Interleukin-1 family signaling (Homo sapiens)

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41, 50, 56, 843, 625451, 58, 71548720, 737490823, 82, 9229517, 55, 75524026, 37, 4823, 24, 82214388927, 623257409476, 8067126, 195438, 40, 51, 7116, 45, 54, 689348, 543938, 40, 51, 7114, 35, 49, 77, 81...15, 538327, 6425, 55, 92862890344634, 52, 6629, 72917, 30, 8338, 40, 51, 7159, 6111861835, 49, 69, 77, 85847, 63, 73, 78, 906015, 36, 536598814, 35, 49, 69, 77...9015, 534270nucleoplasmnucleoplasmcytosolcytosolIL33 UBE2N TOLLIP p-PELI2 NFKB1(1-433):RELAADPiE-DAP IL1R1 IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404)IL18, ALOX5ADPIL1RAPL1 TAB1 IL1RAP-1 RPS27A(1-76) IL1RL2p-S376,T387-IRAK1 UBE2N Myr82K-Myr83K-IL1A PTPN9 gene p-S927,S932-NFKB1(1-968) NFKB1(1-968)UBC(457-532) IL36A PSMD10 ATPIL1R1 IL1F10hp-IRAK1:3xTRAF6UBC(229-304) ATPIL1F10 UBA52(1-76) p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2PSMD13 PSMB4 UBA52(1-76) UBC(533-608) IRAK3IL1F10 PSME1 MAP2K6NOD1 p-PELI2 IL1B,Myr82K-Myr83K-IL1APTPN2 CASP1(317-404) IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1TAK1 activates NFkBby phosphorylationand activation ofIKKs complexp-T342,T345,S346-IRAK4 IL37(?-218) PSMB6 UBC(609-684) PTPN12 gene ATPPSMF1 MAP3K3:SQSTM1:TRAF6IL1RN IL33 IL36B RELA PSME3 IL1F10(?-152)IL37(?-218) TRAF6 IL1F10:IL1RAPL1PSMD12 p-Pellino-1,2,(3)IL1B,Myr82K-Myr83K-IL1A:IL1R1IL1RAP-1p-S218,S222-MAP2K1,p-S257,T261-MAP2K4NFKB1:p-T290-MAP3K8:TNIP2IL1RAP-1 K63polyUb-hp-IRAK1 UBB(1-76) p-2S,S376,T,T209,T387-IRAK1 p-2S,S376,T,T209,T387-IRAK1 FBXW11 UbPSME2 p-PELI1 IL1B p-S177,S181-IKBKBIL36B IL18R1 p-S423,S425-SMAD3 IL18ADPUBC(153-228) MYD88 IL18BP p-PELI1 UBE2V1 IL37(?-218) PSMB3 PSMD8 UBE2V1 p-2S,S376,T,T209,T387-IRAK1 IL37(?-218):p-S423,S425-SMAD3NFKB1(1-433) IL1R1 MAP3K8 PSMD2 MYD88 SKP1 IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1Myr82K-Myr83K-IL1A IL37(?-218) MAP3K3 PSMD1 IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIPIL1RAP-1 UBE2N PSMC2 IL36RN K63polyUb RELA CASP1(120-297) SKP1 PSMD5 PELI1 IL36:IL1RL2:IL1RAP-1IL1R1 IL4, IL13ADPPSME4 p-2S,S376,T,T209,T387-IRAK1 IL33:IL1RL1-2TOLLIP PSMB1 TRAF6 IL1B IL1B p-S400,T290-MAP3K8 BTRC IL33 TRAF6 PSMD14 IL1RL1 hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUbIL1RL1:IL33PTPN13 IL1R2IL18-2(37-189)PSMC3 UBC(153-228) UBE2N:UBE2V1PTPN11 gene NFKB1:RELA:p-S32,S36-NFKBIA:UbK63polyUb-hp-IRAK1p-S257,T261-MAP2K4 p-PELI3 IL1B PSMC5 PSMC4 IL1RAP-1 UBB(77-152) UBB(153-228) IRAK4PTPN6 gene TNIP2 UBC(1-76) IL1R1 p-Y705-STAT3CUL1 p-TBK1IRAK4 IL37(?-218)p-PELI3 PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23IL1RAP-1 ADPATPp-T,Y-MAPK8UBC(1-76) UBC(533-608) Myr82K-Myr83K-IL1A IL37(1-?) K63polyUb TNIP2 PTPN4 UBC(77-152) IL1B(117-269)UBE2N IL1RAP-1PSMD7 TAB3 p-PELI1 p-2S,S376,T,T209,T387-IRAK1 UBE2N ATPIL18 gene MAP3K3 IL18 p-T342,T345,S346-IRAK4 PTPN14 gene IRAK1 MAP3K7 SKP1 IL1R1UBC(305-380) IL1R1 p-2S,S376,T,T209,T387-IRAK1 UBC(1-76) p-2S,S376,T,T209,T387-IRAK1 PSMD6 IL18RAP p-S400,T290-MAP3K8 IL37(?-218):p-S423,S425-SMAD3ATPhp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1ATPIRAK4 IL36A TAB1 PTPN20 gene p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2SHFM1 IL36RN MYD88 p-PELI3 PSMB10 IL1RL1-2 IKBKB UBE2N p-S176,S180-CHUK p-2S,S376,T,T209,T387-IRAK1 IL1RAP-1 IL1RL2 IL37 FBXW11 MAP2K1 IL36G TAB3 UBC(305-380) RPS27A(1-76) K63polyUb-TRAF6 IL36A IL18 UBE2V1 CUL1 IL1RL2 SQSTM1 MYD88 p-IRAK2IL1F10:IL1RL2p-S177,S181-IKBKB p-S32,S36-NFKBIA MYD88 UBC(77-152) CHUK IL1B MDP UBC(153-228) ATPPTPN5 K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1p-S400,T290-MAP3K8 IL1F10(?-152) MAP3K8Pellino 1,2,3UBE2N hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complexMyr82K-Myr83K-IL1A UBE2V1 ATPIKBKG K63polyUb-TRAF6 p-S927,S932-NFKB1(1-968) Ub-209-RIPK2 PSMB5 PSMA1 IL37(?-218) IRAK4 PSMD11 IL18R1 TAB3 TAB1 UBB(1-76) IL1B IL1R1 IL1B,Myr82K-Myr83K-IL1A:IL1R2PSMB8 IL1RL1UBE2V1 TRAF6 UBC(77-152) p-2S,S376,T,T209,T387-IRAK1 MAP3K3:SQSTM1PTPN12 RPS27A(1-76) PELI3 IL1F10 IL1R1 IL37(?-218) p-S32,S36-NFKBIAIL18RAPBTRC IL1R2 K63polyUb-TRAF6 TAB2 Myr82K-Myr83K-IL1A UBC(533-608) NFKB1:MAP3K8:TNIP2IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIPIRAK4 SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2IL1RL1 K63polyUb SQSTM1 3xUb,2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2UBC(609-684) UBB(153-228) TOLLIP p-S32,S36-NFKBIA hp-IRAK1:3xK63polyUb-TRAF6CUL1 NFKB1(1-433):RELATNIP2IRAK1UBB(153-228) IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6p-PELI1 IL37(?-218)SIGIRRMyr82K-Myr83K-IL1A PSMC1 SIGIRR TNIP2 NFKB1(1-433) MYD88 Interleukin-1processingIL1RAPL1IL37(?-218) UBE2V1 MAP2K4 RELA p-PELI3 BTRC IL1B p-S423,S425-SMAD3 TOLLIPIL18:IL18R1:IL18RAPSMAD3 UBC(533-608) p-T342,T345,S346-IRAK4 UBC(457-532) IL1R1:IL1R2UBB(1-76) Myr82K-Myr83K-IL1A p-T342,T345,S346-IRAK4ADPIL18BP:IL37,IL37(?-218)PTPN13 gene IL1R2 IL1R1:IL1:IL1RAPMyr82K-Myr83K-IL1A TAB2 IL1F10(1-?)NFKB1(1-433) MYD88 IRAK4 PELI1 MYD88 3xUb-p-S927,S932-NFKB1(1-968) IL37 TOLLIP IL1RAP-1 PSMA3 TAK1 complexIL18 IL1RNIKBKG ADPIRAK4 TNIP2 p-2S,S376,T,T209,T387-IRAK1:TRAF6PSMA7 IL37(?-218) UBE2V1 MAP3K7 ADPUBA52(1-76) p-PELI2 hp-IRAK1:K6-poly-Uboligo-TRAF6:TAK1complexTBK1UBB(153-228) UBE2V1 p-S400-MAP3K8 PTPN5 gene p-T342,T345,S346-IRAK4 IL36G CASP1(120-297) Activated TAKcomplexesIL1R1 PTPN23 gene UBA52(1-76) PSMD3 CHUK IL1R1 TAB2 IRAK2Myr82K-Myr83K-IL1A PSMA8 TRAF6NFKB1(1-968) BTRC:CUL1:RBX1:SKP1IL18BP:IL18IL1RAPL1 p-2S,S376,T,T209,T387-IRAK1 IL37,IL37(?-218)UBE2N:UBE2V1:K63polyUbNOD2 RELA p-S207,T211-MAP2K6ADPSKP1 UBB(77-152) RELA ADPIL1R1 3xUb-p-S927,S932-NFKB1(1-968)IL37 ALOX5 gene SMAD3PSMB7 IL18BP p-2S,S376,T,T209,T387-IRAK1 TRAF6 UBE2N MYD88 p-T184,T187-MAP3K7 RPS27A(1-76) BTRC UBE2N CUL1 RBX1 UBC(229-304) IL37(?-218) IL18BPPELI3 MAP3K7 K63polyUb-TRAF6 NFKB1:p-S400-MAP3K8:TNIP2UBC(381-456) IKBKG PTPNgenes2,4,5,6,7,9,11,12,13,14,18,20,23IL1RL2 CHUK:IKBKB:IKBKGUBC(229-304) p-2S,S376,T,T209,T387-IRAK1 IL13 IL1F10(?-152):IL1RAPL1IL18(1-193) PELI2 NFKB1(1-433) UBC(77-152) ADPPSMB11 MYD88 dimerp-S32,S36-NFKBIA TNIP2 UBC(153-228) IL1B IL36RN,IL1F10:IL1RL2p-IRAK2 PTPN18 gene IL1RAP-1 PTPN9 IL18 gene, ALOX5geneCASP1(120-297) PTPN18 p-S218,S222-MAP2K1 IL1RAP-1 IL1B IL37(1-?)NFKB1(1-433) UBC(1-76) PSMB9 K63polyUb-TRAF6 PSMA5 Caspase-1 tetramerUBB(1-76) MAP3K8 PSMD4 NFKB1(1-968) IL37,IL37(?-218)CUL1 UBC(305-380) Myr82K-Myr83K-IL1A IL1B UBC(381-456) IL1RAP-1 BTRC IL37 hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUbIL1RL2 IL18R1:IL37,IL37(?-218):SIGIRRIL37(?-218):SMAD3IL37 IL18R1:IL37,IL37(?-218)IRAK1:Pellino:E2complexesIL36B BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:UbPTPN23 IL18R1 UBC(305-380) UBC(457-532) p-T342,T345,S346-IRAK4 TNIP2 NFKBIAUBB(77-152) K63polyUb IL36G PTPN20 p-S927,S932-NFKB1(1-968) PSMA4 p-S423,S425-SMAD3IKBKB hp-IRAK1:Pellino,IRAK4:PellinoTAB3 PTPN4 gene p-PELI3 PTPN7 ATPPELI2 IL1F10 PSMA2 PTPN2 gene Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKGIL1R1:IL1R2:IL1RNIL18R1 SKP1 UBC(609-684) p-PELI1 26S proteasomeRBX1 MAPK8CASP1(317-404) IL1B IKBKG ADPIL36:IL1RL2NFKB1(1-968) hp-IRAK1:p-Pellino,IRAK4:p-PellinoRBX1 PTPN7 gene p-S32,S36-NFKBIA IL4 p-PELI2 PTPN14 CASP1(317-404) MAP3K7 Myr82K-Myr83K-IL1A UBB(77-152) PSMB2 IL18:IL18R1NFKB1(1-433):RELA:p-S32,S36-NFKBIATNIP2 p-2S,S376,T,T209,T387-IRAK1, IRAK4p-2S,S376,T,T209,T387-IRAK1 Myr82K-Myr83K-IL1A IL1RAP-1 PTPN6 IL37IL1RAP-1K63polyUb PSMC6 p-S400,T290-MAP3K8MAP3K8 PSMD9 PSMA6 IL1B IL36RN, IL1F10ALOX5 IL33ATPSTAT3MAP2K1,MAP2K4TAB1 IL37 (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)UBC(381-456) IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKBIL18R1TOLLIP UBC(381-456) TOLLIP IL36RNRELA K63polyUb-hp-IRAK1 UBE2V1 IL33:IL1RL1:IL1RAP-1UBC(229-304) ATPIL1R1 p-PELI2 p-2S,S376,T,T209,T387-IRAK1 IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimerIL1R2 IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1p-2S,S376,T,T209,T387-IRAK1 IL37:2x(CASP1(120-197):CASP1(317-404))UbTAB2 PTPN11 NFKB1(1-433) IL1R1:IL1:IL1RAP:MYD88 dimerUBC(609-684) UBC(457-532) IL36A,IL36B,IL36G202022, 33431833202083110, 13, 443120579, 8313, 441, 83888