Proteasome Degradation (Homo sapiens)

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1Ubiquitin/ProteinActivators of20S ComplexUbiquitin/E2 ComplexOxidatively DamagedCytosolic ProteinsAlpha subunitsDeubiquitinates proteinsUnfolds and DegradesIntact ProteinsAMP Ubiquitin/E1 ComplexProteasome 26 S(PA700) (ATP dependent)p45 ATPase SubunitProteins to be DegradedBeta subunitsProteasome 20SCatalytic Core (p45)E3/ProteinLid subunitsPresentation by MHC class 1Degrades only Peptides2PSMD4PSMC4UCHL1PSMC6UbiquitinPSMD11RPN1PSMB2PSMA2PSMB8PSMD10H2AFZIFNGPSME1PSMD1HLA-HATPUBCPSMA1PSMA3PSMA5PSMB9PSMA4PSMC5HIST1H2ABPSMD5UBE2D2PSME3PSMB4PSMD13UBE1PSMC3PSMC5PSME2UBBPSMC1PSMD7PSMA7HLA-GUBE2BPSMD3PSMD6PSMB6PSMB10HLA-CPSMA6UBE2D3UCHL3PSMB5PSMB1PSMB3H2AFXPSMD12PSMB7HLA-BUBE1LHLA-FHLA-JUBE2D1NEDD4HLA-ERPN2PSMC2HLA-APSMD2PSMD8PSMD9


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Ontology Terms



  1. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed
  2. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed


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95110view14:43, 16 November 2017Mkutmonfixed layout, removed nested groups
81161view12:00, 29 July 2015EgonwUpdated the outdated Uniprot ID. HT to @jervenbolleman for nothing the backpage header!
71712view20:04, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
70098view18:44, 12 July 2013MaintBotupdated to 2013 schema
62695view21:39, 1 May 2013MaintBotupdated uniprot data source
59174view18:40, 22 February 2013MaintBotUpdated Ensembl data source
49661view21:09, 23 July 2012EveloAdded general reference
49654view20:03, 23 July 2012EveloAdded reference for sructure of 26S subunit
45274view18:53, 7 October 2011KhanspersOntology Term : 'ubiquitin/proteasome degradation pathway' added !
41129view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38856view18:07, 24 September 2010Khanspers
34481view18:38, 10 December 2009MaintBotAutomatic update of empty xrefs
32358view13:41, 15 August 2009MaintBotFixed text labels
31990view13:14, 14 August 2009MaintBotFixed group labels
29614view12:13, 23 May 2009MartijnVanIerselUpdated ensembl references
21063view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Proteasome Degradation]] moved to [[Pathway:WP183]]: Moved to stable identifier
14049view08:35, 21 May 2008Thomasadded groups and connected lines
13111view11:16, 17 May 2008MaintBotautomated metabolite conversion
12987view10:59, 17 May 2008MaintBotSticky edges patch by Sjoerd
11404view10:45, 27 March 2008Fdennissenedit deubiquitination proteins
11400view10:42, 27 March 2008FdennissenDeubiquitination
11399view10:37, 27 March 2008FdennissenPeriodical save, work in progress
11394view10:27, 27 March 2008FdennissenPeriodical save, work in progress
11384view10:17, 27 March 2008FdennissenPeriodical save, work in progress
8348view13:46, 7 January 2008MaintBot[[Pathway:Human:Proteasome Degradation]] moved to [[Pathway:Homo sapiens:Proteasome Degradation]]: Renaming species
7792view16:17, 18 December 2007MaintBotfixed category names
7485view12:42, 4 November 2007MaintBotAdded categories to GPML
6364view22:18, 22 May 2007Nsalomonisgpml file for [[Human:Proteasome_Degradation]]

External references


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NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
H2AFXGeneProduct3014 (Entrez Gene)
H2AFZGeneProduct3015 (Entrez Gene)
HIST1H2ABGeneProduct8335 (Entrez Gene)
HLA-AGeneProduct3105 (Entrez Gene)
HLA-BGeneProduct3106 (Entrez Gene)
HLA-CGeneProduct3107 (Entrez Gene)
HLA-EGeneProduct3133 (Entrez Gene)
HLA-FGeneProduct3134 (Entrez Gene)
HLA-GGeneProduct3135 (Entrez Gene)
HLA-HGeneProduct3136 (Entrez Gene)
HLA-JGeneProduct3137 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
NEDD4GeneProduct4734 (Entrez Gene)
PSMA1GeneProduct5682 (Entrez Gene)
PSMA2GeneProduct5683 (Entrez Gene)
PSMA3GeneProduct5684 (Entrez Gene)
PSMA4GeneProduct5685 (Entrez Gene)
PSMA5GeneProduct5686 (Entrez Gene)
PSMA6GeneProduct5687 (Entrez Gene)
PSMA7GeneProduct5688 (Entrez Gene)
PSMB10GeneProduct5699 (Entrez Gene)
PSMB1GeneProduct5689 (Entrez Gene)
PSMB2GeneProduct5690 (Entrez Gene)
PSMB3GeneProduct5691 (Entrez Gene)
PSMB4GeneProduct5692 (Entrez Gene)
PSMB5GeneProduct5693 (Entrez Gene)
PSMB6GeneProduct5694 (Entrez Gene) U13393
PSMB7GeneProduct5695 (Entrez Gene)
PSMB8GeneProduct5696 (Entrez Gene)
PSMB9GeneProduct5698 (Entrez Gene)
PSMC1GeneProduct5700 (Entrez Gene)
PSMC2GeneProduct5701 (Entrez Gene)
PSMC3GeneProduct5702 (Entrez Gene)
PSMC4GeneProduct5704 (Entrez Gene) PRS6 HUMAN
PSMC5GeneProduct5705 (Entrez Gene)
PSMC6GeneProduct5706 (Entrez Gene)
PSMD10GeneProduct5716 (Entrez Gene)
PSMD11GeneProduct5717 (Entrez Gene)
PSMD12GeneProduct5718 (Entrez Gene)
PSMD13GeneProduct5719 (Entrez Gene)
PSMD1GeneProduct5707 (Entrez Gene)
PSMD2GeneProduct5708 (Entrez Gene)
PSMD3GeneProduct5709 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PSMD5GeneProduct5711 (Entrez Gene)
PSMD6GeneProduct9861 (Entrez Gene)
PSMD7GeneProduct5713 (Entrez Gene)
PSMD8GeneProduct5714 (Entrez Gene)
PSMD9GeneProduct5715 (Entrez Gene)
PSME1GeneProduct5720 (Entrez Gene)
PSME2GeneProduct5721 (Entrez Gene)
PSME3GeneProduct10197 (Entrez Gene)
RPN1GeneProduct6184 (Entrez Gene)
RPN2GeneProduct6185 (Entrez Gene)
UBBGeneProductENSG00000170315 (Ensembl)
UBCGeneProduct7316 (Entrez Gene)
UBE1GeneProduct7317 (Entrez Gene)
UBE1LGeneProduct7318 (Entrez Gene)
UBE2BGeneProduct7320 (Entrez Gene)
UBE2D1GeneProduct7321 (Entrez Gene)
UBE2D2GeneProduct7322 (Entrez Gene)
UBE2D3GeneProduct7323 (Entrez Gene)
UCHL1GeneProductENSG00000154277 (Ensembl)
UCHL3GeneProductENSG00000118939 (Ensembl)
UbiquitinProteinP0CG48 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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