RPA2 E2F1:TFDP1,TFDP2:TK1geneCCNA1 geneSKP2 H2OMCM5 DHFRPSMD7 RBL2 CDC7 TFDP2 TFDP1 CUL1 PPP2R2A HDAC1 RB1:RNA primer-DNAprimer:originduplex with DNAdamageLIN9 ADPCDC6 ADPATPTFDP1 TFDP1 TFDP1 CKS1B ORC1 ATPDREAM complex:TOP2Agenep16INK4A RPA4 CDC6 CDK4,CDK6CDKN1A ORC3 CDC7 MCM8 CCNE1 ORC2 E2F1 Pi CCNA1 DNA polymeraseepsilon:origincomplexPSMD4 ATPCDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C)GMNNCDKN2C CUL1 ATPORC4 RBL1 CCNE2 RNA primer-DNAprimer:originduplexPSMD6 RB1 UBB(153-228) E2F1 CKS1B DNA polymerasealpha:primaseH2OORC3 MCM7 RBL2 p-S252-RB1 DNA polymerasealpha:primase:DNApolymerasealpha:origincomplexCCND1 ORC4 TFDP2 Signaling by PTK6E2F4 ORC6 LIN37 E2F4 POLE p-T401,S672,S1035-RBL2CCNE1 CDKN1B RBL2 CCNA p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))UBC(533-608) p-T373-RB1 MCM7 TFDP1 PCNA geneCCNE1 PSMC3 CDK1 ORC6 RRM2 gene Aborted replicationcomplexLIN37 CDC25AE2F1 p-S28-LIN52 CDKN1A DNA primer RRM2 geneUBA52(1-76) LIN37 CCND3 p-Y88-CDKN1B CCNA PPP2CB ADPADPTranscriptionalactivity ofSMAD2/SMAD3:SMAD4heterotrimerPSMC1 E2F1 PPP2R1B CDKN1A,CDKN1BCyclinE/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitinE2F1:TFDP1,TFDP2:CDC45 geneCDC6 TFDP2 LIN37 DNA polymeraseepsilonCDKN1B:(CDK4:CCND1,(CDK2:CCNE1))CCND2 CDK6 PPP2R1A E2F5 TFDP2 E2F1 CDK2MCM6 p-Y342-PTK6 RBL2 E2F1:TFDP1,TFDP2:PCNA geneINK4PRIM2 ADPMCM6 p-S608-RB1 TFDP2 TFDP1 ORC:origin ofreplicationcyclin UBC(77-152) E2F1 CDC6 geneCDC25A gene ORC2 p-Y419-SRC ORC2 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2MCM6 MCM2 CDK2 TFDP2 ADPE2F1CDK4 E2F4 CDC6 p-T160-CDK2 ORC3 UBB(77-152) CDK4 MCM8 origin of replication RB1 UBC(381-456) E2F1:TFDP1,TFDP2:POLA1 geneRNA primer:origin duplex with DNA damage E2F4 E2F1 genep-T305,S472-AKT3 CDK1 gene E2F4 PCNARPS27A(1-76) SKP1 PPP2CA CCNE1 p-Y342-PTK6POLE2 RBL1:E2F4:DP1/2:Cyclin E/A:CDK2UBB(77-152) CDK6 TFDP2 ORC1 p-T826-RB1 E2F4 PPP2R3B RPA4 CCNB1 ATPCDC7 CUL1 p-MCM2-7Cyclin E PSMA3 E2F1 PRIM1 CDKPPP2CB p-S612-RB1 E2F1 p-S230-RB1 MYC RNA primer:origin duplex with DNA damage origin of replication ORC4 TFDP2 E2F5 E2F5 ORC5 E2F1 gene LIN9 PRIM1 E2F1:TFDP1,TFDP2:CDT1 genep-T821-RB1 ORC5 origin of replication MCM6 CCNA2 CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)DYRK1ARBL1:E2F4:TFDP1,TFDP2POLE4 p-T160-CDK2 MCM4 CDK1 p-T160-CDK2 origin of replication MCM5 CDK2 RBL2 CDKN1A TFDP1 PSMB3 PSMA2 TFDP2 RBL1 POLA1 TFDP1 DREAM complexE2F6 CABLES1MuvB complexCCNA1CDKN1BH2ODDKCDC45POLA1 CDC7 CCNE1 gene CDC6 RRM2POLE4 TFDP1 CDKN2B MYBL2 geneMCM4 origin of replication p-Y91-CDKN1C CCNA1 gene MCM10:pre-replicative complexORC1 gene CCNE:p-T160-CDK2:hypophosphorylated RB1CCNE1 ORC1 ORC1TFDP2 CDK:DDK:MCM10:activepre-replicativecomplex:CDC45:RPA1-4CUL1:SKP1:SKP2:CKS1BUBC(229-304) TFDP1 ORC4 SKP1 PSMC6 UBA52(1-76) PSMD13 DREAM complex:CDC25AgeneUBC(381-456) CDK4 MCM3 MCM3 PSMD11 CDC6 gene MNAT1 MCM4 CDC6cyclin CCNA2 MCM8 MCM3 CCND3 CCNE2 TFDP1 E2F5 DBF4 RB1CDKN2C ADPDREAM complex:RBL1geneCDKN1A TFDP1 LIN9 CCND1 TFDP2 UBC(533-608) p-S28-LIN52 CDK2 POLE3 MCM4 CKS1B E2F1 MCM3 p-T172-CDK4 TFDP1 E2F5 p-T821-RB1 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:MYBL2 geneCDK4 RBL1 gene HDAC1 ADPUBB(1-76) H2OPSMD1 CCNE2 TFDP1 CCNE1 CCNE1PSMB7 CDKN1A E2F1 p-S28-LIN52 CDK7 UBC(153-228) RBBP4 RPA1-4RPA2 ATPCDKN1BCDK2 p-S28-LIN52 pre-replicativecomplexCUL1 CCNA1 E2F5 CCND3 CCNA2 geneCCNA2 PSMB8 ORC6 DHFR gene CDKN1B ORC6 TOP2A gene E2F5 ATPLIN54 ORC2 UBB(153-228) RBL1 CCNA POLE2 CKS1B UBC(229-304) TFDP2 UBC(77-152) MCM5 POLE3 p-T401,S672,1035-RBL2:SCF(Skp2):Cks1p-Y226,Y393-ABL1 SKP2 RBBP4 E2F1:TFDP1,TFDP2:CDK1 geneCDKN1B CDC25A gene CDK4 CCNE2 RBL1:Cyclin E/A:CDK2RBL2:E2F4,E2F5:TFDP1,TFDP2MCM10ORC1 MCM2 p-S252-RB1 HDAC1RNA primer E2F1 PSMD10 PIP3 activates AKTsignalingE2F1 PSMF1 E2F1 Cyclin E/A:CDK2CKS1B MCM2 p-T373-RB1 ORC5 LIN54 UBC(153-228) TFDP1 CDK4,CDK6:INK4UBB(1-76) UBC(153-228) UBC(609-684) CCND3 RBL1 E2F4 TFDP2 p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))UBB(77-152) p-T160-CDK2 TFDP1 TFDP1 MCM8 RNA primer:origin duplex with DNA damage E2F1,E2F2,E2F3:TFDP1,TFDP2CCNB1 CDKN1C RBL2 E2F4 PPP2R3B HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2MCM7 CCNE:CDK2TFDP2 ORC6 p-S249-RB1 TFDP1 DREAM complex:PCNAgeneMCM10 E2F5 CCND2 RBL2 CDK2 UBC(457-532) RBL1CDK4 TFDP2 RBL2 HDAC1 ATPCDK2 CCND3 E2F4 UBA52(1-76) LIN37 CDK6 cyclin ORC4 CDK2 p-S811-RB1 CDK4 MCM8 CDK6 RRM2 gene RBL1:E2F4:TFDP1,TFDP2CDKN1A,CDKN1B,(CDKN1C)p-T308,S473-AKT1 CDC25A geneCDKN1AE2F1 UBB(153-228) PiMCM2 DNA primer E2F1 p-S788-RB1 CCNA2 gene RBBP4 p-S28-LIN52 RPA3 CDKN1B UBC(1-76) E2F1:TFDP1,TFDP2:DHFR geneORC5 LIN54 E2F1:TFDP1,TFDP2:CDC25A geneMCM8 CDK2 E2F4 Cdt1:gemininp-T160-CDK2 UBC(229-304) POLA1 gene RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2:MCM8 TFDP2 CDK6 CDK2 MCM10 TFDP2 p-S780-RB1 CDKN2B E2F4 cyclin DREAM complex:E2F1geneORC3 MCM8 RBL2 RBL2:Cyclin E/A:CDK2p-CDK2 CCND1 PiE2F2 MCM2 CDT1ORC3 p-S28-LIN52 ORC4 CCND2 origin of replication CCNE1 ORC2 CDK4 PSMD9 UBC(229-304) p-T309,S474-AKT2 PPP2R1A E2F2 UBC(609-684) PSMD14 CCNE1 E2F1 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CCNA2 genep-T160-CDK2 UBC(305-380) CDT1 E2F1:TFDP1,TFDP2:RRM2 geneADPORC5 CDKN1C MCM10:activepre-replicativecomplexCDC6 gene LIN9 MCM6 monophosphorylatedRB1RB1 CyclinE/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1BMAX SKP1 p-T826-RB1 p-S795-RB1 CDKN1B MCM7 UbMCM7 CDKN1B CDK4 26S proteasomeE2F5 origin of replication CCNA MCM2 Cyclin E UBC(609-684) TFDP2 CCNE1 ORC1 POLA2 TFDP1 p-S780-RB1 CDKN1B p-S130-CDKN1A RBBP4 CCND1 CCNA p16INK4A SKP2 ORC2 TFDP1 E2F4 RPS27A(1-76) TYMSCDKN1A p-S130-CDKN1A TFDP1 TFDP2 RBL1 Oncogene InducedSenescenceORC6 CCND1 E2F4 UBB(1-76) p-S249-RB1 RBL1 RPS27A(1-76) TK1p-Y342-PTK6 POLA2 PSMB4 origin of replication PSME3 E2F5 UBC(305-380) PSMB2 p-Y88-CDKN1B CCNA2TFDP1 p-12Y-JAK2 RPS27A(1-76) TFDP1 TFDP2 TFDP1 E2F1:TFDP1,TFDP2hyperphosphorylatedRB1PSMC2 RBL2WEE1MCM7 E2F4 CDKN1B Cyclin E PSMD12 ORC1 MAX CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C)CCNA1 p-T157-CDKN1B RBL2 POLA1 CCNA1 p-S807-RB1 CCND1 CDT1 gene CDKN1ACCND3 TFDP1 POLA1p-T160-CDK2 ORC5 MCM2 E2F6:(TFDP1,TFDP2):RRM2 genePSMC4 TFDP2 TFDP2 ORC4 TFDP1 Cyclin E CDKN1A DNA primer LIN9 RBL1 UBC(77-152) origin of replication HDAC1:RBL1:E2F4:TFDP1,TFDP2ADPMCM5 PSMA5 p-Y88-CDKN1B CAKCDC45 PSMA1 (p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2)CCND2 CDK2 SKP1 p-S795-RB1 TFDP2 LIN52 PSMB1 MCM3 ORC4 CCNA:p-T160-CDK2,CCNE:p-T160-CDK2DBF4 RBL2 CCNE2 CCND1 PP2AE2F1:TFDP1,TFDP2:CCNE1 genep-S612-RB1 ADPPOLE ATPp-T401,S672,S1035-RBL2 CDC45 CKS1BCCNE1 geneUBC(153-228) CDK:DDK:MCM10:activepre-replicativecomplexRBL1 geneUBC(1-76) MYC RBL2 p-T145-CDKN1A CDK2 POLE2 CDK1 gene p-MuvB complexMCM7 LIN54 MYC:MAXCyclin Dp-Y88-CDKN1B PSMD3 CCNE2 TFDP2 SHFM1 RPA1 SKP1 RPA3 E2F5 MYBL2p-S28-LIN52 E2F5 CyclinE:CDK2:CDKN1A,CDKN1Borigin ofreplicationCDKN1B p-S130-CDKN1A E2F4 PRIM2 PSMD5 MCM10 CCNE1 UBB(1-76) MCM7 RBBP4 HDAC1 E2F1 ORC5 LIN37 E2F4 TFDP1 FBXO5 gene E2F5 LIN54 MCM6 SKP2 RBL2:E2F4,E2F5:TFDP1,TFDP2ORC3 UBB(77-152)