Integration of energy metabolism (Homo sapiens)

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2, 129, 15882, 1148249, 14, 17, 25, 30...20, 60, 62, 82, 137...3836, 41, 74, 75, 78...31, 59, 62, 16121, 137, 138, 150, 1621, 27, 33, 80, 87...5515, 58, 62, 71, 83...9420, 49, 80, 82, 137...11, 60, 62, 113, 116...62, 113, 116, 12310, 43, 69, 73, 91...72, 109, 15422, 36, 41, 54, 77...10616, 19, 62, 113, 116...61, 88, 10410631, 85467, 45, 52, 7939, 9966, 67, 89, 93, 110...12, 31, 111, 142, 144...62, 113, 116, 1235532, 51, 119, 1255, 48, 49, 102, 137...3529, 50, 90, 117, 124...26, 31, 6228, 62, 68, 71, 113...18, 118, 137, 16262, 95, 107, 124, 137...13312966, 67, 89, 93, 110...62, 107, 115, 137, 16266, 137, 146, 1623813, 31, 59, 62, 92...15737, 47, 53, 62, 65...6, 34, 42, 53, 57...31, 63nucleoplasmsecretory granulecytosolendoplasmic reticulum lumenmitochondrial outer membranePRKAR1A GNAS2 GNB4 GNG10 GNAS1 GNAS1 GNAI1 KCNS3 GNB1 KCNC2 ITPR1 ADRA2A,C:ADR,NAdSTX1A Guanine nucleotide-binding protein beta subunit ADCY6 GNB4 Fru(6)PGNB5 KCNB1 GNG10 ACLY GNB4 ADCY2 G-alpha(i,o):GDP:Gbeta:G gammaPRKAR1B GNG10 Mg2+ GNG4 GTPAMPGNG4 ABCC8 R1379C ADIPOQ GNB5 SNAP25 Ca2+GNG3 GNAS1 R5PITPR1 Potassium Channel,closed (pancreaticbeta cell)cAMP TALDO1 GNG4 GTP DDCX ATPADCY6 CACNA2D2(19-1150) KCNG2 Mg2+ ADIPOQ GNG13 ADR Mg2+ ADCY5 GNAI1 ADP PKA:AKAP79:IQGAP1ComplexPentadecanoic acid SYT5PALMPKA catalyticsubunitGNG8 GLP-1:GLP-1R:Heterotrimeric G(s):GTPPKA tetramer:4xcAMPZn2+SH7PSNARE ComplexABCC8 L582V Guanine nucleotide-binding protein gamma subunit GNG3 GNG2 GTP RGZ ADCY9 GNB1 GNG12 SLC2A2 Ca-channel (open)ADCY7 GNA11 PALM GNA14 PPiThDP GNAS1 FFAR1PPP2R5D ITPR2 GNG12 FFAR1 GNGT1 GTP GTPGNG8 RGZ GCG(53-81) DAG KCNS3 GNB3 GNG5 PRKCAAMPAHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerPRKACB ArgN-GCG(98-127) PRKACB phosphoPFKFB1 dimerGNB5 p-4S-MARCKSNAd ADPGDP GNB3 GNB1 PALMGCG(53-81)G-beta:G-gamma(candidates)GA3PPRKAA2 ADCY5 GDP ACSL3,4PPP2CA GNB1 GNG10 G-alpha(s):GTP:G-beta:G-gammaGNAI2 GLP-1 (7-37) ChREBP:MLXGNG10 GNB5 K+GNG7 Guanine nucleotide-binding protein gamma subunit ABCC8 A1185E GLP1R GNG7 GNAS2 Ca2+GTPGTP AGPAT1ADRA2A,CPLCB3 PRKACA GNB2 Mg2+ GNB5 RAP1A:GTPATPCACNA1C ADRA2A G-alpha(q)11,14,15,Q:GTPCACNA1E GNG8 ADIPOR dimersGNAS1 G-alpha(i,o):GTP:G-beta:G-gammaADCY3 ADPCACNB2 ADCY4 GNG2 GNG2 GLP-1R:Heterotrimeric G(s):GDPACACB PRKAR2A GTP GNG2 CACNB3 GNG8 KCNG2 ADCY6 GNB5 GNG5 ADR, NAdG-alpha(q)11,14,15,Q:G-beta:G-gammaADCY3 ADIPOR2 IP3 receptorhomotetramerVoltage-gatedCalcium Channels(pancreatic betacell)PPP2R5D GNG8 ACLY tetramerPLCB2 GNG13 OLEA MLX GNAS2 GNAI2 CACNA1C PPP2R1A PPP2R1B GTP p-S568-MLXIPLPPP2CB Mg2+ Pentadecanoic acid Zn2+ RAPGEF3ADP ITPR3 ADIPOQ trimerADCY1 ADCY6 cAMP p-T666-MLXIPLADPI(1,4,5)P3 ITPR:I(1,4,5)P3tetramerPRKACA GNG3 PRKAR2B PLCbeta1,2,3:G-alpha(q):GTPGNG7 PRKACA ADRA2C Glcp-S196,T666-MLXIPLGDPGNG4 GNG11 GNB2 PRKACG GNG12 PRKAG2 GNGT2 PPP2R1B RAPGEF4:cAMP ComplexGNGT2 GTP ITPR1 GNG12 ADRA2C GNB5 ATPGNG3 RAPGEF4 RAPGEF3:cAMP complexSTXBP1GLUT1,2PRKAR2A SYT5 Adenylate cyclasetype V or VI:G-protein betagamma ComplexGNG10 GNB2 SLC2A1 GNB1 ACLY geneGNG3 ATP GNG7 GTP 6xInsulin:2xZn2+:Ca2+ (docked granule)STXBP1 GNB3 KCNJ11tetramer:ABCC8:Mg2+:ADP tetramerGNG12 PPi(3-)Adenylyl cyclase(pancreatic betacell)GNB3 GNGT1 GNG13 GNAS2 GTP CACNA1A GNB3 GNGT2 GNA14 PRKACB E4PITPR3 ITPR3 GNG11 PFKFB1 dimerGNGT1 GNB2 GNG2 GNG12 GNAS1 SNAP25GNG5 ITPR2 GDPPRKAR1A ADCY8 GNG11 ABCC8 mutants (PNDM,TNDM2)CACNA2D2(19-1150) TKT I(1,4,5)P3 NAd PRKACG G alpha (s):GTPADPPiCHRM3GNG10 GNB1 Core SNARE ComplexGNG7 DDCX GlcATPCa2+ MuscarinicAcetylcholineReceptorM3:AcetylcholineComplexGDP GNG8 PRKAG2 GNB3 DAGABCC8 E382K GNGT2 KCNJ11 GDP ITPR2 CACNA1C ITPR1 GNG4 G alpha(s):GTP:AdenylatecyclaseGuanine nucleotide-binding protein gamma subunit GLP-1:GLP-1R:Heterotrimeric G(s):GDPKCNJ11:ATPtetramer:ABCC8tetramerGNG13 PRKAR2B GNG7 PPP2CA ABCC8 L213R ADCY5 GLP-1 (7-37) PRKAR1A Adenylate cyclase(Mg2+ cofactor)GDPGNA11 GNB4 GNAQ GNG2 CACNA1D ADCY6 InactivePP2A-ABdeltaCcomplexPP2A-ABdeltaCcomplexVAMP2 4xHC-INS(90-110) ATPGNA14 GNAQ GNB2 GNG12 GNB3 GNGT1 ABCC8 GNG4 2xHC-INS(25-54) ADCY6 MLXIPLRAPGEF4cAMP ABCC8 GNG11 GNAS2 GNA11 PRKAR1B GNG8 PRKAB2 GNG11 GNA15 PLCB1 GNG5 ABCC8 P132L ITPR3 GNA15 ITPR2 GNAS1 AMPPRKACB G-beta:G-gamma dimerAcCho GNA15 FASNADCY8 STK11GTP GNG3 ADCY8 GNB1 Ca2+ PPP2R1B Potassiumvoltage-gatedchannels (betacell, open)GNG2 PRKCA CYSLTR2 GNAQ GNG7 GNB3 PRKAR2A CHRM3 GNB4 GNB2 GNGT1 GNG10 NAD+ MLXIPL ADCY5 GNGT1 GLP-1 (7-37) ADR KCNC2 4xHC-INS(90-110) PRKAR1A GTP Potassium Channel,open (pancreaticbeta cell)GNB4 p-T666-MLXIPLGNB3 GNB1 GNG2 GNG10 cAMP ADCY4 AMPKheterotrimer:AMPG-protein with G(s)alpha:GDPRAP1A ATPCACNB2 STX1A ADCY5 VAMP2mature GLP-1cAMP:PKA regulatorysubunitADPCa2+ADCY5,6,8:G-alpha(s):GTPGDP GNAS2 GNG4 GDPGNB4 GNG8 ArgN-GCG(98-127) GNG13 GNG3 PRKAB2 IQGAP1 Btn-ACACA K+GNG5 PRKAG2 STX1A CACNB3 GNG7 ADCY9 GNB4 ACSL3 GNG5 Mg2+:ADPIQGAP1 PP2A-ABdeltaCcomplex2xHC-INS(25-54) GNGT2 PFKFB1 FFAR1 ligandsGNG4 TALDO1 dimerGNG7 PPP2R5D INS(57-87)ADCY8 VAMP2 GNAS2 PI(4,5)P2RAPGEF3 GNG12 GNG13 GNB2 GTPGNG8 GNG4 PRKAR2B GNA14 CACNA2D2(19-1150) H2OGNGT1 PPP2R1A PRKAA2 GNB1 PPP2CB CoA-SHCYSLTR1,2ADRA2A ADPGNB4 Protein Kinase A,catalytic subunitsCACNA1D CACNB2 Voltage-gatedCalcium ChannelsType Cav1 (closed)PRKAR1B G-beta:G-gammaAKAP5 PLC beta1,2,3PALM-CoAG-alpha(q)11,14,15,Q:GDP:G-beta:G-gammaAKAP5 PRKAR2A GNB5 OLEA PRKACG ADCY2 TKT dimerGNG3 ACSL4 GNG11 GNGT2 GNG5 AMP Guanine nucleotide-binding protein beta subunit GNAQ AcChoGTPGDPPLCB3 PRKAR2B GNG4 p-S33-PFKFB1 G-alpha(i,o):GTPGNG3 ADIPOR2 PRKACG GDPArgN-GCG(98-127) PRKACA PRKACG PKA catalyticsubunitGNG10 GNB2 PPP2CB GNG13 GNG13 ACCGNG12 Guanine nucleotide-binding protein beta subunit PRKAB2 PRKAR1B PLCB2 STX1A:STXBP1PLCB1 Adenylate Cyclase Vor VIPRKACB PPP2R1A ADIPOQ trimer:ADIPORdimersABCC8 N72S GNG7 GNAS2 INS(57-87)GNAI2 GNG12 GNAS1 4xPalmC-CD36GNA15 GNG5 AHCYL1 RAP1A GNB1 cAMP:PKA:AKAP79:IQGAP1 ComplexGNGT2 ITPR3 GNG11 AMP FFAR1:FFAR1 ligandsADCY7 PPP2CA GNGT2 GNG3 GNA11 GNG5 GLP1R AMPK heterotrimer(inactive)H2OGNG11 ATPGNAI1 GNG8 CACNB3 Fatty acidsGNG5 GNB2 GNG2 PALM p-T172-PRKAA2 ITPR2 Ca-channel (closed)ATPPiGNB4 PRKACA GNG13 GDP GNG11 I(1,4,5)P3MLXADCY5 CACNA1D cAMPI(1,4,5)P3 ADCY1 GNG13 GNB2 GNGT1 ADIPOR1 GNG11 RAP1A:GDPKCNJ11 XY5PGTPMARCKSGNG2 Protein Kinase C,alpha type: DAGInsulinGLP1R Activated AMPKheterotrimerITPR1 KCNB1 GCGR:GCG(53-81)Voltage-gatedCalcium ChannelsType Cav1 (open)PKLR-1GNB3 Potassiumvoltage-gatedchannels (betacell, closed)ADIPOR1 cAMP 388601543633, 2360, 8264211346045613440726473, 126, 139