Interleukin-1 family signaling (Homo sapiens)

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35, 42, 44, 90946137, 48530, 72, 887910, 83647638, 51, 74, 84, 86822410, 835582885785209166, 78, 9512, 8, 272028, 36, 4172631971240, 56, 70826266, 75, 9513, 1831, 40, 63, 7038, 43, 74, 81, 84...9223, 53, 774, 20, 49, 898032, 608737, 546819, 6538, 51, 74, 81, 84...4720, 2724252015, 19, 24, 46, 6931, 40, 63, 7077, 78, 9869, 26, 6221226810, 59, 83931116, 50331, 40, 63, 7033, 523139, 5424cytosolcytosolnucleoplasmnucleoplasmMAP3K3 PSMD2 iE-DAP IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1UBC(1-76) PSMD8 IL36:IL1RL2:IL1RAP-1IL1RAP-1 K63polyUb-TRAF6 IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIPTAB2 IL1R1 Interleukin-1processingIL1R1:IL1R1inhibitorsPTPN6 TRAF6 BTRC CASP1(120-297) UBC(77-152) IL1RAP-1 IL1R1 IL37(?-218) IL1RAP-1UBC(305-380) PSMA2 IL36A,IL36B,IL36GIL18, ALOX5ATPIL1R1 PTPN4 gene UBB(1-76) ADPMYD88 PELI3 PELI3 IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKBp-IRAK2UBC(533-608) TOLLIP UBC(609-684) PSMB4 IL1B UBC(609-684) PSMB5 PTPN11 Myr82K-Myr83K-IL1A ADPUbPELI1 IL1R1:IL1:IL1RAP:MYD88 dimerMAP3K3:SQSTM1IL36G NFKB1(1-433) NFKB1(1-433):RELA:p-S32,S36-NFKBIAIL36RN,IL1F10:IL1RL2p-IRAK2 PTPN23 gene SIGIRRCUL1 IL37(?-218):SMAD3Myr82K-Myr83K-IL1A PTPN14 Pellino 1,2,3PSMB2 IL36G IL37(?-218) IL37(?-218) IL1RNp-S400,T290-MAP3K8 SHFM1 CUL1 K63polyUb TNIP2 IL1RL1-2 PSMC1 UBC(533-608) BTRC IL1RL1TOLLIP p-S176,S180-CHUK IL1F10 p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2IL1RAPL1 Ubp-S927,S932-NFKB1(1-968) p-PELI3 PSMA6 IL18:IL18R1:IL18RAPK63polyUb-TRAF6 IL1B IL1RAP-1 PSME4 IL1RAP-1 hp-IRAK1:p-Pellino,IRAK4:p-PellinoIL37(?-218) IL1R1 TAB3 p-S32,S36-NFKBIA IL18-2(37-189)TNIP2 UBC(153-228) TAB1 TAB3 p-2S,S376,T,T209,T387-IRAK1 MYD88 p-S257,T261-MAP2K4 IL1F10(?-152)SKP1 IL37(?-218) IL4 p-2S,S376,T,T209,T387-IRAK1:TRAF6PSMD14 ATPIL36:IL1RL2TNIP2 p-T,Y-MAPK8PSMC4 UBC(533-608) IL1R1 PSMC3 IL1RAP-1 IL1B UBB(77-152) IL1RL1 PSME1 IL1R1:IL1:IL1RAPMyr82K-Myr83K-IL1A IRAK4 UBC(305-380) TRAF6 p-2S,S376,T,T209,T387-IRAK1 ADPTBK1IRAK4 CASP1(317-404) MAP2K1 PTPN7 gene IL37(?-218) IL36RN, IL1F10ATPIL1B PSMD13 UBE2V1 ATPIKBKG IL33 TAB1 p-S218,S222-MAP2K1 MYD88 dimerIL1B UBE2N hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1IL18(1-193) MAP3K8 TAK1 complexIL1F10(1-?)p-S423,S425-SMAD3IL1RL2 IL37,IL37(?-218)p-PELI2 PSMD12 PSME2 ADPhp-IRAK1:K6-poly-Uboligo-TRAF6:TAK1complexSMAD3 IL1B p-S32,S36-NFKBIAIL18 UBE2N MAP3K3:SQSTM1:TRAF6IL1RL2 IL13 p-PELI2 IL1B PSMD5 p-S400,T290-MAP3K8 UBC(153-228) IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIPPTPNgenes2,4,5,6,7,9,11,12,13,14,18,20,23TOLLIP ATPUBC(381-456) UBC(77-152) MAPK8IKBKB K63polyUb-TRAF6 IL18 TAB2 IL1RAPL1 IRAK4 IL18R1:IL37,IL37(?-218)p-2S,S376,T,T209,T387-IRAK1 NFKB1(1-433) p-TBK1IL33 p-Pellino-1,2,(3)p-S423,S425-SMAD3 TOLLIP UBB(153-228) PSMA8 IL1B,Myr82K-Myr83K-IL1Ap-S423,S425-SMAD3 MAP2K6TAB1 ADPIL37 p-S32,S36-NFKBIA SQSTM1 IL37 IL18 gene, ALOX5geneIL1RAP-1 p-PELI1 IL1RAP-1 UBE2V1 BTRC:CUL1:RBX1:SKP1PTPN4 UBC(609-684) p-S177,S181-IKBKB UBC(457-532) IL36B PTPN9 hp-IRAK1:3xK63polyUb-TRAF6p-2S,S376,T,T209,T387-IRAK1 IL1F10ATPp-S927,S932-NFKB1(1-968) PTPN9 gene PSMD7 IRAK2IL36B TRAF6 PTPN6 gene IL18 gene UBE2N NFKB1(1-433):RELAPSMF1 IKBKG 3xUb,2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2PSMD10 PSMB9 PTPN2 gene K63polyUb RBX1 PTPN7 SKP1 UBE2N IL1B,Myr82K-Myr83K-IL1A:IL1R2UBE2V1 IRAK4 K63polyUb p-2S,S376,T,T209,T387-IRAK1 p-S376,T387-IRAK1 PSMD9 IL1RAP-1 IL1RL1 IL36A IL1RAP-1IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1STAT3UBB(77-152) CUL1 UBC(609-684) IL18R1:IL37,IL37(?-218):SIGIRRIL1F10 p-S400,T290-MAP3K8 BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:UbIRAK1:Pellino:E2complexesp-2S,S376,T,T209,T387-IRAK1 p-T342,T345,S346-IRAK4 IL37(1-?) IL18RAPp-S177,S181-IKBKBUBC(153-228) IL1F10 p-S32,S36-NFKBIA TNIP2 p-T342,T345,S346-IRAK4 p-S400-MAP3K8 FBXW11 Caspase-1 tetramerIL1F10(?-152) NFKB1:RELA:p-S32,S36-NFKBIA:UbNFKB1:p-T290-MAP3K8:TNIP2IL1R2 PTPN5 gene IL37:2x(CASP1(120-197):CASP1(317-404))IL18 IL1RAP-1 p-2S,S376,T,T209,T387-IRAK1 IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404)SKP1 UBC(229-304) 3xUb-p-S927,S932-NFKB1(1-968) UBB(153-228) IL1R1 UBE2N:UBE2V1IL1B(117-269)TAB3 IRAK4 PSMC5 p-S207,T211-MAP2K6K63polyUb-TRAF6 UBE2V1 K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1IL1RAP-1p-PELI2 PSMD3 IL37(1-?)PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23ADPIL1RL2 PSMB8 p-S32,S36-NFKBIA p-PELI1 IL1B,Myr82K-Myr83K-IL1A:IL1R1IL1B IL33:IL1RL1-2IRAK1 UBC(457-532) p-PELI3 IL1RN p-T342,T345,S346-IRAK4 PSMD1 UBC(153-228) 26S proteasomeADPUBC(1-76) PSMA7 MAP3K3 p-PELI1 UBA52(1-76) IL37(?-218)IL18BP SMAD3IRAK1UBC(229-304) MAP3K7 IL18BP:IL37,IL37(?-218)IL1R1:IL1R2IL36RN PELI2 UBE2N IL18R1IL18:IL18R1NFKB1:MAP3K8:TNIP2UBB(77-152) IL37(?-218) IL1RL1:IL33UBC(1-76) PTPN12 gene IL1R1 PSMA4 NFKB1(1-968)MAP3K8 p-S400,T290-MAP3K8Myr82K-Myr83K-IL1A IL36RNIL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6PSMB11 IL37IL18R1 IL1B PSMD11 MYD88 IL36RN UBC(381-456) IL18R1 CASP1(317-404) UBC(381-456) PTPN18 IL18R1 SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2ADPIL1F10:IL1RL2IL1F10:IL1RAPL1IKBKB TOLLIPIL37,IL37(?-218)UBC(229-304) p-S400,T290-MAP3K8 UBC(457-532) IL37 p-2S,S376,T,T209,T387-IRAK1 Myr82K-Myr83K-IL1A IL33:IL1RL1:IL1RAP-1RELA IL1RAPL1K63polyUb-TRAF6 CASP1(317-404) PTPN20 gene UBE2N IL36B PSME3 IL1R1 PTPN13 hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUbNFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1IL1F10 IRAK3IL1B Myr82K-Myr83K-IL1A K63polyUb RBX1 RPS27A(1-76) TAB1 UBC(457-532) IL37(?-218):p-S423,S425-SMAD3IL1R2 hp-IRAK1:3xTRAF6p-2S,S376,T,T209,T387-IRAK1 MYD88 p-2S,S376,T,T209,T387-IRAK1 UBC(77-152) IL1R1 UBC(229-304) UBC(533-608) PSMA1 IL1B IRAK4 p-PELI1 IL37(?-218):p-S423,S425-SMAD3p-T342,T345,S346-IRAK4hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complexIL1R1p-PELI3 PELI2 IL33IL1R1 RPS27A(1-76) p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2IL18BP IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1IL37(?-218)(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)CHUK TRAF6IL1RL2 hp-IRAK1:Pellino,IRAK4:PellinoATPNOD2 TNIP2 PSMD6 p-PELI2 IKBKG ADPPSMA3 PSMC2 ATPBTRC p-PELI3 UBE2V1 MAP2K1,MAP2K4UBE2V1 PSMB7 IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimerPTPN14 gene UBB(153-228) Activated TAKcomplexesp-S927,S932-NFKB1(1-968) IL37(?-218) p-PELI3 IRAK4PTPN23 TNIP2 Ub-209-RIPK2 TAB2 ALOX5 NFKB1(1-968) p-2S,S376,T,T209,T387-IRAK1 NFKB1(1-433) p-2S,S376,T,T209,T387-IRAK1 Myr82K-Myr83K-IL1A IL1RAP-1 UBC(305-380) PSMB3 PTPN18 gene BTRC MAP3K7 p-T184,T187-MAP3K7 UBE2N IL18IL18RAP K63polyUb-hp-IRAK1 MYD88 IL36G PTPN12 UBA52(1-76) TAK1 activates NFkBby phosphorylationand activation ofIKKs complexRELA Myr82K-Myr83K-IL1A MAP2K4 IL33 p-S218,S222-MAP2K1,p-S257,T261-MAP2K4IL1RL2UBA52(1-76) NFKB1(1-968) CUL1 MYD88 p-Y705-STAT3Myr82K-Myr83K-IL1A IL37 IL1F10(?-152):IL1RAPL1TAB2 MYD88 SQSTM1 NFKBIAp-2S,S376,T,T209,T387-IRAK1 p-PELI2 NOD1 BTRC FBXW11 IL36A CASP1(120-297) PTPN11 gene NFKB1(1-968) RELA TRAF6 ADPRELA UBB(1-76) IL37 ALOX5 gene Myr82K-Myr83K-IL1A PSMB6 p-2S,S376,T,T209,T387-IRAK1 TAB3 MAP3K7 hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUbUBC(305-380) UBC(77-152) IL37 p-T342,T345,S346-IRAK4 IL1B CUL1 RPS27A(1-76) SKP1 PTPN13 gene UBE2V1 NFKB1(1-433) MAP3K8UBE2V1 IL4, IL13UBA52(1-76) K63polyUb SIGIRR UBB(153-228) TNIP2 PTPN20 3xUb-p-S927,S932-NFKB1(1-968)IKBKG IL1RAP-1 UBB(1-76) p-T342,T345,S346-IRAK4 IL18R1 Myr82K-Myr83K-IL1A PSMA5 IL1R2ATPUBC(381-456) IL18BP:IL18PTPN5 ATPPSMC6 PTPN2 IL1R2 Myr82K-Myr83K-IL1A TNIP2p-2S,S376,T,T209,T387-IRAK1, IRAK4RBX1 RPS27A(1-76) p-PELI1 ATPATPIL37(?-218) IL1R1:IL1R2:IL1RNTRAF6 MDP UBE2N Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKGTOLLIP UBC(1-76) IL1R1 K63polyUb-hp-IRAK1 p-2S,S376,T,T209,T387-IRAK1 PELI1 NFKB1:p-S400-MAP3K8:TNIP2IL1R1 PSMB1 K63polyUb-hp-IRAK1NFKB1(1-433) CHUK RELA IL1R1 inhibitorsUBB(1-76) NFKB1(1-433) CASP1(120-297) NFKB1(1-433):RELAUBE2V1 MAP3K7 TOLLIP IL18BPADPADPIL36A UBE2N:UBE2V1:K63polyUbMYD88 PSMB10 UBE2N PSMD4 RELA CHUK:IKBKB:IKBKGSKP1 UBB(77-152) MYD88 736529, 58, 96828265828217, 8867, 713467658214, 886558, 9634456534