Interleukin-1 family signaling (Homo sapiens)
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24, 28, 47, 91
45
22, 64
42
65
1, 31, 60, 77
63
43
1, 31, 60, 77
1, 66, 77
69
30, 81, 82
17, 26, 41, 57, 71
6, 54, 68
23, 69
70
52
12
5, 27, 78
79
19, 56, 69, 98
25
57
10, 92
16
13, 18, 35, 40, 51...
4
69
7
57
32, 37, 94
31
87
9
58
10, 48
21
46
32, 94
96
8
57
74
2, 76
38, 83, 93
97
90
20
54
9
38, 83, 86
53, 85
36
34
67
13, 18, 40, 51, 59
32, 94
44, 82, 93
12
23, 29, 33
31
39, 71
1, 31, 60, 77
9
75
69
13, 18, 35, 51, 59...
62
11, 15
3, 92
58, 95, 97
nucleoplasm
nucleoplasm
cytosol
cytosol
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1
TNIP2
K63polyUb
UBE2V1
PSMA5
p-S32,S36-NFKBIA
RPS27A(1-76)
hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex
NFKB1:p-T290-MAP3K8:TNIP2
IL37(?-218):p-S423,S425-SMAD3
PELI1
UBE2V1
p-S423,S425-SMAD3
ADP
PSMB5
PSMA7
RELA
UBE2N
IL18R1
IL36RN, IL1F10
PSMC6
3xUb-p-S927,S932-NFKB1(1-968)
PSME2
Caspase-1 tetramer
PTPN23
p-IRAK2
p-S376,T387-IRAK1
UBC(305-380)
UBA52(1-76)
IL1R1
p-T342,T345,S346-IRAK4
IL18R1
IL18R1:IL37,IL37(?-218)
CHUK:IKBKB:IKBKG
IL37
TAB1
MYD88
K63polyUb-TRAF6
IL1B
IL1F10:IL1RL2
IL18BP
p-2S,S376,T,T209,T387-IRAK1
IRAK4
MYD88
PSMD2
BTRC
PSMB2
RBX1
IL1B,Myr82K-Myr83K-IL1A:IL1R1
p-S423,S425-SMAD3
UBC(533-608)
RPS27A(1-76)
SQSTM1
TAB3
PSMD8
MAP2K1
UBC(77-152)
p-S176,S180-CHUK
IL33:IL1RL1:IL1RAP-1
PSMB1
IL1RL1
PTPN20 gene
CUL1
PSMB10
UBC(153-228)
TAB1
UBB(77-152)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1
TOLLIP
PSMA4
K63polyUb-hp-IRAK1
TRAF6
p-S177,S181-IKBKB
IL36B
MAP3K8
NFKB1(1-433):RELA
PSMD6
UBE2N:UBE2V1
IL1R1
UBE2N
PTPN2
UBA52(1-76)
p-PELI3
TAB2
IL37
p-S207,T211-MAP2K6
CHUK
PSME1
p-2S,S376,T,T209,T387-IRAK1
p-S32,S36-NFKBIA
UBC(229-304)
PSMC1
IKBKG
PTPN18
p-T342,T345,S346-IRAK4
NFKB1(1-968)
IL1RL1:IL33
p-2S,S376,T,T209,T387-IRAK1
IL1R1
NFKB1(1-433)
IL1F10(1-?)
PTPN12
IL1F10
hp-IRAK1:
p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb
IL1F10:IL1RAPL1
NFKB1(1-968)
RBX1
IL1RAP-1
CASP1(120-297)
p-2S,S376,T,T209,T387-IRAK1
K63polyUb
PELI3
IL1RAP-1
RPS27A(1-76)
Myr82K-Myr83K-IL1A
BTRC
IL18
p-2S,S376,T,T209,T387-IRAK1
UBB(1-76)
p-2S,S376,T,T209,T387-IRAK1
p-2S,S376,T,T209,T387-IRAK1
hp-IRAK1:p-Pellino,
IRAK4:p-Pellino
UBC(381-456)
PTPN13 gene
PTPN20
p-S32,S36-NFKBIA
ADP
IRAK4
IKBKG
MAP3K8
PTPN2 gene
IL37(?-218)
IKBKB
IRAK1:Pellino:E2
complexes
PSMB9
UBE2V1
TRAF6
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2
ATP
PTPN12 gene
p-S927,S932-NFKB1(1-968)
IL18R1
p-2S,S376,T,T209,T387-IRAK1
IL37(?-218)
IL1RAPL1
IL1B
K63polyUb-TRAF6
PTPN4
IL1F10
IL36G
IL1RAP-1
TNIP2
IL1R2
UBC(229-304)
NFKB1(1-433)
ALOX5
PSMA3
IL1RL2
IL1R1:IL1R2
PSMD14
IL36G
IL1RL2
p-S400-MAP3K8
IL1RAP-1
p-S218,S222-MAP2K1
IL37(?-218)
IL37(1-?)
p-S400,T290-MAP3K8
UBB(1-76)
TNIP2
IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1
PSMD11
PSMD7
PSMB3
p-S400,T290-MAP3K8
PTPN5
Activated TAK
complexes
UBE2N
IL1R1
p-T184,T187-MAP3K7
IL18-2(37-189)
IL1RL1
PTPN
genes2,4,5,6,7,9,11,12,13,14,18,20,23
PELI3
ADP
IL37(?-218)
IL1B
UBB(153-228)
p-PELI1
UBC(457-532)
p-T,Y-MAPK8
TRAF6
IL36A
ADP
CASP1(120-297)
IL18BP
MAP3K3:SQSTM1
IL1B
UBE2V1
ATP
IL36B
TAK1 complex
Pellino 1,2,3
UBE2N
SQSTM1
IL1B
ADP
K63polyUb-TRAF6
ADP
IL18:IL18R1
IL33
K63polyUb
p-T342,T345,S346-IRAK4
BTRC:CUL1:RBX1:SKP1
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG
p-PELI1
NFKB1:p-S400-MAP3K8:TNIP2
TOLLIP
IL18
IL1F10(?-152):IL1RAPL1
IL36RN,IL1F10:IL1RL2
TAB3
PSMD1
UBB(1-76)
ATP
IL1B
PSMB11
TRAF6
UBE2N
SIGIRR
IL1RAP-1
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1
IL1R1
SKP1
PSMD9
p-S400,T290-MAP3K8
UBA52(1-76)
PSME4
IL37
IL18:IL18R1:IL18RAP
RELA
IL37
ALOX5 gene
IL1R1:IL1R2:IL1RN
IL37(?-218)
p-Y705-STAT3
p-2S,S376,T,T209,T387-IRAK1, IRAK4
MAP2K1,MAP2K4
BTRC
IL1R1
IRAK4
IL18BP:IL18
PSMF1
Myr82K-Myr83K-IL1A
CUL1
Myr82K-Myr83K-IL1A
IL1B
IL37,IL37(?-218)
PSMC2
IL1RL2
ATP
hp-IRAK1:Pellino,
IRAK4:Pellino
UBC(609-684)
IL18R1
IRAK4
MAPK8
IL13
PELI2
UBC(153-228)
TAB1
PSMA6
IL1R1
IL1B,Myr82K-Myr83K-IL1A:IL1R2
IL36A,IL36B,IL36G
hp-IRAK1:K6-poly-Ub
oligo-TRAF6:TAK1
complex
BTRC
IL33
Myr82K-Myr83K-IL1A
IL1RAP-1
UBC(381-456)
CUL1
p-PELI3
ADP
UBC(1-76)
p-S927,S932-NFKB1(1-968)
p-T342,T345,S346-IRAK4
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6
UBC(153-228)
SHFM1
p-S218,S222-MAP2K1,p-S257,T261-MAP2K4
PTPN9
IL33:IL1RL1-2
p-PELI1
K63polyUb-TRAF6
IL18 gene
ADP
NFKB1:RELA:p-S32,S36-NFKBIA:Ub
PTPN14 gene
iE-DAP
PSME3
IKBKG
PSMA2
IL1F10
PSMB4
UBC(77-152)
IL1R1 inhibitors
p-PELI2
TOLLIP
PTPN18 gene
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb
Myr82K-Myr83K-IL1A
p-2S,S376,T,T209,T387-IRAK1
p-T342,T345,S346-IRAK4
p-PELI2
ADP
IL1RAP-1
IL1B(117-269)
IRAK4
IL36A
TAB2
Myr82K-Myr83K-IL1A
TOLLIP
UBB(77-152)
SMAD3
IL36:IL1RL2
NFKB1(1-968)
UBE2N
CASP1(317-404)
UBC(457-532)
IL1RL1
MAP3K8
IL1R2
IRAK2
Interleukin-1
processing
UBC(229-304)
UBE2N
PTPN11 gene
Myr82K-Myr83K-IL1A
p-T342,T345,S346-IRAK4
NOD1
PSMA8
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB
UBE2V1
IL1B
IRAK4
UBC(533-608)
IL18(1-193)
p-PELI3
CASP1(120-297)
RELA
Myr82K-Myr83K-IL1A
IL1R1
MDP
PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23
TNIP2
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub
TOLLIP
TAB2
K63polyUb-TRAF6
PTPN11
UBE2V1
PSMD5
STAT3
p-2S,S376,T,T209,T387-IRAK1
UBC(533-608)
UBB(77-152)
TRAF6
p-PELI3
MAP2K4
IL37(?-218)
p-IRAK2
MAP3K7
UBC(229-304)
PSMC5
MYD88
RELA
IL1R1:IL1:IL1RAP
IL37
IL1F10
TAK1 activates NFkB
by phosphorylation
and activation of
IKKs complex
MAP3K7
IL1RAP-1
UBE2V1
UBE2N
ATP
MYD88
ATP
PSMD12
IKBKG
IRAK1
RPS27A(1-76)
IL37(?-218)
p-S423,S425-SMAD3
TOLLIP
MYD88 dimer
NFKB1(1-433)
p-S32,S36-NFKBIA
IL1RL2
PSMD4
SKP1
IL37(?-218)
PTPN23 gene
p-2S,S376,T,T209,T387-IRAK1:TRAF6
IL1B,Myr82K-Myr83K-IL1A
IL37
TBK1
PTPN9 gene
IL1R1:IL1:IL1RAP:MYD88 dimer
Ub-209-RIPK2
MAP2K6
UBC(1-76)
IL37(?-218):p-S423,S425-SMAD3
IL1RL2
MYD88
SKP1
IL36RN
p-2S,S376,T,T209,T387-IRAK1
IL1R1
CHUK
PSMD10
IL37:2x(CASP1(120-197):CASP1(317-404))
IRAK1
p-PELI2
IL1RAP-1
NFKB1(1-433)
UBC(457-532)
FBXW11
PELI2
IL36RN
PSMB6
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)
PSMB8
IL1R1
IL1B
IL1R2
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer
IL1RAPL1
TOLLIP
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1
IL1RAP-1
IL18RAP
UBB(77-152)
p-S32,S36-NFKBIA
IL1B
SKP1
UBE2N:UBE2V1:K63polyUb
MAP3K3:SQSTM1:TRAF6
IL1RN
Ub
MYD88
ATP
CASP1(317-404)
PSMB7
UBC(1-76)
PELI1
MYD88
IL33
UBC(457-532)
IL33
UBC(305-380)
IRAK4
Myr82K-Myr83K-IL1A
FBXW11
MAP3K7
UBE2V1
IKBKB
PSMA1
IL1R1
p-PELI1
p-PELI2
PTPN6
TNIP2
UBC(381-456)
ADP
IL36B
SKP1
IL36A
UBC(609-684)
PTPN7
SMAD3
Myr82K-Myr83K-IL1A
IL1RAP-1
NFKB1(1-433):RELA
IL18
UBB(153-228)
UBC(153-228)
p-S400,T290-MAP3K8
TAB3
NFKB1(1-968)
BTRC
IL1RAPL1
p-S927,S932-NFKB1(1-968)
PTPN14
IL1RN
TAB2
IL37(?-218)
IL37(?-218):SMAD3
UBE2V1
IL18, ALOX5
26S proteasome
TNIP2
IL18BP:IL37,IL37(?-218)
IL18RAP
ATP
3xUb-p-S927,S932-NFKB1(1-968)
MAP3K7
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP
MAP3K3
p-2S,S376,T,T209,T387-IRAK1
IL1RAP-1
p-PELI3
IL1RAP-1
IL4
IL1F10(?-152)
IL18
IL37
IL37,IL37(?-218)
UBC(609-684)
PSMD13
p-S257,T261-MAP2K4
p-S177,S181-IKBKB
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2
IL1R2
ATP
hp-IRAK1:3xTRAF6
PTPN5 gene
IL37(1-?)
PTPN4 gene
IL18 gene, ALOX5
gene
UBC(305-380)
IRAK3
ATP
NFKB1(1-433)
IL36:IL1RL2:IL1RAP-1
IL1B
p-PELI1
IL1R1:IL1R1
inhibitors
RELA
TAB3
IL1F10(?-152)
IL37(?-218)
CUL1
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1
K63polyUb-hp-IRAK1
hp-IRAK1:3xK63polyUb-TRAF6
IL1RL1-2
RELA
UBB(153-228)
TAB1
RBX1
K63polyUb
K63polyUb
PSMC4
IL18R1
ADP
PSMC3
MYD88
IL1R1
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2
Myr82K-Myr83K-IL1A
UBC(609-684)
UBC(533-608)
p-2S,S376,T,T209,T387-IRAK1
p-S400,T290-MAP3K8
NFKB1(1-433):RELA:p-S32,S36-NFKBIA
UBE2N
UBC(1-76)
PTPN13
PTPN6 gene
IL37(?-218)
K63polyUb-hp-IRAK1
UBC(77-152)
ATP
p-TBK1
MAP3K3
CASP1(317-404)
CUL1
NFKB1:MAP3K8:TNIP2
PTPN7 gene
p-PELI2
UBB(153-228)
p-2S,S376,T,T209,T387-IRAK1
Ub
TNIP2
IL18R1:IL37,IL37(?-218):SIGIRR
SIGIRR
UBC(305-380)
NFKB1(1-433)
Myr82K-Myr83K-IL1A
IL36G
TNIP2
IL1RAP-1
TRAF6
MYD88
UBC(77-152)
IL1F10
NOD2
ATP
p-Pellino-1,2,(3)
p-2S,S376,T,T209,T387-IRAK1
IL36RN
IL18BP
3xUb,
2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2
UBC(381-456)
IL1B
IL4, IL13
IL1R1
UBA52(1-76)
PSMD3
ADP
UBB(1-76)
NFKBIA
39
89
72
72
9
49, 89
39
9
54, 88
39
39
9
54, 80
72
9
14
73
9
50, 55
39
50, 55, 84