Interleukin-1 family signaling (Homo sapiens)

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24, 28, 47, 914522, 6442651, 31, 60, 7763431, 31, 60, 771, 66, 776930, 81, 8217, 26, 41, 57, 716, 54, 6823, 697052125, 27, 787919, 56, 69, 98255710, 921613, 18, 35, 40, 51...46975732, 37, 94318795810, 48214632, 9496857742, 7638, 83, 9397902054938, 83, 8653, 8536346713, 18, 40, 51, 5932, 9444, 82, 931223, 29, 333139, 711, 31, 60, 779756913, 18, 35, 51, 59...6211, 153, 9258, 95, 97nucleoplasmnucleoplasmcytosolcytosolNFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1TNIP2 K63polyUb UBE2V1 PSMA5 p-S32,S36-NFKBIA RPS27A(1-76) hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complexNFKB1:p-T290-MAP3K8:TNIP2IL37(?-218):p-S423,S425-SMAD3PELI1 UBE2V1 p-S423,S425-SMAD3 ADPPSMB5 PSMA7 RELA UBE2N IL18R1 IL36RN, IL1F10PSMC6 3xUb-p-S927,S932-NFKB1(1-968)PSME2 Caspase-1 tetramerPTPN23 p-IRAK2p-S376,T387-IRAK1 UBC(305-380) UBA52(1-76) IL1R1 p-T342,T345,S346-IRAK4 IL18R1 IL18R1:IL37,IL37(?-218)CHUK:IKBKB:IKBKGIL37 TAB1 MYD88 K63polyUb-TRAF6 IL1B IL1F10:IL1RL2IL18BPp-2S,S376,T,T209,T387-IRAK1 IRAK4 MYD88 PSMD2 BTRC PSMB2 RBX1 IL1B,Myr82K-Myr83K-IL1A:IL1R1p-S423,S425-SMAD3 UBC(533-608) RPS27A(1-76) SQSTM1 TAB3 PSMD8 MAP2K1 UBC(77-152) p-S176,S180-CHUK IL33:IL1RL1:IL1RAP-1PSMB1 IL1RL1 PTPN20 gene CUL1 PSMB10 UBC(153-228) TAB1 UBB(77-152) K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1TOLLIPPSMA4 K63polyUb-hp-IRAK1 TRAF6p-S177,S181-IKBKBIL36B MAP3K8 NFKB1(1-433):RELAPSMD6 UBE2N:UBE2V1IL1R1 UBE2N PTPN2 UBA52(1-76) p-PELI3 TAB2 IL37 p-S207,T211-MAP2K6CHUK PSME1 p-2S,S376,T,T209,T387-IRAK1 p-S32,S36-NFKBIA UBC(229-304) PSMC1 IKBKG PTPN18 p-T342,T345,S346-IRAK4NFKB1(1-968) IL1RL1:IL33p-2S,S376,T,T209,T387-IRAK1 IL1R1 NFKB1(1-433) IL1F10(1-?)PTPN12 IL1F10 hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUbIL1F10:IL1RAPL1NFKB1(1-968) RBX1 IL1RAP-1CASP1(120-297) p-2S,S376,T,T209,T387-IRAK1 K63polyUb PELI3 IL1RAP-1 RPS27A(1-76) Myr82K-Myr83K-IL1A BTRC IL18 p-2S,S376,T,T209,T387-IRAK1 UBB(1-76) p-2S,S376,T,T209,T387-IRAK1 p-2S,S376,T,T209,T387-IRAK1 hp-IRAK1:p-Pellino,IRAK4:p-PellinoUBC(381-456) PTPN13 gene PTPN20 p-S32,S36-NFKBIA ADPIRAK4 IKBKG MAP3K8PTPN2 gene IL37(?-218) IKBKB IRAK1:Pellino:E2complexesPSMB9 UBE2V1 TRAF6 p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2ATPPTPN12 gene p-S927,S932-NFKB1(1-968) IL18R1p-2S,S376,T,T209,T387-IRAK1 IL37(?-218) IL1RAPL1 IL1B K63polyUb-TRAF6 PTPN4 IL1F10 IL36G IL1RAP-1 TNIP2 IL1R2UBC(229-304) NFKB1(1-433) ALOX5 PSMA3 IL1RL2 IL1R1:IL1R2PSMD14 IL36G IL1RL2 p-S400-MAP3K8 IL1RAP-1p-S218,S222-MAP2K1 IL37(?-218) IL37(1-?) p-S400,T290-MAP3K8 UBB(1-76) TNIP2 IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404)IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1PSMD11 PSMD7 PSMB3 p-S400,T290-MAP3K8 PTPN5 Activated TAKcomplexesUBE2N IL1R1 p-T184,T187-MAP3K7 IL18-2(37-189)IL1RL1PTPNgenes2,4,5,6,7,9,11,12,13,14,18,20,23PELI3 ADPIL37(?-218) IL1B UBB(153-228) p-PELI1 UBC(457-532) p-T,Y-MAPK8TRAF6 IL36A ADPCASP1(120-297) IL18BP MAP3K3:SQSTM1IL1B UBE2V1 ATPIL36B TAK1 complexPellino 1,2,3UBE2N SQSTM1 IL1B ADPK63polyUb-TRAF6 ADPIL18:IL18R1IL33 K63polyUb p-T342,T345,S346-IRAK4 BTRC:CUL1:RBX1:SKP1Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKGp-PELI1 NFKB1:p-S400-MAP3K8:TNIP2TOLLIP IL18 IL1F10(?-152):IL1RAPL1IL36RN,IL1F10:IL1RL2TAB3 PSMD1 UBB(1-76) ATPIL1B PSMB11 TRAF6 UBE2N SIGIRRIL1RAP-1 IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1IL1R1 SKP1 PSMD9 p-S400,T290-MAP3K8UBA52(1-76) PSME4 IL37 IL18:IL18R1:IL18RAPRELA IL37ALOX5 gene IL1R1:IL1R2:IL1RNIL37(?-218) p-Y705-STAT3p-2S,S376,T,T209,T387-IRAK1, IRAK4MAP2K1,MAP2K4BTRC IL1R1 IRAK4 IL18BP:IL18PSMF1 Myr82K-Myr83K-IL1A CUL1 Myr82K-Myr83K-IL1A IL1B IL37,IL37(?-218)PSMC2 IL1RL2 ATPhp-IRAK1:Pellino,IRAK4:PellinoUBC(609-684) IL18R1 IRAK4MAPK8IL13 PELI2 UBC(153-228) TAB1 PSMA6 IL1R1 IL1B,Myr82K-Myr83K-IL1A:IL1R2IL36A,IL36B,IL36Ghp-IRAK1:K6-poly-Uboligo-TRAF6:TAK1complexBTRC IL33 Myr82K-Myr83K-IL1A IL1RAP-1 UBC(381-456) CUL1 p-PELI3 ADPUBC(1-76) p-S927,S932-NFKB1(1-968) p-T342,T345,S346-IRAK4 IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6UBC(153-228) SHFM1 p-S218,S222-MAP2K1,p-S257,T261-MAP2K4PTPN9 IL33:IL1RL1-2p-PELI1 K63polyUb-TRAF6 IL18 gene ADPNFKB1:RELA:p-S32,S36-NFKBIA:UbPTPN14 gene iE-DAP PSME3 IKBKG PSMA2 IL1F10 PSMB4 UBC(77-152) IL1R1 inhibitorsp-PELI2 TOLLIP PTPN18 gene hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUbMyr82K-Myr83K-IL1A p-2S,S376,T,T209,T387-IRAK1 p-T342,T345,S346-IRAK4 p-PELI2 ADPIL1RAP-1 IL1B(117-269)IRAK4 IL36A TAB2 Myr82K-Myr83K-IL1A TOLLIP UBB(77-152) SMAD3 IL36:IL1RL2NFKB1(1-968) UBE2N CASP1(317-404) UBC(457-532) IL1RL1 MAP3K8 IL1R2 IRAK2Interleukin-1processingUBC(229-304) UBE2N PTPN11 gene Myr82K-Myr83K-IL1A p-T342,T345,S346-IRAK4 NOD1 PSMA8 IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKBUBE2V1 IL1B IRAK4 UBC(533-608) IL18(1-193) p-PELI3 CASP1(120-297) RELA Myr82K-Myr83K-IL1A IL1R1 MDP PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23TNIP2BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:UbTOLLIP TAB2 K63polyUb-TRAF6 PTPN11 UBE2V1 PSMD5 STAT3p-2S,S376,T,T209,T387-IRAK1 UBC(533-608) UBB(77-152) TRAF6 p-PELI3 MAP2K4 IL37(?-218) p-IRAK2 MAP3K7 UBC(229-304) PSMC5 MYD88 RELA IL1R1:IL1:IL1RAPIL37 IL1F10 TAK1 activates NFkBby phosphorylationand activation ofIKKs complexMAP3K7 IL1RAP-1 UBE2V1 UBE2N ATPMYD88 ATPPSMD12 IKBKG IRAK1RPS27A(1-76) IL37(?-218) p-S423,S425-SMAD3TOLLIP MYD88 dimerNFKB1(1-433) p-S32,S36-NFKBIA IL1RL2 PSMD4 SKP1 IL37(?-218)PTPN23 gene p-2S,S376,T,T209,T387-IRAK1:TRAF6IL1B,Myr82K-Myr83K-IL1AIL37 TBK1PTPN9 gene IL1R1:IL1:IL1RAP:MYD88 dimerUb-209-RIPK2 MAP2K6UBC(1-76) IL37(?-218):p-S423,S425-SMAD3IL1RL2MYD88 SKP1 IL36RN p-2S,S376,T,T209,T387-IRAK1 IL1R1 CHUK PSMD10 IL37:2x(CASP1(120-197):CASP1(317-404))IRAK1 p-PELI2 IL1RAP-1 NFKB1(1-433) UBC(457-532) FBXW11 PELI2 IL36RNPSMB6 (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1)PSMB8 IL1R1 IL1B IL1R2 IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimerIL1RAPL1 TOLLIP IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1IL1RAP-1 IL18RAPUBB(77-152) p-S32,S36-NFKBIAIL1B SKP1 UBE2N:UBE2V1:K63polyUbMAP3K3:SQSTM1:TRAF6IL1RNUbMYD88 ATPCASP1(317-404) PSMB7 UBC(1-76) PELI1 MYD88 IL33UBC(457-532) IL33 UBC(305-380) IRAK4 Myr82K-Myr83K-IL1A FBXW11 MAP3K7 UBE2V1 IKBKB PSMA1 IL1R1p-PELI1 p-PELI2 PTPN6 TNIP2 UBC(381-456) ADPIL36B SKP1 IL36A UBC(609-684) PTPN7 SMAD3Myr82K-Myr83K-IL1A IL1RAP-1 NFKB1(1-433):RELAIL18 UBB(153-228) UBC(153-228) p-S400,T290-MAP3K8 TAB3 NFKB1(1-968)BTRC IL1RAPL1p-S927,S932-NFKB1(1-968) PTPN14 IL1RN TAB2 IL37(?-218) IL37(?-218):SMAD3UBE2V1 IL18, ALOX526S proteasomeTNIP2 IL18BP:IL37,IL37(?-218)IL18RAP ATP3xUb-p-S927,S932-NFKB1(1-968) MAP3K7 IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIPMAP3K3 p-2S,S376,T,T209,T387-IRAK1 IL1RAP-1p-PELI3 IL1RAP-1 IL4 IL1F10(?-152) IL18IL37 IL37,IL37(?-218)UBC(609-684) PSMD13 p-S257,T261-MAP2K4 p-S177,S181-IKBKB SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2IL1R2 ATPhp-IRAK1:3xTRAF6PTPN5 gene IL37(1-?)PTPN4 gene IL18 gene, ALOX5geneUBC(305-380) IRAK3ATPNFKB1(1-433) IL36:IL1RL2:IL1RAP-1IL1B p-PELI1 IL1R1:IL1R1inhibitorsRELA TAB3 IL1F10(?-152)IL37(?-218)CUL1 hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1K63polyUb-hp-IRAK1 hp-IRAK1:3xK63polyUb-TRAF6IL1RL1-2 RELA UBB(153-228) TAB1 RBX1 K63polyUb K63polyUb PSMC4 IL18R1 ADPPSMC3 MYD88 IL1R1 IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIPp-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2Myr82K-Myr83K-IL1A UBC(609-684) UBC(533-608) p-2S,S376,T,T209,T387-IRAK1 p-S400,T290-MAP3K8 NFKB1(1-433):RELA:p-S32,S36-NFKBIAUBE2N UBC(1-76) PTPN13 PTPN6 gene IL37(?-218) K63polyUb-hp-IRAK1UBC(77-152) ATPp-TBK1MAP3K3 CASP1(317-404) CUL1 NFKB1:MAP3K8:TNIP2PTPN7 gene p-PELI2 UBB(153-228) p-2S,S376,T,T209,T387-IRAK1 UbTNIP2 IL18R1:IL37,IL37(?-218):SIGIRRSIGIRR UBC(305-380) NFKB1(1-433) Myr82K-Myr83K-IL1A IL36G TNIP2 IL1RAP-1 TRAF6 MYD88 UBC(77-152) IL1F10NOD2 ATPp-Pellino-1,2,(3)p-2S,S376,T,T209,T387-IRAK1 IL36RN IL18BP 3xUb,2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2UBC(381-456) IL1B IL4, IL13IL1R1 UBA52(1-76) PSMD3 ADPUBB(1-76) NFKBIA39897272949, 8939954, 883939954, 807291473950, 553950, 55, 84