31, 2, 45666nucleoplasmcytosol2xMyri-IL1A CASP1(317-404) CASP1(317-404) Interleukin-1 familyIL1A(1-271) CASP1(298-316)CASP1(1-119)Interleukin-1 familyN-terminalpropeptidesRELA NFKB2(1-454) IL18 CASP1(120-297) IL18(1-193) NFkB ComplexIL18 IL1B(1-116) CASP1(317-404)CASP1(120-197):CASP1(317-404)CASP1(1-404)Interleukin-1 familyIL1B(117-269) CASP1(120-297) IL1B IL1A(1-112) IL18(1-36) NFKB1(1-433) Myr82K-Myr83K-IL1A IL1B(1-269) CASP1(120-297)Caspase-1 tetramerInterleukin-1 familypropeptides